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Journal J Acquir Immune Defic Syndr

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Resilience and Frailty in People Living With HIV During the COVID Era: Two Complementary Constructs Associated With Health-Related Quality of Life.

Giovanni Guaraldi, Jovana Milic, Sara Barbieri, Tommaso Marchiò, Agnese Caselgrandi, Sara Volpi, Emanuele Aprile, Michela Belli, Maria Venuta, Cristina Mussini,

<h4>Background</h4>Resilience is defined as an individual's positive adaptation to stressors. The COVID-19 pandemic represents a generalized stressor which may affect differently people living with HIV (PLWH). The objective of this study was to characterize resilience in PLWH with particular regarding the identification of frailty-resilience phenotypes, which may differently affect health-related ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(Suppl 1):S65-S72]

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Effects of Aging on Metabolic Characteristics of Human B Cells.

Daniela Frasca, Suresh Pallikkuth, Savita Pahwa,

<h4>Abstract</h4>Metabolic changes represent the most common sign of aging and lead to increased risk of developing diseases typical of old age. Age-associated metabolic changes, such as decreased insulin sensitivity, decreased mitochondrial function, and dysregulated nutrient uptake, fuel the low-grade chronic systemic inflammation, known as inflammaging, a leading cause of morbidity ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(Suppl 1):S23-S28]

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Mental Health Mediates the Association Between Gender-Based Violence and HIV Treatment Engagement in US Women.

Amy A Conroy, Jennifer P Jain, Lila Sheira, Edward A Frongillo, Torsten B Neilands, Mardge H Cohen, Tracey E Wilson, Aruna Chandran, Adaora A Adimora, Seble Kassaye, Anandi N Sheth, Margaret A Fischl, Adebola Adedimeji, Janet M Turan, Phyllis C Tien, Sheri D Weiser,

<h4>Background</h4>Gender-based violence (GBV) is associated with poorer engagement in HIV care and treatment. However, there is a dearth of research on the psychological (eg, mental health) and structural (eg, food insecurity) factors that mediate and moderate this association. GBV could lead to poor mental health, which in turn affects adherence, ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(2):151-158]

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HIV, Aging, and Comorbidities Research in Clinical Cohorts: 3 Lessons Learned Using Examples From the CNICS Cohort.

Heidi M Crane, Lydia Drumright,

<h4>Background</h4>Owing to ongoing improvements in antiretroviral therapy, people with HIV (PWH) are achieving near-normal lifespans with many surviving into middle and old age. Despite this success, PWH have a higher than expected risk of developing non-AIDS comorbidities, multimorbidity, and functional decline at ages younger than those without HIV.<h4>Methods</h4>As part of ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(Suppl 1):S10-S14]

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Human Immunodeficiency Virus transmission by HIV Risk Group and Along the HIV Care Continuum: A Contrast of 6 US Cities.

Xiao Zang, Cassandra Mah, Amanda My Linh Quan, Jeong Eun Min, Wendy S Armstrong, Czarina N Behrends, Carlos Del Rio, Julia C Dombrowski, Daniel J Feaster, Gregory D Kirk, Brandon D L Marshall, Shruti H Mehta, Lisa R Metsch, Ankur Pandya, Bruce R Schackman, Steven Shoptaw, Steffanie A Strathdee, Emanuel Krebs, Bohdan Nosyk, ,

<h4>Background</h4>Understanding the sources of HIV transmission provides a basis for prioritizing HIV prevention resources in specific geographic regions and populations. This study estimated the number, proportion, and rate of HIV transmissions attributable to individuals along the HIV care continuum within different HIV transmission risk groups in 6 US cities.<h4>Methods</h4>We used ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(2):143-150]

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Randomized, Blinded, Placebo-Controlled Trial of De Simone Formulation Probiotic During HIV-Associated Suboptimal CD4+ T Cell Recovery.

Rodney K Rousseau, Sharon L Walmsley, Terry Lee, Ron Rosenes, Robert J Reinhard, Fat Malazogu, Erika Benko, Sanja Huibner, Colin M Kovacs, Joel Singer, Connie J Kim, Rupert Kaul,

<h4>Objective</h4>To assess whether probiotic supplementation may reduce disease-linked systemic immune activation in people living with HIV with the immunologic nonresponder phenotype.<h4>Design</h4>Phase 2b, randomized, double-blind, placebo-controlled pilot trial.<h4>Methods</h4>HIV-positive individuals with blood CD4+ T-cell counts <350/mm3 despite viral suppression were randomized to 2:1 to receive De Simone Formulation Probiotic (DSFP; "Visbiome" commercially) ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(2):199-207]

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Single Oral Doses of MK-8507, a Novel Non-Nucleoside Reverse Transcriptase Inhibitor, Suppress HIV-1 RNA for a Week.

