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Resistin as a Biomarker for the Prediction of Left Atrial Substrate and Recurrence in Patients with Drug-Refractory Atrial Fibrillation Undergoing Catheter Ablation.

Ting-Yung Chang, Ya-Wen Hsiao, Shu-Mei Guo, Shih-Lin Chang, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Tze-Fan Chao, Jo-Nan Liao, Ta-Chuan Tuan, Chin-Yu Lin, Satoshi Higa, Shih-Ann Chen,

Resistin is an adipocytokine that is abundantly secreted from lipid cells and is related to the inflammatory process and cardiometabolic diseases. This study aimed to examine the role of resistin on inflammation and its effect on the clinical outcome of patients with atrial fibrillation (AF) following catheter ablation.A total of ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):517-523]

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Differential Atrial Pacing to Detect Reconnection Gaps After Pulmonary Vein Isolation in Atrial Fibrillation.

Mai Tahara, Ritsushi Kato, Yoshifumi Ikeda, Koji Goto, So Asano, Hitoshi Mori, Shiro Iwanaga, Toshihiro Muramatsu, Kazuo Matsumoto,

High-resolution mapping is useful to identify reconnection gaps in the pulmonary vein after pulmonary vein isolation for atrial fibrillation. However, it is sometimes difficult to differentiate pulmonary vein potentials from far-field potentials because of very low amplitudes. Our purpose was to evaluate the usefulness of a novel differential atrial pacing ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):503-509]

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Clinical Significance of the Controlling Nutritional Status (CONUT) Score in Patients with Infective Endocarditis.

Yuki Saito, Yoshihiro Aizawa, Kiyoshi Iida, Naoya Matsumoto, Akira Sezai, Masashi Tanaka, Yasuo Okumura,

Risk stratification of patients with infective endocarditis (IE) is difficult. The Controlling Nutritional Status (CONUT) score is an index of immune function and nutritional status. We investigated the prognostic value of the CONUT score in IE and whether its prognostic value differed between IE patients with and without indications for ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):531-538]

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Blood Pressure Increases Before Pulse Rate During the Nocturnal Period in Hypertensive Patients.

Miho Kuramoto, Masami Aizawa, Yuki Kuramoto, Masaaki Okabe, Yasushi Sakata, Yoshifusa Aizawa,

Ambulatory blood pressure monitoring (ABPM) is used for the evaluation of out-of-office blood pressure (BP), however, knowledge concerning the detailed behavior of nocturnal blood pressure (BP) and pulse rate (PR) is limited.A total of 190 participants (64 ± 15 years, 46.3% males) underwent ABPM for diagnosis of hypertension or evaluation ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):579-584]

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Percutaneous Atrial Septal Defect Closure in Adult Ebstein's Anomaly with Exertional Hypoxemia.

Kensuke Oka, Mitsuru Seki, Koichi Kataoka, Tomoyuki Sato, Yasushi Imai, Takanori Yamagata,

In Ebstein's anomaly, percutaneous atrial septal defect (ASD) closure for the treatment of hypoxemia due to a right-to-left interatrial shunt remains controversial. We report the case of a 40-year-old woman with Ebstein's anomaly who developed cyanosis and shortness of breath on exercise. Her symptoms improved after percutaneous ASD closure and ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):620-623]

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Neutrophil to Lymphocyte Ratio and Long-Term Cardiovascular Outcomes in Coronary Artery Disease Patients with Low High-Sensitivity C-Reactive Protein Level.

Hideki Wada, Tomotaka Dohi, Katsumi Miyauchi, Ryota Nishio, Mitsuhiro Takeuchi, Norihito Takahashi, Hirohisa Endo, Manabu Ogita, Hiroshi Iwata, Takatoshi Kasai, Shinya Okazaki, Kikuo Isoda, Satoru Suwa, Hiroyuki Daida,

Although an elevated neutrophil to lymphocyte ratio (NLR) has been associated with the adverse outcomes of coronary artery disease (CAD), less is known about its prognostic value among patients with low high-sensitivity C-reactive protein (hs-CRP) levels. We enrolled 2,591 consecutive patients with stable CAD who underwent elective percutaneous coronary intervention ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):447-453]

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Reduction of Cold Ischemic Injury with the Addition of Compound Glycyrrhizin in HTK Solution in a Mouse Heart Transplantation Model.

