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Journal Int J Mol Sci

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GOLPH3 Regulates EGFR in T98G Glioblastoma Cells by Modulating Its Glycosylation and Ubiquitylation.

Cecilia Arriagada, Viviana A Cavieres, Charlotte Luchsinger, Alexis E González, Vanessa C Muñoz, Jorge Cancino, Patricia V Burgos, Gonzalo A Mardones,

Protein trafficking is altered when normal cells acquire a tumor phenotype. A key subcellular compartment in regulating protein trafficking is the Golgi apparatus, but its role in carcinogenesis is still not well defined. Golgi phosphoprotein 3 (GOLPH3), a peripheral membrane protein mostly localized at the trans-Golgi network, is overexpressed in ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(22):]

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Combination Therapy to Treat Fungal Biofilm-Based Infections.

Jana Tits, Bruno P A Cammue, Karin Thevissen,

An increasing number of people is affected by fungal biofilm-based infections, which are resistant to the majority of currently-used antifungal drugs. Such infections are often caused by species from the genera Candida, Aspergillus or Cryptococcus. Only a few antifungal drugs, including echinocandins and liposomal formulations of amphotericin B, are available ... Read more >>

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[2020, 21(22):]

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Hypoxia-Responsive Class III Peroxidases in Maize Roots: Soluble and Membrane-Bound Isoenzymes.

Anne Hofmann, Stefanie Wienkoop, Sönke Harder, Fabian Bartlog, Sabine Lüthje,

Flooding induces low-oxygen environments (hypoxia or anoxia) that lead to energy disruption and an imbalance of reactive oxygen species (ROS) production and scavenging enzymes in plants. The influence of hypoxia on roots of hydroponically grown maize (Zea mays L.) plants was investigated. Gene expression (RNA Seq and RT-qPCR) and proteome ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(22):]

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Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action.

Jakub Mlost, Marta Bryk, Katarzyna Starowicz,

Cannabis has a long history of medical use. Although there are many cannabinoids present in cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two components found in the highest concentrations. CBD itself does not produce typical behavioral cannabimimetic effects and was thought not to be responsible for psychotropic effects of ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(22):]

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Cardioprotection via Metabolism for Rat Heart Preservation Using the High-Pressure Gaseous Mixture of Carbon Monoxide and Oxygen.

Chiharu Suzuki, Naoyuki Hatayama, Tadashi Ogawa, Eri Nanizawa, Shun Otsuka, Koichiro Hata, Hiroshi Seno, Munekazu Naito, Shuichi Hirai,

The high-pressure gas (HPG) method with carbon monoxide (CO) and oxygen (O2) mixture maintains the preserved rat heart function. The metabolites of rat hearts preserved using the HPG method (HPG group) and cold storage (CS) method (CS group) by immersion in a stock solution for 24 h were assessed to ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(22):]

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Connexin43 Region 266-283, via Src Inhibition, Reduces Neural Progenitor Cell Proliferation Promoted by EGF and FGF-2 and Increases Astrocytic Differentiation.

Rocío Talaverón, Esperanza R Matarredona, Alejandro Herrera, José M Medina, Arantxa Tabernero,

Neural progenitor cells (NPCs) are self-renewing cells that give rise to the major cells in the nervous system and are considered to be the possible cell of origin of glioblastoma. The gap junction protein connexin43 (Cx43) is expressed by NPCs, exerting channel-dependent and -independent roles. We focused on one property ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(22):]

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Emerging Kinase Therapeutic Targets in Pancreatic Ductal Adenocarcinoma and Pancreatic Cancer Desmoplasia.

Justin F Creeden, Khaled Alganem, Ali S Imami, Nicholas D Henkel, F Charles Brunicardi, Shi-He Liu, Rammohan Shukla, Tushar Tomar, Faris Naji, Robert E McCullumsmith,

Kinase drug discovery represents an active area of therapeutic research, with previous pharmaceutical success improving patient outcomes across a wide variety of human diseases. In pancreatic ductal adenocarcinoma (PDAC), innovative pharmaceutical strategies such as kinase targeting have been unable to appreciably increase patient survival. This may be due, in part, ... Read more >>

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Extracellular Vesicles, Influential Players of Intercellular Communication within Adult Neurogenic Niches.

Morris Losurdo, Mariagrazia Grilli,

Adult neurogenesis, involving the generation of functional neurons from adult neural stem cells (NSCs), occurs constitutively in discrete brain regions such as hippocampus, sub-ventricular zone (SVZ) and hypothalamus. The intrinsic structural plasticity of the neurogenic process allows the adult brain to face the continuously changing external and internal environment and ... Read more >>

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[2020, 21(22):]

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Correction: Shi, H., et al. Arctigenin Attenuates Breast Cancer Progression through Decreasing GM-CSF/TSLP/STAT3/β-Catenin Signaling. Int. J. Mol. Sci. 2020, 21, 6357.