Dirk Schürmann, Deanne Jackson Rudd, Andrea Schaeffer, Inge De Lepeleire, Evan J Friedman, Martine Robberechts, Saijuan Zhang, Yang Liu, Bhargava Kandala, Christian Keicher, Martin Däumer, Jörg Hofmann, Jay A Grobler, S Aubrey Stoch, Marian Iwamoto, Wendy Ankrom,

<h4>Background</h4>MK-8507 is a novel HIV-1 non-nucleoside reverse transcriptase inhibitor being developed for treatment of HIV-1 infection. MK-8507 has high antiviral potency in vitro and pharmacokinetic (PK) properties that support once-weekly dosing.<h4>Setting</h4>A phase 1, open-label, proof-of-concept study was conducted in treatment-naive adults with HIV-1 infection to assess monotherapy antiviral activity.<h4>Methods</h4>In 3 ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(2):191-198]

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HIV Disease Dynamics and Markers of Inflammation and CNS Injury During Primary HIV Infection and Their Relationship to Cognitive Performance.

August A Longino, Robert Paul, Yixin Wang, Javier R Lama, Peter Brandes, Eduardo Ruiz, Cecilia Correa, Sheila Keating, Serena S Spudich, Christopher Pilcher, Alyssa Vecchio, Siavash Pasalar, Rachel A Bender Ignacio, Rogelio Valdez, Sayan Dasgupta, Kevin Robertson, Ann Duerr,

<h4>Introduction</h4>Early systemic and central nervous system viral replication and inflammation may affect brain integrity in people with HIV, leading to chronic cognitive symptoms not fully reversed by antiretroviral therapy (ART). This study examined associations between cognitive performance and markers of CNS injury associated with acute HIV infection and ART.<h4>Methods</h4>HIV-infected MSM ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(2):183-190]

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Chronic HIV Infection and Aging: Application of a Geroscience-Guided Approach.

Mary C Masters, Alan L Landay, Paul D Robbins, Tamar Tchkonia, James L Kirkland, George A Kuchel, Laura J Niedernhofer, Frank J Palella,

<h4>Abstract</h4>The ability of virally suppressive antiretroviral therapy use to extend the life span of people with HIV (PWH) implies that the age of PWH will also increase. Among PWH, extended survival comes at a cost of earlier onset and increased rates of aging-associated comorbidities and geriatric syndromes, with persistent inflammation ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(Suppl 1):S34-S46]

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HIV and Aging in the Era of ART and COVID-19: Symposium Overview.

Monty Montano, Alan Landay, Molly Perkins, Marcia Holstad, Suresh Pallikkuth, Savita Pahwa, ,

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(Suppl 1):S3-S9]

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An Epidemic of Pediatric HIV From Reuse of Infusion Equipment in Pakistan.

Muhammad Asif Syed, Adnan Khan, Ambreen Chaudhry, Mirza Amir Baig, Naveed Masood Memon, Santosh Kumar, Saeed Ahmed Bhurt, Munaza Qadri, Anum Vighio, Zeeshan Iqbal Baig, Elizabeth M Rabold, Hammad Ali, Curtis Blanton, Rana Jawad Asghar, Aamer Ikram, Musa Rahim, Masood Solangi, Palitha Mahipala, Robert E Fontaine,

<h4>Background</h4>From April to June 2019, a total of 909 new HIV infections were identified in Larkana, Pakistan; 86% was children younger than 15 years. To identify the possible transmission links in this outbreak, a case-control study was conducted in June 2019.<h4>Methods</h4>For cases, we selected a systematic random sample of 100 ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(2):121-128]

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Associations Between Central Obesity and Lifelong Antiviral Therapy in Adults Living With HIV Acquired From Early Childhood.

Seynt Jiro Sahagun, Teja Yeramosu, Julia B Purdy, James C Reynolds, Colleen M Hadigan,

<h4>Background</h4>Little is known regarding the long-term effects of antiretroviral (ARV) exposure on body composition for people living with HIV (PLWH) since early childhood. This study explores changes in body fat distribution in relation to ARV exposure.<h4>Methods</h4>We conducted a prospective study of adults with perinatal HIV (n = 70) using dual-energy ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(2):208-214]

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Age-Associated Gut Dysbiosis, Marked by Loss of Butyrogenic Potential, Correlates With Altered Plasma Tryptophan Metabolites in Older People Living With HIV.

