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Journal Ital J Pediatr

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Oral vitamin A supplementation for ROP prevention in VLBW preterm infants.

Francesca Garofoli, Donatella Barillà, Micol Angelini, Iolanda Mazzucchelli, Annalisa De Silvestri, Rosanna Guagliano, Lidia Decembrino, Chryssoula Tzialla,

Vitamin A administration may decrease any stage of retinopathy of prematurity (ROP) in preterm infants. To evaluate whether vitamin A oral supplementation could be preventive in ROP incidence and severity in VLBW infants, we compared results from 31 preterm infants, (< 1500 g or < 32 weeks) who, during a previous investigation, prospectively received 3000 ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):77]

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Prevalence of hypertension in relation to anthropometric indices among secondary adolescents in Mbarara, Southwestern Uganda.

Godfrey Katamba, David Collins Agaba, Richard Migisha, Agnes Namaganda, Rosemary Namayanja, Eleanor Turyakira,

BACKGROUND:Studies investigating the prevalence of hypertension and its correlation with anthropometric indices among adolescents are still scarce compared to those conducted in adults of greater than 40 years. So far, no other study estimating the prevalence and correlates of hypertension among adolescents in Uganda has been found. OBJECTIVE:The purpose of this ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):76]

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The link between varicella and immune system: which children will develop acute cerebellitis?

Elena Bozzola, Rita Carsetti, Eva Piano Mortari, Marco Masci, Giulia Spina, Alberto Villani,

INTRODUCTION:Varicella may complicate with cerebellitis in previously healthy children, requiring hospitalization. Aim of our study was to define whether children who experienced varicella cerebellitis have a normal immune system. METHODS:Patients over 3 years of age admitted at Bambino Gesù Children from January 2006 till June 2016 for cerebellitis in varicella were ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):75]

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What a paediatrician should know about congenital clubfoot.

Daniela Dibello, Valentina Di Carlo, Giulia Colin, Egidio Barbi, Anna M C Galimberti,

Clubfoot is the most frequent congenital malformation of the foot, affecting more than 1-2 subjects per 1.000 newborns. Without appropriate treatment, a child with congenital clubfoot will never be able to walk physiologically with a dramatic impact on the quality of life. In the last decades, different corrective solutions have ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):78]

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Growth patterns and associated risk factors of congenital malformations in twins.

Ettore Piro, Ingrid Anne Mandy Schierz, Gregorio Serra, Giuseppe Puccio, Mario Giuffrè, Giovanni Corsello,

BACKGROUND:The rate of twinning continues to increase due to the combined effect of a rise in parental age and increased use of assisted reproductive technology. The risk of congenital anomalies in twins is higher than in singletons, but it is less well reported in relation to growth patterns. We focused ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):73]

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Association between maternal HIV infection and birthweight in a tertiary hospital in southern Ethiopia: retrospective cohort study.

Andualem Zenebe, Betelhem Eshetu, Samson Gebremedhin,

BACKGROUND:Human Immunodeficiency Virus (HIV) infection and low birth weight (LBW) continue to be significant public health concerns in many low-income countries including Ethiopia. Yet the effect of maternal HIV infection on birth weight has not been thoroughly explored and the existing studies reported opposing findings. We examined the association between ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):70]

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Proteomics analysis of plasma protein changes in patent ductus arteriosus patients.

Cheng Xu, Xiaoqi Su, Yong Chen, Yang Xu, Zhiqi Wang, Xuming Mo,

OBJECTIVE:Patent ductus arteriosus (PDA) is a congenital heart defect with an unclear etiology that occurs commonly among newborns. Adequately understanding the molecular pathogenesis of PDA can contribute to improved treatment and prevention. Plasma proteins may provide evidence to explore the molecular mechanisms of abnormal cardiac development. METHODS:Isobaric tags for relative ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):64]

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The recurrent SETBP1 c.2608G > A, p.(Gly870Ser) variant in a patient with Schinzel-Giedion syndrome: an illustrative case of the utility of whole exome sequencing in a critically ill neonate.

Maria Pia Leone, Pietro Palumbo, Orazio Palumbo, Ester Di Muro, Massimiliano Chetta, Nicola Laforgia, Nicoletta Resta, Alessandro Stella, Stefano Castellana, Tommaso Mazza, Marco Castori, Massimo Carella, Nenad Bukvic,

BACKGROUND:Schinzel-Giedion syndrome (SGS) is a multiple malformation syndrome mainly characterized by severe intellectual disability, distinctive facial features, and multiple congenital anomalies, including skeletal abnormalities, genitourinary and renal malformations, cardiac defects, as well as an increased pediatric cancer risk. Recently, SGS has been associated with de novo heterozygous deleterious variants in ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):74]

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A randomized controlled study of immediate versus delayed umbilical cord clamping in infants born by elective caesarean section.

