Full Text Journal Articles in
Journal Int J Mol Sci

Advertisement

Find full text journal articles






Molecular Mechanisms of Nitric Oxide (NO) Signaling and Reactive Oxygen Species (ROS) Homeostasis during Abiotic Stresses in Plants.

Kaiser Iqbal Wani, M Naeem, Christian Danve M Castroverde, Hazem M Kalaji, Mohammed Albaqami, Tariq Aftab,

Abiotic stressors, such as drought, heavy metals, and high salinity, are causing huge crop losses worldwide. These abiotic stressors are expected to become more extreme, less predictable, and more widespread in the near future. With the rapidly growing human population and changing global climate conditions, it is critical to prevent ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Characterization of Protocatechuate 4,5-Dioxygenase from Pseudarthrobacter phenanthrenivorans Sphe3 and In Situ Reaction Monitoring in the NMR Tube.

Epameinondas Tsagogiannis, Elpiniki Vandera, Alexandra Primikyri, Stamatia Asimakoula, Andreas G Tzakos, Ioannis P Gerothanassis, Anna-Irini Koukkou,

The current study aims at the functional and kinetic characterization of protocatechuate (PCA) 4,5-dioxygenase (PcaA) from <i>Pseudarthrobacter phenanthrenivorans</i> Sphe3. This is the first single subunit Type II dioxygenase characterized in Actinobacteria. RT-PCR analysis demonstrated that <i>pca</i>A and the adjacent putative genes implicated in the PCA <i>meta</i>-cleavage pathway comprise a single ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Advertisement

In Silico Screening of Novel α1-GABAA Receptor PAMs towards Schizophrenia Based on Combined Modeling Studies of Imidazo [1,2-a]-Pyridines.

Xiaojiao Zheng, Chenchen Wang, Na Zhai, Xiaogang Luo, Genyan Liu, Xiulian Ju,

The ionotropic GABA<sub>A</sub> receptor (GABA<sub>A</sub>R) has been proven to be an important target of atypical antipsychotics. A novel series of imidazo [1,2-a]-pyridine derivatives, as selective positive allosteric modulators (PAMs) of α1-containing GABA<sub>A</sub>Rs with potent antipsychotic activities, have been reported recently. To better clarify the pharmacological essentiality of these PAMs and ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Aggregation Condition-Structure Relationship of Mouse Prion Protein Fibrils.

Jēkabs Fridmanis, Zigmantas Toleikis, Tomas Sneideris, Mantas Ziaunys, Raitis Bobrovs, Vytautas Smirnovas, Kristaps Jaudzems,

Prion diseases are associated with conformational conversion of cellular prion protein into a misfolded pathogenic form, which resembles many properties of amyloid fibrils. The same prion protein sequence can misfold into different conformations, which are responsible for variations in prion disease phenotypes (prion strains). In this work, we use atomic ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Flame Retardant Functionalization of Microcrystalline Cellulose by Phosphorylation Reaction with Phytic Acid.

Hua-Bin Yuan, Ren-Cheng Tang, Cheng-Bing Yu,

The functionalization of microcrystalline cellulose (MCC) is an important strategy for broadening its application fields. In the present work, MCC was functionalized by phosphorylation reaction with phytic acid (PA) for enhanced flame retardancy. The conditions of phosphorylation reaction including PA concentration, MCC/PA weight ratio and temperature were discussed, and the ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Increase in Akkermansiaceae in Gut Microbiota of Prostate Cancer-Bearing Mice.

Pin-Yu Huang, Yu-Chih Yang, Chun-I Wang, Pei-Wen Hsiao, Hsin-I Chiang, Ting-Wen Chen,

Gut microbiota are reported to be associated with many diseases, including cancers. Several bacterial taxa have been shown to be associated with cancer development or response to treatment. However, longitudinal microbiota alterations during the development of cancers are relatively unexplored. To better understand how microbiota changes, we profiled the gut ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Transcriptome and Resequencing Analyses Provide Insight into Differences in Organic Acid Accumulation in Two Pear Varieties.

