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LncRNA SNHG7 promotes glioma cells viability, migration and invasion by regulating miR-342-3p/AKT2 axis.

Gaopeng Cheng, Jian Zheng, Long Wang,

PURPOSE:Glioma has been categorized as the most common primary malignant brain tumor. Long non-coding RNA SNHG7 (lncRNA SNHG7) has been recognized in various cancers as a possible oncogene. In this study, the effect of SNHG7 on glioma cells was investigated. MATERIALS AND METHODS:Thirty glioma tissues and adjacent normal tissues were ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-13]

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Genetic variants of vitamin D metabolism-related DHCR7/NADSYN1 locus and CYP2R1 gene are associated with clinical features of Parkinson's disease.

Merve Alaylıoğlu, Erdinç Dursun, Gençer Genç, Büşra Şengül, Başar Bilgiç, Ayşegül Gündüz, Hülya Apaydın, Güneş Kızıltan, Hakan Gürvit, Haşmet Hanağası, Özgür Öztop Çakmak, Sibel Ertan, Selma Yılmazer, Duygu Gezen-Ak,

PURPOSE/AIM OF THE STUDY:Parkinson's disease (PD) is the second most common neurodegenerative disorder. Vitamin D deficiency is suggested to be related to PD. A genome-wide association study indicated that genes involved in vitamin D metabolism affect vitamin D levels. Among these genes, single nucleotide polymorphisms (SNPs) of the vitamin D ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-11]

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Combined treatment of a medulla oblongata hemangioblastoma via permanent cysto-cisternal drainage and (postponed) gamma knife radiosurgery: a case report and review of the literature.

Robert Bartoš, Jan Lodin, Tomas Marek, Martin Sameš, Veronika Němcová, Roman Liščák,

BACKGROUND:Hemangioblastomas are histologically benign tumors with a variable degree of morbidity and mortality based on various factors, including their anatomical location. The following paper illustrates a unique approach of combined therapy of a brainstem hemangioblastoma (HB) not associated with von Hippel-Lindau disease (vHLd) located in the medulla oblongata. CASE DESCRIPTION:A ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-5]

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Spontaneous morphological remodelling of the O-C1 joint after posterior fusion for occipitocervical dislocation.

Chizuo Iwai, Kazunari Fushimi, Satoshi Nozawa, Naofumi Mitsuishi, Hiroyasu Ogawa, Masato Maeda, Norishige Kuramitsu, Haruhiko Akiyama,

BACKGROUND:Traumatic occipitocervical dislocation (OCD) occurs due to fatal high-energy injury. Modern screw-based constructs enable successful reduction and stabilisation. In view of this, there are no previous reports on the spontaneous remodelling of the O-C1 joint after posterior fusion. We report the first case of postoperative spontaneous remodelling and stabilisation of ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-6]

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Tadalafil ameliorates memory deficits, oxidative stress, endothelial dysfunction and neuropathological changes in rat model of hyperhomocysteinemia induced vascular dementia.

Pankaj Bhatia, Nirmal Singh,

AIM:The present study investigates the potential of Tadalafil, a phosphodiesterase-5 inhibitor, in a rat model of hyperhomocysteinemia induced vascular dementia. METHODS:Hyperhomocysteinemia induced vascular dementia in Wistar rats was produced by administering l-Methionine (1.7 g/kg/day; p.o.×8 weeks). Learning and memory was assessed by employing Morris water maze (MWM) test. Endothelial dysfunction was assessed ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-13]

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The effect of socioeconomic status on age at diagnosis and overall survival in patients with intracranial meningioma.

Ryan Brewster, Sayantan Deb, Arjun Vivek Pendharkar, John Ratliff, Gordon Li, Atman Desai,

BACKGROUND:Intracranial meningiomas are the most common primary tumors of the central nervous system. How socioeconomic status (SES) impacts treatment access and outcomes for brain tumor subtypes is an emerging area of research. Few studies have examined the relationship between SES and meningioma survival and management with reference to relevant clinical ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-8]

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Clinically suspected fibrocartilaginous embolism: a case report and literature review.

