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Impact of Sacubitril/Valsartan on Right Heart Failure.

Teruhiko Imamura, Masakazu Hori, Hiroshi Ueno, Koichiro Kinugawa,

Sacubitril/valsartan improves mortality and morbidity in patients with heart failure with reduced ejection fraction. However, its impact on right heart failure remains unknown. We experienced a 70-year-old man who was started on sacubitril/valsartan to treat his right heart failure with moderate tricuspid regurgitation. Following the 3-month sacubitril/valsartan treatment, a functional ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Efficacy of Continuing SGLT2 Inhibitors on Outcomes in Patients with Acute Decompensated Heart Failure.

Masaki Nakagaito, Teruhiko Imamura, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura, Koichiro Kinugawa,

Sodium-glucose cotransporter 2 inhibitor (SGLT2i) reduces mortality and morbidity in patients with chronic heart failure (HF). However, the clinical implication of SGLT2i therapy in patients with acute decompensated HF remains uncertain. We prospectively studied 86 type 2 diabetic mellitus (T2DM) patients (71.8 ± 12.1 years, 55 men) who were hospitalized ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Clinical Significance of the Fibrosis-4 Index in Patients with Acute Heart Failure Requiring Intensive Care.

Akihiro Shirakabe, Hirotake Okazaki, Masato Matsushita, Yusaku Shibata, Shota Shigihara, Suguru Nishigoori, Tomofumi Sawatani, Kenichi Tani, Kazutaka Kiuchi, Yusuke Otsuka, Masanori Atsukawa, Norio Itokawa, Taeang Arai, Nobuaki Kobayashi, Kuniya Asai, Wataru Shimizu,

The Fibrosis-4 (FIB4) index could indicate the liver fibrosis in patients with chronic hepatic diseases. It was calculated using the following formula: (age × aspartate aminotransferase [U/L]) / (platelet count [10<sup>3</sup>/μL] × √alanine aminotransferase [U/L]). However, the clinical impact of the FIB4 index in the acute phase of acute heart ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Relationship Between HbA1c Level and Effectiveness of SGLT2 Inhibitors in Decompensated Heart Failure Patients with Type 2 Diabetes Mellitus.

Masaki Nakagaito, Teruhiko Imamura, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura, Koichiro Kinugawa,

The DAPA-HF trial demonstrated that sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduced worsening heart failure (HF) events in chronic HF patients with or without type 2 diabetic mellitus (T2DM). However, it remains unclear whether the effectiveness of SGLT2i is also observed in patients with decompensated HF irrespective of HbA1c level. Eighty-one ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Efficacy of a Subcutaneous Implantable Cardioverter Defibrillator in a Child with Early Repolarization Syndrome.

Moe Taki, Shota Muraji, Hitoshi Mori, Taisuke Nabeshima, Koich Toda, Yoichi Iwamoto, Satoshi Masutani, Takuro Kojima, Shigeki Yoshiba, Toshiki Kobayashi, Naokata Sumitomo,

An early repolarization (ER) pattern or J waves are considered to be a benign finding observed in the healthy population, however, it has been pointed out that the ER pattern seen in the inferolateral leads could be an independent risk factor for fatal arrhythmias. We present a pediatric case in ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Association Between Albumin-Bilirubin Score at Admission and In-Hospital Mortality in Patients with Acute Heart Failure.

Takayuki Kawata, Atsushi Ikeda, Hiroshi Masuda, Shunsuke Komatsu,

Liver dysfunction is one of the most recognized complications in patients with acute heart failure (HF) and therefore a liver function score may be useful for risk-stratification in those patients. Recently, the albumin-bilirubin (ALBI) score was developed as a new model to assess liver function in liver disease. We explored ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Evaluation of Autonomous Actions on Bystander-Initiated Cardiopulmonary Resuscitation and Public Access Defibrillation in Tokyo.

Ichiro Hirayama, Kent Doi, Miyuki Yamamoto, Chiaki Toida, Naoto Morimura,

The frequencies of autonomous bystander-initiated cardiopulmonary resuscitation (CPR) and public access defibrillation have not yet been clarified. We aimed to evaluate the frequency of autonomous actions by citizens not having a duty to act.This retrospective observational study included patients who suffered an out-of-hospital cardiac arrest (OHCA) in Tokyo between January ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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How to Estimate the Optimal Heart Rate in Patients with Heart Failure with Preserved Ejection Fraction.