Hui Shi, Luping Zhao, Xinlin Guo, Runping Fang, Hui Zhang, Guanjun Dong, Jia Fu, Fenglian Yan, Junfeng Zhang, Zhaochen Ning, Qun Ma, Zhihua Li, Chunxia Li, Jun Dai, Chuanping Si, Huabao Xiong,

The authors wish to make the following correction to this paper [...]. ... Read more >>

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[2020, 21(22):]

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Unraveling the Role of Epicardial Adipose Tissue in Coronary Artery Disease: Partners in Crime?

Glória Conceição, Diana Martins, Isabel M Miranda, Adelino F Leite-Moreira, Rui Vitorino, Inês Falcão-Pires,

The role of epicardial adipose tissue (EAT) in the pathophysiology of coronary artery disease (CAD) remains unclear. The present systematic review aimed at compiling dysregulated proteins/genes from different studies to dissect the potential role of EAT in CAD pathophysiology. Exhaustive literature research was performed using the keywords "epicardial adipose tissue ... Read more >>

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[2020, 21(22):]

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GLP-2 Prevents Neuronal and Glial Changes in the Distal Colon of Mice Chronically Treated with Cisplatin.

Patrizia Nardini, Alessandro Pini, Anne Bessard, Emilie Duchalais, Elena Niccolai, Michel Neunlist, Maria Giuliana Vannucchi,

Cisplatin is a chemotherapeutic agent widely used for the treatment of solid cancers. Its administration is commonly associated with acute and chronic gastrointestinal dysfunctions, likely related to mucosal and enteric nervous system (ENS) injuries, respectively. Glucagon-like peptide-2 (GLP-2) is a pleiotropic hormone exerting trophic/reparative activities on the intestine, via antiapoptotic ... Read more >>

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TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP.

Maria Feoktistova, Roman Makarov, Martin Leverkus, Amir S Yazdi, Diana Panayotova-Dimitrova,

cFLIP is required for epidermal integrity and skin inflammation silencing via protection from TNF-induced keratinocyte apoptosis. Here, we generated and analyzed cFLIP epidermal KO mice with additional TNF deficiency. Intriguingly, the ablation of TNF rescued the pathological phenotype of epidermal cFLIP KO from characteristic weight loss and increased mortality. Moreover, ... Read more >>

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[2020, 21(22):]

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Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds.

André Campaniço, Shrika G Harjivan, Digby F Warner, Rui Moreira, Francisca Lopes,

Despite being discovered and isolated more than one hundred years ago, tuberculosis (TB) remains a global public health concern arch. Our inability to eradicate this bacillus is strongly related with the growing resistance, low compliance to current drugs, and the capacity of the bacteria to coexist in a state of ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(22):]

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The Body's Cellular and Molecular Response to Protein-Coated Medical Device Implants: A Review Focused on Fibronectin and BMP Proteins.

Yi-Fan Chen, Clyde Goodheart, Diego Rua,

Recent years have seen a marked rise in implantation into the body of a great variety of devices: hip, knee, and shoulder replacements, pacemakers, meshes, glucose sensors, and many others. Cochlear and retinal implants are being developed to restore hearing and sight. After surgery to implant a device, adjacent cells ... Read more >>

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[2020, 21(22):]

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Plasmin-Induced Activation of Human Platelets Is Modulated by Thrombospondin-1, Bona Fide Misfolded Proteins and Thiol Isomerases.

Claudia Pielsticker, Martin F Brodde, Lisa Raum, Kerstin Jurk, Beate E Kehrel,

Inflammatory processes are triggered by the fibrinolytic enzyme plasmin. Tissue-type plasminogen activator, which cleaves plasminogen to plasmin, can be activated by the cross-β-structure of misfolded proteins. Misfolded protein aggregates also represent substrates for plasmin, promoting their degradation, and are potent platelet agonists. However, the regulation of plasmin-mediated platelet activation by ... Read more >>

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[2020, 21(22):]

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Effect of Acute Sprint Exercise on Myokines and Food Intake Hormones in Young Healthy Men.

Jan Bilski, Agnieszka Irena Mazur-Bialy, Marcin Surmiak, Magdalena Hubalewska-Mazgaj, Janusz Pokorski, Jacek Nitecki, Ewa Nitecka, Joanna Pokorska, Aneta Targosz, Agata Ptak-Belowska, Jerzy A Zoladz, Tomasz Brzozowski,

Physical exercise is known to influence hormonal mediators of appetite, but the effect of short-term maximal intensity exercise on plasma levels of appetite hormones and cytokines has been little studied. We investigated the effect of a 30 s Wingate Test, followed by a postprandial period, on appetite sensations, food intake, ... Read more >>

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[2020, 21(22):]

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Regulation of Glutamatergic Activity via Bidirectional Activation of Two Select Receptors as a Novel Approach in Antipsychotic Drug Discovery.

