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Journal Invest. Ophthalmol. Vis. Sci.

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A Deep Learning Approach to Digitally Stain Optical Coherence Tomography Images of the Optic Nerve Head.

Sripad Krishna Devalla, Khai Sing Chin, Jean-Martial Mari, Tin A Tun, Nicholas G Strouthidis, Tin Aung, Alexandre H Thiéry, Michaël J A Girard,

To develop a deep learning approach to digitally stain optical coherence tomography (OCT) images of the optic nerve head (ONH).A horizontal B-scan was acquired through the center of the ONH using OCT (Spectralis) for one eye of each of 100 subjects (40 healthy and 60 glaucoma). All images were enhanced ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2018, 59(1):63-74]

Cited: 12 times

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The Prognostic Value of AJCC Staging in Uveal Melanoma Is Enhanced by Adding Chromosome 3 and 8q Status.

Mehmet Dogrusöz, Mette Bagger, Sjoerd G van Duinen, Wilma G Kroes, Claudia A L Ruivenkamp, Stefan Böhringer, Klaus Kaae Andersen, Gregorius P M Luyten, Jens F Kiilgaard, Martine J Jager,

The American Joint Committee on Cancer (AJCC) staging system has been validated for use as a prognostic parameter in uveal melanoma (UM). We studied whether adding information regarding chromosome 3 and 8q status further enhances the prognostic value of this staging system.We retrospectively studied a cohort of 522 patients who ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2017, 58(2):833-842]

Cited: 17 times

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Automated Quantification of Nonperfusion in Three Retinal Plexuses Using Projection-Resolved Optical Coherence Tomography Angiography in Diabetic Retinopathy.

Miao Zhang, Thomas S Hwang, Changlei Dongye, David J Wilson, David Huang, Yali Jia,

Purpose:The purpose of this study was to evaluate an automated algorithm for detecting avascular area (AA) in optical coherence tomography angiograms (OCTAs) separated into three individual plexuses using a projection-resolved technique. Methods:A 3 × 3 mm macular OCTA was obtained in 13 healthy and 13 mild nonproliferative diabetic retinopathy (NPDR) ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2016, 57(13):5101-5106]

Cited: 42 times

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Retinal ischemia/reperfusion injury is mediated by Toll-like receptor 4 activation of NLRP3 inflammasomes.

Yun Qi, Min Zhao, Yujing Bai, Lvzhen Huang, Wenzhen Yu, Zongmei Bian, Mingwei Zhao, Xiaoxin Li,

Retinal ischemia/reperfusion (IR) is common in eye disorders. Pattern-recognition receptors (PRRs) are reported to initiate sterile inflammatory response. The role of PRRs in retinal IR injury is currently unknown. Thus, we investigated the expression and function of membrane and cytoplasmic PRRs during retinal IR.Retinal IR was induced in adult Brown ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2014, 55(9):5466-5475]

Cited: 30 times

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The roles of urokinase-type plasminogen activator in leukocyte infiltration and inflammatory responses in mice corneas treated with lipopolysaccharide.

Koji Sugioka, Aya Kodama, Koji Yoshida, Kiyotaka Okada, Hiroshi Mishima, Keiichi Aomatsu, Osamu Matsuo, Yoshikazu Shimomura,

PURPOSE: Urokinase-type plasminogen activator (u-PA) plays an important role in corneal wound healing, yet its role in corneal inflammation remains poorly understood. We investigated the role of u-PA in a murine model of lipopolysaccharide (LPS)-induced corneal inflammation. METHODS: The corneal epithelium was scraped and LPS was applied to u-PA wild-type ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2014, 55(8):5338-5350]

Cited: 3 times

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Systemic vascular dysregulation and retrobulbar hemodynamics in normal-tension glaucoma.