Jiali Wu, Xiangdong Liu, Maohua Wang, Xiaobin Wang, De Luo, Song Su,

Cold ischemic injury in heart storage is an important issue pertaining to heart transplantation. This study aims to evaluate the addition of compound glycyrrhizin (CG) in histidine-tryptophan-ketoglutarate (HTK) solution on chronic isograft injury in comparison to traditional HTK solution.Hearts of mouse were stored for 8 h in 4°C cold preservation ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):595-600]

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Future Perspectives of Intra-Aortic Balloon Pumping for Cardiogenic Shock.

Takeo Fujino, Teruhiko Imamura, Koichiro Kinugawa,

An intra-aortic balloon pump (IABP) is a device of internal counterpulsation. Inflation of the balloon in diastole results in a potential increase in coronary blood flow and an improvement in systemic perfusion, and deflation at the end of diastole reduces left ventricular afterload, although the hemodynamic effects are relatively small. ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):424-428]

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Comparison of the Transdermal Bisoprolol Patch with Oral Bisoprolol Fumarate Administration as a Therapeutic Agent for Idiopathic Frequent Premature Ventricular Contractions.

Masaya Shinohara, Ryou Wada, Shintaro Yao, Kensuke Yano, Katsuya Akitsu, Hideki Koike, Toshio Kinoshita, Hitomi Yuzawa, Takeya Suzuki, Tadashi Fujino, Takanori Ikeda,

The transdermal bisoprolol patch (TB) was designed to maintain a sustained concentration of bisoprolol in plasma by a higher trough concentration than oral bisoporolol (OB). We compared the efficacy between TB and OB in patients with idiopathic premature ventricular contractions (PVCs) while considering their duration of action.A total of 78 ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):510-516]

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Benefit of Rate Response with Closed-Loop Stimulation in Patients with Difficult Hemodialysis.

Toshiko Nakai, Yukitoshi Ikeya, Naotoshi Tsuchiya, Hiroaki Mano, Sayaka Kurokawa, Koichi Nagashima, Kimie Ohkubo, Ichiro Watanabe, Yasuo Okumura,

Rate-responsive pacing is known to improve quality of life (QOL) in patients with sick sinus syndrome and chronotropic incompetence. However, the sensors for rate response include accelerometers, closed-loop stimulation (CLS), and minute ventilation sensors (MV sensors), each of which has a different mode of action. For this reason, it is ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):611-615]

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Kaempferol Regulates miR-15b/Bcl-2/TLR4 to Alleviate OGD-Induced Injury in H9c2 Cells.

Linping Li, Yuanxia Shao, Hongjian Zheng, Heng Niu,

Ischemic heart disease (IHD) is one of the world's leading causes of human death. Kaempferol (Kae) was proved to have anti-inflammatory, antioxidant, and anticancer effects. Such properties suggested that it might play protective roles in IHD. In this study, we have attempted to disclose the potential regulating mechanisms of Kae ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):585-594]

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Paracorporeal Ventricular Assist Device Implantation in a Patient with Transposition of the Great Arteries After Senning Operation.

Makiko Nakamura, Teruhiko Imamura, Hiroyuki Kuwahara, Masaki Nakagaito, Shigeki Yokoyama, Toshio Doi, Kazuaki Fukahara, Naoki Yoshimura, Koichiro Kinugawa,

We experienced a 33-year-old patient with D-looped transposition of the great arteries (D-TGA) and a history of Senning operation who was referred to our institute with cardiogenic shock and subsequently underwent urgent paracorporeal ventricular assist device (VAD) implantation, which was a first in Japan, that was eventually converted to a ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):616-619]

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Usefulness of the Simplified Frailty Scale in Predicting Risk of Readmission or Mortality in Elderly Patients Hospitalized with Cardiovascular Disease.

