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Journal Int. J. Radiat. Oncol. Biol. Phys.

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Phase II study of neoadjuvant treatment of sequential S-1-based concurrent chemoradiotherapy followed by systemic chemotherapy with gemcitabine for borderline resectable pancreatic adenocarcinoma (HOPS-BR 01).

Tsuyoshi Hayashi, Toru Nakamura, Yasutoshi Kimura, Makoto Yoshida, Masanori Someya, Hiroshi Kawakami, Yusuke Sakuhara, Norio Katoh, Kuniyuki Takahashi, Yoshiyasu Ambo, Katsutoshi Miura, Masayo Motoya, Eiichi Tanaka, Katsuhiko Murakawa, Takumi Yamabuki, Hajime Yamazaki, Akio Katanuma, Satoshi Hirano, ,

BACKGROUND:Preoperative treatment is recommended for borderline resectable pancreatic ductal adenocarcinoma (BR-PC). However, the standard treatment has not yet been determined. We conducted a multicenter phase II study to investigate the efficacy of neoadjuvant treatment of sequential chemoradiation followed by chemotherapy. METHODS:All enrolled patients were treated by preoperative chemoradiation (a total ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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The Impact of Set-Up Uncertainty on Dose-Response Estimates.

Won Sup Yoon, Shiva K Das, Lawrence B Marks,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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Biologic Dose and Imaging Changes in Pediatric Brain Tumor Patients Receiving Spot Scanning Proton Therapy.

Kristofer W Roberts, Hok Seum Wan Chan Tseung, Laurence J Eckel, William S Harmsen, Chris Beltran, Nadia N Laack,

PURPOSE:To evaluate the incidence of imaging changes in our pediatric brain tumor population treated with spot scanning proton therapy, and analyze the spatial correlation of imaging changes with a novel biologic dose model. METHODS AND MATERIALS:All pediatric patients treated during the first year of our institution's experience who received a ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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The development of radiotherapy, image technology and chemotherapy prolongs the survival of patients with nasopharyngeal carcinoma: a cohort study with 20305 patients from 1990 to 2012.

Xue-Song Sun, Sai-Lan Liu, Mei-Juan Luo, Xiao-Yun Li, Qiu-Yan Chen, Shan-Shan Guo, Yue-Feng Wen, Li-Ting Liu, Hao-Jun Xie, Qing-Nan Tang, Yu-Jing Liang, Jin-Jie Yan, Da-Feng Lin, Ming-Min Bi, Ying Liu, Yu-Fan Liang, Jun Ma, Lin-Quan Tang, Hai-Qiang Mai,

PURPOSE:Previous studies demonstrated that the radiotherapy, image technology and the application of chemotherapy have developed in last two decades. This study explored the survival trends and treatment failure patterns of patients with non-metastatic nasopharyngeal carcinoma (NPC) treated with radiotherapy. Furthermore, we evaluated the survival benefit brought by the development of ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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Targeted intervention to improve the quality of head and neck radiotherapy treatment planning in the Netherlands: short and long-term impact.

W F A R Verbakel, P A H Doornaert, C P J Raaijmakers, L J Bos, M Essers, J B Vd Kamer, M Dahele, C H J Terhaard, J H A M Kaanders,

PURPOSE:To benchmark and improve, through means of a targeted intervention, the quality of intensity modulated radiotherapy treatment planning for locally-advanced head-and-neck cancer (HNC) in the Netherlands. The short and long-term impact of this intervention was assessed. MATERIALS AND METHODS:Benchmark: A delineated CT-scan of an oropharynx HNC case was sent to ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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Clinical-Genomic Models of Node-Positive Breast Cancer: Training, Testing, and Validation.

Tzu-Ting Huang, Andre Ching-Hsuan Chen, Tzu-Pin Lu, Lei Lei, Skye Hung-Chun Cheng,

PURPOSE:There is no useful model for predicting the risk of recurrence in node-positive patients regardless of breast cancer subtype. We developed and validated two clinical-genomic models (recurrence index [RI]-local recurrence [LR]) and -distant recurrence (RI-DR) for stratifying these patients into low- and high-risk groups. PATIENTS AND METHODS:The four datasets were: ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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Palliative radiotherapy in bladder cancer - importance of patient selection: A retrospective multicenter study.

