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Journal Int J Cancer

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Non-invasive risk stratification of IPMN with malignant potential by serum apolipoprotein-A2-isoforms.

Klaus Felix, Kazufumi Honda, Kengo Nagashima, Ayumi Kashiro, Keiko Takeuchi, Takashi Kobayashi, Sascha Hinterkopf, Matthias M Gaida, Hien Dang, Niall Brindl, Jörg Kaiser, Markus W Büchler, Oliver Strobel,

Intraductal papillary mucinous neoplasms (IPMNs) are premalignant lesions of pancreatic cancer. An accurate serum biomarker, which allows earlier identification of asymptomatic individuals with high-risk for developing cancer, is of urgent need. ApolipoproteinA2-isoforms (apoA2-i) have previously been identified as biomarkers in pancreatic cancer. This study investigates a potential clinical application of ... Read more >>

Int J Cancer (International journal of cancer)
[2021, :]

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Genetically determined cutaneous nevi and risk of cancer.

Jean Claude Dusingize, Matthew H Law, Nirmala Pandeya, Rachel E Neale, Jue-Sheng Ong, Stuart MacGregor, David C Whiteman, Catherine M Olsen,

Numerous epidemiologic studies have reported positive associations between higher nevus counts and internal cancers. Whether this association represents a true relationship or is due to bias or confounding by factors associated with both nevus counts and cancer remains unclear. We used germline genetic variants for nevus count to test whether ... Read more >>

Int J Cancer (International journal of cancer)
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CD33-directed immunotherapy with third-generation chimeric antigen receptor T cells and gemtuzumab ozogamicin in intact and CD33-edited acute myeloid leukemia and hematopoietic stem and progenitor cells.

Yi Liu, Sanmei Wang, Maria-Luisa Schubert, Annika Lauk, Hao Yao, Maximilian Felix Blank, Chunhong Cui, Maike Janssen, Christina Schmidt, Stefanie Göllner, Christian Kleist, Fengbiao Zhou, Jens-Ulrich Rahfeld, Tim Sauer, Michael Schmitt, Carsten Müller-Tidow,

Immunotherapies, such as chimeric antigen receptor (CAR) modified T cells and antibody-drug conjugates (ADCs), have revolutionized the treatment of cancer, especially of lymphoid malignancies. The application of targeted immunotherapy to patients with acute myeloid leukemia (AML) has been limited in particular by the lack of a tumor-specific target antigen. Gemtuzumab ... Read more >>

Int J Cancer (International journal of cancer)
[2021, :]

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The effects of TNF-α/TNFR2 in regulatory T cells on the microenvironment and progression of gastric cancer.

Yang Qu, Xianhao Wang, Shuai Bai, Liling Niu, Gang Zhao, Yuan Yao, Bin Li, Hui Li,

TNFR2+ regulatory T cells preferentially accumulate in the tumor microenvironment, express high levels of immunosuppressive molecules and possess strong suppressive activity. Our study aimed to explore the characteristics and role of TNFR2+ Tregs in the microenvironment and progression of gastric cancer via polychromatic immunofluorescence, single-cell RNA sequencing and flow cytometry ... Read more >>

Int J Cancer (International journal of cancer)
[2021, :]

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"The clinical utility and safety of Short-course Immune check point inhibitors (ICI) in multiple tumors - A real world multicentric study from India".

George Abraham, Vanita Noronha, Senthil Rajappa, Amit Agarwal, Ullas Batra, Naresh Somani, Thirumalairaj Raja, Shekhar Patil, Ashish M Kaushal, Ashish Joshi, Vivek Radhakrishnan, Navneet Singh, Govind Babu K, Rohan Tewani, Saphalta Baghmar, Chandragouda Dodagoudar, Ramya Ananthakrishnan, Shashidhara H P, Vibhor Sharma, Nandini Menon, Vijay Patil, Amit Joshi, Sudeep Gupta, Kumar Prabhash, Jyoti Bajpai,

The real-world data on short-course of ICI use is sparse and merits exploration. A multi-centric observational study on the safety and efficacy of ICI in oncology patients between August 2014 to October 2020 involving 1011 patients across 13 centers in India. The median age was 59 (min 16- max 98) ... Read more >>

Int J Cancer (International journal of cancer)
[2021, :]

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Statin use and incidence and mortality of breast and gynecology cancer: A cohort study using the National Health Insurance claims database.

Dong-Sook Kim, Hyeong Sik Ahn, Hyun Jung Kim,

Previous studies have reported inconsistent findings concerning the impact of statin use on cancer prevention. This study examined the association between statin use and cancer incidence and mortality related to breast and gynecologic cancers in South Korea. A population-based cohort study was conducted using the National Health Insurance claims database. ... Read more >>

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SIRT1-mediated deacetylation of FOXO3a transcription factor supports pro-angiogenic activity of IFN-deficient tumor-associated neutrophils.