Paulina Cieślik, Joanna M Wierońska,

Schizophrenia is a mental disorder that affects approximately 1-2% of the population and develops in early adulthood. The disease is characterized by positive, negative, and cognitive symptoms. A large percentage of patients with schizophrenia have a treatment-resistant disease, and the risk of developing adverse effects is high. Many researchers have ... Read more >>

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[2020, 21(22):]

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A Rice Immunophilin Homolog, OsFKBP12, Is a Negative Regulator of Both Biotic and Abiotic Stress Responses.

Ming-Yan Cheung, Wan-Kin Auyeung, Kwan-Pok Li, Hon-Ming Lam,

A class of proteins that were discovered to bind the immunosuppressant drug FK506, called FK506-binding proteins (FKBPs), are members of a sub-family of immunophilins. Although they were first identified in human, FKBPs exist in all three domains of life. In this report, a rice FKBP12 homolog was first identified as ... Read more >>

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[2020, 21(22):]

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Thymus-Pineal Gland Axis: Revisiting Its Role in Human Life and Ageing.

Rita Rezzani, Caterina Franco, Rüdiger Hardeland, Luigi Fabrizio Rodella,

For years the thymus gland (TG) and the pineal gland (PG) have been subject of increasingly in-depth studies, but only recently a link that can associate the activities of the two organs has been identified. Considering, on the one hand, the well-known immune activity of thymus and, on the other, ... Read more >>

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[2020, 21(22):]

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New Aspects of the Kidney in the Regulation of Fibroblast Growth Factor 23 (FGF23) and Mineral Homeostasis.

Maria L Mace, Klaus Olgaard, Ewa Lewin,

The bone-derived hormone fibroblast growth factor 23 (FGF23) acts in concert with parathyroid hormone (PTH) and the active vitamin D metabolite calcitriol in the regulation of calcium (Ca) and phosphate (P) homeostasis. More factors are being identified to regulate FGF23 levels and the endocrine loops between the three hormones. The ... Read more >>

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Currently Applied Molecular Assays for Identifying ESR1 Mutations in Patients with Advanced Breast Cancer.

Nuri Lee, Min-Jeong Park, Wonkeun Song, Kibum Jeon, Seri Jeong,

Approximately 70% of breast cancers, the leading cause of cancer-related mortality worldwide, are positive for the estrogen receptor (ER). Treatment of patients with luminal subtypes is mainly based on endocrine therapy. However, ER positivity is reduced and ESR1 mutations play an important role in resistance to endocrine therapy, leading to ... Read more >>

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Rbm38 Reduces the Transcription Elongation Defect of the SMEK2 Gene Caused by Splicing Deficiency.

Shintaro Muraoka, Kazuhiro Fukumura, Megumi Hayashi, Naoyuki Kataoka, Akila Mayeda, Daisuke Kaida,

Pre-mRNA splicing is an essential mechanism for ensuring integrity of the transcriptome in eukaryotes. Therefore, splicing deficiency might cause a decrease in functional proteins and the production of nonfunctional, aberrant proteins. To prevent the production of such aberrant proteins, eukaryotic cells have several mRNA quality control mechanisms. In addition to ... Read more >>

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Endothelial Damage in Acute Respiratory Distress Syndrome.

Alice G Vassiliou, Anastasia Kotanidou, Ioanna Dimopoulou, Stylianos E Orfanos,

The pulmonary endothelium is a metabolically active continuous monolayer of squamous endothelial cells that internally lines blood vessels and mediates key processes involved in lung homoeostasis. Many of these processes are disrupted in acute respiratory distress syndrome (ARDS), which is marked among others by diffuse endothelial injury, intense activation of ... Read more >>

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Nanomechanics in Monitoring the Effectiveness of Drugs Targeting the Cancer Cell Cytoskeleton.

Andrzej Kubiak, Tomasz Zieliński, Joanna Pabijan, Małgorzata Lekka,

Increasing attention is devoted to the use of nanomechanics as a marker of various pathologies. Atomic force microscopy (AFM) is one of the techniques that could be applied to quantify the nanomechanical properties of living cells with a high spatial resolution. Thus, AFM offers the possibility to trace changes in ... Read more >>

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Anti-PD-1 Immunotherapy in Preclinical GL261 Glioblastoma: Influence of Therapeutic Parameters and Non-Invasive Response Biomarker Assessment with MRSI-Based Approaches.

Shuang Wu, Pilar Calero-Pérez, Carles Arús, Ana Paula Candiota,

Glioblastomas (GBs) are malignant brain tumours with poor prognosis even after aggressive therapy. Programmed cell death-1 (PD-1) immune checkpoint blockade is a promising strategy in many types of cancer, but its therapeutic effects in GB remain low and associated with immune infiltration. Previous work suggests that oscillations of magnetic resonance ... Read more >>

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