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Journal Int J Mol Sci

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The Abuse Potential of Novel Synthetic Phencyclidine Derivative 1-(1-(4-Fluorophenyl)Cyclohexyl)Piperidine (4'-F-PCP) in Rodents.

In Soo Ryu, Oc-Hee Kim, Young Eun Lee, Ji Sun Kim, Zhan-Hui Li, Tae Wan Kim, Ri-Na Lim, Young Ju Lee, Jae Hoon Cheong, Hee Jin Kim, Yong Sup Lee, Scott C Steffensen, Bong Hyo Lee, Joung-Wook Seo, Eun Young Jang,

The dissociative anesthetic phencyclidine (PCP) and PCP derivatives, including 4'-F-PCP, are illegally sold and abused worldwide for recreational and non-medical uses. The psychopharmacological properties and abuse potential of 4'-F-PCP have not been fully characterized. In this study, we evaluated the psychomotor, rewarding, and reinforcing properties of 4'-F-PCP using the open-field ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(13):]

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Experimental Models in Neovascular Age Related Macular Degeneration.

Olivia Rastoin, Gilles Pagès, Maeva Dufies,

Neovascular age-related macular degeneration (vAMD), characterized by the neo-vascularization of the retro-foveolar choroid, leads to blindness within few years. This disease depends on angiogenesis mediated by the vascular endothelial growth factor A (VEGF) and to inflammation. The only available treatments consist of monthly intravitreal injections of antibodies directed against VEGF ... Read more >>

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Pharmacological Treatment of Alzheimer's Disease: Insights from Drosophila melanogaster.

Xingyi Cheng, Chaochun Song, Yanjiao Du, Uma Gaur, Mingyao Yang,

Aging is an ineluctable law of life. During the process of aging, the occurrence of neurodegenerative disorders is prevalent in the elderly population and the predominant type of dementia is Alzheimer's disease (AD). The clinical symptoms of AD include progressive memory loss and impairment of cognitive functions that interfere with ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(13):]

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Effects of Apigenin on RBL-2H3, RAW264.7, and HaCaT Cells: Anti-Allergic, Anti-Inflammatory, and Skin-Protective Activities.

Che-Hwon Park, Seon-Young Min, Hye-Won Yu, Kyungmin Kim, Suyeong Kim, Hye-Ja Lee, Ji-Hye Kim, Young-Jin Park,

Apigenin (4',5,7-trihydroxyflavone, flavonoid) is a phenolic compound that is known to reduce the risk of chronic disease owing to its low toxicity. The first study on apigenin analyzed its effect on histamine release in the 1950s. Since then, anti-mutation and antitumor properties of apigenin have been widely reported. In the ... Read more >>

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[2020, 21(13):]

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Protocatechuic Aldehyde Attenuates UVA-Induced Photoaging in Human Dermal Fibroblast Cells by Suppressing MAPKs/AP-1 and NF-κB Signaling Pathways.

Yuling Ding, Chanipa Jiratchayamaethasakul, Seung-Hong Lee,

Ultraviolet radiation (UV) is a major causative factor of DNA damage, inflammatory responses, reactive oxygen species (ROS) generation and a turnover of various cutaneous lesions resulting in skin photoaging. The purpose of this study is to investigate the protective effect of protocatechuic aldehyde (PA), which is a nature-derived compound, against ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(13):]

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Integrated RNA-Seq Analysis and Meta-QTLs Mapping Provide Insights into Cold Stress Response in Rice Seedling Roots.

Weilong Kong, Chenhao Zhang, Yalin Qiang, Hua Zhong, Gangqing Zhao, Yangsheng Li,

Rice (Oryza sativa L.) is a widely cultivated food crop around the world, especially in Asia. However, rice seedlings often suffer from cold stress, which affects their growth and yield. Here, RNA-seq analysis and Meta-QTLs mapping were performed to understand the molecular mechanisms underlying cold tolerance in the roots of ... Read more >>

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[2020, 21(13):]

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Exploration of the Effects of Different Blue LED Light Intensities on Flavonoid and Lipid Metabolism in Tea Plants via Transcriptomics and Metabolomics.