Toshihide Izumida, Teruhiko Imamura, Takuya Fukui, Takatoshi Koi, Yohei Ueno, Masakazu Hori, Masaki Nakagaito, Shuhei Tanaka, Naoya Kataoka, Ryuichi Ushijima, Makiko Nakamura, Mitsuo Sobajima, Nobuyuki Fukuda, Hiroshi Ueno, Koichiro Kinugawa,

Ideal heart rate (HR), particularly for those with heart failure with preserved ejection fraction (HFpEF), remains unknown. We hypothesized that cardiac output would be maximum when the overlap between E-wave and A-wave at the trans-mitral flow is "zero" in the Doppler echocardiography. We retrospectively investigated the association among the overlap ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Values of Radial Artery Provocation Tests at Different Doses of Ergonovine in the Diagnosis of Coronary Artery Spasm.

Qing Zhang, Bo Zhang, Ye-Fei Li, Liang Chen, Kou-Long Zheng, Hui-He Lu, Zhen-Qiang Sheng,

The intracoronary drug provocation test has been the gold standard for diagnosis of coronary artery spasm (CAS); however, it has been identified with severe complications. In this study, we investigated the sensitivity, specificity, and safety of radial artery provocation test at different doses of ergonovine in the diagnosis of CAS. ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Relationship Between Myocardial Perfusion and Myocardial Function in Dilated Cardiomyopathy by Shown Ultrasonography.

Juan Ma, Lina Guan, Lingjie Yang, Ailiman Mahemuti, Yuming Mu,

Myocardial contrast echocardiography (MCE) and two-dimensional speckle tracking echocardiography (2D-STE) were used to detect left ventricular myocardial microcirculation perfusion and myocardial systolic function in dilated cardiomyopathy (DCM) and to explore the relationship between the two.Conventional ultrasound, MCE, and 2D-STE examinations were performed on 30 patients and 30 controls. Left ventricular ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Portable Device Improves the Detection of Atrial Fibrillation After Ablation.

Songqun Huang, Teng Zhao, Chao Liu, Aihong Qin, Shaohua Dong, Binhang Yuan, Wenhui Xing, Zhifu Guo, Xinmiao Huang, Yongmei Cha, Jiang Cao,

Asymptomatic recurrences of atrial fibrillation (AF) have been found to be common after ablation.A randomized controlled trial of AF screening using a handheld single-lead ECG monitor (BigThumb<sup>®</sup>) or a traditional follow-up strategy was conducted in patients with non-valvular AF after catheter ablation. Consecutive patients were randomized to either BigThumb Group ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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High Apolipoprotein E Levels Predict Adverse Limb Events in Patients with Peripheral Artery Disease Due to Peripheral Artery Disease Undergoing Endovascular Treatment and On-Statin Treatment.

Tatsuya Fukase, Tomotaka Dohi, Yoshiteru Kato, Yuichi Chikata, Norihito Takahashi, Hirohisa Endo, Shinichiro Doi, Hiroki Nishiyama, Iwao Okai, Hiroshi Iwata, Shinya Okazaki, Kikuo Isoda, Katsumi Miyauchi, Hiroyuki Daida, Tohru Minamino,

Little is known about the association between limb prognosis in peripheral artery disease and apolipoprotein E (apoE). We evaluated the long-term impact of apoE on adverse limb events in patients with intermittent claudication receiving statin treatment.A total of 218 consecutive patients (mean age, 73 ± 8 years; 81% men) with ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Clinical Factors Associated with Renal Outcome After Heart Transplantation.

Junseok Jeon, Hee Jin Kwon, Heejin Yoo, Darae Kim, Yang Hyun Cho, Jin-Oh Choi, Kyunga Kim, Kiick Sung, Hye Ryoun Jang,

Cardiorenal syndrome (CRS) frequently occurs in end-stage heart failure patients waiting for heart transplantation (HT). Decision-making regarding simultaneous heart and kidney transplantation is an unresolved issue in these patients. We investigated clinical factors associated with renal outcome after HT. A total of 180 patients who received HT from 1996 to ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Cardiovascular Catheterization Using a New Antiseptic Agent Olanexidine Gluconate.