Keita Aida, Kentaro Kamiya, Nobuaki Hamazaki, Ryota Matsuzawa, Kohei Nozaki, Takafumi Ichikawa, Takeshi Nakamura, Masashi Yamashita, Emi Maekawa, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako,

The simplified frailty scale is a simple frailty assessment tool modified from Fried's phenotypic frailty criteria, which is easy to administer in hospitalized patients. The applicability of the simplified frailty scale to indicate prognosis in elderly hospitalized patients with cardiovascular disease (CVD) was examined.This cohort study was performed in 895 ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):571-578]

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Association Between MTHFR C677T Polymorphism and Congenital Heart Disease.

Peng-Fei Liu, Bing Ding, Jun-Yi Zhang, Xiao-Fei Mei, Fei Li, Peng Wu, Chun-Hao Mei, Ya-Feng Zhou, Tan Chen,

Many published studies have evaluated the association between the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) polymorphism and the risk of congenital heart disease (CHD); however, the specific conclusion is still controversial.To get a more accurate conclusion, we used a meta-analysis to evaluate the association between the MTHFR gene C677T polymorphism and ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):553-561]

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Further Validation of a Novel Acute Myocardial Infarction Risk Stratification (nARS) System for Patients with Acute Myocardial Infarction.

Shinnosuke Sawano, Kenichi Sakakura, Kei Yamamoto, Yousuke Taniguchi, Takunori Tsukui, Masaru Seguchi, Hiroshi Wada, Shin-Ichi Momomura, Hideo Fujita,

Recently, we developed a novel acute myocardial infarction (AMI) risk stratification system (nARS), which stratifies AMI patients into low- (L), intermediate- (I), and high- (H) risk groups. We have shown that the nARS shortened the length of intensive care unit (ICU) stay as well as that of hospitalization. However, the ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):463-469]

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Prognostic Value of Serum N-Terminal Pro-Brain Natriuretic Peptide Level over Heart Failure for Stroke Events and Deaths in Patients with Atrial Fibrillation.

Keiichiro Kuronuma, Yasuo Okumura, Tomoyuki Morikawa, Katsuaki Yokoyama, Naoya Matsumoto, Eizo Tachibana, Koji Oiwa, Michiaki Matsumoto, Toshiaki Kojima, Hironori Haruta, Kazumiki Nomoto, Kazumasa Sonoda, Ken Arima, Rikitake Kogawa, Fumiyuki Takahashi, Tomobumi Kotani, Kimie Ohkubo, Seiji Fukushima, Satoru Itou, Kunio Kondo, Masaaki Chiku, Yasumi Ohno, Motoyuki Onikura, Atsushi Hirayama, ,

Atrial fibrillation (AF) and heart failure (HF) often coexist. The aims of this study were to explore the factors associated with the serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), and the association between prognosis and a history of HF or the serum NT-proBNP level in Japanese patients with AF.The ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):492-502]

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Surviving Case of a Blowout-Type Left Ventricular Free Wall Rupture During Percutaneous Coronary Intervention for a Lateral Acute Myocardial Infarction.

Riku Arai, Daisuke Fukamachi, Naotaka Akutsu, Masashi Tanaka, Yasuo Okumura,

A 76-year-old man suffering from chest pain was admitted to our hospital with a suspected acute myocardial infarction (AMI). Emergent coronary angiography revealed a totally occluded proximal left circumflex artery (LCX). During primary percutaneous coronary intervention, his blood pressure suddenly fell within seconds, and he developed pulseless electrical activity (PEA). ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):606-610]

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Imatinib Dramatically Improved Pulmonary Hypertension Caused by Pulmonary Tumor Thrombotic Microangiopathy (PTTM) Associated with Metastatic Breast Cancer.

Sachiko Yoshikawa, Tetsuya Hara, Masataka Suzuki, Miyu Fujioka, Yu Taniguchi, Ken-Ichi Hirata,

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare malignancy-related respiratory complication, showing rapid progression of respiratory dysfunction and pulmonary hypertension (PH). Accumulating evidence suggests that imatinib, a platelet-derived growth factor (PDGF) receptor-tyrosine kinase inhibitor, might be effective and improve severe PH in patients with PTTM associated with gastric cancer. However, ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):624-628]

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Red Blood Cell Distribution Width Predicts Postoperative Death of Infective Endocarditis.