Qionghou Li, Xin Qiao, Luting Jia, Yuxin Zhang, Shaoling Zhang,

Fruit acidity is one of the main determinants of fruit flavor and a target trait in fruit breeding. However, the genomic mechanisms governing acidity variation among different pear varieties remain poorly understood. In this study, two pear varieties with contrasting organic acid levels, 'Dangshansuli' (low-acidity) and 'Amute' (high-acidity), were selected, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



K-Mer Analyses Reveal Different Evolutionary Histories of Alpha, Beta, and Gamma Papillomaviruses.

Zigui Chen, Filippo Utro, Daniel Platt, Rob DeSalle, Laxmi Parida, Paul K S Chan, Robert D Burk,

Papillomaviruses (PVs) are a heterogeneous group of DNA viruses that can infect fish, birds, reptiles, and mammals. PVs infecting humans (HPVs) phylogenetically cluster into five genera (Alpha-, Beta-, Gamma-, Mu- and Nu-PV), with differences in tissue tropism and carcinogenicity. The evolutionary features associated with the divergence of <i>Papillomaviridae</i> are not ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Entropy-Enthalpy Compensations Fold Proteins in Precise Ways.

Jiacheng Li, Chengyu Hou, Xiaoliang Ma, Shuai Guo, Hongchi Zhang, Liping Shi, Chenchen Liao, Bing Zheng, Lin Ye, Lin Yang, Xiaodong He,

Exploring the protein-folding problem has been a longstanding challenge in molecular biology and biophysics. Intramolecular hydrogen (H)-bonds play an extremely important role in stabilizing protein structures. To form these intramolecular H-bonds, nascent unfolded polypeptide chains need to escape from hydrogen bonding with surrounding polar water molecules under the solution conditions ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Genome-Wide Identification and Analysis of the Metallothionein Genes in Oryza Genus.

Mingxing Cheng, Huanran Yuan, Ruihua Wang, Jianing Zou, Ting Liang, Fang Yang, Shaoqing Li,

Metallothionein (MT) proteins are low molecular mass, cysteine-rich, and metal-binding proteins that play an important role in maintaining metal homeostasis and stress response. However, the evolutionary relationships and functional differentiation of <i>MT</i> in the <i>Oryza</i> genus remain unclear. Here we identified 53 <i>MT</i> genes from six <i>Oryza</i> genera, including <i>O. ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



New Advances in the Research of Resistance to Neoadjuvant Chemotherapy in Breast Cancer.

Junsha An, Cheng Peng, Hailin Tang, Xiuxiu Liu, Fu Peng,

Breast cancer has an extremely high incidence in women, and its morbidity and mortality rank first among female tumors. With the increasing development of medicine today, the clinical application of neoadjuvant chemotherapy has brought new hope to the treatment of breast cancer. Although the efficacy of neoadjuvant chemotherapy has been ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Perspectives on hiPSC-Derived Muscle Cells as Drug Discovery Models for Muscular Dystrophies.

Elena Abati, Emanuele Sclarandi, Giacomo Pietro Comi, Valeria Parente, Stefania Corti,

Muscular dystrophies are a heterogeneous group of inherited diseases characterized by the progressive degeneration and weakness of skeletal muscles, leading to disability and, often, premature death. To date, no effective therapies are available to halt or reverse the pathogenic process, and meaningful treatments are urgently needed. From this perspective, it ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



De Novo Missense Mutations in TNNC1 and TNNI3 Causing Severe Infantile Cardiomyopathy Affect Myofilament Structure and Function and Are Modulated by Troponin Targeting Agents.