Giuseppe De Bernardo, Maurizio Giordano, Rita De Santis, Paola Castelli, Desiree Sordino, Daniele Trevisanuto, Giuseppe Buonocore, Serafina Perrone,

BACKGROUND:Delayed umbilical cord clamping is associated with greater haemoglobin concentration and iron storage between 3 and 6 months of life and with less need of blood transfusion and lower incidence of neonatal hypotension compared to early umbilical cord clamping. METHODS:The aim was to test the hypothesis that delayed cord clamping is ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):71]

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The psycho-social effects of COVID-19 on Italian adolescents' attitudes and behaviors.

Carlo Buzzi, Maurizio Tucci, Riccardo Ciprandi, Ilaria Brambilla, Silvia Caimmi, Giorgio Ciprandi, Gian Luigi Marseglia,

BACKGROUND:COVID-19 is an emerging issue that has significant consequences on psycho-social well-being. METHODS:In this regard, a survey was conducted on a large group of adolescents in Italy. The survey investigated four items: concerns and fears, information on the pandemic, provisions of public authorities (e.g., lockdown), and impact on everyday life. ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):69]

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Neonatal ten-year retrospective study on neural tube defects in a second level University Hospital.

Ettore Piro, Gregorio Serra, Ingrid Anne Mandy Schierz, Mario Giuffrè, Giovanni Corsello,

BACKGROUND:Aim of this retrospective study was to describe clinical characteristics, diagnostic work-up, management and follow-up of newborns with neural tube defects (NTDs), admitted to the Mother and Child Department of the University Hospital of Palermo, in a ten years period. METHODS:The medical records of 7 newborns (5 males and 2 ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):72]

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Faecal calprotectin and ultrasonography as non-invasive screening tools for detecting colorectal polyps in children with sporadic rectal bleeding: a prospective study.

Giovanni Di Nardo, Francesco Esposito, Chiara Ziparo, Caterina Strisciuglio, Francesca Vassallo, Marco Di Serafino, Maria Pia Villa, Pasquale Parisi, Melania Evangelisti, Claudia Pacchiarotti, Vito Domenico Corleto,

BACKGROUND:Colorectal polyps are reported in 6,1% of paediatric colonoscopies and in 12% of those performed for lower gastrointestinal bleeding. Although colonoscopy is widely used in paediatric patients, it requires bowel preparation and general anaesthesia or deep sedation, and in rare cases, it can cause complications. Non-invasive screening techniques able to ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):66]

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What's the name? Weight stigma and the battle against obesity.

Rita Tanas, Sergio Bernasconi, Maria Marsella, Giovanni Corsello,

Childhood obesity has spread worldwide, it is on the rise, starts earlier and is more severe, despite all treatment attempts.According to recent studies, weight stigma is a factor that can hinder the success of therapies. Healthcare workers, mainly paediatricians, need to feel the urgency of anti-stigma training. The use of ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):60]

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Jaffe-Campanacci syndrome or neurofibromatosis type 1: a case report of phenotypic overlap with detection of NF1 gene mutation in non-ossifying fibroma.

Silvia Vannelli, Raffaele Buganza, Federica Runfola, Ilaria Mussinatto, Antonio Andreacchio, Luisa de Sanctis,

BACKGROUND:Jaffe-Campanacci syndrome is characterized by multiple non-ossifying fibromas, café-au-lait macules and giant cell granulomas of the jaw. Even if the association between all these peculiar features and neurofibromatosis type 1 have been described, it has not yet been clarified whether Jaffe-Campanacci syndrome represents a distinct entity or it can be ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):58]

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Identified plasma proteins related to vascular structure are associated with coarctation of the aorta in children.

Siyu Ma, Junqiang Zheng, Yang Xu, Zhaocong Yang, Yu Zhu, Xiaoqi Su, Xuming Mo,

BACKGROUND:Coarctation of the aorta (CoA), presenting with local stenosis of the aorta is involved in many cardiovascular processes. However, there has been little research on the mechanism of coarctation of the aorta. METHODS:Altered proteins were identified by isobaric tag for relative and absolute quantitation (iTRAQ) technology in 8 participants, and ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):63]

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Humanization of care in pediatric wards: differences between perceptions of users and staff according to department type.

C Mandato, M A Siano, A G E De Anseris, M Tripodi, G Massa, R De Rosa, M Buffoli, A Lamanna, P Siani, P Vajro,

BACKGROUND:As the quality and quantity of patient-centered care may be perceived differently by recipients and independent observers, assessment of humanization of pediatric care remains an elusive issue. Herein we aim to analyze differences between the degrees of verified existing vs. perceived humanization issues of a pediatric ward. Furthermore, we examine ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):65]

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The Italian paediatric society raccomandations on children and adolescents extra-domestic activities during the SARS COV-2 emergency phase 2.

Alberto Villani, Elena Bozzola, Paolo Siani, Giovanni Corsello,

BACKGROUND:Due to novel coronavirus infection emergency, restricting measures have been imposed in Italy. As well as adults, also children are limited in their daily routine. MAIN TEXT:As the lockdown period is expected to end on 3rd May 2020, we discuss the opportunity for children to practice safely recreational or physical ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):62]

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Genetics of atrioventricular canal defects.