Pengjie Wang, Sirong Chen, Mengya Gu, Xiaomin Chen, Xuejin Chen, Jiangfan Yang, Feng Zhao, Naixing Ye,

Blue light extensively regulates multiple physiological processes and secondary metabolism of plants. Although blue light quantity (fluence rate) is important for plant life, few studies have focused on the effects of different blue light intensity on plant secondary metabolism regulation, including tea plants. Here, we performed transcriptomic and metabolomic analyses ... Read more >>

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Self-Organized Liver Microtissue on a Bio-Functional Surface: The Role of Human Adipose-Derived Stromal Cells in Hepatic Function.

Seokheon Hong, Seung Ja Oh, Dongho Choi, Yongsung Hwang, Sang-Heon Kim,

The maintenance of hepatocyte function is a critical research topic in liver tissue engineering. Although an increasing number of strategies have been developed, liver tissue engineering using hepatocytes as a therapeutic alternative remains challenging owing to its poor efficacy. In this study, we developed a multicellular hepatic microtissue to enhance ... Read more >>

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[2020, 21(13):]

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miRNA Clusters with Down-Regulated Expression in Human Colorectal Cancer and Their Regulation.

Paulína Pidíkova, Richard Reis, Iveta Herichova,

Regulation of microRNA (miRNA) expression has been extensively studied with respect to colorectal cancer (CRC), since CRC is one of the leading causes of cancer mortality worldwide. Transcriptional control of miRNAs creating clusters can be, to some extent, estimated from cluster position on a chromosome. Levels of miRNAs are also ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(13):]

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Self-Repair in Cacti Branches: Comparative Analyses of Their Morphology, Anatomy, and Biomechanics.

Max D Mylo, Friederike Krüger, Thomas Speck, Olga Speck,

Damage-repair is particularly important for the maintenance of the water-storing abilities of succulent plants such as cacti. Comparative morphological, anatomical, and biomechanical analyses of self-repair were performed on artificially wounded branches of Opuntia ficus-indica and Cylindropuntia bigelovii. Macroscopic observations, contrast staining, and lignin-proof staining were used to investigate morphological and ... Read more >>

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Plasma Extracellular Vesicle-Derived TIMP-1 mRNA as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma: A Pilot Study.

Francisca Dias, Ana Luísa Teixeira, Inês Nogueira, Mariana Morais, Joana Maia, Cristian Bodo, Marta Ferreira, Isabel Vieira, José Silva, João Lobo, José Pedro Sequeira, Joaquina Maurício, Jorge Oliveira, Carlos Palmeira, Gabriela Martins, Klaas Kok, Bruno Costa-Silva, Rui Medeiros,

The tumor microenvironment has gained a lot of attention from the scientific community since it has a proven impact in the development of tumor progression and metastasis. Extracellular vesicles (EVs) are now considered one of the key players of tumor microenvironment modulation. Clear cell renal cell carcinoma (ccRCC) is the ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(13):]

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An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities.

Francesca Annunziata, Cecilia Pinna, Sabrina Dallavalle, Lucia Tamborini, Andrea Pinto,

Privileged structures have been widely used as an effective template for the research and discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and it can be found in a considerable number of plants as well as in some fungi and bacteria. In the last years, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(13):]

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Bispicolyamine-Based Supramolecular Polymeric Gels Induced by Distinct Different Driving Forces with and Without Zn2.

Jaehyeon Park, Ka Young Kim, Seok Gyu Kang, Shim Sung Lee, Ji Ha Lee, Jong Hwa Jung,

Metal-coordination polymeric gels are interesting areas as organic/inorganic hybrid supramolecular materials. The bispicolylamine (BPA) based gelator (1) showed excellent gelation with typical fibrillar morphology in acetonitrile. Upon complexing 1 with Zn2+, complexes ([1 + Zn + ACN]2+ and [1 + zinc trifluoromethanesulfonate (ZnOTf)]+) with four coordination numbers were formed, which ... Read more >>

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HMGB1-Mediated Neuroinflammatory Responses in Brain Injuries: Potential Mechanisms and Therapeutic Opportunities.