Roua Hassoun, Heidi Budde, Hans Georg Mannherz, Mária Lódi, Setsuko Fujita-Becker, Kai Thorsten Laser, Anna Gärtner, Karin Klingel, Desirée Möhner, Robert Stehle, Innas Sultana, Thomas Schaaf, Mario Majchrzak, Verena Krause, Christian Herrmann, Marc M Nowaczyk, Andreas Mügge, Gabriele Pfitzer, Rasmus R Schröder, Nazha Hamdani, Hendrik Milting, Kornelia Jaquet, Diana Cimiotti,

Rare pediatric non-compaction and restrictive cardiomyopathy are usually associated with a rapid and severe disease progression. While the non-compaction phenotype is characterized by structural defects and is correlated with systolic dysfunction, the restrictive phenotype exhibits diastolic dysfunction. The molecular mechanisms are poorly understood. Target genes encode among others, the cardiac ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Novel Nitrogen-Based Chalcone Analogs Provoke Substantial Apoptosis in HER2-Positive Human Breast Cancer Cells via JNK and ERK1/ERK2 Signaling Pathways.

Balsam Rizeq, Ishita Gupta, Hadeel Kheraldine, Dana Elkhalifa, Halema F Al-Farsi, Ala-Eddin Al Moustafa, Ashraf Khalil,

Natural chalcones possess antitumor properties and play a role as inducers of apoptosis, antioxidants and cytotoxic compounds. We recently reported that novel nitrogen chalcone-based compounds, which were generated in our lab, have specific effects on triple-negative breast cancer cells. However, the outcome of these two new compounds on human epidermal ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



The Role of the Gut Microbiome in Diabetes and Obesity-Related Kidney Disease.

Amgad Zaky, Sarah J Glastras, May Y W Wong, Carol A Pollock, Sonia Saad,

Diabetic kidney disease (DKD) is a progressive disorder, which is increasing globally in prevalence due to the increased incidence of obesity and diabetes mellitus. Despite optimal clinical management, a significant number of patients with diabetes develop DKD. Hence, hitherto unrecognized factors are likely to be involved in the initiation and ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Multiple Imputation Approaches Applied to the Missing Value Problem in Bottom-Up Proteomics.

Miranda L Gardner, Michael A Freitas,

Analysis of differential abundance in proteomics data sets requires careful application of missing value imputation. Missing abundance values widely vary when performing comparisons across different sample treatments. For example, one would expect a consistent rate of "missing at random" (MAR) across batches of samples and varying rates of "missing not ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Deletion of Cdk5 in Macrophages Ameliorates Anti-Inflammatory Response during Endotoxemia through Induction of C-Maf and Il-10.

Pauline Pfänder, Ann-Kathrin Eiers, Ute Burret, Sabine Vettorazzi,

Immune response control is critical as excessive cytokine production can be detrimental and damage the host. Interleukin-10 (Il-10), an anti-inflammatory cytokine produced primarily by macrophages, is a key regulator that counteracts and controls excessive inflammatory response. Il-10 expression is regulated through the transcription factor c-Maf. Another regulator of Il-10 production ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



NK Cells Lose Their Cytotoxicity Function against Cancer Stem Cell-Rich Radiotherapy-Resistant Breast Cancer Cell Populations.

Hana Jin, Hye Jung Kim,

Cancer stem cells (CSCs) can be induced from differentiated cancer cells in the tumor microenvironment or in response to treatments and exhibit chemo- and radioresistance, leading to tumor recurrence and metastasis. We previously reported that triple negative breast cancer (TNBC) cells with acquired radioresistance exhibited more aggressive features due to ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Modification of a Single Atom Affects the Physical Properties of Double Fluorinated Fmoc-Phe Derivatives.

Moran Aviv, Dana Cohen-Gerassi, Asuka A Orr, Rajkumar Misra, Zohar A Arnon, Linda J W Shimon, Yosi Shacham-Diamand, Phanourios Tamamis, Lihi Adler-Abramovich,

Supramolecular hydrogels formed by the self-assembly of amino-acid based gelators are receiving increasing attention from the fields of biomedicine and material science. Self-assembled systems exhibit well-ordered functional architectures and unique physicochemical properties. However, the control over the kinetics and mechanical properties of the end-products remains puzzling. A minimal alteration of ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Role of Brown and Beige Adipose Tissues in Seasonal Adaptation in the Raccoon Dog (Nyctereutes procyonoides).

