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A Factorial Approach for Optimizing the Design Parameters of a Tissue Attachment Mechanism for Drug Delivery.

Sunandita Sarker, Benjamin Wankum, Jeff Shimizu, Ryan Jones, Benjamin Spencer Terry,

Biological macromolecule drugs or biologics are not suited for commonly preferred oral delivery due to their intrinsic instability and physical, chemical, or immunological barriers to the gastrointestinal tract. Ingestible capsule robots (ICR) have become a versatile platform, including use for drug delivery applications for various gastrointestinal pathologies with future potential ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2021, PP:]

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Robust R-Peak Detection in Low-Quality Holter ECGs using 1D Convolutional Neural Network.

Muhammad Uzair Zahid, Serkan Kiranyaz, Turker Ince, Ozer Can Devecioglu, Muhammad Enamul Hoque Chowdhury, Amith Khandakar, Anas Tahir, Moncef Gabbouj,

<h4>Objective</h4>Noise and low quality of ECG signals acquired from Holter or wearable devices deteriorate the accuracy and robustness of R-peak detection algorithms. This paper presents a generic and robust system for R-peak detection in Holter ECG signals. While many proposed algorithms have successfully addressed the problem of ECG R-peak detection, ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
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Controlled injection of bone cement for percutaneous vertebroplasty.

Nicole Neumann, Laurence Meylheuc, Laurent Barbe, Julien Garnon, Guillaume Koch, Afshin Gangi, Bernard Bayle,

In this article, assistance to bone cement in- jection is studied, with a focus on vertebroplasty, a procedure dedicated to the treatment of painful vertebral compression fractures. A robotic system that can remotely be operated at pressures up to 140 bar is presented. It is specifically designed to improve cement ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
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Effects of Gene Delivery Approaches on Differentiation Potential and Gene Function of Mesenchymal Stem Cells.

Zhangyan Guan, Shuxun Chen, Fei Pan, Lei Fan, Dong Sun,

Introduction of a gene to mesenchymal stem cells (MSCs) is a well-known strategy to purposely manipulate the cell fate and further enhance therapeutic performance in cell-based therapy. Viral and chemical approaches for gene delivery interfere with differentiation potential. Although microinjection as a physical delivery method is commonly used for transfection, ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
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Living Rat SSVEP Mapping with Acoustoelectric Brain Imaging.

Xizi Song, Xinrui Chen, Jiande Guo, Minpeng Xu, Dong Ming,

Acoustoelectric Brain Imaging (ABI) is a potential method for mapping brain electrical activity with high spatial resolution (millimeter). To resolve the key issue for eventual realization of ABI, testing the hypothesis that recorded acoustoelectric (AE) signal can be used to decode intrinsic brain electrical activity, the experiment of living rat ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
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Smart ultrasound device for non-invasive real-time myocardial stiffness quantification of the human heart.

Olivier Pedreira, Mafalda Correia, Simon Chatelin, Olivier Villemain, Guillaume Goudot, Stephane Thiebaut, Gioia Bassan, Emmanuel Messas, Mickael Tanter, Clement Papadacci, Mathieu Pernot,

Quantitative assessment of myocardial stiffness is crucial to understand and evaluate cardiac biomechanics and function. Despite the recent progresses of ultrasonic shear wave elastography, quantitative evaluation of myocardial stiffness still remains a challenge because of strong elastic anisotropy. In this paper we introduce a smart ultrasound approach for non-invasive real-time ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
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C2MA-Net: Cross-modal Cross-Attention Network for Acute Ischemic Stroke Lesion Segmentation based on CT Perfusion Scans.

Tianyu Shi, Huiyan Jiang, Bin Zheng,

<h4>Objective</h4>Based on the hypothesis that adding a cross-modal and cross-attention (C<sup>2</sup>MA) mechanism into a deep learning network improves accuracy and efficacy of medical image segmentation, we propose to test a novel network to segment acute ischemic stroke (AIS) lesions from four CT perfusion (CTP) maps.<h4>Methods</h4>The proposed network uses a C<sup>2</sup>MA ... Read more >>

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Implications of wound healing on subcutaneous photovoltaic energy harvesting.

Maximilien Victor Tholl, Marc Spring, Simone de Brot, Daniela Casoni, Adrian Zurbuchen, Hildegard Tanner, Andreas Haeberlin,

<h4>Objective</h4>Implanted cardiac pacemakers must be regularly replaced due to depleted batteries. A possible alternative is proposed by subcutaneous photovoltaic energy harvesting. The bodys reaction to an implant can cause device encapsulation. Potential changes in spectral light transmission of skin can inuence the performance of subcutaneous photovoltaic cells and has not ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
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Photoplethysmography Fast Upstroke Time Intervals Can Be Useful Features for Cuff-Less Measurement of Blood Pressure Changes in Humans.

