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Journal Int. J. Radiat. Oncol. Biol. Phys.

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Stereotactic body radiation therapy to the prostate bed: results of a phase I dose escalation trial.

Sagus Sampath, Paul Frankel, Bianca Del Vecchio, Nora Ruel, Bertram Yuh, An Liu, Tsung Tsai, Jeffrey Wong,

PURPOSE:The primary objectives of this study were to evaluate toxicity of escalating doses of prostate bed SBRT and provide dose recommendations for phase II study. METHODS AND MATERIALS:Patients with organ-confined, node-negative prostate cancer who had biochemical failure (Prostate-specific antigen [PSA] less than 2.0) following prostatectomy were eligible for this phase ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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Commentary on "A Dose of Reality: How 20 Years of Incomplete Physics and Dosimetry Reporting in Radiobiology Studies May Have Contributed to the Reproducibility Crisis".

Brian Marples,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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A Prospective Study of 18F-DCFPyL PSMA PET/CT Restaging in Recurrent Prostate Cancer following Primary External Beam Radiotherapy or Brachytherapy.

Wei Liu, Katherine Zukotynski, Louise Emmett, Hans T Chung, Peter Chung, Robert Wolfson, Irina Rachinsky, Anil Kapoor, Ur Metser, Andrew Loblaw, Gerard Morton, Tracy Sexton, Michael Lock, Joelle Helou, Alejandro Berlin, Colm Boylan, Susan Archer, Greg Pond, Glenn Bauman,

PURPOSE:Radio-recurrent prostate cancer is typically detected by a rising PSA and may reflect local or distant disease. PET radiotracers targeting PSMA such as 18F-DCFPyL have shown promise in restaging men with recurrent disease post-prostatectomy but are less well characterized in the setting of radio-recurrent disease. MATERIALS AND METHODS:A prospective, multi-institutional ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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TEMPORARY REMOVAL: In the Hotseat.

June Corry,

This article is a Gray Zone opinion that will be published at a later date The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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Solitary plasmacytoma: Lenalidomide-Dexamethasone combined with radiation therapy improves progression-free survival and multiple myeloma-free survival.

Fabien Mignot, Antoine Schernberg, Alexandre Arsène-Henry, Marguerite Vignon, Didier Bouscary, Youlia Kirova,

PURPOSE:To evaluate the results of the concurrent use of lenalidomide-dexamethasone with intensity-modulated radiation therapy (IMRT) for solitary plasmacytoma in terms of toxicity and outcome Materials & Methods: Forty-six patients were treated for histologically proven SP between June 2007 and June 2018 in our Department (XXX). All patients received IMRT. The ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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Long-term patient-reported outcomes after high-dose chemoradiotherapy for non-surgical management of distal rectal cancer.

Edina Dizdarevic, Torben Frøstrup Hansen, John Pløen, Lars Henrik Jensen, Jan Lindebjerg, Søren Rafaelsen, Anders Jakobsen, Ane Appelt,

BACKGROUND:Surgery is standard treatment for rectal cancer, but neoadjuvant chemoradiotherapy (CRT) may result in clinical complete response (cCR) in select patients, allowing for non-surgical management (NSM). Prospective studies of NSM strategies are sparse however, and long-term data on quality of life (QoL) are limited. We conducted a single-arm phase II ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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dosimetric multicenter planning comparison studies for SBRT: methodology and future perspectives.

Francesca Romana Giglioli, Cristina Garibaldi, Oliver Blanck, Elena Villaggi, Serenella Russo, Marco Esposito, Carmelo Marino, Michele Stasi, Pietro Mancosu,

In this review a summary of the published literature pertaining to the stereotactic body radiation therapy (SBRT) multiplanning comparison, data sharing strategies, and implementation of benchmark planning cases to improve the skills and knowledge of the participating centers was investigated. A total of 30 full-text articles were included. The studies ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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Statement From the Editors.

Anthony L Zietman, Sue S Yom,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 105(4):905]

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The Red Journal's Top Downloads of 2018.

Anthony L Zietman,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 105(4):695-697]

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Management of Unruptured AVMs: The Pendulum Swings.

Michael D Chan, Scott G Soltys, Lia M Halasz, Nadia N Laack, Giuseppe Minniti, John P Kirkpatrick,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 105(4):687-689]

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In Regard to DeCesaris et al.

Francesco Tommasino, Laura Cella, Paolo Farace,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 105(3):676-677]

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Age Old Recurrence Meets Modern Radiation Kitchen Sink.

Neil R Parikh, Phillip Beron,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 105(3):474-475]

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A Phase II Trial of Stereotactic Ablative Radiotherapy as a Boost for Locally Advanced Cervical Cancer.