Laura Niiranen, Kari A Mäkelä, Shivaprakash J Mutt, Riikka Viitanen, Anna Kaisanlahti, David Vicente, Tommi Noponen, Anu Autio, Anne Roivainen, Pirjo Nuutila, Seppo Saarela, Karl-Heinz Herzig,

Brown adipose tissue (BAT) expresses uncoupling protein-1 (UCP1), which enables energy to be exerted towards needed thermogenesis. Beige adipocytes are precursor cells interspersed among white adipose tissue (WAT) that possess similar UCP1 activity and capacity for thermogenesis. The raccoon dog (<i>Nyctereutes procyonoides</i>) is a canid species that utilizes seasonal obesity ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Megakaryopoiesis and Platelet Biology: Roles of Transcription Factors and Emerging Clinical Implications.

Ji-Yoon Noh,

Platelets play a critical role in hemostasis and thrombus formation. Platelets are small, anucleate, and short-lived blood cells that are produced by the large, polyploid, and hematopoietic stem cell (HSC)-derived megakaryocytes in bone marrow. Approximately 3000 platelets are released from one megakaryocyte, and thus, it is important to understand the ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Utility of Platelet Endothelial Cell Adhesion Molecule 1 in the Platelet Activity Assessment in Mouse and Human Blood.

Natalia Marcinczyk, Tomasz Misztal, Anna Gromotowicz-Poplawska, Agnieszka Zebrowska, Tomasz Rusak, Piotr Radziwon, Ewa Chabielska,

In our previous study, we introduced the platelet endothelial cell adhesion molecule 1 (PECAM-1)/thrombus ratio, which is a parameter indicating the proportion of PECAM-1 in laser-induced thrombi in mice. Because PECAM-1 is an antithrombotic molecule, the higher the PECAM-1/thrombus ratio, the less activated the platelets. In this study, we used ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Functional Characterization of the Stipa purpurea P5CS Gene under Drought Stress Conditions.

Danni Yang, Ruize Ni, Shihai Yang, Yanan Pu, Min Qian, Yunqiang Yang, Yongping Yang,

Free proline has multiple functions in plant cells, such as regulating osmotic potential and protecting both proteins and cell membranes. The expression of Δ1-Pyrroline-5-carboxylate synthase (P5CS), a key enzyme in the proline biosynthetic pathway, increases under drought, salt and cold stress conditions, causing plant cells to accumulate large amounts of ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



High-Throughput Gene and Protein Analysis Revealed the Response of Disc Cells to Vitamin D, Depending on the VDR FokI Variants.

Alessandra Colombini, Paola De Luca, Davide Cangelosi, Carlotta Perucca Orfei, Enrico Ragni, Marco Viganò, Michela Malacarne, Mauro Castagnetta, Marco Brayda-Bruno, Domenico Coviello, Laura de Girolamo,

Vitamin D showed a protective effect on intervertebral disc degeneration (IDD) although conflicting evidence is reported. An explanation could be due to the presence of the FokI functional variant in the vitamin D receptor (<i>VDR</i>), observed as associated with spine pathologies. The present study was aimed at investigating-through high-throughput gene ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Brain Metabolic Profile after Intranasal vs. Intraperitoneal Clomipramine Treatment in Rats with Ultrasound Model of Depression.

Olga Abramova, Yana Zorkina, Timur Syunyakov, Eugene Zubkov, Valeria Ushakova, Artemiy Silantyev, Kristina Soloveva, Olga Gurina, Alexander Majouga, Anna Morozova, Vladimir Chekhonin,

<h4>Background</h4>Molecular mechanisms of depression remain unclear. The brain metabolome after antidepressant therapy is poorly understood and had not been performed for different routes of drug administration before the present study. Rats were exposed to chronic ultrasound stress and treated with intranasal and intraperitoneal clomipramine. We then analyzed 28 metabolites in ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

Cited: 0 times

View full text PDF listing >>



Advertisement


Disclaimer

1.1376 s