Takahiro Matsumoto, Eiji Tamiya, Haruyo Yamashita, Tomosato Takabe, Akihito Nakajima, Shouichi Yamamoto, Shuko Nojiri, Tatsuji Kanoh, Hiroyuki Daida,

Olanexidine gluconate 1.5% (Olanedine<sup>®</sup>) is a colorless and transparent antiseptic agent introduced in 2015. In this study, we examined its usefulness and safety for cardiovascular catheterization and compared them to 10% povidone-iodine (PI). The study included 1,001 and 1,000 consecutively enrolled patients using Olanedine<sup>®</sup> and PI, respectively [649 (PI, 687) ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Optimal Heart Rate Modulation Using Ivabradine.

Teruhiko Imamura, Koichiro Kinugawa,

Heart rate modulation therapy using ivabradine improves mortality and morbidity in patients with systolic dysfunction. However, a target heart rate remains uncertain. Echocardiography-guided ivabradine therapy, in which we attempt to approach zero overlap between two diastolic filling inflow waves, has recently been proposed to maximize cardiac output, facilitate reverse remodeling, ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Prognostic Value of Liver Stiffness Measured by Two-Dimensional Elastography in Acute Decompensated Heart Failure with Preserved Ejection Fraction.

Yuki Saito, Naoki Matsumoto, Yoshihiro Aizawa, Daisuke Fukamachi, Daisuke Kitano, Kazuto Toyama, Hidesato Fujito, Akira Sezai, Yasuo Okumura,

Liver stiffness (LS) assessed by ultrasound elastography reflects right-sided filling pressure and offers additional prognostic information in patients with acute decompensated heart failure (ADHF). However, the prognostic value of LS in heart failure (HF) with preserved ejection fraction (HFpEF) remains unclear. This study aimed to investigate the prognostic value of ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Pulmonary Vein Isolation and Pacemaker Implantation in a Patient with Dextrocardia Situs Inversus.

Yasuhiro Yokoyama, Takeshi Aiba, Koji Miyamoto, Hideaki Kanzaki, Nobuhiko Ueda, Kenzaburo Nakajima, Tsukasa Kamakura, Mitsuru Wada, Kenichiro Yamagata, Kohei Ishibashi, Yuko Inoue, Satoshi Nagase, Takashi Noda, Chisato Izumi, Kengo Kusano,

A 70-year-old female with dextrocardia with situs inversus (DSI) totalis and inferior vena cava occlusion underwent radiofrequency catheter ablation because she had symptomatic paroxysmal atrial fibrillation (AF). Careful preoperative examination made successful pulmonary vein isolation through the left jugular vein approach. One-year later, however, AF recurred, and symptomatic sinus bradycardia ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Clinical Performance of a Powered Surgical Stapler for Left Atrial Appendage Resection in a Video-Assisted Thoracoscopic Ablation for Patients with Nonvalvular Atrial Fibrillation.

Tao Yan, Shijie Zhu, Miao Zhu, Kai Zhu, Lili Dong, Chunsheng Wang, Changfa Guo,

Left atrial appendage (LAA) has been found to be associated with the occurrence of thromboembolism in patients with nonvalvular atrial fibrillation (NVAF). Stapling exclusion of LAA during surgical ablation could be an alternative to oral anticoagulation for NVAF patients. However, its safety and efficacy have rarely been examined. Thus, in ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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The Use of Angiotensin-Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers Is Associated with the Recovered Ejection Fraction in Patients with Dilated Cardiomyopathy.

Nobuyuki Enzan, Shouji Matsushima, Tomomi Ide, Hidetaka Kaku, Takeshi Tohyama, Kouta Funakoshi, Taiki Higo, Hiroyuki Tsutsui,

Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) have been shown to prevent left ventricular remodeling and improve outcomes of patients with heart failure (HF). This study aimed to investigate whether the use of ACEi/ARB could be associated with HF with recovered ejection fraction (HFrecEF) in patients with ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Factors Associated with In-Hospital Death in Patients with Killip Class 3 Acute Myocardial Infarction.