Sharareh Bordbari, Britta Mörchen, Ekaterina Pylaeva, Elena Siakaeva, Ilona Spyra, Maksim Domnich, Freya Droege, Oliver Kanaan, Karl Sebastian Lang, Dirk Schadendorf, Stephan Lang, Iris Helfrich, Jadwiga Jablonska,

Angiogenesis plays an important role during tumor growth and metastasis. We could previously show that type I IFN-deficient tumor-associated neutrophils show strong pro-angiogenic activity, and stimulate tumor angiogenesis and growth. However, the exact mechanism responsible for their pro-angiogenic shift is not clear. Here, we set out to delineate the molecular ... Read more >>

Int J Cancer (International journal of cancer)
[2021, :]

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Comparison of East-Asia and West-Europe cohorts explains disparities in survival outcomes and highlights predictive biomarkers of early gastric cancer aggressiveness.

Carla Pereira, Ji-Hyeon Park, Sofia Campelos, Irene Gullo, Carolina Lemos, Leslie Solorzano, Diana Martins, Gilza Gonçalves, Dina Leitão, Hyuk-Joon Lee, Seong-Ho Kong, Ana André, Clara Borges, Daniela Almeida, Carolina Wälbhy, Raquel Almeida, Woo Ho Kim, Fátima Carneiro, Han-Kwang Yang, Gabriela M Almeida, Carla Oliveira,

Surgical resection with lymphadenectomy and peri-operative chemotherapy is the universal mainstay for curative treatment of gastric cancer (GC) patients with loco-regional disease. However, GC survival remains asymmetric in West- and East-world regions. We hypothesize this asymmetry derives from differential clinical management. Therefore, we collected chemo-naïve GC patients from Portugal and ... Read more >>

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[2021, :]

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Potential Effectiveness of a Therapeutic HPV Intervention Campaign in Uganda.

Jennifer C Spencer, Nicole G Campos, Emily A Burger, Stephen Sy, Jane J Kim,

Cervical cancer is a major source of morbidity and mortality in Uganda. In addition to prophylactic HPV vaccination, secondary prevention strategies are needed to reduce cancer burden. We evaluated the potential cancer reductions associated with a hypothetical single-contact therapeutic HPV intervention- with 70% coverage and variable efficacy [30-100%]- using a ... Read more >>

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[2021, :]

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Sialic acids in gynaecological cancer development and progression: impact on diagnosis and treatment.

Anna Y Berghuis, Johan Fa Pijnenborg, Thomas J Boltje, Johanna Ma Pijnenborg,

Gynaecological cancers are in the top 10 of most common cancers in women. Survival and outcome are strongly related to the stage at diagnosis. Therefore, early diagnosis is essential in reducing morbidity and mortality. The high mortality rate of gynaecological cancers can mainly be attributed to ovarian cancer (OC). OC ... Read more >>

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Pazopanib with 5-FU and oxaliplatin as first line therapy in advanced gastric cancer: a randomized phase-II study - the PaFLO trial. A study of the Arbeitsgemeinschaft Internistische Onkologie AIO-STO-0510.

Anica Högner, Salah-Eddin Al-Batran, Jens T Siveke, Mario Lorenz, Prisca Bartels, Kirstin Breithaupt, Peter Malfertheiner, Nils Homann, Alexander Stein, Dietrich Gläser, Ingo Tamm, Axel Hinke, Arndt Vogel, Peter Thuss-Patience, ,

VEGF inhibition in gastric cancer has a proven benefit in the second line setting [1-3]. Pazopanib, an oral tyrosine kinase inhibitor, selectively inhibits VEGFR-1, -2 and - 3, c-kit and PDGF-R resulting in inhibition of angiogenesis. This open-label randomized phase II trial (2:1) investigated the efficacy of combining pazopanib with FLO (5-fluorouracil, ... Read more >>

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[2021, :]

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Safety, pharmacokinetic, pharmacodynamic and clinical activity of molibresib for the treatment of NUT carcinoma and other cancers: results of a phase I/II open-label, dose escalation study.