Wencan Ke, Chao Chen, Shuai Li, Bingjin Wang, Saideng Lu, Cao Yang,

Spinal cord infarction (SCI) occurs rarely and is characterized by abrupt onset of neck or back pain and neurologic deterioration. Fibrocartilaginous embolism (FCE) of the spinal cord is a rare but possible cause of acutely progressive spinal cord symptoms. Here, we report the case of an older woman who developed ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-6]

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Study on the ameliorating effect of miR-221-3p on the nerve cells injury induced by sevoflurane.

Qirui Wang, Xin Tian, Qijuan Lu, Kun Liu, Jiekun Gong,

PURPOSE:Sevoflurane is a widely used anesthetics, however, it has been reported that sevoflurane has neurotoxic effects. Studies have shown that miR-221-3p can ameliorate neuron damage. This study was to investigate whether miR-221-3p could reduce the neurotoxic effect of sevoflurane on nerve cells. MATERIALS AND METHODS:The rat hippocampal neuron cells were ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-11]

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A controlled, randomized phase II clinical trial for efficacy and safety evaluation of mannuronic acid in secondary progressive form of multiple sclerosis.

Soheil Najafi, Nahid Beladi Moghadam, Payam Saadat, Seyyedeh Masoomeh Noorbakhsh, Anita Vali Mohammadi, Ali Manouchehrinia, Mostafa Hosseini, Hidenori Matsuo, Abbas Mirshafiey,

BACKGROUND:The β-D-Mannuronic acid (M2000) as a novel immunosuppressive drug, patented (PCT/EP2017/067920), has shown positive effects in experimental model of multiple sclerosis (MS). In this study, our aim was to assess efficacy and safety outcomes in MS treated patients with mannuronic acid compared to the conventional drug. METHODS:In a 6-month, randomized ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-10]

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Transverse myelitis associated with primary biliary cirrhosis: clinical, laboratory, and neuroradiological features.

Mangsuo Zhao, Mingjie Zhang, Shimei Zhou, Bingxin Shi, Yan Wei, Fangjie Huang, Jing Wang, Jingfeng Huang, Liyan Qiao,

PURPOSE:Only five patients diagnosed with transverse myelitis (TM) associated with primary biliary cirrhosis (PBC) have been reported in the literature to date. We report two additional patients with TM associated with PBC at our hospital and review all seven cases. MATERIALS AND METHODS:An association between neuromyelitis optic spectrum disease (NMOSD) ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-8]

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Striatal asymmetry index and its correlation with the Hoehn & Yahr stage in Parkinson's disease.

Wei Lin, Chuan-Tao Zuo, Jian-Jun Wu, Li-Kun Yang, Jie Zhu, Yu-Hai Wang,

PURPOSE:Striatal asymmetry is a common feature in Parkinson's disease (PD), which changes with the progression of the disease. However, the correlation between the striatal asymmetry and severity of PD remains unclear. The present study aimed to investigate the characteristics of asymmetry in PD, and analyze the correlation between the striatal ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-6]

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Pediatric pituitary adenoma with mixed FSH and TSH immunostaining and FSH hypersecretion in a 6 year-old girl with precocious puberty: case report and multidisciplinary management.

Marco Ceraudo, Diego Criminelli Rossi, Natascia Di Iorgi, Armando Cama, Gianluca Piatelli, Alessandro Consales,

OBJECTIVE:We describe a rare case of functioning gonadotropins-producing pediatric adenoma immunostaining positively for FSH and focally for TSH causing central precocious puberty associated to central hypothyroidism in a 6 year-old girl. MATERIALS AND METHODS:Clinical evaluation revealed precocious puberty, as confirmed by hormonal determination with elevated FSH and estradiol, while central hypothyroidism ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-8]

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Correction.