Keerthana Natarajan, Robert C Block, Mohammad Yavarimanesh, Anand Chandrasekhar, Lalit K Mestha, Omer Inan, Jin-Oh Hahn, Ramakrishna Mukkamala,

<h4>Objective</h4>Photoplethysmography (PPG) waveform analysis is being increasingly investigated for continuous, non-invasive, and cuff-less blood pressure (BP) measurement. However, the efficacy of this approach and the useful features and models remain largely unclear. The objectives were to develop easy-to-understand models relating PPG waveform features to BP changes (after a cuff calibration) ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
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In-Vitro Study of Speed and Alignment Angle in Cochlear Implant Electrode Array Insertions.

Philipp Aebischer, Georgios Mantokoudis, Stefan Weder, Lukas Anschutz, Marco Caversaccio, Wilhelm Wimmer,

<h4>Objective</h4>The insertion of the electrode array is a critical step in cochlear implantation. Herein we comprehensively investigate the impact of the alignment angle and feed-forward speed on deep insertions in artificial scala tympani models with accurate macro-anatomy and controlled frictional properties.<h4>Methods</h4>Motorized insertions (n=1033) were performed in six scala tympani models ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
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Robust Single-Probe Quantitative Ultrasonic Imaging System with a Target-Aware Deep Neural Network.

Myeong-Gee Kim, Seok Hwan Oh, Youngmin Kim, Hyuksool Kwon, Hyeon-Min Bae,

<h4>Objective</h4>The speed of sound (SoS) has great potential as a quantitative imaging biomarker since it is sensitive to pathological changes in tissues. In this paper, a target-aware deep neural (TAD) network reconstructing an SoS image quantitatively from pulse-echo phase-shift maps gathered from a single conventional ultrasound probe is presented.<h4>Methods</h4>In the ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
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Steady-State and Transient Performance of Ion-Sensitive Electrodes Suitable for Wearable and Implantable Electro-chemical Sensing.

Xin Jin, Ajanta Saha, Hongjie Jiang, Muhammed R Oduncu, Qingyu Yang, Sotoudeh Sedaghat, Darrel Kerry Maize, Jan P Allebach, Ali Shakouri, Nicholas J Glassmaker, Alexander Wei, Rahim Rahimi, Muhammad Alam,

Traditional Potentiometric Ion-selective Electrodes (ISE) are widely used in industrial and clinical settings. The simplicity and small footprint of ISE have encouraged their recent adoption as wearable/implantable sensors for personalized healthcare and precision agriculture, creating a new set of unique challenges absent in traditional ISE. In this paper, we develop ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
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Intramuscular EMG-driven Musculoskeletal Modelling: Towards Implanted Muscle Interfacing in Spinal Cord Injury Patients.

Moon Ki Jung, Silvia Muceli, Camila Rodrigues, Alvaro Megia-Garcia, Alejandro Pascual Valdunciel, Antonio J Del-Ama, Angel Gil-Agudo, Juan C Moreno, Filipe Barroso, Jose Luis Pons, Dario Farina,

<h4>Objective</h4>Surface EMG-driven modelling has been proposed as a means to control assistive devices by estimating joint torques. Implanted EMG sensors have several advantages over wearable sensors but provide a more localized information on muscle activity, which may impact torque estimates. Here, we tested and compared the use of surface and ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
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Membrane charge oscillations during ultrasonic neuromodulation by intramembrane cavitation.

Thomas Tarnaud, Wout Joseph, Ruben Schoeters, Luc Martens, Emmeric Tanghe,

<h4>Objective</h4>To investigate the importance of membrane charge oscillations and redistribution in multi-compartmental ultrasonic neuromodulation (UNMOD) intramembrane cavitation models.<h4>Methods</h4>The Neuronal Intramembrane Cavitation Excitation (NICE) model and multiScale Optimized model of Neuronal Intramembrane Cavitation (SONIC) of UNMOD are compared for a nanoscale multi-compartmental and point neuron approximation of the bilayer sonophore and ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
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Mix Contrast for COVID-19 Mild-to-critical Prediction.

Yongbei Zhu, Shuo Wang, Siwen Wang, Qingxia Wu, Liusu Wang, Hongjun Li, Meiyun Wang, Meng Niu, Yunfei Zha, Jie Tian,

<b><i>Objective</i></b>: In a few patients with mild COVID-19, there is a possibility of the infection becoming severe or critical in the future. This work aims to identify high-risk patients who have a high probability of changing from mild to critical COVID-19 (only account for 5% of cases). <b><i>Methods</i></b>: Using traditional ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
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Modeling of Glioma Growth with Mass Effect by Longitudinal Magnetic Resonance Imaging.

Birkan Tunc, David Hormuth, George Biros, Thomas E Yankeelov,

It is well-known that expanding glioblastomas typically induce significant deformations of the surrounding parenchyma (i.e., the so-called ?mass effect?). In this study, we evaluate the performance of three mathematical models of tumor growth: 1) a reaction-diffusion-advection model which accounts for mass effect (RDAM), 2) a reaction-diffusion model with mass effect ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
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Flexible Electromagnetic Cap for Three-Dimensional Electromagnetic Head Imaging.

