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Journal Inflammopharmacology

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Correction to: 4-Phenylbutyric acid protects against vasculitic peripheral neuropathy induced by ischaemia-reperfusion through attenuating endoplasmic reticulum stress.

Cay-Huyen Chen, Ping-Chen Shih, Han-Yu Lin, Po-Kai Wang, Po-Ting Pan, Ching-Wei Chuang, Ming-Chang Kao,

Unfortunately, Fig. 5 was incorrectly published in the original publication. The complete corrected Fig. 5 is given below. ... Read more >>

Inflammopharmacology (Inflammopharmacology)
[2020, 28(6):1753-1754]

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Correction to: Evaluation of in vivo anti-inflammatory and anti-angiogenic attributes of methanolic extract of Launaea spinosa.

Muhammad Asif, Mahrukh, Malik Saadullah, Hafiza Sidra Yaseen, Mohammad Saleem, Hafiz Muhammad Yousaf, Ikram Ullah Khan, Maria Yaseen, Muhammad Usman Shams,

Unfortunately, a section under the heading "Materials and Method" has been published with errors. ... Read more >>

Inflammopharmacology (Inflammopharmacology)
[2020, 28(6):1751]

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Oral administration of dermatan sulphate reduces venous thrombus formation in vivo: potential use as a formulation for venous thromboembolism.

Simone A Osborne, Paul P Masci, Qianyun Sharon Du, Robyn A Daniel, Kirthi Desilva, Luis Vitetta, Kong-Nan Zhao, Robert B Seymour,

Dermatan sulphate (DS) is a sulphated polysaccharide that displays complexity in constituent sulphated disaccharides and interacts with proteins and signalling molecules to modulate numerous biological processes, including inhibition of the coagulation cascade and regulation of blood clotting and fibrinolysis. This study shows the antithrombotic and anticoagulant effects of DS prepared ... Read more >>

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[2020, :]

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COVID-19 and nutriceutical therapies, especially using zinc to supplement antimicrobials.

Desley Butters, Michael Whitehouse,

The nutritional status of a patient can be critical for the efficacy of other pharmaceuticals, especially organic antibiotics, to treat viral pandemics. There may be political and scientific difficulties in achieving a constructive synergy of nutritional and prescribed allopathic remedies. For adequate treatment, timelines may need to extend well beyond ... Read more >>

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[2020, :]

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Donepezil attenuates injury following ischaemic stroke by stimulation of neurogenesis, angiogenesis, and inhibition of inflammation and apoptosis.

Arian Madani Neishaboori, Solmaz Nasseri Maleki, Mahdi Saberi Pirouz, Sara Golmohammadi, Donya Nazarinia, Nahid Aboutaleb,

Donepezil has proven to be an effective drug to reduce neuronal death and subsequently injury in neurodegenerative diseases. The current study evaluated the neuroprotective effects of donepezil in a rat model of ischaemic stroke and explored possible mechanisms which by this drug may reduce cell death. Temporary middle cerebral artery ... Read more >>

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[2020, :]

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Neuroprotective potential of isothiocyanates in an in vitro model of neuroinflammation.

Tiziana Latronico, Marilena Larocca, Serafina Milella, Anna Fasano, Rocco Rossano, Grazia Maria Liuzzi,

Isothiocyanates (ITCs), present as glucosinolate precursors in cruciferous vegetables, have shown anti-inflammatory, antioxidant and anticarcinogenic activities. Here, we compared the effects of three different ITCs on ROS production and on the expression of matrix metalloproteinase (MMP)-2 and -9, which represent important pathogenetic factors of various neurological diseases. Primary cultures of ... Read more >>

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[2020, :]

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Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea.