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1]

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Toll-like receptors 2 and 4 expression on peripheral blood lymphocytes and neutrophils of Egyptian multiple sclerosis patients.

Dalia Ahmed Labib, Ingy Ashmawy, Alaa Elmazny, Hanan Helmy, Rania Shehata Ismail,

BACKGROUND:Studies have just started delineating the role of Toll-like receptors (TLRs) in the pathogenesis of multiple sclerosis (MS). OBJECTIVES:To investigate the expression of TLR-2 and TLR-4 on peripheral blood neutrophils and lymphocytes in Egyptian patients with MS, and to examine the role of TLR-2 and TLR-4 expression as a candidate ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-5]

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Real-world safety and effectiveness of rotigotine in patients with Parkinson's disease: analysis of a post-marketing surveillance study in Japan.

Hidefumi Ito, Tomoyo Takayama, Hiroyuki Kondo, Yasuhiko Fukuta,

OBJECTIVE:The aim of this study was to evaluate the safety and effectiveness of rotigotine under daily clinical practice in Parkinson's disease patients. METHODS:The study was a prospective, non-interventional, observational study targeting patients who were treated with rotigotine for the first time, with a 1-year follow-up period from September 2013 to ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-11]

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Assessing the cervico-ocular reflex system via modifying the ocular vestibular-evoked myogenic potential test.

Shuo-Yen Hsu, Yi-Ho Young,

PURPOSE:The aim of this study was to devise a novel test for assessing the cervico-ocular reflex (COR) system via head vibration (termed h-COR) or neck vibration (termed n-COR) method. MATERIALS AND METHODS:Thirteen patients with complete loss of bilateral vestibulo-ocular reflex (VOR) showing oscillopsia were assigned to Group A, while 13 ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-10]

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Chronic morphine intoxication reduces binding of HuD to BDNF long 3'-UTR, while morphine withdrawal stimulates BDNF expression in the frontal cortex of male Wistar rats.

Danil Peregud, Leonid Panchenko, Natalia Gulyaeva,

BACKGROUND:Brain-derived neurotrophic factor (BDNF) mediates opiate dependence phenomenon. In the brain of morphine dependent animals BDNF level is controlled transcriptionally, however, post-transcriptional mechanisms of BDNF regulation in this context remain unknown. Regulation of mRNA by binding of specific proteins to the 3'-untranslated region (3'-UTR) is one of such mechanisms. Among ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-13]

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S100B protein: general characteristics and pathophysiological implications in the Central Nervous System.

Ana Cristina Arrais, Lívia Helena M F Melo, Bianca Norrara, Marina Abuquerque B Almeida, Kalina Fernandes Freire, Acydalia Madruga M F Melo, Lucidio Clebeson de Oliveira, Francisca Overlânia Vieira Lima, Rovena Clara G J Engelberth, Jeferson de Souza Cavalcante, Dayane Pessoa de Araújo, Fausto Pierdoná Guzen, Marco Aurelio M Freire, José Rodolfo L P Cavalcanti,

BACKGROUND:Calcium-binding proteins are heterogeneous proteins that act binding this ion in specific domains, performing numerous functions. OBJECTIVE:In the present review, we aim to gather principal information about S100B protein in the Central Nervous System (CNS), highlighting its particularities, mapping, functionalities, and consequences on CNS dysfunction. METHODS:The research was carried out ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-9]

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MiR-17-5p inhibits cerebral hypoxia/reoxygenationinjury by targeting PTEN through regulation of PI3K/AKT/mTOR signaling pathway.