Yam Nath Paudel, Efthalia Angelopoulou, Christina Piperi, Iekhsan Othman, Mohd Farooq Shaikh,

Brain injuries are devastating conditions, representing a global cause of mortality and morbidity, with no effective treatment to date. Increased evidence supports the role of neuroinflammation in driving several forms of brain injuries. High mobility group box 1 (HMGB1) protein is a pro-inflammatory-like cytokine with an initiator role in neuroinflammation ... Read more >>

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[2020, 21(13):]

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Lactobacillus plantarum DR7 Modulated Bowel Movement and Gut Microbiota Associated with Dopamine and Serotonin Pathways in Stressed Adults.

Guoxia Liu, Hui-Xian Chong, Fiona Yi-Li Chung, Yin Li, Min-Tze Liong,

We have previously reported that the administration of Lactobacillus plantarum DR7 for 12 weeks reduced stress and anxiety in stressed adults as compared to the placebo group, in association with changes along the brain neurotransmitters pathways of serotonin and dopamine-norepinephrine. We now aim to evaluate the effects of DR7 on ... Read more >>

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Burns in the Elderly: Potential Role of Stem Cells.

Margarita Elloso, Ankita Kambli, Ayesha Aijaz, Alex van de Kamp, Mark G Jeschke,

Burns in the elderly continue to be a challenge despite advances in burn wound care management. Elderly burn patients continue to have poor outcomes compared to the younger population. This is secondary to changes in the quality of the aged skin, leading to impaired wound healing, aggravated immunologic and inflammatory ... Read more >>

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Abnormal Social Interactions in a Drosophila Mutant of an Autism Candidate Gene: Neuroligin 3.

Ryley T Yost, J Wesley Robinson, Carling M Baxter, Andrew M Scott, Liam P Brown, M Sol Aletta, Ramtin Hakimjavadi, Asad Lone, Robert C Cumming, Reuven Dukas, Brian Mozer, Anne F Simon,

Social interactions are typically impaired in neuropsychiatric disorders such as autism, for which the genetic underpinnings are very complex. Social interactions can be modeled by analysis of behaviors, including social spacing, sociability, and aggression, in simpler organisms such as Drosophila melanogaster. Here, we examined the effects of mutants of the ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(13):]

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Trace Element Bioaccumulation in Stone Curlew (Burhinus oedicnemus, Linnaeus, 1758): A Case Study from Sicily (Italy).

Chiara Copat, Margherita Ferrante, Béatrice V Hernout, Flavia Giunta, Alfina Grasso, Andrea Messina, Rosario Grasso, Maria Teresa Spena,

: The study aimed to highlight the degree of trace element contamination along three sites of Sicily: the Magnisi peninsula (MP), located in proximity to the Augusta-Priolo-Melilli petrochemical plant; the Ragusa agro-ecosystem (RA), characterized by a rural landscape; and the Gela plain (GP), characterized by intensive agriculture and a disused ... Read more >>

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Promoter Methylation of Selected Genes in Non-Small-Cell Lung Cancer Patients and Cell Lines.

Victoria Sarne, Samuel Huter, Sandrina Braunmueller, Lisa Rakob, Nico Jacobi, Melitta Kitzwögerer, Christoph Wiesner, Peter Obrist, Rita Seeboeck,

Specific gene promoter DNA methylation is becoming a powerful epigenetic biomarker in cancer diagnostics. Five genes (CDH1, CDKN2Ap16, RASSF1A, TERT, and WT1) were selected based on their frequently published potential as epigenetic markers. Diagnostic promoter methylation assays were generated based on bisulfite-converted DNA pyrosequencing. The methylation patterns of 144 non-small-cell ... Read more >>

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PchE Regulation of Escherichia coli O157:H7 Flagella, Controlling the Transition to Host Cell Attachment.