Masashi Hatori, Kenichi Sakakura, Yousuke Taniguchi, Hiroyuki Jinnouchi, Takunori Tsukui, Kei Yamamoto, Masaru Seguchi, Hiroshi Wada, Hideo Fujita,

The clinical outcomes in acute myocardial infarction (AMI) patients with Killip class 3 are often inconsistent with those in the literature, and the factors associated with poor outcomes have not been sufficiently investigated. The purpose of this study was to identify factors associated with in-hospital death in AMI patients with ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Plasma Level of Elabela in Patients with Coronary Heart Disease and Its Correlation with the Disease Classification.

Qing-Ping Tian, Mei-Lin Liu, Ya-Rong Zhang, Deng-Ren Ji, Shi-Meng Liu, Jie Zhao, Yong-Fen Qi,

This study aimed to evaluate the concentration of plasma elabela (ELA) in patients with coronary heart disease (CHD) and its correlation with the disease classification.We enrolled 238 patients diagnosed by coronary angiography as CHD and 86 controls. The CHD group was divided into three subgroups: stable angina (SA), unstable angina ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Features Suggesting Preferential Conduction in Pulmonary Artery Ventricular Arrhythmia for Identification of Successful Ablation Sites.

Hitoshi Hachiya, Shigeki Kusa, Naoyuki Miwa, Yoshikazu Sato, Yasuaki Tsumagari, Satoshi Hara, Hiroaki Ohya, Kazuya Yamao, Hirotaka Muramoto, Koji Higuchi, Atsushi Suzuki, Osamu Inaba, Yasuteru Yamauchi, Tetsuo Sasano, Yoshito Iesaka,

Radiofrequency catheter ablation (RFCA) for pulmonary artery ventricular arrhythmia (PAVA) can be difficult because of the occasional existence of PAVA with preferential conduction.This study described the characteristics of PAVA that demonstrate preferential conduction.We analyzed electrocardiographic and electrophysiological data from 8 patients found to have PAVAs with preferential conduction out of ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Obesity May Not Be a Risk of Non-Target Lesion Revascularization in the Elderly Patients.

Kenichi Shibata, Masataka Kameshima, Hiroaki Fujiyama, Mariko Ehara, Yoriyasu Suzuki, Sumio Yamada,

Obesity is assumed to be one of the robust risk factors for coronary artery disease. However, the effects of obesity on the progression of atherosclerosis in patients in different age groups after percutaneous coronary intervention (PCI) remain unclear. This study aimed to examine the effect of obesity on prognosis in ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Diltiazem Inhibits Coronary Spasm via Inhibition of Cav1.2Phosphorylation and Protein Kinase C Activation in a Mouse Model of Coronary Spastic Angina.

Yuji Ishida, Kazutaka Kitayama, Kenji Hanada, Shuji Shibutani, Kimitaka Nishizaki, Takahiko Kinjo, Tomohide Endo, Akiko Suzuki, Shunta Tateyama, Fumie Nishizaki, Takanori Sukekawa, Makoto Tanaka, Tomohiro Osanai, Ken Okumura, Hirofumi Tomita,

Calcium antagonists are used for coronary spastic angina (CSA) treatment. We previously identified a phospholipase C (PLC) -δ1 gene variant that results in enhanced PLC activity in patients with CSA and developed a CSA animal model by generating vascular smooth muscle cell-specific human variant PLC-δ1 overexpression (PLC-TG) mice. In this ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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Inhibition of Calpain Alleviates Apoptosis in Coxsackievirus B3-induced Acute Virus Myocarditis Through Suppressing Endoplasmic Reticulum Stress.

Hui Shi, Ying Yu, Yucheng Wang, Xiaoxiao Liu, Yong Yu, Minghui Li, Yunzeng Zou, Ruizhen Chen, Junbo Ge,

Virus myocarditis (VMC) is a common cardiovascular disease and a major cause of sudden death in young adults. However, there is still a lack of effective treatments. Our previous studies found that calpain activation was involved in VMC pathogenesis. This study aims to explore the underlying mechanisms further. Neonatal rat ... Read more >>

Int Heart J (International heart journal)
[2021, :]

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