Flaminia Pugnaloni, Maria Cristina Digilio, Carolina Putotto, Enrica De Luca, Bruno Marino, Paolo Versacci,

Atrioventricular canal defect (AVCD) represents a quite common congenital heart defect (CHD) accounting for 7.4% of all cardiac malformations. AVCD is a very heterogeneous malformation that can occur as a phenotypical cardiac aspect in the context of different genetic syndromes but also as an isolated, non-syndromic cardiac defect. AVCD has ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):61]

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Judicial outcome and follow up of abused child protection acts in a pediatric emergency department: 12-year experience in a third level pediatric hospital.

Federico Poropat, Arianna Canuto, Giulia Caddeo, Erica Predonzani, Laura Novello, Alessandra Zorzetto, Claudio Germani, Egidio Barbi,

BACKGROUND:Italian laws allow the protection of a child who is suspected to be a victim of abuse through a procedure that can be put in motion by the attending physician in any Emergency Department (article nr. 403 Civil Code) with a temporarily suspension of parental authority. This study aims at ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):59]

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The development of a Consensus Conference on Pediatric Procedural Sedation in the Emergency Department in Italy: from here where to?

Idanna Sforzi, Silvia Bressan, Claudia Saffirio, Salvatore De Masi, Leonardo Bussolin, Liviana Da Dalt, Fabio De Iaco, Itai Shavit, Baruch Krauss, Egidio Barbi, ,

BACKGROUND:In Italy, as in many European countries, Pediatric Emergency Medicine is not formally recognized as a pediatric subspecialty, hindering nation-wide adoption of standards of care, especially in the field of procedural sedation and analgesia (PSA) in the Emergency Department (ED). For this reason PSA in Italy is mostly neglected or ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):57]

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Clinical and molecular features of children with Beckwith-Wiedemann syndrome in China: a single-center retrospective cohort study.

Ruixue Wang, Yongmei Xiao, Dan Li, Hui Hu, Xiaolu Li, Ting Ge, Ronghua Yu, Yizhong Wang, Ting Zhang,

BACKGROUND:Beckwith-Wiedemann syndrome (BWS) is a genetic overgrowth disorder with variable clinical features and cancer predisposition. In this study, we aim to characterize the clinical features and molecular defects of BWS patients in China. METHODS:Thirty-one patients with clinical suspicion of BWS were retrospectively recruited to the study from Shanghai Children's Hospital ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):55]

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A case series of CHARGE syndrome: identification of key features for a neonatal diagnosis.

Maria Francesca Bedeschi, Beatrice Letizia Crippa, Lorenzo Colombo, Martina Buscemi, Cesare Rossi, Roberta Villa, Silvana Gangi, Odoardo Picciolini, Claudia Cinnante, Viola Giulia Carlina Fergnani, Paola Francesca Ajmone, Elisa Scola, Fabio Triulzi, Fabio Mosca,

BACKGROUND:An early diagnosis of CHARGE syndrome is challenging, especially for the primary care physicians who often take care of neonates with multiple congenital anomalies. Here we report eight cases of CHARGE syndrome whose diagnosis was made early in life with the intent to identify the most helpful features allowing a ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):53]

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Risk factors and treatments for disseminated intravascular coagulation in neonates.

Hayato Go, Hitoshi Ohto, Kenneth E Nollet, Nozomi Kashiwabara, Kei Ogasawara, Mina Chishiki, Shun Hiruta, Ichiri Sakuma, Yukihiko Kawasaki, Mitsuaki Hosoya,

BACKGROUND:Although disseminated intravascular coagulation (DIC) is a critical disease, there is few gold standard interventions in neonatal medicine. The aim of this study is to reveal factors affecting neonatal DIC at birth and to assess the effectiveness of rTM and FFP for DIC in neonates at birth. METHODS:We retrospectively evaluated ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):54]

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Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far.

Domenico Umberto De Rose, Fiammetta Piersigilli, Maria Paola Ronchetti, Alessandra Santisi, Iliana Bersani, Andrea Dotta, Olivier Danhaive, Cinzia Auriti, ,

Recently, an outbreak of viral pneumonitis in Wuhan, Hubei, China successively spread as a global pandemia, led to the identification of a novel betacoronavirus species, the 2019 novel coronavirus, successively designated 2019-nCoV then SARS-CoV-2). The SARS-CoV-2 causes a clinical syndrome designated coronavirus disease 2019 (COVID19) with a spectrum of manifestations ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):56]

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The effect of massage on feeding intolerance in preterm infants: a systematic review and meta-analysis study.

Leila Seiiedi-Biarag, Mojgan Mirghafourvand,

BACKGROUND:Feeding intolerance in premature infants is one of the main causes of their long-term hospitalization in NICUs. Massage therapy is a cost-effective intervention that has a positive impact on the health of infants and their parents. This systematic review investigates the effect of massage on feeding intolerance in preterm infants. ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):52]

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