Amin Ali, Yee Pei Song, Shaveta Mehta, Hitesh Mistry, Ruth Conroy, Catherine Coyle, John Logue, Anna Tran, James Wylie, Tanzeel Janjua, Lisa Joseph, Joji Joseph, Ananya Choudhury,

OBJECTIVE:Investigate the effectiveness of palliative pelvic radiotherapy (PRT) in bladder cancer patients and identify factors associated with treatment outcome. MATERIAL AND METHODS:Patients with bladder cancer receiving PRT were identified retrospectively from two cancer centres between 2014 and 2017. Patients were stratified by age, stage, performance status, co-morbidities, previous chemotherapy, previous ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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Quality Assurance of Dose Escalated Radiation Therapy in a Randomized Trial for Locally Advanced Oesophageal Cancer.

Jihane Boustani, Eleonor Rivin Del Campo, Julie Blanc, Didier Peiffert, Karine Benezery, Renata Pereira, Emmanuel Rio, Elisabeth Le Prisé, Gilles Créhange, Florence Huguet,

PURPOSE:The ongoing phase II/III XXX trial compares chemoradiotherapy with and without dose escalation in patients with locally advanced or unresectable oesophageal cancer. The results of a benchmark case procedure are reported here to evaluate the protocol compliance of participating centers as part of a quality assurance for radiation therapy (QART). ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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Single-Fraction Stereotactic Radiosurgery vs. Hippocampal-Avoidance Whole Brain Radiotherapy for Patients with 10-30 Brain Metastases: A Dosimetric Analysis.

Timothy K Nguyen, Arjun Sahgal, Jay Detsky, Hany Soliman, Sten Myrehaug, Chia-Lin Tseng, Zain A Husain, Anne Carty, Sunit Das, Victor Yang, Young Lee, Arman Sarfehnia, Brige P Chugh, Collins Yeboah, Mark Ruschin,

PURPOSE:To compare normal tissue dosimetry between hippocampal-avoidance whole brain radiotherapy (HA-WBRT) vs. stereotactic radiosurgery (SRS) in patients with 10-30 brain metastases, and describe a novel SRS strategy termed Spatially Partitioned Adaptive RadiosurgEry (SPARE). METHODS:A retrospective review identified SRS treatment plans with >10 brain metastases located >5mm from the hippocampi. Our ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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Genomic validation of three-tiered clinical sub-classification of high-risk prostate cancer.

Vinayak Muralidhar, Jingbin Zhang, Qiqi Wang, Brandon A Mahal, Santino S Butler, Daniel E Spratt, Elai Davicioni, Oliver Sartor, Felix Y Feng, Kent W Mouw, Paul L Nguyen,

BACKGROUND:Recent data and National Comprehensive Cancer Network (NCCN) guidelines suggest that high-risk prostate cancer (cT3-4, Gleason score ≥ 8, or prostate-specific antigen [PSA] > 20 ng/mL) is a heterogenous group in terms of long-term patient outcomes. We sought to determine whether sub-classification of high-risk prostate cancer based on clinical factors ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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Long-Term Benefits of Dose-Escalation in Localized Prostate Cancer.

Daniel E Spratt, Jeff M Michalski,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 104(4):798-800]

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Check the Reports and Check the Brain.

Cécile Le Péchoux,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 104(4):711-712]

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In Reply to Yadav and Gupta, and Hannoun-Levi et al.

Atif J Khan,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 104(3):700]

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In Regard to Halperin.

David Bowes,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 104(3):694-695]

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Hypofractionated Radiation Therapy or Staged Stereotactic Radiosurgery for Large Brain Metastasis.

Tony J C Wang,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 104(3):484-485]

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Executive Summary of the ARS Appropriate Use Criteria for Treatment of Anal Cancer.