Aline Aparecida Saldanha, Letícia Vieira, Débora Soares da Silva Maia, Flávio Martins de Oliveira, Rosy Iara Maciel de Azambuja Ribeiro, Ralph Gruppi Thomé, Hélio Batista Dos Santos, Débora de Oliveira Lopes, Carlos Alexandre Carollo, Denise Brentan Silva, Adriana Cristina Soares, João Máximo de Siqueira,

A previous study reported the in vivo anti-inflammatory and antinociceptive activities of essential oil of the underground stem bark of Duguetia furfuracea, termed EODf. This study aimed to obtain a phenylpropanoid-enriched fraction from the D. furfuracea (EFDf) essential oil and to investigate its anti-inflammatory and antinociceptive effects. The chemical composition ... Read more >>

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[2020, :]

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Emerging concepts and directed therapeutics for the management of asthma: regulating the regulators.

Madhur D Shastri, Wai Chin Chong, Kamal Dua, Gregory M Peterson, Rahul P Patel, Malik Q Mahmood, Murtaza Tambuwala, Dinesh K Chellappan, Nicole G Hansbro, Shakti D Shukla, Philip M Hansbro,

Asthma is a common, heterogeneous and serious disease, its prevalence has steadily risen in most parts of the world, and the condition is often inadequately controlled in many patients. Hence, there is a major need for new therapeutic approaches. Mild-to-moderate asthma is considered a T-helper cell type-2-mediated inflammatory disorder that ... Read more >>

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[2020, :]

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The anti-inflammatory role of SSRI and SNRI in the treatment of depression: a review of human and rodent research studies.

Vlad Dionisie, Gabriela Adriana Filip, Mihnea Costin Manea, Mirela Manea, Sorin Riga,

RATIONALE:Depression has the topmost prevalence of all psychiatric diseases. It is characterized by a high recurrence rate, disability, and numerous and mostly unclear pathogenic mechanisms. Besides the monoamine or the neurotrophic hypothesis of depression, the inflammatory mechanism has begun to be supported by more and more evidence. At the same ... Read more >>

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[2020, :]

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The Role and Therapeutic Potential of NF-kappa-B Pathway in Severe COVID-19 Patients.

Apurva Hariharan, Abdul Rahman Hakeem, Subathra Radhakrishnan, Mettu Srinivas Reddy, Mohamed Rela,

Coronavirus disease 2019 (COVID-19) pandemic has affected health care systems worldwide. Severe presentations of COVID-19 such as severe pneumonia and acute respiratory distress syndrome (ARDS) have been associated with the post-viral activation and release of cytokine/chemokines which leads to a "cytokine storm" causing inflammatory response and destruction, mainly affecting the ... Read more >>

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[2020, :]

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Methanolic extracts of a selected Egyptian Vicia faba cultivar mitigate the oxidative/inflammatory burden and afford neuroprotection in a mouse model of Parkinson's disease.

Essam Abdel-Sattar, Engy A Mahrous, Mareena M Thabet, Dina M Yousry Elnaggar, Amal M Youssef, Reda Elhawary, Sawsan A Zaitone, Celia Rodríguez-Pérez, Antonio Segura-Carretero, Reham Hassan Mekky,

Vicia faba L. is a legume from the family Fabaceae. Ancient Egyptians consumed fava beans thousands of years ago and they are still one of the most popular foods in Egypt. The current study examined the anti-Parkinson effect of 80% methanolic extracts of seeds or sprouts of the fava 'Sakha ... Read more >>

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[2020, :]

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NSAID-enteropathy and intestinal microbes.

Ingvar Bjarnason, K D Rainsford,

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[2020, :]

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Pharmacodynamic mechanisms of anti-inflammatory drugs on the chemosensitization of multidrug-resistant cancers and the pharmacogenetics effectiveness.

Neda Gholamian Dehkordi, Seyed Abbas Mirzaei, Fatemeh Elahian,

Drug resistance as a remarkable issue in cancer treatment is associated with inflammation which occurs through complex chemical reactions in the tumor microenvironment. Recent studies have implicated that glucocorticoids and NSAIDs are mainly useful combinations for inflammatory response modulation in chemotherapeutic protocols for cancer treatment. Immunosuppressive actions of glucocorticoids and ... Read more >>

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[2020, :]

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Neuroinflammatory responses in Parkinson's disease: relevance of Ibuprofen in therapeutics.

