Full Text Journal Articles in
Journal Int. J. Cancer

Advertisement

Find full text journal articles






Metabolic perturbations prior to hepatocellular carcinoma diagnosis - Findings from a prospective observational cohort study.

Magdalena Stepien, Pekka Keski-Rahkonen, Agneta Kiss, Nivonirina Robinot, Talita Duarte-Salles, Neil Murphy, Gabriel Perlemuter, Vivian Viallon, Anne Tjønneland, Agnetha Linn Rostgaard-Hansen, Christina C Dahm, Kim Overvad, Marie-Christine Boutron-Ruault, Francesca Romana Mancini, Yahya Mahamat-Saleh, Krasimira Aleksandrova, Rudolf Kaaks, Tilman Kühn, Antonia Trichopoulou, Anna Karakatsani, Salvatore Panico, Rosario Tumino, Domenico Palli, Giovanna Tagliabue, Alessio Naccarati, Roel C H Vermeulen, H Bas Bueno-de-Mesquita, Elisabete Weiderpass, Guri Skeie, J Ramón Quirós, Eva Ardanaz, Olatz Mokoroa, Núria Sala, Maria-Jose Sánchez, José María Huerta, Anna Winkvist, Sophia Harlid, Bodil Ohlsson, Klas Sjöberg, Julie A Schmidt, Nick Wareham, Kay-Tee Khaw, Pietro Ferrari, Joseph A Rothwell, Marc Gunter, Elio Riboli, Augustin Scalbert, Mazda Jenab,

Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations in HCC is derived mostly from case-control designs, with sparse information from prospective cohorts. Our objective was to apply comprehensive metabolite profiling to detect metabolites whose serum concentrations are associated with HCC development, using biological samples ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Poor clinical outcomes and immunoevasive contexture in interleukin-9 abundant muscle-invasive bladder cancer.

Quan Zhou, Hongyu Zhang, Zewei Wang, Han Zeng, Zhaopei Liu, Qiuren Huang, Zhiyuan Lin, Yang Qu, Ying Xiong, Jiajun Wang, Yuan Chang, Qi Bai, Yu Xia, Yiwei Wang, Li Liu, Bo Dai, Jianming Guo, Yu Zhu, Le Xu, Jiejie Xu,

Chemotherapy and immunotherapy yield survival benefits for muscle-invasive bladder cancer (MIBC) patients, in which tumor microenvironment has been found to exert crucial roles through tipping the balance between anti-tumor immunity and immune evasion. This study aims to explore the clinical significance and therapeutic role of intratumoral interleukin-9-producing cells (IL-9+ cells) ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Chronic lymphocytic leukemia patients with IGH translocations are characterized by a distinct genetic landscape with prognostic implications.

Claudia Pérez-Carretero, María Hernández-Sánchez, Teresa González, Miguel Quijada-Álamo, Marta Martín-Izquierdo, Jesús-María Hernández-Sánchez, María-Jesús Vidal, Alfonso García de Coca, Carlos Aguilar, Manuel Vargas-Pabón, Sara Alonso, Magdalena Sierra, Araceli Rubio-Martínez, Julio Dávila, José R Díaz-Valdés, José-Antonio Queizán, José-Ángel Hernández-Rivas, Rocío Benito, Ana E Rodríguez-Vicente, Jesús-María Hernández-Rivas,

Chromosome 14q32 rearrangements/translocations involving the immunoglobulin heavy chain (IGH) are rarely detected in chronic lymphocytic leukemia (CLL). The prognostic significance of the IGH translocation is controversial and its mutational profile remains unknown. Here, we present for the first time a comprehensive next-generation sequencing (NGS) analysis of 46 CLL patients with ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Impact of the addition of carboplatin to anthracycline-taxane-based neoadjuvant chemotherapy on survival in BRCA1/2-mutated triple-negative breast cancer.

Juan Zhang, Lu Yao, Yiqiang Liu, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie,

Whether adding carboplatin to standard neoadjuvant chemotherapy improves survival in BRCA1/2-mutated triple-negative breast cancer is unknown. In this retrospective study, we aimed to explore the efficacy of anthracycline-taxane- or anthracycline-taxane/carboplatin-based neoadjuvant chemotherapy in BRCA1/2-mutated triple-negative breast cancer. 1,585 operable primary breast cancer patients were treated with either neoadjuvant anthracycline followed ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Estimated global cancer incidence in the oldest adults in 2018 and projections to 2050.