Smita Ghare, Richa Singhal, Vaughn Bryant, Sabina Gautam, Chanakya Charan Tirumala, Praneet Kumar Srisailam, Andrea Reyes-Vega, Dushan Ghooray, Craig J McClain, Kristi Hoffman, Joseph Petrosino, Kendall Bryant, Varan Govind, Ronald Cohen, Robert L Cook, Shirish Barve,

<h4>Background</h4>Imbalance in tryptophan (TRP) metabolism and its neuroactive metabolites, serotonin and kynurenine (KYN), is a known pathogenic mechanism underlying neurocognitive impairment. Gut microbiota plays an important role in TRP metabolism, and the production of these neuroactive molecules affects neurocognitive function. Although both HIV infection and normal aging independently induce gut ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(Suppl 1):S56-S64]

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Reduced Levels of NAD in Skeletal Muscle and Increased Physiologic Frailty Are Associated With Viral Coinfection in Asymptomatic Middle-Aged Adults.

Thanh Tran, Karol M Pencina, Michael B Schultz, Zhuoying Li, Catherine Ghattas, Jackson Lau, David A Sinclair, Monty Montano,

<h4>Background</h4>People living with HIV (PLWH) are disproportionately burdened with multimorbidity and decline in physiologic function compared with their uninfected counterparts, but biological mechanisms that differentially contribute to the decline in muscle function in PLWH compared with uninfected people remain understudied.<h4>Setting</h4>The study site was Brigham and Women's Hospital, Harvard Medical School, ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(Suppl 1):S15-S22]

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DigiPrEP: A Pilot Trial to Evaluate the Feasibility, Acceptability, and Accuracy of a Digital Pill System to Measure PrEP Adherence in Men Who Have Sex With Men Who Use Substances.

Peter R Chai, Yassir Mohamed, Maria J Bustamante, Georgia R Goodman, Jesse Najarro, Jose Castillo-Mancilla, Alejandro Baez, Olivia Bronzi, Matthew C Sullivan, Luis M Pereira, Susan L Baumgartner, Tony C Carnes, Kenneth H Mayer, Rochelle K Rosen, Edward W Boyer, Conall O'Cleirigh,

<h4>Background</h4>Adherence to once daily oral preexposure prophylaxis (PrEP) for HIV prevention can be challenging for men who have sex with men (MSM) with substance use. Digital pill systems (DPS) comprise a radiofrequency emitter integrated into a gelatin capsule containing PrEP, which transmits data to a wearable Reader following ingestion, thereby ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(2):e5-e15]

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Intimate Partner Violence and the HIV Care and Treatment Cascade Among Adolescent Girls and Young Women in DREAMS, South Africa.

Andrew Gibbs, Tarylee Reddy, Kalysha Closson, Cherie Cawood, David Khanyile, Abigail Hatcher,

<h4>Background</h4>Intimate partner violence (IPV) may affect the HIV-treatment cascade.<h4>Setting</h4>Four high HIV-prevalence DREAMS health districts in South Africa.<h4>Methods</h4>Secondary analysis of cross-sectional data collected March 2017-June 2018, using random household sample of young (12-24 years) girls and women. Face-to-face interviews assessed IPV and HIV-status knowledge, and finger-prick blood draws assessed ART (antiretroviral ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(2):136-142]

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Effect of an Unsanctioned Safe Consumption Site in the United States on Syringe Sharing, Rushed Injections, and Isolated Injection Drug Use: A Longitudinal Cohort Analysis.

Leslie W Suen, Peter J Davidson, Erica N Browne, Barrot H Lambdin, Lynn D Wenger, Alex H Kral,

<h4>Background</h4>HIV and other medical complications of drug use, including overdose, are rising among people who inject drugs in the United States (US). Risk of complications and mortality increase with injection behaviors such as syringe sharing, rushing injections, and injecting in isolated places. Studies suggest safe consumption sites (SCS) reduce high-risk ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(2):172-177]

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Brief Report: No Differences Between Lopinavir/Ritonavir and Nonnucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy on Clearance of Plasmodium falciparum Subclinical Parasitemia in Adults Living With HIV Starting Treatment (A5297).

Douglas Shaffer, Johnstone Kumwenda, Huichao Chen, Victor Akelo, Francis Angira, Josphat Kosgei, Ronald Tonui, Francis Ssali, Ashley McKhann, Evelyn Hogg, V Ann Stewart, Sean C Murphy, Robert Coombs, Robert Schooley, ,

<h4>Background</h4>HIV protease inhibitors anti-Plasmodium falciparum activity in adults remains uncertain.<h4>Methods</h4>Adults with HIV CD4+ counts >200 cells/mm3 starting antiretroviral therapy (ART) with P. falciparum subclinical parasitemia (Pf SCP) were randomized 1:1 to (step 1) protease inhibitor lopinavir/ritonavir (LPV/r)-based (arm A) or nonnucleoside reverse transcriptase inhibitor (nNRTI)-based ART (arm B) for 15 ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(2):178-182]

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Long-term HIV Pre-exposure Prophylaxis Trajectories Among Racial & Ethnic Minority Patients: Short, Declining, & Sustained Adherence.

