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Journal J Acquir Immune Defic Syndr

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Clinical Outcomes and Inflammatory Markers by HIV Serostatus and Viral Suppression in a Large Cohort of Patients Hospitalized With COVID-19.

Viraj V Patel, Uriel R Felsen, Molly Fisher, Melissa J Fazzari, Mindy S Ginsberg, Robert Beil, Matthew J Akiyama, Kathryn Anastos, David B Hanna,

<h4>Background</h4>Limited data exist about clinical outcomes and levels of inflammatory and immune markers among people hospitalized with COVID-19 by HIV serostatus and by HIV viral suppression.<h4>Setting</h4>Large tertiary care health system in the Bronx, NY, USA.<h4>Methods</h4>We conducted a retrospective cohort study of 4613 SARS-CoV-2 PCR-positive patients admitted between March 10, 2020, ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):224-230]

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Near Point-of-Care HIV Viral Load: Targeted Testing at Large Facilities.

Prakash Ganesh, Tom Heller, Boniface Chione, Joe Gumulira, Salem Gugsa, Shaukat Khan, Seth McGovern, Angellina Nhlema, Lyse Nkhoma, Jilian A Sacks, Clement Trapence, Hannock Tweya, Peter Ehrenkranz, Sam Phiri,

<h4>Introduction</h4>Point-of-care (POC) technologies in resource-limited settings can circumvent challenges of centralized laboratory testing, improving clinical management. However, higher device costs and uncertain indications for use have inhibited scaling up POC modalities. To address this gap, we investigated the feasibility and cost of targeted near-POC viral load (VL) testing in 2 ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):258-263]

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Embedding a Linkage to Preexposure Prophylaxis Care Intervention in Social Network Strategy and Partner Notification Services: Results From a Pilot Randomized Controlled Trial.

Daniel Teixeira da Silva, Alida Bouris, Arthi Ramachandran, Olivia Blocker, Billy Davis, James Harris, Maria Pyra, Laura K Rusie, Russell Brewer, Jade Pagkas-Bather, Anna Hotton, Jessica P Ridgway, Moira McNulty, Ramona Bhatia, John A Schneider,

<h4>Background</h4>Increased preexposure prophylaxis (PrEP) uptake among black men who have sex with men and black transgender women (BMSM/TW) is needed to end the HIV epidemic. Embedding a brief intervention in network services that engage individuals in HIV transmission networks for HIV/ sexually transmitted infections testing may be an important strategy ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):191-199]

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Brief Report: Seroadaptive Behaviors Varied Among Geographically Diverse iPrEx Participants.

Hong-Ha M Truong, Megha L Mehrotra, Robert M Grant, ,

<h4>Background</h4>Seroadaptive behaviors refer to a wide range of harm reduction practices to decrease HIV transmission risk. Effective implementation of seroadaptive behaviors is dependent on knowledge of one's own serostatus and that of one's sexual partners. Partner-level and environmental-level attributes may affect seroadaptation practices. We assessed factors associated with seroadaptive behaviors.<h4>Methods</h4>Men ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):e43-e47]

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Brief Report: Differences in Types of Myocardial Infarctions Among People Aging With HIV.

Heidi M Crane, Robin M Nance, Bridget M Whitney, Susan R Heckbert, Matthew Budoff, Kevin High, Alan Landay, Matthew Feinstein, Richard D Moore, William Christopher Mathews, Katerina Christopoulos, Michael S Saag, Amanda Willig, Joseph J Eron, Mari M Kitahata, Joseph A C Delaney, ,

<h4>Background</h4>Type 1 myocardial infarctions (T1MIs) result from atherosclerotic plaque instability, rupture, and/or erosion. Type 2 MIs (T2MIs) are secondary to causes such as sepsis and cocaine-induced vasospasm resulting in an oxygen demand-supply mismatch and are associated with higher mortality than T1MIs. T2MIs account for a higher proportion of MIs among ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):208-212]

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COVID-19 Related Medical Mistrust, Health Impacts, and Potential Vaccine Hesitancy Among Black Americans Living With HIV.