Sophie Pilleron, Enrique Soto-Perez-de-Celis, Jerome Vignat, Jacques Ferlay, Isabelle Soerjomataram, Freddie Bray, Diana Sarfati,

Using GLOBOCAN estimates, we describe the estimated cancer incidence among adults aged 80 years or older at the regional and global level in 2018, reporting the number of new cancer cases, and the truncated age-standardised incidence rates (per 100,000) for all cancer sites combined for this age group. We also presented ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Choosing the optimal HPV vaccine: The health impact and economic value of the nonavalent and bivalent HPV vaccines in 48 Gavi-eligible countries.

Emily A Burger, Allison Portnoy, Nicole G Campos, Stephen Sy, Catherine Regan, Jane J Kim,

The human papillomavirus (HPV) vaccines may provide some level of cross-protection against high-risk HPV genotypes not directly targeted by the vaccines. We evaluated the long-term health and economic impacts of routine HPV vaccination using either the nonavalent HPV vaccine or the bivalent HPV vaccine in the context of 48 Gavi-eligible ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



The Response Rate of Alternative Treatments for Drugs Approved On the Basis of Response Rate.

Alyson Haslam, Jennifer Gill, Vinay Prasad,

We assessed the frequency that oncology drugs approved by the US Food and Drug Administration (FDA) based on a single arm study when there is already evidence of existing and available treatments. For this, we conducted a retrospective cross-sectional analysis of FDA approved oncology drugs, based on a single arm ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Systems analysis of protein signatures predicting Cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenografts models of metastatic colorectal cancer.

Andreas U Lindner, Steven Carberry, Naser Monsefi, Ana Barat, Manuela Salvucci, Robert O'Byrne, Eugenia R Zanella, Mattia Cremona, Bryan T Hennessy, Andrea Bertotti, Livio Trusolino, Jochen H M Prehn,

Antibodies targeting the human epidermal growth factor receptor (EGFR) are used for the treatment of RAS wild-type metastatic colorectal cancer. A significant proportion of patients remains unresponsive to this therapy. Here, we performed a reverse phase protein array-based (phospho)protein analysis of 63 KRAS, NRAS, BRAF and PIK3CA wild-type metastatic CRC ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Comprehensive Genomic Landscape and Precision Therapeutic Approach in Biliary Tract Cancers.

Ryosuke Okamura, Razelle Kurzrock, Robert J Mallory, Paul T Fanta, Adam M Burgoyne, Bryan M Clary, Shumei Kato, Jason K Sicklick,

Biliary tract cancers have dismal prognoses even when cytotoxic chemotherapy is administered. There is an unmet need to develop precision treatment approaches using comprehensive genomic profiling. A total of 121 patients with biliary tract cancers were analyzed for circulating-tumor DNA (ctDNA) and/or tissue-based tumor DNA (tissue-DNA) using clinical-grade next-generation sequencing: ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Lung mechanics modifications facilitating metastasis are mediated in part by breast cancer derived extracellular vesicles.

Tamar Barenholz-Cohen, Yulia Merkher, Jozafina Haj, Dvir Shechter, Daniela Kirchmeier, Yuval Shaked, Daphne Weihs,

Tumor microenvironment-mechanics greatly affect tumor-cell characteristics such as invasion and proliferation. We and others have previously shown that following chemotherapy, tumor cells shed more extracellular vesicles (EVs), leading to tumor growth and even spread, via angiogenesis and the mobilization of specific bone marrow derived cells contributing to metastasis. However, physical, ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Time-dependent changes in proliferation, DNA damage and clock gene expression in hepatocellular carcinoma and normal liver of a transgenic mouse model.

Soha A Hassan, Christian Schmithals, Maike von Harten, Albrecht Piiper, Horst-Werner Korf, Charlotte von Gall,

Hepatocellular carcinoma (HCC) is highly resistant to anticancer therapy and novel therapeutic strategies are needed. Chronotherapy may become a promising approach because it may improve the efficacy of antimitotic radiation and chemotherapy by considering timing of treatment. To date little is known about time-of-day dependent changes of proliferation and DNA ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Profile and outcome of receptor conversion in breast cancer metastases: a nation-wide multicenter epidemiological study.

