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Journal Int. J. Cancer

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Impact of the addition of carboplatin to anthracycline-taxane-based neoadjuvant chemotherapy on survival in BRCA1/2-mutated triple-negative breast cancer.

Juan Zhang, Lu Yao, Yiqiang Liu, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie,

Whether adding carboplatin to standard neoadjuvant chemotherapy improves survival in BRCA1/2-mutated triple-negative breast cancer (TNBC) is unknown. In this retrospective study, we aimed to explore the efficacy of anthracycline-taxane (A-T)-based or anthracycline-taxane/carboplatin (A-TP)-based neoadjuvant chemotherapy in BRCA1/2-mutated TNBC. A total of 1585 operable primary breast cancer patients were treated with ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

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Ibrutinib for improved chimeric antigen receptor T-cell production for chronic lymphocytic leukemia patients.

Fuli Fan, Hyeon Joo Yoo, Sophia Stock, Lei Wang, Yibin Liu, Maria-Luisa Schubert, Sanmei Wang, Brigitte Neuber, Angela Hückelhoven-Krauss, Ulrike Gern, Anita Schmitt, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt, Leopold Sellner,

Chimeric antigen receptor T (CART) cells targeting CD19 have shown promising results in the treatment of chronic lymphocytic leukemia (CLL). However, efficacy seems to be inferior compared to diffuse large B-cell lymphoma or acute lymphoblastic leukemia. Impaired T-cell fitness of CLL patients may be involved in treatment failure. Less-differentiated naïve-like ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

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Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC.

Clemens Messerschmidt, Benedikt Obermayer, Konrad Klinghammer, Sebastian Ochsenreither, Denise Treue, Albrecht Stenzinger, Hanno Glimm, Stefan Fröhling, Thomas Kindler, Christian H Brandts, Klaus Schulze-Osthoff, Wilko Weichert, Ingeborg Tinhofer, Frederick Klauschen, Ulrich Keilholz, Dieter Beule, Damian T Rieke,

Immune checkpoint inhibition leads to response in some patients with head and neck squamous cell carcinoma (HNSCC). Robust biomarkers are lacking to date. We analyzed viral status, gene expression signatures, mutational load and mutational signatures in whole exome and RNA-sequencing data of the HNSCC TCGA dataset (n = 496) and ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, 147(8):2293-2302]

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Oxaliplatin-induced neuropathic pain involves HOXA6 via a TET1-dependent demethylation of the SOX10 promoter.

Jie Deng, Huan-Huan Ding, Jia-Li Long, Su-Yan Lin, Meng Liu, Xue-Qin Zhang, Wen-Jun Xin, Xiangcai Ruan,

Chemotherapy-induced neuropathic pain is a common dose-limiting side effect of cancer treatment but the underlying mechanisms are largely unknown. Here, we used a whole-genome expression microarray and gene ontology analysis to identify the upregulation of a sequence-specific DNA-binding protein, HOXA6, in the spinal dorsal horn on Day 10 after injection ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

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An EGFR signature predicts cell line and patient sensitivity to multiple tyrosine kinase inhibitors.

Chao Cheng, Yanding Zhao, Evelien Schaafsma, Yi-Lan Weng, Christopher Amos,

EGFR is an oncogene with a high frequency of activating mutations in nonsmall cell lung cancer (NSCLC). EGFR inhibitors have been FDA-approved for NSCLC and have shown efficacy in patients with certain EGFR mutations. However, only 9% to 26% of these patients achieve objective responses. In our study, we developed ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

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Efficacy and safety of pembrolizumab for the treatment of advanced biliary cancer: Results from the KEYNOTE-158 and KEYNOTE-028 studies.

Sarina A Piha-Paul, Do-Youn Oh, Makoto Ueno, David Malka, Hyun Cheol Chung, Adnan Nagrial, Robin K Kelley, Willeke Ros, Antoine Italiano, Kazuhiko Nakagawa, Hope S Rugo, Filippo de Braud, Andrea Iolanda Varga, Aaron Hansen, Hui Wang, Suba Krishnan, Kevin G Norwood, Toshihiko Doi,

We present data from patients with advanced biliary tract cancer (BTC) receiving pembrolizumab in the KEYNOTE-158 (NCT02628067; phase 2) and KEYNOTE-028 (NCT02054806; phase 1b) studies. Eligible patients aged ≥18 years from both studies had histologically/cytologically confirmed incurable BTC that progressed after standard treatment regimen(s), measurable disease per Response Evaluation Criteria in ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, 147(8):2190-2198]

Cited: 2 times

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Effectiveness of sorafenib dose modifications on treatment outcome of hepatocellular carcinoma: Analysis in real-life settings.