Suzanne Russo, Christopher J Anker, May Abdel- Wahab, Nilofer Azad, Nancy Bianchi, Prajnan Das, Jadranka Dragovic, Karyn A Goodman, William Jones, Timothy Kennedy, Rachit Kumar, Percy Lee, Navesh Sharma, William Small, W Warren Suh, Salma K Jabbour,

PURPOSE:The American Radium Society Appropriate Use Criteria (ARS AUC) presented in this manuscript are evidence-based guidelines for curative- intent treatment of non-metastatic anal squamous cell cancer that are developed by a multidisciplinary expert panel. METHODS:Guideline development and systematic review using PRISMA methodology include an extensive analysis of current medical literature ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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Fractionated and acute proton radiation show differential intestinal tumorigenesis and DNA damage and repair pathway response in ApcMin/+ mice.

Shubhankar Suman, Bhaskar V S Kallakury, Albert J Fornace, Kamal Datta,

PURPOSE:Proton radiation is a major component of the radiation field in outer space and is also used clinically in radiotherapy of resistant cancers. Although epidemiological studies in atom bomb survivors and radiological workers have established radiation as a risk factor for colorectal cancer (CRC), we have yet to determine the ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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Defining the Optimal Schedule for External Beam Partial Breast Irradiation.

Jean L Wright, Jennifer R Bellon,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 104(4):867-868]

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The Role of Adjuvant Radiotherapy for Resected Non-Small Cell Lung Cancer in the Modern Era.

Steven H Lin,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 104(4):712-713]

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In Regard to Jackson et al.

Ryan Slovak, David S Lu, Junaid Raja, Ronald S Arellano, Hyun S Kim,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 104(3):695-696]

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Think Carefully, Publish Safely: Co-Authorship and Conflict of Interest Verification in the ASTRO Journals.

Lisa C Braverman, Sue S Yom, Anthony L Zietman,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 104(3):486-487]

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In Memoriam: Giulio D'Angio, MD, May 2, 1922-September 14, 2018.

John M Maris, Giorgio Perilongo, Edward C Halperin, Carl T D'Angio, Christian Carrie, Patrick Thomas, John Kalapurakal, Karen J Marcus,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 104(3):478-480]

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Determining the "Organ-at-Risk" for Lymphedema Following Regional Nodal Irradiation in Breast Cancer.

Jeffrey P Gross, Connor M Lynch, Anne Marie Flores, Sumanas W Jordan, Irene B Helenowski, Mahesh Gopalakrishnan, Dan Cutright, Eric D Donnelly, Jonathan B Strauss,

PURPOSE:Lymphedema following regional nodal irradiation (RNI) is a severe complication that could be minimized without significantly compromising nodal coverage if the anatomic region(s) associated with lymphedema was better defined. This study sought to correlate dose-volume relationships within sub-regions of the axilla with lymphedema outcomes in order to generate treatment planning ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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A Dose of Reality: How 20 years of incomplete physics and dosimetry reporting in radiobiology studies may have contributed to the reproducibility crisis.

Emily Draeger, Amit Sawant, Christopher Johnstone, Brandon Koger, Stewart Becker, Zeljko Vujaskovic, Isabel-Lauren Jackson, Yannick Poirier,

PURPOSE:A large proportion of pre-clinical or translational studies utilizing radiation have poor replicability. For a study involving radiation exposure to be replicable, interpretable, and comparable, its experimental methodology must be well reported, particularly in terms of irradiation protocol including the amount, rate, quality, and geometry of radiation delivery. Here we ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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A Systematic Review of the Clinical Implementation of Pelvic Magnetic Resonance Imaging (MR)-Only Planning for External Beam Radiation Therapy.

David Bird, Ann M Henry, David Sebag-Montefiore, David L Buckley, Bashar Al-Qaisieh, Richard Speight,

The use of magnetic resonance imaging (MRI) scans alone for radiotherapy treatment planning (MR-only planning) has been highlighted as one method of improving patient outcomes. Recent technological advances have meant that introducing MR-only planning to the clinic is now becoming a reality, with several specialist radiotherapy clinics treating patients with ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

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