Fernando Galassi, Barbara Giambene, Roberta Varriale,

PURPOSE: To investigate the influence of systemic vascular dysregulation on retrobulbar hemodynamics in normal-tension glaucoma (NTG). METHODS: Forty-four untreated patients with NTG and 40 healthy controls matched for age, sex, and intraocular pressure were included. Cold-induced nailfold capillaroscopic features, mean and diastolic ocular perfusion pressures (mOPP, dOPP), endothelin-1 (ET-1) and ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2011, 52(7):4467-4471]

Cited: 31 times

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Parstatin suppresses ocular neovascularization and inflammation.

Hu Huang, Panagiotis Vasilakis, Xiufeng Zhong, Ji-Kui Shen, Katerina Geronatsiou, Helen Papadaki, Michael E Maragoudakis, Sotirios P Gartaganis, Stanley A Vinores, Nikos E Tsopanoglou,

Parstatin is a 41-mer peptide formed by proteolytic cleavage on activation of the PAR1 receptor. The authors recently showed that parstatin is a potent inhibitor of angiogenesis. The purpose of the present study was to evaluate the therapeutic effect of parstatin on ocular neovascularization.Choroidal neovascularization was generated in mice using ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2010, 51(11):5825-5832]

Cited: 10 times

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The effect of growth factor signaling on keratocytes in vitro and its relationship to the phases of stromal wound repair.

Latia Etheredge, Bradley P Kane, John R Hassell,

PURPOSE: To determine the relationship between signaling by different growth factors and the phases of corneal stromal wound repair. The authors hypothesize that the process involves sequential signaling, resulting first in proliferation and then in extracellular matrix (ECM) synthesis. METHODS: The effects of IGF-I, TGF-beta1, FGF-2, and PDGF on proliferation ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2009, 50(7):3128-3136]

Cited: 38 times

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Lack of long-term drift in timolol's effectiveness in patients with ocular hypertension.

Bengtsson, Heijl,

PURPOSE: To report the change over time in intraocular pressure in patients treated with topical timolol or placebo. METHODS: Ninety patients with untreated ocular hypertension, defined as elevated intraocular pressure and normal visual fields, were randomly assigned to treatment and prospectively observed at 3-month intervals for up to 10 years ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2001, 42(12):2839-2842]

Cited: 4 times

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Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues.

A F Clark, H T Steely, J E Dickerson, S English-Wright, K Stropki, M D McCartney, N Jacobson, A R Shepard, J I Clark, H Matsushima, E R Peskind, J B Leverenz, C W Wilkinson, R E Swiderski, J H Fingert, V C Sheffield, E M Stone,

To examine the intracellular and extracellular expression of myocilin in the human and primate trabecular meshwork (TM) in the presence and absence of glucocorticoids.Myocilin expression was examined in cultured human TM cells by Northern blot analysis and myocilin antibody-mediated immunoprecipitation. Myocilin expression was quantified using high-resolution two-dimensional polyacrylamide gel electrophoresis ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2001, 42(8):1769-1780]

Cited: 76 times

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FGFR1, signaling, and AP-1 expression after retinal detachment: reactive Müller and RPE cells.

Geller, Lewis, Fisher,

PURPOSE: To identify changes in cellular signaling pathways and AP-1 expression in retina and retinal pigmented epithelium (RPE) after experimental retinal detachment (RD). METHODS: Cat and rabbit neural retinas were separated from the RPE in vivo for 5 minutes to 28 days. Tissues were removed and processed for Western blotting, ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2001, 42(6):1363-1369]

Cited: 66 times

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Toxicity of natural tear substitutes in a fully defined culture model of human corneal epithelial cells.

Geerling, Daniels, Dart, Cree, Khaw,

PURPOSE: Serum and saliva have recently been advocated as natural tear substitutes for intractable aqueous-deficient dry eyes, but the effects of these fluids on corneal epithelium have not been well characterized. A laboratory study was performed in a defined test model to compare the toxicity of natural and pharmaceutical tear ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2001, 42(5):948-956]

Cited: 52 times

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Endogenous rhythms in axial length and choroidal thickness in chicks: implications for ocular growth regulation.