Laura M Bogart, Bisola O Ojikutu, Keshav Tyagi, David J Klein, Matt G Mutchler, Lu Dong, Sean J Lawrence, Damone R Thomas, Sarah Kellman,

<h4>Background</h4>Medical mistrust, a result of systemic racism, is prevalent among Black Americans and may play a role in COVID-19 inequities. In a convenience sample of HIV-positive Black Americans, we examined associations of COVID-19-related medical mistrust with COVID-19 vaccine and COVID-19 treatment hesitancy and negative impacts of COVID-19 on antiretroviral therapy ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):200-207]

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Expanding the Vision for Differentiated Service Delivery: A Call for More Inclusive and Truly Patient-Centered Care for People Living With HIV.

Peter Ehrenkranz, Anna Grimsrud, Charles B Holmes, Peter Preko, Miriam Rabkin,

<h4>Background</h4>Simplifying antiretroviral therapy for clinically stable people living with HIV (PLHIV) is important but insufficient to meet their health care needs, including prevention and treatment of tuberculosis and noncommunicable diseases, routine primary care, and family planning. Integrating these services into differentiated service delivery (DSD) platforms is a promising avenue to ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):147-152]

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Brief Report: Drug Overdose Deaths Among People With HIV in New York City, 2007-2017.

Sarah L Braunstein, Rebekkah S Robbins, Chitra Ramaswamy, Demetre C Daskalakis,

<h4>Background</h4>Preventable deaths, including those because of drug overdose (OD), are a significant public health concern in New York City (NYC). Trends in drug OD death among people with HIV (PWH) in NYC have not been described.<h4>Methods</h4>We selected PWH from the NYC HIV Registry who died during 2007-2017, resided in NYC ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):e18-e22]

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Brief Report: Changes in PrEP Use, Sexual Practice, and Use of Face Mask During Sex Among MSM During the Second Wave of COVID-19 in Melbourne, Australia.

Eric P F Chow, Jane S Hocking, Jason J Ong, Tiffany R Phillips, Tina Schmidt, Andrew Buchanan, Elena Rodriguez, Kate Maddaford, Christopher K Fairley,

<h4>Background</h4>A second wave of COVID-19 began in late June in Victoria, Australia. Stage 3 then Stage 4 restrictions were introduced in July-August. This study aimed to compare the use of pre-exposure prophylaxis (PrEP) and sexual practices among men who have sex with men taking PrEP between May-June (post-first lockdown) and ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):153-156]

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Brief Report: Group Sex Among Men Who Have Sex With Men in the Era of PrEP: A Cross-Sectional Study.

Tiffany R Phillips, Christopher K Fairley, Catriona S Bradshaw, Jane S Hocking, Edmond P H Choi, Jason J Ong, Marjan Tabesh, Kate Maddaford, Eric P F Chow,

<h4>Background</h4>Group sex has been commonly reported among gay and bisexual men who have sex with men (GBMSM); however, there are limited studies on the factors associated with participating in group sex.<h4>Setting</h4>A cross-sectional study among GBMSM attending a sexual health clinic in Melbourne, Australia.<h4>Methods</h4>Univariable and multivariable logistic regression were performed to ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):e23-e27]

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Effectiveness and Safety of Interferon-Free Direct-Acting Antiviral Hepatitis C Virus Therapy in HIV/Hepatitis C Virus Coinfected Individuals: Results From a Pan-European Study.