Abdulrahman S M Alqadami, Ali Zamani, Adnan Trakic, Amin Abbosh,

The timely treatment is the crucial element for the survival of patients with brain stroke. Thus, a fast, cost-effective, and portable device is needed for the early and on-the-spot diagnosis of stroke patients. A 3D electromagnetic head imaging system for rapid brain stroke diagnosis with a wearable and lightweight platform ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
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Effective Ultrasonic Stimulation in Human Peripheral Nervous System.

Thomas Riis, Jan Kubanek,

<h4>Objective</h4>Low-intensity ultrasound can stimulate excitable cells in a noninvasive and targeted manner, but which parameters are effective has remained elusive. This question has been difficult to answer because differences in transducers and parametersfrequency in particularlead to profound differences in the stimulated tissue volumes. The objective of this study is to ... Read more >>

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Biomechanical Comparison of Assistance Strategies Using a Bilateral Robotic Knee Exoskeleton.

Dawit Lee, Bailey Jaymes Mclain, Inseung Kang, Aaron Young,

Despite there being studies that have investigated the effects of human augmentation using a knee exoskeleton, comparing different assistance schemes on a single knee exoskeleton has not been studied. Using a light-weight, low-profile bilateral knee exoskeleton system, this study examined and compared the biomechanical effects of three common assistance strategies ... Read more >>

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Cardiac Output Estimation: Online Implementation for Left Ventricular Assist Device Support.

Anastasios Petrou, Menelaos Kanakis, Konstantinos Magkoutas, Bob de Vries, Mirko Meboldt, Marianne Schmid Daners,

<h4>Objective</h4>We present a novel pipeline that consists of various algorithms for the estimation of the cardiac output (CO) during ventricular assist devices (VADs) support using a single pump inlet pressure (PIP) sensor as well as pump intrinsic signals.<h4>Methods</h4>A machine learning (ML) model was constructed for the prediction of the aortic ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2021, 68(6):1990-1998]

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Transcranial Focused Ultrasound Neuromodulation of Voluntary Movement-Related Cortical Activity in Humans.

Kai Yu, Chang Liu, Xiaodan Niu, Bin He,

<h4>Objective</h4>Transcranial focused ultrasound (tFUS) is an emerging non-invasive brain stimulation tool for safely and reversibly modulating brain circuits. The effectiveness of tFUS on human brain has been demonstrated, but how tFUS influences the human voluntary motor processing in the brain remains unclear.<h4>Methods</h4>We apply low-intensity tFUS to modulate the movement-related cortical ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2021, 68(6):1923-1931]

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Quantification and Modeling of Ankle Stiffness During Standing Balance.

Varun Nalam, Ermyntrude Adjei, Hyunglae Lee,

<h4>Objective</h4>This study investigates the factors contributing to the modulation of ankle stiffness during standing balance and evaluates the reliability of linear stiffness models.<h4>Methods</h4>A dual-axis robotic platform and a visual feedback display were used to quantify ankle stiffness in both the sagittal and frontal planes while subjects controlled different levels of ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2021, 68(6):1828-1837]

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Non-invasive Treatment for Coronary In-stent Restenosis via Wireless Revascularization with Nitinol Active Stent.

Yong Xian Ang, Ahmad Zahran Md Khudzari, Mohamed Sultan Mohamedali,

This paper reports a novel shape memory alloy (SMA) nitinol type active stent for non-invasive restenosis treatment, which operates using a radiofrequency (RF) electro-thermo-mechanical actuation technique for wireless revascularization. The developed stent is equipped with a capacitive pressure sensor for in-artery blood pressure measurement and can provide multiple expansion to ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
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A Correlation Between Electric Fields That Target the Cell Membrane Potential and Dividing HeLa Cancer Cell Growth Inhibition.

Xing Li, Fan Yang, Boris Rubinsky,

<h4>Objective</h4>Clinical studies show that low intensity (single V/cm), intermediate-frequency (100 kHz-300 kHz) electric fields inhibit the growth of cancer cells, while the mechanism is not yet understood. We examine the hypothesis that electric fields modify the cell membrane potential of dividing cancer cells in a way that correlates with cells growth inhibition.<h4>Methods</h4>A ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2021, 68(6):1951-1956]

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Model-Based Evaluation of Methods for Respiratory Sinus Arrhythmia Estimation.

John Morales, Jonathan Moeyersons, Pablo Armanac, Michele Orini, Luca Faes, Sebastiaan Overeem, Merel Van Gilst, Johannes Van Dijk, Sabine Van Huffel, Raquel Bailon, Carolina Varon,

<h4>Objective</h4>Respiratory sinus arrhythmia (RSA) refers to heart rate oscillations synchronous with respiration, and it is one of the major representations of cardiorespiratory coupling. Its strength has been suggested as a biomarker to monitor different conditions, and diseases. Some approaches have been proposed to quantify the RSA, but it is unclear ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2021, 68(6):1882-1893]

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