Ashish Singh, Pratibha Tripathi, Sarika Singh,

Parkinson's disease (PD) pathogenesis inevitably involves neuroinflammatory responses attained through contribution of both neuron and glial cells. Investigation done in both experimental models of PD and in samples of PD patients suggested the involvement of both central and peripheral inflammatory responses during PD pathogenesis. Such neuroinflammatory responses could be regulated ... Read more >>

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[2020, :]

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Asphodelus tenuifolius extracts arrested inflammation and arthritis through modulation of TNF-α, NF-κB, ILs, and COX-2 activities in in vivo models.

Mohammad Saleem, Anam Iftikhar, Muhammad Asif, Khalid Hussain, Alamgeer, Pervaiz Akhtar Shah, Ammara Saleem, Muhammad Furqan Akhtar, Muhammad Tanzeem, Hafiza Sidra Yaseen,

Asphodelus tenuifolius is traditionally used in the management of rheumatic pain and inflamed body parts. The current study validated its traditional use as an anti-arthritic and anti-inflammatory agent using a series of in vivo models. Carrageenan and histamine-induced acute oedema models were employed to study the effects of n-hexane (n-HeAT) and ethanolic ... Read more >>

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[2020, :]

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Quercetin inhibits caerulein-induced acute pancreatitis through regulating miR-216b by targeting MAP2K6 and NEAT1.

Bo Sheng, Lei Zhao, Xuefeng Zang, Jie Zhen, Yang Liu, Weishuai Bian, Wei Chen,

Acute pancreatitis (AP) is a common acute abdominal disease with high mortality and mortality rates. Increasing evidences clarified that Traditional Chinese Medicine (TCM) adjuvant therapy for AP can be used and it gives a positive effect. Quercetin (3,3',4',5,7-pentahydroxyflavone, QE) is a type of flavone compound with positive effect on cancer ... Read more >>

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[2020, :]

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Memantine and Ibuprofen pretreatment exerts anti-inflammatory effect against streptozotocin-induced astroglial inflammation via modulation of NMDA receptor-associated downstream calcium ion signaling.

Sandeep K Mishra, Mahendra Hidau, Shivika Rai,

We had previously reported that neuroinflammation and memory impairment associated with intracerebroventricular streptozotocin (ICV STZ) injection in rats was due to glial activation and modulation of the N-methyl-D-aspartate (NMDA) receptor function. However, the exact role of the NMDA receptor and the molecules associated with downstream calcium ion signaling in STZ-induced ... Read more >>

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[2020, :]

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Euterpe oleracea Mart. (Açaí) attenuates experimental colitis in rats: involvement of TLR4/COX-2/NF-ĸB.

Carlos Eduardo da Silva Monteiro, Humberto Barbosa da Costa Filho, Francisca Géssica Oliveira Silva, Maria de Fathima Felipe de Souza, Johnatan Alisson Oliveira Sousa, Álvaro Xavier Franco, Ângela Castro Resende, Roberto Soares de Moura, Marcellus Henrique Loiola de Souza, Pedro Marcos Gomes Soares, André Luiz Dos Reis Barbosa,

Euterpe oleracea Mart., commonly known as açaí, has been demonstrated to exhibit significantly antioxidant and inflammatory activities in experimental models. These effects of the hydroalcoholic extract from the açaí seed (ASE) were investigated in TNBS-induced (2,4,6-trinitrobenzenesulfonic acid) acute colitis model in rats. Wistar rats (180-220 g) were orally pretreated with saline ... Read more >>

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[2020, :]

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Innate immune response in systemic autoimmune diseases: a potential target of therapy.

Alireza Hejrati, Alireza Rafiei, Mohsen Soltanshahi, Shahnaz Hosseinzadeh, Mina Dabiri, Mahdi Taghadosi, Saeid Taghiloo, Davood Bashash, Fatemeh Khorshidi, Parisa Zafari,

Innate immunity refers to defense mechanisms that are always present, ready to combat microbes and other offending agents. Innate immunity acts as a first-line defense and activates the conventional immune responses; however, it has been speculated that the importance of innate immunity in initiation and development of some disorders is ... Read more >>

Inflammopharmacology (Inflammopharmacology)
[2020, 28(6):1421-1438]

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Commemorating life and works of the late Barrie Vernon-Roberts and leading Australian scientists in the fields of inflammation and pharmacotherapy of inflammatory diseases.