Shixiong Wei, Huimin Cui, Shaowei Zhang, Anling Zhang, Yuhai Zhang, Shengli Jiang,

Infectious endocarditis (IE) is a rare disease with high mortality rate. Recently, red cell distribution width (RDW) has drawn special attention for predicting cardiovascular disease. This study aims to explore the relationship between RDW value and postoperative death of IE patients.Clinical records of patients with definite IE from Chinese People's ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):524-530]

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Comparison of Archival Angiographic Findings in Patients Later Developing Acute Coronary Syndrome or Stable Angina.

Shohei Yamaya, Yoshihiro Morino, Yuya Taguchi, Ryo Ninomiya, Masaru Ishida, Tetsuya Fusazaki, Tomonori Itoh, Takumi Kimura,

Acute coronary syndrome (ACS) can develop in patients with mildly to moderately stenotic lesions. However, the angiographic characteristics of lesions in patients who will later develop ACS have not been systematically investigated. For this reason, we examined the earlier angiographic findings of such patients in a retrospective study.The study population ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):454-462]

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Clinical Management and Long-Term Prognosis of Combined Left-Sided Valvular Heart Disease.

Anne-Sophie Sillesen, Niels Thue Olsen, Thomas Fritz-Hansen, Peter Godsk Jørgensen,

In studies on left-sided valve disease, patients with combined lesions are generally excluded. We aimed to describe the clinical management and prognosis of patients with combined left-sided valve disease.From a single, tertiary care center, a total of 122 patients with combined left-sided valve disease of at least moderate severity were ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):539-546]

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Opioid Use and Morbidities during Left Ventricular Assist Device Support.

Pamela S Combs, Teruhiko Imamura, Umar Siddiqi, Saeid Mirzai, Robert Spiller, Corinne Stonebraker, Colleen LaBuhn, Heather Bullard, Pamela Simone, Valluvan Jeevanandam,

The use of opioids during left ventricular assist device (LVAD) support is increasing, but the implication remains unknown. We investigated the association between the use of opioid and morbidities during LVAD supports. We retrospectively reviewed the clinical data of patients who received LVAD between 2014 and 2017, which were stratified ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):547-552]

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Prevalence, Outcomes, and Risk Factors of New-Onset Atrial Fibrillation in Critically Ill Patients.

Zesheng Wu, Jinyan Fang, Yi Wang, Fanghui Chen,

The purpose of this article is to systematically evaluate the prevalence, outcomes, and risk factors of new-onset atrial fibrillation (AF) in critically ill patients.Medline, Embase, Science Citation Index, Wanfang, CNKI, and Wiley Online Library were thoroughly searched to identify relevant studies. Studies were assessed for methodological quality using the Grading ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):476-485]

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ALDH2 Gene rs671 Polymorphism May Decrease the Risk of Essential Hypertension.

Xiao-Fei Mei, Sheng-Da Hu, Peng-Fei Liu, Fei Li, Xian-Yong Zhou, Ya-Feng Zhou, Tan Chen,

Aldehyde dehydrogenase-2 (ALDH2) rs671 G>A polymorphism can influence the activity of ALDH2 and may be associated with the risk of essential hypertension (EH). Although many previous studies have explored such a relationship, the conclusion is still controversial.The PubMed, Embase, and China National Knowledge Infrastructure databases were searched on the ALDH2 ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):562-570]

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Impact of LR11 as Residual Risk on Long-Term Clinical Outcomes in Patients with Coronary Artery Disease Treated with Statins after First Percutaneous Coronary Intervention.

Satoru Suwa, Manabu Ogita, Norihito Takahashi, Hideki Wada, Tomotaka Dohi, Takatoshi Kasai, Shinya Okazaki, Kazunori Shimada, Katsumi Miyauchi, Hideaki Bujo, Hiroyuki Daida,

Cardiovascular events still occur despite statin-based lipid-lowering therapy in patients with coronary artery disease (CAD). LR11, a member of the low-density lipoprotein receptor family, is a novel marker for the proliferation of intimal smooth muscle cells, which are critical to atherosclerotic plaque formation. We evaluated the impact of LR11 on ... Read more >>

Int Heart J (International heart journal)
[2020, 61(3):470-475]

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