Kwon Yong Tak, Hee Chul Nam, Jong Young Choi, Seung Kew Yoon, Chang Wook Kim, Hee Yeon Kim, Sung Won Lee, Hae Lim Lee, U Im Chang, Do Seon Song, Jin Mo Yang, Jung Hyun Kwon, Sun Hong Yoo, Pil Soo Sung, Sang Wook Choi, Myeong Jun Song, Seok Hwan Kim, Jeong Won Jang,

Controlling adverse events (AEs) through dose reduction can enhance drug adherence and treatment response. Currently, there is no guide for sorafenib dosing. The aim of this study was to evaluate whether sorafenib dosing could affect treatment outcomes. A total of 782 hepatocellular carcinoma (HCC) patients treated with sorafenib were evaluated ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, 147(7):1970-1978]

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Efficacy of late concurrent hypofractionated radiotherapy in advanced melanoma patients failing anti-PD-1 monotherapy.

Elisa Funck-Brentano, Bouchra Baghad, Magali Fort, Iman Aouidad, Anissa Roger, Alain Beauchet, Yves Otmezguine, Astrid Blom, Christine Longvert, Blandine Boru, Philippe Saiag,

Advanced melanoma patients who failed anti-PD-1 therapy have limited options. We analyzed a cohort of 133 advanced melanoma patients receiving anti-PD-1 monotherapy in a referral center between April 2015 and December 2017, and included the 26 patients with confirmed progressive (PD) or stable disease who received additional radiotherapy with an ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, 147(6):1707-1714]

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Erratum.

Int. J. Cancer (International journal of cancer)
[2020, 146(11):E6]

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Blood arsenic levels and the risk of familial breast cancer in Poland.

Wojciech Marciniak, Róża Derkacz, Magdalena Muszyńska, Piotr Baszuk, Jacek Gronwald, Tomasz Huzarski, Cezary Cybulski, Anna Jakubowska, Michał Falco, Tadeusz Dębniak, Marcin Lener, Oleg Oszurek, Katherine Pullella, Joanne Kotsopoulos, Ping Sun, Steven A Narod, Jan Lubiński,

Arsenic is recognized as a potent carcinogen at high concentrations, but the relationship between environmental arsenic and breast cancer risk has not well been studied. Most research has focused on the effect of arsenic in populations with high endemic exposure, and not in populations with arsenic levels within normal limits. ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, 146(10):2721-2727]

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A prospective study of tea and coffee intake and risk of glioma.

David J Cote, Alaina M Bever, Kathryn M Wilson, Timothy R Smith, Stephanie A Smith-Warner, Meir J Stampfer,

Tea and coffee have antioxidant and neuroprotective effects. Observational studies suggest that tea and coffee intake may reduce cancer risk, but data on glioma risk are inconclusive. We evaluated the association between tea, coffee and caffeine intake and glioma risk in the female Nurses' Health Study (NHS) and Nurses' Health ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, 146(9):2442-2449]

Cited: 1 time

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Author's reply to: A note on competing risks in analyses of cancer-specific mortality.

Henrik Benoni, Karin E Smedby, Sandra Eloranta,

Int. J. Cancer (International journal of cancer)
[2019, 145(6):1706-1707]

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Education and gastric cancer risk-An individual participant data meta-analysis in the StoP project consortium.

Matteo Rota, Gianfranco Alicandro, Claudio Pelucchi, Rossella Bonzi, Paola Bertuccio, Jinfu Hu, Zuo-Feng Zhang, Kenneth C Johnson, Domenico Palli, Monica Ferraroni, Guo-Pei Yu, Carlotta Galeone, Lizbeth López-Carrillo, Joshua Muscat, Nuno Lunet, Ana Ferro, Weimin Ye, Amelie Plymoth, Reza Malekzadeh, David Zaridze, Dmitry Maximovitch, Manolis Kogevinas, Nerea Fernández de Larrea, Jesus Vioque, Eva M Navarrete-Muñoz, Shoichiro Tsugane, Gerson S Hamada, Akihisa Hidaka, Mohammadreza Pakseresht, Alicja Wolk, Niclas Håkansson, Raúl Ulises Hernández-Ramírez, Malaquias López-Cervantes, Mary Ward, Farhad Pourfarzi, Lina Mu, Robert C Kurtz, Areti Lagiou, Pagona Lagiou, Paolo Boffetta, Stefania Boccia, Eva Negri, Carlo La Vecchia,

Low socioeconomic position (SEP) is a strong risk factor for incidence and premature mortality from several cancers. Our study aimed at quantifying the association between SEP and gastric cancer (GC) risk through an individual participant data meta-analysis within the "Stomach cancer Pooling (StoP) Project". Educational level and household income were ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, 146(3):671-681]

Cited: 3 times

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Bridging genomics and phenomics of gastric carcinoma.