Inflammopharmacology (Inflammopharmacology)
[2020, 28(5):1387-1393]

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Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages.

Chun-Ying Qiao, Ying Li, Yue Shang, Min Jiang, Jian Liu, Zi-Ying Zhan, Huan Ye, Yong-Ce Lin, Jing-Ya Jiao, Rong-Hui Sun, Zhi-Hong Zhang, Mei-Hua Piao, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian,

Gout, the most prevalent inflammatory arthritis worldwide, released interleukin-1β (IL-1β) and Cathepsin B inflammatory mediators that constitute the hallmark of the disease. Herein we aimed to investigate whether procyanidin B2 (PCB2), a natural dietary compound, can suppress MSU crystals-stimulated gouty inflammation. Treated with lipopolysaccharide (LPS) plus MSU, both mouse peritoneal ... Read more >>

Inflammopharmacology (Inflammopharmacology)
[2020, 28(6):1481-1493]

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Current and novel therapeutic targets in the treatment of rheumatoid arthritis.

Genu George, G L Shyni, K G Raghu,

Rheumatoid arthritis (RA), a multifactorial disease characterized by synovitis, cartilage destruction, bone erosion, and periarticular decalcification, finally results in impairment of joint function. Both genetic and environmental factors are risk factors in the development of RA. Unwanted side effects accompany most of the current treatment strategies, and around 20-40% of ... Read more >>

Inflammopharmacology (Inflammopharmacology)
[2020, 28(6):1457-1476]

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Melatonin ameliorates spatial memory and motor deficits via preserving the integrity of cortical and hippocampal dendritic spine morphology in mice with neurotrauma.

Xiao-Jing Lin, Ruoxu Liu, Chenyi Li, Xueqing Yi, Bo Fu, M J Walker, Xiao-Ming Xu, Gang Sun, Cheng-Hsien Lin,

We aimed to elucidate the role of cortical and hippocampal dendritic spines on neurological deficits associated with hippocampal microgliosis, hippocampal neurogenesis, and neuroinflammation in mice with cortical compact impact (CCI) injury. In the present study, we found that CCI reduced spatial memory mean latency (10 s. vs 50 s) and motor dysfunction ... Read more >>

Inflammopharmacology (Inflammopharmacology)
[2020, 28(6):1553-1566]

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Chemical constituents and gastro-protective potential of Pachira glabra leaves against ethanol-induced gastric ulcer in experimental rat model.

Mariam I Gamal El-Din, Fadia S Youssef, Riham S Said, Mohamed L Ashour, Omayma A Eldahshan, Abdel Nasser B Singab,

Gastric ulcer is a very common illness that adversely affects a significant number of people all over the globe. Phytochemical investigation of P. glabra leaf alcohol extract (PGLE) resulted in the isolation and Characterization of a new nature compound, quercetin-3- O-α -L-rhamnosyl-(1'''-6'')-(4''- O -acetyl)-β -D-galactoside (4), in addition to seven ... Read more >>

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[2020, :]

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Antinociception induced by artemisinin nanocapsule in a model of postoperative pain via spinal TLR4 inhibition.

L M S Elisei, T R Moraes, I H Malta, I Charlie-Silva, I M O Sousa, F P Veras, M A Foglio, L F Fraceto, G Galdino,

Artemisinin (ART) was initially described for the control of inflammation and pain. However, the mechanisms involved with its antinociceptive effect are still poorly understood. Thus, this present study aimed to investigate the effect of ART in both free and nanocapsulated form on postoperative pain, as well as the participation of ... Read more >>

Inflammopharmacology (Inflammopharmacology)
[2020, 28(6):1537-1551]

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