Sophie Cousin, Jean-Yves Blay, Irene Braña Garcia, Johann S de Bono, Christophe Le Tourneau, Victor Moreno, Jose Trigo, Christine L Hann, Arun A Azad, Seock-Ah Im, Philippe A Cassier, Christopher A French, Antoine Italiano, Vicki L Keedy, Ruth Plummer, Marie-Paule Sablin, Matthew L Hemming, Geraldine Ferron-Brady, Anastasia Wyce, Ahmed Khaled, Antara Datta, Shawn W Foley, Michael T McCabe, Yuehui Wu, Thierry Horner, Brandon E Kremer, Arindam Dhar, Peter J O'Dwyer, Geoffrey I Shapiro, Sarina A Piha-Paul,

Molibresib is an orally bioavailable, selective, small molecule BET protein inhibitor. Results from a first time in human study in solid tumors resulted in the selection of a 75 mg once daily dose of the besylate formulation of molibresib as the recommended Phase 2 dose (RP2D). Here we present the results ... Read more >>

Int J Cancer (International journal of cancer)
[2021, :]

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Citrus-Gene interaction and melanoma risk in the UK Biobank.

Andrew R Marley, Ming Li, Victoria L Champion, Yiqing Song, Jiali Han, Xin Li,

High citrus consumption may increase melanoma risk; however, little is known about the biological mechanisms of this association, or whether it is modified by genetic variants. We conducted a genome-wide analysis of gene-citrus consumption interactions on melanoma risk among 1563 melanoma cases and 193 296 controls from the UK Biobank. Both ... Read more >>

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[2021, :]

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Effect and mechanism of circRNAs in tumor angiogenesis and clinical application.

Luyang Zhao, Yuying Guo, Yaxin Guo, Xiang Ji, Dandan Fan, Chen Chen, Weitang Yuan, Zhenqiang Sun, Zhenyu Ji,

Tumor blood vessels provide oxygen and necessary nutrients for the tumor, which provides the basis for tumor metastasis. Therefore, tumor angiogenesis plays a very important role in tumor growth and metastasis. In contrast to linear RNAs, circRNAs represent a type of closed-loop RNA with diverse biological functions. At the same ... Read more >>

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A disease network-based deep learning approach for characterizing melanoma.

Xin Lai, Jinfei Zhou, Anja Wessely, Markus Heppt, Andreas Maier, Carola Berking, Julio Vera, Le Zhang,

Multiple types of genomic variations are present in cutaneous melanoma and some of the genomic features may have an impact on the prognosis of the disease. The access to genomics data via public repositories such as TCGA (The Cancer Genome Atlas) allows for a better understanding of melanoma at the ... Read more >>

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[2021, :]

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NKG2A is a late immune checkpoint on CD8 T cells and marks repeated stimulation and cell division.

Linda Borst, Marjolein Sluijter, Gregor Sturm, Pornpimol Charoentong, Saskia J Santegoets, Mandy van Gulijk, Marit J van Elsas, Christianne Groeneveldt, Nadine van Montfoort, Francesca Finotello, Zlatko Trajanoski, Szymon M Kiełbasa, Sjoerd H van der Burg, Thorbald van Hall,

The surface inhibitory receptor NKG2A forms heterodimers with the invariant CD94 chain and is expressed on a subset of activated CD8 T cells. As antibodies to block NKG2A are currently tested in several efficacy trials for different tumor indications, it is important to characterize the NKG2A<sup>+</sup> CD8 T cell population ... Read more >>

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[2021, :]

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Feedback-regulated transcriptional repression of FBXO31 by c-Myc triggers ovarian cancer tumorigenesis.

Sehbanul Islam, Parul Dutta, Osheen Sahay, K Gopalakrishnan, Sushrita Roy Muhury, Parinitha Parameshwar, Praveenkumar Shetty, Manas Kumar Santra,

FBXO31, a member of F-box protein family, has been shown to play an important role in preventing tumorigenesis by preserving genomic stability during cell proliferations as well as upon genotoxic stresses. Inactivation of FBXO31 due to loss of heterozygosity is associated with various cancers, including ovarian cancer, one of the ... Read more >>

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Accuracy of different triage strategies for human papillomavirus positivity in an Italian screening population.

Daniela Gustinucci, Maria Benevolo, Elena Cesarini, Pamela Mancuso, Basilio Passamonti, Maria Donata Giaimo, Rosa Corvetti, Valeria Nofrini, Simonetta Bulletti, Morena Malaspina, Beatrice Tintori, Paolo Giorgi Rossi, ,

How to manage human papillomavirus (HPV)-positive women in cervical cancer screening remains debated. Our study compared different strategies to triage HPV positivity in a large cohort of women participating in a population HPV-based screening program. Women were tested for HPV (Cobas 4800; Roche), and those positive were triaged with cytology; ... Read more >>

Int J Cancer (International journal of cancer)
[2021, :]

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Social inequalities in treatment receipt for childhood cancers in Ireland: a population-based analysis.