Junhun Cho, Soomin Ahn, Dae-Soon Son, Nayoung Kd Kim, Ki-Wook Lee, Seungtae Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Won Ki Kang, Ji Yeong An, Min Gew Choi, Jun-Ho Lee, Tae Sung Sohn, Jae Moon Bae, Sung Kim, Kyoung-Mee Kim,

Genetic alterations are the starting point leading to numerous changes in clinical and pathologic features (phenotypes) of individual cancers; however, their inter-relationships in gastric cancers (GC) are unclear. We performed massive parallel sequencing of 381 cancer-related genes and compared the results with clinical and pathologic findings in 330 GC. High ... Read more >>

Int. J. Cancer (International journal of cancer)
[2019, 145(9):2407-2417]

Cited: 4 times

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The value of preoperative antithyroidperoxidase antibody as a novel predictor of recurrence in papillary thyroid carcinoma.

Eyun Song, Hye-Seon Oh, Min Ji Jeon, Ki Wook Chung, Suck Joon Hong, Jin Sook Ryu, Jung Hwan Baek, Jeong Hyun Lee, Won Gu Kim, Won Bae Kim, Young Kee Shong, Tae Yong Kim,

The link between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC) is widely recognized. Considering the strong association between raised antithyroidperoxidase antibody (TPOAb) and CLT, we postulated that the preoperative TPOAb can predict the prognosis of PTC, particularly for recurrence. A total of 2,070 patients who underwent total thyroidectomy ... Read more >>

Int. J. Cancer (International journal of cancer)
[2019, 144(6):1414-1420]

Cited: 0 times

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Sex differences in the prognosis after surgery for esophageal squamous cell carcinoma and adenocarcinoma.

Joonas H Kauppila, Karl Wahlin, Pernilla Lagergren, Jesper Lagergren,

Some investigations suggest a better prognosis in women compared to men with esophageal cancer but these differences are uncertain. The aim of our study was to clarify whether sex influences the prognosis after esophagectomy for esophageal squamous cell carcinoma and esophageal adenocarcinoma. A population-based and nationwide cohort study included almost ... Read more >>

Int. J. Cancer (International journal of cancer)
[2019, 144(6):1284-1291]

Cited: 2 times

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NAMPT signaling is critical for the proangiogenic activity of tumor-associated neutrophils.

Ekaterina Pylaeva, Mozhgan Dehghan Harati, Ilona Spyra, Sharareh Bordbari, Sarah Strachan, Basant Kumar Thakur, Benedikt Höing, Cindy Franklin, Julia Skokowa, Karl Welte, Dirk Schadendorf, Agnes Bankfalvi, Sven Brandau, Stephan Lang, Jadwiga Jablonska,

Tumor-associated neutrophils (TANs) regulate many processes associated with tumor progression, and depending on the microenvironment, they can exhibit pro- or antitumor functions. However, the molecular mechanisms regulating their tumorigenicity are not clear. Using transplantable tumor models, we showed here that nicotinamide phosphoribosyltransferase (NAMPT), a molecule involved in CSF3R downstream signaling, ... Read more >>

Int. J. Cancer (International journal of cancer)
[2019, 144(1):136-149]

Cited: 7 times

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Maternal residential pesticide use and risk of childhood leukemia in Costa Rica.

Carly Hyland, Robert B Gunier, Catherine Metayer, Michael N Bates, Catharina Wesseling, Ana M Mora,

Evidence suggests that early-life exposure to pesticides inside the home may be associated with childhood leukemia, however data from Latin American countries are limited. We examined whether self-reported maternal residential pesticide use and nearby pesticide applications-before and after child's birth-were associated with acute lymphoblastic leukemia (ALL) in the Costa Rican ... Read more >>

Int. J. Cancer (International journal of cancer)
[2018, 143(6):1295-1304]

Cited: 1 time

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WT1 peptide-based immunotherapy for advanced thymic epithelial malignancies.

Yusuke Oji, Masayoshi Inoue, Yoshito Takeda, Naoki Hosen, Yasushi Shintani, Manabu Kawakami, Takuya Harada, Yui Murakami, Miki Iwai, Mari Fukuda, Sumiyuki Nishida, Jun Nakata, Yoshiki Nakae, Satoshi Takashima, Toshiaki Shirakata, Hiroko Nakajima, Kana Hasegawa, Hiroshi Kida, Takashi Kijima, Soyoko Morimoto, Fumihiro Fujiki, Akihiro Tsuboi, Eiichi Morii, Satoshi Morita, Junichi Sakamoto, Atsushi Kumanogoh, Yoshihiro Oka, Meinoshin Okumura, Haruo Sugiyama,

Thymic epithelial tumors are rare malignancies, and no optimal therapeutic regimen has been defined for patients with advanced disease. Patients with advanced thymic epithelial tumors, which were resistant or intolerable to prior therapies, were eligible for this study. Patients received 9 mer-WT1-derived peptide emulsified with Montanide ISA51 adjuvant via intradermal ... Read more >>

Int J Cancer (International journal of cancer)
[2018, 142(11):2375-2382]

Cited: 6 times

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DCLK1 promotes epithelial-mesenchymal transition via the PI3K/Akt/NF-κB pathway in colorectal cancer.