Kevin Albuquerque, Vasu Tumati, Jayanthi Lea, Chul Ahn, Debra Richardson, David Miller, Robert Timmerman,

PURPOSE:Assess the feasibility, safety and efficacy of Stereotactic ablative radiotherapy (SAbR) as alternative for intracavitary (ICBT) /interstitial brachytherapy (IBT) boost for locally advanced cervical cancer (LACC) after initial chemoradiation METHODS: A single arm institutional phase II study of SAbR as boost for LACC was conducted .Eligible patients had LACC FIGO ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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A Phase Ib Study of Cetuximab and BYL719 (Alpelisib) Concurrent with Intensity-Modulated Radiation Therapy in Stage III-IVB Head and Neck Squamous Cell Carcinoma.

Lara A Dunn, Nadeem Riaz, Matthew G Fury, Sean M McBride, Loren Michel, Nancy Y Lee, Eric J Sherman, Shrujal S Baxi, Sofia S Haque, Nora Katabi, Richard J Wong, Han Xiao, Alan L Ho, David G Pfister,

PURPOSE:Activation of the PI3K/mTOR signaling pathway is common in head and neck squamous cell carcinoma (HNSCC). BYL719 is an α-specific PI3K inhibitor that is synergistic and efficacious when combined with cetuximab, an FDA-approved radiosensitizing agent in the treatment of HNSCC. The agent independently has been shown to enhance radiosensitivity. This ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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Human CCR6+Th17 lymphocytes are highly sensitive to radiation-induced senescence and are a potential target for prevention of radiation-induced toxicity.

Hoang Quy Nguyen, Yazid Belkacemi, Carl Mann, Françoise Hoffschir, Stéphane Kerbrat, Mathieu Surenaud, Patricia Zadigue, Alexandre de La Taille, Paul-Henri Romeo, Sabine Le Gouvello,

PURPOSE:To study the sensitivity of different peripheral CD4+ T-lymphocyte subsets to IR and identify potential targets for the prevention and/or treatment of radiation-induced toxicity. METHODS AND MATERIALS:This study was performed on peripheral blood mononuclear cells (PBMCs) or sorted peripheral memory lymphocytes of CCR6+ mucosa-homing Th17/CCR6negTh and regulatory T (Treg) subtypes ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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Immune and circulating tumor DNA profiling following radiation treatment for oligometastatic NSCLC; translational correlatives from a mature randomized phase II trial.

Chad Tang, Won-Chul Lee, Alexandre Reuben, Lianpeng Chang, Hai Tran, Latasha Little, Curtis Gumbs, Jennifer Wargo, Andrew Futreal, Zhongxing Liao, Xuefeng Xia, Xin Yi, Steven G Swisher, John V Heymach, Daniel Gomez, Jianjun Zhang,

PURPOSE:NCTXXXXXX was a phase II prospective trial in which non-small lung cancer patients were randomized to local consolidative therapy (LCT) versus maintenance therapy or observation (MT/O). METHODS AND MATERIALS:Peripheral blood from patients enrolled on NCTXXXXXX were labelled as 1) baseline, 2) early follow-up (FU) if obtained in the 1st or ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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In Regard to Foster et al.

Mark Trombetta,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 105(4):904]

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Save the Surgery for Salvage.

Emi J Yoshida,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 105(4):693-694]

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Radiation Oncology Clinical Trial Design: An Opportunity to Evaluate Value.

Chirag Shah, Matthew Ward, Mendel E Singer,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 105(3):674-675]

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Reirradiation Required.

Naamit K Gerber,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 105(3):473-474]

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Predicting Survival for Patients with Metastatic Disease.

Kathryn Rk Benson, Sonya Aggarwal, Justin N Carter, Rie von Eyben, Pooja Pradhan, Nicolas D Prionas, Justin L Bui, Scott G Soltys, Steven Hancock, Michael F Gensheimer, Albert C Koong, Daniel T Chang,

PURPOSE:This prospective study aimed to determine the accuracy of radiation oncologists in predicting the survival of patients with metastatic disease receiving radiotherapy and to understand factors associated with their accuracy. METHODS AND MATERIALS:This single-institution study surveyed 22 attending radiation oncologists to estimate patient survival. Survival predictions were defined as accurate ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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In Regard to Minniti et al.

Shearwood McClelland, Gordon A Watson,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 105(4):903-904]

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IMRT all the way.

Ann H Klopp, Patricia J Eifel,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 105(4):692-693]

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Cetuximab and Radiation Therapy in Head and Neck Cancer.

Marta Maddalo, Luca Triggiani, Stefano Maria Magrini, Michela Buglione,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 105(3):678-679]

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Commentary on Systematic Review of Intensity Modulated Brachytherapy (IMBT): Static and Dynamic Techniques.

William Y Song, Shirin A Enger,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 105(3):493-494]

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