Sarah Amele, Lars Peters, Alison Rodger, Jens Lundgren, Jurgen Rockstroh, Raimonda Matulionyte, Clifford Leen, Elzbieta Jabłonowska, Lars Østergaard, Sanjay Bhagani, Mario Sarcletti, Amanda Clarke, Karolin Falconer, Gilles Wandeler, Pere Domingo, Fernando Maltez, Mauro Zaccarelli, Nikoloz Chkhartisvili, Janos Szlavik, Christoph Stephan, Laurent Fonquernie, Inka Aho, Amanda Mocroft, ,

<h4>Objectives</h4>To investigate the effectiveness, safety, and reasons for premature discontinuation of direct-acting antivirals (DAAs) in a diverse population of HIV/hepatitis C virus (HCV) coinfected individuals in Europe.<h4>Methods</h4>All HIV/HCV coinfected individuals in the EuroSIDA study that started interferon free DAA treatment between January 6, 2014, and January 3, 2018, with ≥12 ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):248-257]

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Brief Report: Syphilis Incidence and Effect on Viral Load, CD4, and CD4/CD8 Ratio in a Thai Cohort of Predominantly Men Who Have Sex With Men Living With HIV.

Camilla Muccini, Trevor A Crowell, Suteeraporn Pinyakorn, Eugène Kroon, Carlo Sacdalan, Jintanat Ananworanich, Sandhya Vasan, Nittaya Phanuphak, Donn J Colby, ,

<h4>Background</h4>Syphilis has been increasing in the past years, especially among men who have sex with men (MSM). The aim of the study was to assess syphilis prevalence and incidence and changes in CD4 count and viremia in the RV254 cohort of persons living with HIV who initiated antiretroviral therapy during ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):219-223]

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Mathematical Model Impact Analysis of a Real-Life Pre-exposure Prophylaxis and Treatment-As-Prevention Study Among Female Sex Workers in Cotonou, Benin.

Lily Geidelberg, Kate M Mitchell, Michel Alary, Aminata Mboup, Luc Béhanzin, Fernand Guédou, Nassirou Geraldo, Ella Goma-Matsétsé, Katia Giguère, Marlène Aza-Gnandji, Léon Kessou, Mamadou Diallo, René K Kêkê, Moussa Bachabi, Kania Dramane, Christian Lafrance, Dissou Affolabi, Souleymane Diabaté, Marie-Pierre Gagnon, Djimon M Zannou, Flore Gangbo, Romain Silhol, Fiona Cianci, Peter Vickerman, Marie-Claude Boily,

<h4>Background</h4>Daily pre-exposure prophylaxis (PrEP) and treatment-as-prevention (TasP) reduce HIV acquisition and transmission risk, respectively. A demonstration study (2015-2017) assessed TasP and PrEP feasibility among female sex workers (FSW) in Cotonou, Benin.<h4>Setting</h4>Cotonou, Benin.<h4>Methods</h4>We developed a compartmental HIV transmission model featuring PrEP and antiretroviral therapy (ART) among the high-risk (FSW and clients) ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):e28-e42]

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Brief Report: Virologic and Immunologic Outcomes for HIV Patients With Coronavirus Disease 2019.

Rong Hu, Han Yan, Manqing Liu, Li Tang, Wenhua Kong, Zerong Zhu, Pan Liu, Wenjuan Bai, Xuejiao Hu, Jie Ding, Xia Wang, Nianhua Xie,

<h4>Background</h4>To describe the virologic and immunologic outcomes among people living with HIV (PLHIV) coinfected with SARS-CoV-2.<h4>Setting</h4>Wuhan, China.<h4>Methods</h4>Thirty-five coinfected patients were identified by matching the reported cases in National Notifiable Infectious Disease Report system for COVID-19 and HIV in Wuhan by time of April 19, 2020. Questionnaire-based survey and follow-up with ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):213-218]

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Clinical, Immunological, and Virological Outcomes Among Youths With Perinatal HIV After Transition to Adult Units in Spain From 1997 to 2016.