Weiying Liu, Shixing Wang, Qi Sun, Zhen Yang, Min Liu, Hua Tang,

Double cortin-like kinase 1 (DCLK1) plays important roles during the epithelial-mesenchymal transition (EMT) process in human colorectal cancer (CRC). However, the role of DCLK1 in regulating the EMT of CRC is still poorly understood. In this study, we report evidence that DCLK1 acts as a potent oncogene to drive its ... Read more >>

Int. J. Cancer (International journal of cancer)
[2018, 142(10):2068-2079]

Cited: 12 times

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Glucocorticoids promote a glioma stem cell-like phenotype and resistance to chemotherapy in human glioblastoma primary cells: Biological and prognostic significance.

Ourania N Kostopoulou, Abdul-Aleem Mohammad, Jiri Bartek, Julia Winter, Masany Jung, Giuseppe Stragliotto, Cecilia Söderberg-Nauclér, Natalia Landázuri,

Glioma stem cells (GSCs) are glioblastoma (GBM) cells that are resistant to therapy and can give rise to recurrent tumors. The identification of patient-related factors that support GSCs is thus necessary to design effective therapies for GBM patients. Glucocorticoids (GCs) are used to treat GBM-associated edema. However, glucocorticoids participate in ... Read more >>

Int. J. Cancer (International journal of cancer)
[2018, 142(6):1266-1276]

Cited: 3 times

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How many cancer cases and deaths are potentially preventable? Estimates for Australia in 2013.

Louise F Wilson, Annika Antonsson, Adele C Green, Susan J Jordan, Bradley J Kendall, Christina M Nagle, Rachel E Neale, Catherine M Olsen, Penelope M Webb, David C Whiteman,

Cancer is a leading cause of disease burden in Australia, particularly fatal burden, accounting for an estimated thirty percent of deaths. Many cancers develop because of exposure to lifestyle and environmental factors that are potentially modifiable. We aimed to quantify the proportions and numbers of cancer deaths and cases in ... Read more >>

Int. J. Cancer (International journal of cancer)
[2018, 142(4):691-701]

Cited: 10 times

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Familial associations of female breast cancer with other cancers.

Guoqiao Zheng, Hongyao Yu, Akseli Hemminki, Asta Försti, Kristina Sundquist, Kari Hemminki,

Familial risks of breast cancer (BC) are well established but whether BC clusters with other, i.e. discordant, cancers is less certain but of interest for the identification of common genetic and possible environmental factors contributing to a general cancer susceptibility. We apply a novel approach to search for familial associations ... Read more >>

Int. J. Cancer (International journal of cancer)
[2017, 141(11):2253-2259]

Cited: 2 times

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Risk stratification and long-term risk prediction of E6 oncoprotein in a prospective screening cohort in China.

Qian Zhang, Li Dong, Shangying Hu, Ruimei Feng, Xun Zhang, Qinjing Pan, Junfei Ma, Li Zhang, Xuelian Zhao, Rengaswamy Sankaranarayanan, Youlin Qiao, Fanghui Zhao,

E6 oncoprotein is a necessary agent of HPV driven oncogenic transformation. This study is aimed at evaluating the risk stratification potency of HPV 16/18 E6 oncoprotein (E6) as a triage method for HPV positivity. Moreover, it also acts as a predictor of cervical intraepithelial neoplasia grade 3 or worse (CIN3+). ... Read more >>

Int. J. Cancer (International journal of cancer)
[2017, 141(6):1110-1119]

Cited: 4 times

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Patient monitoring through liquid biopsies using circulating tumor DNA.

Peter Ulz, Ellen Heitzer, Jochen B Geigl, Michael R Speicher,

Tumors release components such as circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and tumor-derived extracellular vesicles into the circulation. Multiple studies have demonstrated that molecular information about tumors and metastases can be extracted from these factors, which are therefore frequently referred to as "liquid biopsies." Liquid biopsies allow the ... Read more >>

Int. J. Cancer (International journal of cancer)
[2017, 141(5):887-896]

Cited: 15 times

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