Elisa Andreozzi, Gaylen A Uhlich,

Shiga toxins and intimate adhesion controlled by the locus of enterocyte effacement are major enterohemorrhagic Escherichia coli (EHEC) virulence factors. Curli fimbriae also contribute to cell adhesion and are essential biofilm components. The transcriptional regulator PchE represses the expression of curli and their adhesion to HEp-2 cells. Past studies indicate ... Read more >>

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Anti-Inflammatory and General Glucocorticoid Physiology in Skeletal Muscles Affected by Duchenne Muscular Dystrophy: Exploration of Steroid-Sparing Agents.

Sandrine Herbelet, Arthur Rodenbach, Boel De Paepe, Jan L De Bleecker,

In Duchenne muscular dystrophy (DMD), the activation of proinflammatory and metabolic cellular pathways in skeletal muscle cells is an inherent characteristic. Synthetic glucocorticoid intake counteracts the majority of these mechanisms. However, glucocorticoids induce burdensome secondary effects, including hypertension, arrhythmias, hyperglycemia, osteoporosis, weight gain, growth delay, skin thinning, cushingoid appearance, and ... Read more >>

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Crosstalk between Hydrogen Sulfide and Other Signal Molecules Regulates Plant Growth and Development.

Lijuan Xuan, Jian Li, Xinyu Wang, Chongying Wang,

Hydrogen sulfide (H2S), once recognized only as a poisonous gas, is now considered the third endogenous gaseous transmitter, along with nitric oxide (NO) and carbon monoxide (CO). Multiple lines of emerging evidence suggest that H2S plays positive roles in plant growth and development when at appropriate concentrations, including seed germination, ... Read more >>

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An AP2/ERF Gene, HuERF1, from Pitaya (Hylocereus undatus) Positively Regulates Salt Tolerance.

Yujie Qu, Quandong Nong, Shuguang Jian, Hongfang Lu, Mingyong Zhang, Kuaifei Xia,

Pitaya (Hylocereus undatus) is a high salt-tolerant fruit, and ethylene response factors (ERFs) play important roles in transcription-regulating abiotic tolerance. To clarify the function of HuERF1 in the salt tolerance of pitaya, HuERF1 was heterogeneously expressed in Arabidopsis. HuERF1 had nuclear localization when HuERF1::GFP was expressed in Arabidopsis protoplasts and ... Read more >>

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RIP1 Is a Novel Component of γ-ionizing Radiation-Induced Invasion of Non-Small Cell Lung Cancer Cells.

A-Ram Kang, Jeong Hyun Cho, Na-Gyeong Lee, Jie-Young Song, Sang-Gu Hwang, Dae-Hee Lee, Hong-Duck Um, Jong Kuk Park,

Abstract: Previously, we demonstrated that γ-ionizing radiation (IR) triggers the invasion/migration of A549 cells via activation of an EGFR-p38/ERK-STAT3/CREB-1-EMT pathway. Here, we have demonstrated the involvement of a novel intracellular signaling mechanism in γ-ionizing radiation (IR)-induced migration/invasion. Expression of receptor-interacting protein (RIP) 1 was initially increased upon exposure of A549, ... Read more >>

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Impaired ECM Remodeling and Macrophage Activity Define Necrosis and Regeneration Following Damage in Aged Skeletal Muscle.

Fasih Ahmad Rahman, Sarah Anne Angus, Kyle Stokes, Phillip Karpowicz, Matthew Paul Krause,

Regenerative capacity of skeletal muscle declines with age, the cause of which remains largely unknown. We investigated extracellular matrix (ECM) proteins and their regulators during early regeneration timepoints to define a link between aberrant ECM remodeling, and impaired aged muscle regeneration. The regeneration process was compared in young (three month ... Read more >>

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