David Aguilera-Alonso, Talía Sainz, Santiago Jimenez de Ory, Ignacio Bernardino, Cristina Díez, Berta Torres, Dolores Merino, José A Iribarren, Irene Portilla, María José Ríos, Sofía Ibarra, José Sanz, José María Bellón, Itziar Carrasco, María Ángeles Muñoz-Fernández, José Tomás Ramos, María Luisa Navarro, ,

<h4>Background</h4>Children living with HIV are reaching adulthood and transitioning to adult clinics. This study aimed to describe clinical and immunovirological status after transition in patients with perinatal HIV.<h4>Methods</h4>Patients participating in the Spanish multicenter pediatric HIV cohort (CoRISpe) transferred to adult care (FARO cohort) from 1997 to 2016 were included. Clinical ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):240-247]

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Fecal Calprotectin Is Elevated in HIV and Related to Systemic Inflammation.

Allison Ross Eckard, Heather Y Hughes, Nancy L Hagood, Mary Ann O'Riordan, Danielle Labbato, Julia C Kosco, Sarah E Scott, Grace A McComsey,

<h4>Background</h4>Fecal calprotectin (FC), a biomarker of gastrointestinal (GI) inflammation, is used in the diagnosis and management of inflammatory bowel disease. HIV infection severely damages gut-associated lymphoid and epithelial tissues leading to GI inflammation that drives systemic inflammation and increases subsequent risk of comorbidities. For the first time, we compared FC ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):231-239]

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Benchmarks for HIV Testing: What Is Needed to Achieve Universal Testing Coverage at U.S. Ambulatory Healthcare Facilities.

Karen W Hoover, George M Khalil, Betsy L Cadwell, Charles E Rose, Philip J Peters,

<h4>Background</h4>Black and Hispanic men have the highest rates of HIV diagnoses. To decrease the number of U.S. men who are unaware of their HIV status, they should be tested at least once. Our objective was to estimate the increases needed in HIV testing rates at ambulatory health care visits to ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):e48-e53]

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Development of a Mathematical Model to Estimate the Cost-Effectiveness of HRSA's Ryan White HIV/AIDS Program.

Ravi Goyal, Cindy Hu, Pamela W Klein, John Hotchkiss, Eric Morris, Paul Mandsager, Stacy M Cohen, Dara Luca, Jessica Gao, Andrew Jones, West Addison, Margaret O'Brien-Strain, Laura W Cheever, Boyd Gilman,

<h4>Background</h4>The Health Resources and Services Administration's Ryan White HIV/AIDS Program provides services to more than half of all people diagnosed with HIV in the United States. We present and validate a mathematical model that can be used to estimate the long-term public health and cost impact of the federal program.<h4>Methods</h4>We ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):164-173]

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Reduction in Stigma Drivers Partially Mediates the Effect of a Stigma Reduction Intervention Among Nursing Students in India: The DriSti Cluster Randomized Controlled Trial.

Krishnamachari Srinivasan, Elsa Heylen, Tony Raj, Laura Nyblade, Dhinagaran Devadass, Matilda Pereira, Maria L Ekstrand,

<h4>Background</h4>HIV stigma in health care settings acts as a significant barrier to health care. Stigma drivers among health professionals include transmission fears and misconceptions and pre-existing negative attitudes toward marginalized groups vulnerable to HIV. The DriSti intervention, consisted of 2 sessions with videos and interactive exercises on a computer tablet ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):182-190]

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Cost-Effectiveness of HRSA's Ryan White HIV/AIDS Program?

Ravi Goyal, Dara Luca, Pamela W Klein, Eric Morris, Paul Mandsager, Stacy M Cohen, Cindy Hu, John Hotchkiss, Jessica Gao, Andrew Jones, West Addison, Margaret O'Brien-Strain, Laura W Cheever, Boyd Gilman,

<h4>Background</h4>With an annual budget of more than $2 billion, the Health Resources and Services Administration's Ryan White HIV/AIDS Program (RWHAP) is the third largest source of public funding for HIV care and treatment in the United States, yet little analysis has been done to quantify the long-term public health and ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):174-181]

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Schistosoma mansoni Infection Is Associated With a Higher Probability of Tuberculosis Disease in HIV-Infected Adults in Kenya.