Zong-Bi Yi, Pei Yu, Su Zhang, Wen-Na Wang, Yi-Qun Han, Qu-Chang Ouyang, Min Yan, Xiao-Jia Wang, Xi-Chun Hu, Ze-Fei Jiang, Tao Huang, Zhong-Sheng Tong, Shu-Sen Wang, Yong-Mei Yin, Hui Li, Run-Xiang Yang, Hua-Wei Yang, Yue-E Teng, Tao Sun, Li Cai, Hong-Yuan Li, Xi Chen, Jian-Jun He, Xin-Lan Liu, Shun-E Yang, Jia-Yu Wang, Jin-Hu Fan, You-Lin Qiao, Bing-He Xu,

Although receptor status included estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) of the primary breast tumors was related to the prognosis of breast cancer patients, little information is yet available on whether patient management and survival are impacted by receptor conversion in breast ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Risk of secondary hematologic malignancies associated with breast cancer chemotherapy and G-CSF support: a nationwide population-based cohort.

M-J Jabagi, N Vey, A Goncalves, T Le Tri, M Zureik, R Dray-Spira,

This study aimed to analyze the risk of hematologic malignancies (HM) associated with the use of G-CSF with chemotherapy for BC. Using the French National Health Data System, we examined the HM risks in patients diagnosed with an incident breast cancer between 2007 and 2015, who received chemotherapy for BC. ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Cancer associates with risk and severe events of COVID-19: A systematic review and meta-analysis.

Yehong Tian, Xiaowei Qiu, Chengxiang Wang, Jianxin Zhao, Xin Jiang, Wenquan Niu, Jinchang Huang, Fengyu Zhang,

Evidence is mounting to indicate that cancer patients may have more likelihood of having coronavirus disease 2019 (COVID-19) but lack consistency. A robust estimate is urgently needed to convey appropriate information to the society and the public, in the time of ongoing COVID-19 pandemic. We performed a systematic review and ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Risk of cerebrovascular disease among 13,457 five-year survivors of childhood cancer: a population based cohort study.

Raoul C Reulen, Joyeeta Guha, Chloe J Bright, Katherine E Henson, Richard G Feltbower, Marlous Hall, Julie S Kelly, David L Winter, Michelle Kwok-Williams, Rod Skinner, David J Cutter, Clare Frobisher, Mike M Hawkins,

Survivors of childhood cancer treated with cranial irradiation are at risk of cerebrovascular disease (CVD), but the risks beyond age 50 are unknown.13,457 survivors of childhood cancer included in the population-based British Childhood Cancer Survivor Study cohort were linked to Hospital Episode Statistics data for England. Risk of CVD related ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



A chemical conjugation of JQ-1 and a TLR7 agonist induces tumoricidal effects in a murine model of melanoma via enhanced immunomodulation.

Xiaodong Wang, Bingying Yu, Birong Cao, Ji Zhou, Yongqiang Deng, Zhulin Wang, Guangyi Jin,

In recent year, inhibitors of the BET bromodomain proteins, such as BRD4 inhibitors, have demonstrated robust antitumor activity. JQ-1, a representative small molecular BRD4 inhibitor, is also effective to block PD-1/PD-L1 signaling by significantly decreasing the PD-L1 expression on tumor cells. However, toxicity of BRD4 inhibitors on lymphoid and hematopoietic ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Use of cancer data for cancer control in the Eastern Mediterranean Region: results of a survey among population-based cancer registries.

Ariana Znaor, Heba Fouad, Fosca Majnoni d'Intignano, Asmus Hammerich, Slim Slama, Nasim Pourghazian, Sultan Eser, Marion Piñeros Petersen, Freddie Bray,

Data from population-based cancer registries (PBCR) are critical for planning, monitoring and evaluation of cancer control programmes, but are frequently underutilised by key stakeholders. As part of the ongoing partnership of the International Agency for Research on Cancer (IARC) and the WHO Eastern Mediterranean Regional Office (EMRO) in cancer surveillance, ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Ibrutinib for improved chimeric antigen receptor T-cell production for chronic lymphocytic leukemia patients.

Fuli Fan, Hyeon Joo Yoo, Sophia Stock, Lei Wang, Yibin Liu, Maria-Luisa Schubert, Sanmei Wang, Brigitte Neuber, Angela Hückelhoven-Krauss, Ulrike Gern, Anita Schmitt, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt, Leopold Sellner,

Chimeric antigen receptor T (CART) cells targeting CD19 have shown promising results in the treatment of chronic lymphocytic leukemia (CLL). However, efficacy seems to be inferior compared to diffuse large B-cell lymphoma or acute lymphoblastic leukemia. Impaired T-cell fitness of CLL patients may be involved in treatment failure. Less-differentiated naïve-like ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Trends in hysterectomy-corrected uterine cancer mortality rates during 2002-2015: mortality of non-endometrioid cancer on the rise?