Maria Pyra, Russell Brewer, Laura Rusie, Jeanelle Kline, India Willis, John Schneider,

<h4>Background</h4>HIV pre-exposure prophylaxis (PrEP) requires continued use at an effective dosage to reduce HIV incidence. Data suggest early PrEP drop-off among many populations. We sought to describe PrEP use over the first year among racial and ethnic minority patients in the US.<h4>Setting</h4>Racial and ethnic minority patients initiating PrEP at a ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(2):166-171]

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Differential Associations Between BDNF and Memory Across Older Black and White Adults With HIV Disease.

Pariya L Fazeli, Steven P Woods, Crystal C Lambert, Wei Li, Cierra N Hopkins, David E Vance,

<h4>Background</h4>Brain-derived neurotrophic factor (BDNF) shows consistent associations with memory across many clinical populations, including dementia. Less is understood about the association between BDNF and memory functioning in people living with HIV (PWH).<h4>Methods</h4>A sample of 173 adults aged 50+ (n = 100 HIV+ and n = 73 HIV seronegative) completed a ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(2):129-135]

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Aging With Grace for People Living With HIV: Strategies to Overcome Leaky Gut and Cytomegalovirus Coinfection.

Jean-Pierre Routy, Léna Royston, Stéphane Isnard,

<h4>Abstract</h4>The intestinal epithelial layer acts as a mechanical and functional barrier between the intraluminal microbiota and the immunologically active submucosa. A progressive loss of gut barrier function (leaky gut) leads to enhanced translocation of microbial products, which in turn contributes as endotoxins to inflammaging. Th17 T cell represents the main ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(Suppl 1):S29-S33]

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HIV and Aging in the Era of ART and COVID-19.

Suresh Pallikkuth, Savita Pahwa,

<h4>Abstract</h4>Our understanding of HIV/AIDS has been reframed during the recent past because the use of novel antiretroviral therapy has enabled clinicians and patients to control the progression of the disease. This supplement provides an overview of the HIV and Aging in the Era of ART and COVID-19, a virtual symposium ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(Suppl 1):S1-S2]

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Association of Poor Sleep With Depressive and Anxiety Symptoms by HIV Disease Status: Women's Interagency HIV Study.

Elizabeth Daubert, Audrey L French, Helen J Burgess, Anjali Sharma, Deborah Gustafson, Sushma K Cribbs, Deborah Jones Weiss, Catalina Ramirez, Deborah Konkle-Parker, Seble Kassaye, Kathleen M Weber,

<h4>Background</h4>Sleep disturbances are prevalent in women living with HIV (WLWH) and can affect mental health and overall quality of life. We examined the prevalence and predictors of poor sleep quality in a US cohort of WLWH and HIV-uninfected controls and the relationship between sleep quality and mental health symptom burden ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(2):222-230]

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A Counseling and Monitoring Approach for Supporting Breastfeeding Women Living With HIV in Botswana.

Lena J Volpe, Kathleen M Powis, Justine Legbedze, Shan Sun, Elaine J Abrams, Nicholas K Mmasa, Samuel Kgole, Gosego Masasa, Joseph Makhema, Mompati Mmalane, Jennifer Jao,

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(2):e16]

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HIV-1 Treatment Failure, Drug Resistance, and Clinical Outcomes in Perinatally Infected Children and Adolescents Failing First-Line Antiretroviral Therapy in Western Kenya.

Winstone Nyandiko, Sabina Holland, Rachel Vreeman, Allison K DeLong, Akarsh Manne, Vladimir Novitsky, Festus Sang, Celestine Ashimosi, Anthony Ngeresa, Ashley Chory, Josephine Aluoch, Millicent Orido, Eslyne Jepkemboi, Soya S Sam, Angela M Caliendo, Samuel Ayaya, Joseph W Hogan, Rami Kantor, ,

<h4>Background</h4>Long-term impact of drug resistance in perinatally infected children and adolescents living with HIV (CALWH) is poorly understood. We determined drug resistance and examined its long-term impact on failure and mortality in Kenyan CALWH failing first-line non-nucleoside reverse transcriptase inhibitor-based antiretroviral therapy (ART).<h4>Setting</h4>Academic Model Providing Access to Healthcare, western Kenya.<h4>Methods</h4>Participants ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2022, 89(2):231-239]

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