Michal Molcho, Audrey A Thomas, Paul M Walsh, Roderick Skinner, Linda Sharp,

Treatment advances over the past five decades have resulted in significant improvements in survival from childhood cancer. Although survival rates are relatively high, social disparities in outcomes have been sometimes observed. In a population-based study, we investigated social inequalities by sex and deprivation in treatment receipt in childhood cancer in ... Read more >>

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Can miRNAs be useful biomarkers in improving prognostic stratification in endometrial cancer patients? An update review.

Gloria Ravegnini, Francesca Gorini, Eugenia De Crescenzo, Antonio De Leo, Dario De Biase, Marco Di Stanislao, Patrizia Hrelia, Sabrina Angelini, Pierandrea De Iaco, Anna Myriam Perrone,

Endometrial cancer (EC) is the most common gynecological cancer, with annual incidence rates in Western countries ranging between 15 and 25 per 100.000 women. About 15-20% of patients with EC have high-risk disease and follow an aggressive clinical course. Unfortunately, the assessment of histologic parameters is poorly reproducible and conventional ... Read more >>

Int J Cancer (International journal of cancer)
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High complexity cellular barcoding and clonal tracing reveals stochastic and deterministic parameters of radiation resistance.

Anne Wursthorn, Christian Schwager, Ina Kurth, Claudia Peitzsch, Christel Herold-Mende, Jürgen Debus, Amir Abdollahi, Ali Nowrouzi,

It is elusive whether clonal selection of tumor cells in response to ionizing radiation (IR) is a deterministic or stochastic process. With high resolution clonal barcoding and tracking of over 400.000 HNSCC patient-derived tumor cells the clonal dynamics of tumor cells in response to IR was analyzed. Fractionated IR induced ... Read more >>

Int J Cancer (International journal of cancer)
[2021, :]

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In-depth molecular analysis of combined and co-primary pulmonary large cell neuroendocrine carcinoma and adenocarcinoma.

Bregtje C M Hermans, Jules L Derks, Lisa M Hillen, Irene van der Baan, Esther C van den Broek, Jan H von der Thüsen, Robert-Jan van Suylen, Peggy N Atmodimedjo, T Dorine den Toom, Cecile Coumans-Stallinga, Wim Timens, Winand N M Dinjens, Hendrikus J Dubbink, Ernst-Jan M Speel, Anne-Marie C Dingemans, ,

Up to 14% of large cell neuroendocrine carcinomas (LCNECs) are diagnosed in continuity with nonsmall cell lung carcinoma. In addition to these combined lesions, 1% to 7% of lung tumors present as co-primary tumors with multiple synchronous lesions. We evaluated molecular and clinicopathological characteristics of combined and co-primary LCNEC-adenocarcinoma (ADC) ... Read more >>

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[2021, :]

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Camrelizumab for relapsed or refractory classical Hodgkin lymphoma: Extended follow-up of the multicenter, single-arm, Phase 2 study.

Jianqiu Wu, Yuqin Song, Xinchuan Chen, Tongyu Lin, Junning Cao, Yanyan Liu, Yaozhong Zhao, Jie Jin, Haiwen Huang, Jianda Hu, Jun Luo, Liling Zhang, Hongwei Xue, Qingyuan Zhang, Weiwei Wang, Chunxia Chen, Jifeng Feng, Jun Zhu,

Camrelizumab (a humanized high-affinity IgG4 mAb against programmed death-l) showed potent antitumor activity, well tolerance and controllable safety in patients with relapsed or refractory classical Hodgkin lymphoma (r/r cHL), based on the primary analysis of a Phase 2 study. Here, we present the extended follow-up outcomes. Seventy-five patients who had failed ... Read more >>

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Nut consumption in association with overall mortality and recurrence/disease-specific mortality among long-term breast cancer survivors.

Cong Wang, Kai Gu, Fei Wang, Hui Cai, Wei Zheng, Pingping Bao, Xiao-Ou Shu,

High nut consumption is associated with reduced total and certain cause-specific mortality in general populations. However, its association with cancer outcomes among long-term breast cancer survivors remains unknown. We examined the associations of nut consumption (including peanuts and tree nuts), assessed at 5-year postdiagnosis, with overall survival (OS) and disease-free ... Read more >>

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[2021, :]

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Impact of human papillomavirus on the tumor microenvironment in oropharyngeal squamous cell carcinoma.

Xinyi Liu, Ping Liu, Rebecca D Chernock, Krystle A Lang Kuhs, James S Lewis, Hua Li, Hiram A Gay, Wade L Thorstad, Xiaowei Wang,

Increasing evidence has elucidated the clinicopathological significance of tumor microenvironment (TME) cells. However, TME differences associated with human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) have not been well characterized. In our study, we comprehensively determined the TME infiltration patterns in 315 OPSCC patients, and systematically correlated the ... Read more >>

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