Line W Gustafson, Berit B Booth, Johnny Kahlert, Gitte Ørtoft, Else Mejlgaard, Megan A Clarke, Nicolas Wentzensen, Anne F Rositch, Anne Hammer,

Corpus uteri cancer is the most common gynecological malignancy in most developed countries. The disease is typically diagnosed at an early stage, is of endometrioid histologic subtype, and has a fairly good prognosis. Here, we describe hysterectomy-corrected mortality rates of corpus uteri cancer, overall and stratified by age, stage, and ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



The "unnatural" history of colorectal cancer in Lynch syndrome: lessons from colonoscopy surveillance.

Aysel Ahadova, Toni T Seppälä, Christoph Engel, Richard Gallon, John Burn, Elke Holinski-Feder, Verena Steinke-Lange, Gabriela Möslein, Maartje Nielsen, Sanne Ten Broeke, Luigi Laghi, Mev Dominguez-Valentin, Gabriel Capella, Finlay Macrae, Rodney Scott, Robert Hüneburg, Jacob Nattermann, Michael Hoffmeister, Hermann Brenner, Hendrik Bläker, Magnus von Knebel Doeberitz, Julian R Sampson, Hans Vasen, Jukka-Pekka Mecklin, Pål Møller, Matthias Kloor,

Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Liquid biopsies: potential and challenges.

Isabel Heidrich, Lucija Ačkar, Parinaz Mossahebi Mohammadi, Klaus Pantel,

The analysis of tumor cells or tumor cell products obtained from blood or other body fluids ("liquid biopsy") provides a broad range of opportunities in the field of oncology. Clinical application areas include early detection of cancer or tumor recurrence, individual risk assessment and therapy monitoring. Liquid biopsy allows to ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



The potential of breast cancer screening in Europe.

Nadine Zielonke, Lindy M Kregting, Eveline A M Heijnsdijk, Piret Veerus, Sirpa Heinävaara, Martin McKee, Inge M C M de Kok, Harry J de Koning, Nicolien T van Ravesteyn, ,

Currently, all European countries offer some form of breast cancer screening. Nevertheless, disparities exist in the status of implementation, attendance and the extent of opportunistic screening. As a result, breast cancer screening has not yet reached its full potential. We examined how many breast cancer deaths could be prevented if ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



"Category of Evidence and Consensus Underlying NCCN Guidelines: Is there evidence of progress?"

Aakash P Desai, Ronald S Go, Thejaswi K Poonacha,

National Comprehensive Cancer Network (NCCN) guidelines are the most comprehensive and widely used standard for clinical care, financial reimbursements and quality improvement initiatives in oncology. We studied the distribution of categories of evidence and consensus (EC) in the guidelines for the common cancers in the US. We evaluated the EC ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Diagnosis of Digestive System Tumours.

M Kay Washington, Richard M Goldberg, George J Chang, Paul Limburg, Alfred K Lam, Manuel Salto-Tellez, Mark J Arends, Iris D Nagtegaal, David S Klimstra, Massimo Rugge, Peter Schirmacher, Alexander J Lazar, Robert D Odze, Fatima Carneiro, Masashi Fukayama, Ian A Cree, ,

The WHO Classification of Tumours provides the international standards for the classification and diagnosis of tumours. It enables direct comparisons to be made between different countries. In the new 5th Edition, the series has gone digital with the launch of a website as well as a series of books, known ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Estimating the direct effect of human papillomavirus vaccination on the lifetime risk of screen-detected cervical precancer.

Federica Inturrisi, Birgit I Lissenberg-Witte, Nienke J Veldhuijzen, Johannes A Bogaards, Guglielmo Ronco, Chris J L M Meijer, Johannes Berkhof,

Birth cohorts vaccinated against human papillomavirus (HPV) are now entering cervical cancer screening. Assessment of (pre)cancer (CIN3+) risk is needed to assess the residual screening need in vaccinated women. We estimated the lifetime (screen-detected) CIN3+ risk under five-yearly primary HPV screening between age 30 and 60, using HPV genotyping and histology ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
0.9915 s