Taryn A McLaughlin, Azhar Nizam, Felix Odhiambo Hayara, Gregory Sadat Ouma, Angela Campbell, Jeremiah Khayumbi, Joshua Ongalo, Samuel Gurrion Ouma, N Sarita Shah, John D Altman, Deepak Kaushal, Jyothi Rengarajan, Joel D Ernst, Henry M Blumberg, Lance A Waller, Neel R Gandhi, Cheryl L Day, David Benkeser,

<h4>Background</h4>Helminth infections can modulate immunity to Mycobacterium tuberculosis (Mtb). However, the effect of helminths, including Schistosoma mansoni (SM), on Mtb infection outcomes is less clear. Furthermore, HIV is a known risk factor for tuberculosis (TB) disease and has been implicated in SM pathogenesis. Therefore, it is important to evaluate whether ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):157-163]

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Perceived interruptions to HIV prevention and treatment services associated with COVID-19 for gay, bisexual, and other men who have sex with men in 20 countries.

Amrita Rao, Katherine Rucinski, Brooke Jarrett, Benjamin Ackerman, Sara Wallach, Julia Marcus, Tyler Adamson, Alex Garner, Glenn-Milo Santos, Chris Beyrer, Sean Howell, Stefan Baral,

<h4>Background</h4>The coronavirus pandemic has necessitated a range of population-based measures in order to stem the spread of infection. These measures may be associated with disruptions to other health services including for gay, bisexual, and other men who have sex with men (MSM) at risk for or living with HIV. Here, ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
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Youth living with perinatally-acquired HIV have lower physical activity levels as they age compared to HIV-exposed uninfected youth.

Sahera Dirajlal-Fargo, Paige L Williams, Carly Broadwell, Elizabeth J McFARLAND, Kathleen M Powis, Denise L Jacobson, Jennifer Jao, ,

<h4>Background</h4>Few studies have evaluated physical activity patterns or their association with vascular inflammation among youth living with perinatally-acquired HIV (YPHIV).<h4>Methods</h4>We assessed YPHIV and youth perinatally HIV-exposed but uninfected (YPHEU) in the PHACS Adolescent Master Protocol with at least one Block physical activity questionnaire (PAQ) completed between ages 7-19 years. Physical ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, :]

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Efficacy, pharmacokinetics and safety over 48 weeks with ibalizumab-based therapy in treatment-experienced adults infected with HIV-1: A Phase 2a study.

Joseph C Gathe, Robin L Hardwicke, Fernando Garcia, Steven Weinheimer, Stanley T Lewis, R Brandon Cash,

<h4>Abstract</h4>Ibalizumab, a humanized monoclonal antibody targeting CD4, blocks HIV-1 entry into cells and is the first FDA-approved long-acting agent for HIV-1 treatment. In this Phase 2a study, 82 HIV-infected adults failing antiretroviral therapy were assigned an individually optimized background regimen (OBR) and randomized 1:1:1 to Arm A (15 mg/kg ibalizumab ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
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Factors Associated With And Characteristic of HIV/Tuberculosis Co-Infection: A Retrospective Analysis of SECOND-LINE Clinical Trial Participants.

Rebecca Trudy Henry, Awachana Jiamsakul, Matthew Law, Marcelo Losso, Adeeba Kamarulzaman, Praphan Phanuphak, Nagalingeswaran Kumarasamy, Sharne Foulkes, Lerato Mohapi, Chidi Nwizu, Robin Wood, Anthony Kelleher, Mark Polizzotto,

<h4>Background</h4>Tuberculosis (TB) is a common infection in people living with HIV. However, the risk factors for HIV/TB co-infection in second-line HIV therapy are poorly understood. We aimed to determine the incidence and risk factors for TB co-infection in SECOND-LINE, an international randomised clinical trial of second-line HIV therapy.<h4>Methods</h4>We did a ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
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