Nickla, Wildsoet, Troilo,

PURPOSE: To determine whether the diurnal rhythms in axial length and choroidal thickness in the chick eye are endogenous circadian rhythms. METHODS: Six chickens, 14 days of age, were put into darkness for 4 days. Beginning on the 3rd day, ocular dimensions were measured using high-frequency A-scan ultrasonography, in darkness, ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2001, 42(3):584-588]

Cited: 29 times

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Reduced severity of oxygen-induced retinopathy in eNOS-deficient mice.

Brooks, Gu, Samuel, Marcus, Bartoli, Huang, Caldwell,

PURPOSE: Exposure of premature human infants to hyperoxia results in the obliteration of developing retina capillaries, leading to a vision-threatening retinopathy termed retinopathy of prematurity (ROP). The authors hypothesized that this process may be mediated in part by endothelial nitric oxide (NO)-derived oxidants such as peroxynitrite and tested this hypothesis ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2001, 42(1):222-228]

Cited: 79 times

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Expression of E-cadherin by human retinal pigment epithelium: delayed expression in vitro.

Burke, Cao, Irving, Skumatz,

PURPOSE: To determine whether retinal pigment epithelial (RPE) cells, which reportedly express N-cadherin as their major cadherin cell adhesion protein, also express the more common epithelial cadherin, E-cadherin. METHODS: Cadherins expressed by human RPE cells in situ were examined by western blot analysis of extracts prepared from the RPE of ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[1999, 40(12):2963-2970]

Cited: 29 times

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Multifocal electroretinogram delays reveal local retinal dysfunction in early diabetic retinopathy.

Fortune, Schneck, Adams,

PURPOSE: To identify local retinal abnormalities in diabetic patients with and without retinopathy, by using the multifocal electroretinogram (M-ERG). METHODS: Electroretinograms were recorded at 103 discrete retinal locations in each eye of eight persons with nonproliferative diabetic retinopathy (NPDR) and eight diabetic persons without retinopathy, using VERIS (EDI, San Mateo, ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[1999, 40(11):2638-2651]

Cited: 102 times

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Muscarinic acetylcholine receptor antagonists inhibit chick scleral chondrocytes.

Lind, Chew, Marzani, Wallman,

PURPOSE: Muscarinic acetylcholine receptors (mAChRs) have been implicated in the control of myopia in humans and in animal models. This study was conducted to determine whether mAChRs influence the growth of the chick sclera and, if so, which mAChR subtypes are involved. METHODS: Sclera and scleral chondrocytes from normal and ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[1998, 39(12):2217-2231]

Cited: 57 times

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Macular function impairment in eyes with early age-related macular degeneration.

Midena, Degli Angeli, Blarzino, Valenti, Segato,

PURPOSE: To study different aspects of macular function in eyes with early age-related macular degeneration (early AMD: drusen with or without retinal pigment epithelium alterations) and normal visual acuity, to obtain a complete evaluation of macular function impairment in early AMD and to study the relationship between macular function and ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[1997, 38(2):469-477]

Cited: 86 times

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Localization of mRNAs for insulin-like growth factor-I (IGF-I), IGF-I receptor, and IGF binding proteins in rat eye.

Burren, Berka, Edmondson, Werther, Batch,

PURPOSE: To localize mRNAs for insulin-like growth factor (IGF)-I, IGF-I receptor (IGF-IR), and IGF binding protein (BP)-1 to IGFBP-6 in the rat eye. METHODS: cDNA sequences for IGF-I, IGF-IR, and IGFBP-1 to IGFBP-6 were used to synthesize 35S-CTP labeled antisense and sense probes for in situ hybridization on 5-microns sections ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[1996, 37(7):1459-1468]

Cited: 35 times

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Analysis of progressive change in automated visual fields in glaucoma.

Smith, Katz, Quigley,

PURPOSE: To detect and estimate the rate of progression of visual field loss in subjects with glaucoma who undergo long-term automated perimetric visual field testing. METHODS: Automated visual field data were obtained for subjects with glaucomatous visual field loss and a minimum of seven threshold field tests over at least ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[1996, 37(7):1419-1428]

Cited: 99 times

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