Xiang Ren, Ying-Xia Jing, Zhi-Wen Zhou, Qi-Ming Yang,

OBJECTIVE:To investigate the role and mechanism of miR-17-5p in cerebral hypoxia/reoxygenation (H/R)-induced apoptosis. METHODS:The present study used human brain microvascular endothelial cells (HBMVECs) to establish cerebral H/R model. MTT was used to measure the cell viability. Flow cytometry was used to detect the cell apoptosis. The interaction between miR-17-5p and ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-9]

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The effects of glial cells inhibition on spatial reference, reversal and working memory deficits in a rat model of traumatic brain injury (TBI).

Amir Rezagholizadeh, Seyed Asaad Karimi, Narges Hosseinmardi, Mahyar Janahmadi, Mohammad Sayyah,

AIMS:Evidence suggests that glial cells are influenced by Traumatic brain injury (TBI). Both protective and damaging roles have been attributed to reactive glial cells, but their role after TBI has not been well understood. In this study, the role of glial cells in TBI-induced cognitive impairment was investigated. MATERIALS AND ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-11]

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Is there a correlation between dyslipidemia and cognitive impairment in patients with multiple sclerosis?

Adriana Andaloro, Margherita Russo, Concetta Pastura, Edoardo Sessa, Patrizia Calatozzo, Maria Grazia Maggio, Placido Bramanti,

Background. Multiple sclerosis (MS) is an autoimmune and demyelination disease of the central nervous system that causes progressive accumulation of disability over time. Recent studies have highlighted the correlation between metabolic disorders and cognitive dysfunctions. The present study aims to evaluate the correlation between components of the lipid profile and ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-6]

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A preliminary study of atypical cortical change ability of dynamic whole-brain functional connectivity in autism spectrum disorder.

Bo Chen,

OBJECTIVES:Designing new objectively diagnostic methods of autism spectrum disorder (ASD) are burning questions. Dynamic functional connectivity (DFC) methodology based on fMRI data are an effective lever to investigate changeability evolution of signal synchronization in macroscopic neural activity patterns. METHODS:Embracing the network dynamics concepts, this paper introduces changeability index ([Formula: see ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-13]

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Persistent effects of the orexin-1 receptor antagonist SB-334867 on naloxone precipitated morphine withdrawal symptoms and nociceptive behaviors in morphine dependent rats.

Masoumeh Kourosh-Arami, Mohammad-Taghi Joghataei, Alireza Komaki, Masoumeh Gholami, Zohreh Najafi, Mostafa Lavaie,

AIM OF THE STUDY:In this study, we investigated the effect of long-term administration of orexin receptor 1 (OXR1) antagonist on naloxone-precipitated morphine withdrawal symptoms and nociceptive behaviors in morphine-dependent rats. MATERIALS AND METHODS:Wistar rats received subcutaneous (s.c.) injections of morphine (6, 16, 26, 36, 46, 56, and 66 mg/kg, 2 ml/kg) at ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-10]

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Brain microstructural changes and cognitive function in non-demented essential tremor patients: a diffusion tensor imaging study.

Y Sengul, H O Temur, Z Corakcı, H S Sengul, H Dowd, I Ustun, A Alkan, E D Louis,

BACKGROUND:Essential tremor (ET) is disease with both motor and non-motor features. Notable among the non-motor features is cognitive impairment. While this impairment has been attributed to cortico-thalamo-cerebellar pathway pathology, it is likely that a more complicated involvement of brain structures underlies cognitive function in ET. OBJECTIVE:To evaluate the brain microstructural ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-11]

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Motor behavior-induced prefrontal cortex activation and episodic memory function.

Paul D Loprinzi, Lindsay Crawford, Damien Moore, Jeremiah Blough, Grace Burnett, Morgan Chism, Gina Robinson,

BACKGROUND:The objective of this paper was to evaluate the potential individual and combined effects of acute exercise coupled with bilateral interhemispheric activation on episodic memory function. Six experiments were conducted. METHODS:Experiment 1 was a within-subject, counterbalanced experiment. Participants completed four visits, including 1) exercise and saccadic eye movements, 2) exercise ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-21]

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