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Journal Hum. Pathol.

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Morphological Correlation of Urinary Bladder Cancer Molecular Subtypes in Radical Cystectomies.

Lisa Han, Alexander J Gallan, Gary D Steinberg, Randy F Sweis, Gladell P Paner,

Several molecular subtypes of bladder cancer were identified with differing clinical behavior and responses to platinum-based chemotherapy. But so far, their urothelial histomorphologic features, besides association to some variant histologies, remained fully undefined. We sought to characterize the histological features of genomically-classified bladder cancers more extensively to tumor in radical ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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Clinicopathological features and immunohistochemical utility of NTRK, ALK and ROS1-rearranged papillary thyroid carcinomas and anaplastic thyroid carcinomas.

Yui Nozaki, Hidetaka Yamamoto, Takeshi Iwasaki, Masanobu Sato, Rina Jiromaru, Takahiro Hongo, Ryuji Yasumatsu, Yoshinao Oda,

NTRK1/3, ALK and ROS1 translocations have been reported in a minor subset of papillary thyroid carcinoma (PTC). We aimed to elucidate the prevalence and clinicopathological characteristics of these gene rearrangements and the utility of immunohistochemistry (IHC) in PTC and anaplastic thyroid carcinoma (ATC). We screened non-radiation exposed cases of 307 ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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p53 immunostaining cannot be used to predict TP53 mutations in gastric cancer - Results from a large Central European cohort.

Isabelle Schoop, Saffiyeh Saboor Maleki, Hans-Michael Behrens, Sandra Krüger, Jochen Haag, Christoph Röcken,

Four molecular subgroups of gastric cancer (GC) have been proposed, i.e. Epstein Barr virus-positive (EBV), microsatellite instable (MSI), chromosomal instable (CIN) and genomically stable GC. Based on the complex relationship between CIN and TP53 mutational status, we hypothesized that the typical clinicopathological characteristics caused by CIN are correlated with the ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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Structured analysis of histopathological characteristics of vulvar lichen sclerosus in a juvenile population.

Beth Morrel, Patricia C Ewing-Graham, Irene A M van der Avoort, Suzanne G M A Pasmans, Jeffrey Damman,

Genital lichen sclerosus, a chronic non-infectious dermatosis, is not rare in pediatric dermatology. The histopathological diagnosis in children and adults in both genital and non-genital lichen sclerosus (LS) is considered to be the same and encompasses a broad range of possible characteristics. Clinical manifestations and treatment options of genital LS ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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Inflammatory Myofibroblastic Tumors associated with the placenta, a series of 9 cases.

Sara Makhdoum, Valentina Nardi, Kelly A Devereaux, Christian A Kunder, G Petur Nielsen, Esther Oliva, Robert H Young, Drucilla J Roberts,

Inflammatory myofibroblastic tumors (IMT) of the uterus are often associated with pregnancy and are delivered with the placenta. We describe the clinical, pathologic, and molecular findings in nine cases of placental associated IMT (PaIMT). All the lesions were incidentally discovered at delivery or on placental pathological examination. Maternal age ranged ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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Hepatocellular Carcinomas can be SATB2 positive: An Important Diagnostic Pitfall.

Whayoung Lee, Xiaodong Li, Vishal S Chandan,

SATB2 is a sensitive and specific marker for tumors originating with the colon and appendix. It is now commonly used in surgical pathology, while working up carcinomas of unknown primary. We had anecdotally encountered occasional hepatocellular carcinomas (HCC) that were SATB2 positive. Immunohistochemical expression of SATB2 in hepatocellular carcinoma (HCC) ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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Intestinal Metaplasia Around The Gastroesophageal Junction Is Frequently Associated With Antral Reactive Gastropathy: Implications For Carcinoma At The Gastroesophageal Junction.

Monika Vyas, Romulo Celli, Manpreet Singh, Natalie Patel, Harry R Aslanian, Daniel Boffa, Yanhong Deng, Maria M Ciarleglio, Loren Laine, Dhanpat Jain,

Increasing evidence suggests that bile reflux (BR) plays a major role in mucosal injury leading to adenocarcinoma of the proximal stomach and distal esophagus. However, gastric BR is difficult to diagnose and investigate. Reactive gastropathy (RG), in the absence of non-steroidal anti-inflammatory drugs (NSAIDs) and other known causes likely represents ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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Lack of Distinct Molecular Profile of Primary Dermal Melanoma.

Sheila Shaigany, Basile Tessier-Cloutier, Klaus J Busam, Basil Horst,

BACKGROUND:Primary dermal melanoma (PDM) is a rare variant of melanoma which simulates metastatic melanoma to the skin. Diagnosis of PDM cannot be established on histologic grounds alone, but requires absence of evidence of melanoma elsewhere by clinical history and/or imaging studies. Despite this entity being clinically well documented, limited data ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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Data set for reporting carcinoma of the thyroid: Recommendations from the International Collaboration on Cancer Reporting (ICCR).

Ronald Ghossein, Justine A Barletta, Martin Bullock, Sarah J Johnson, Kennichi Kakudo, Alfred K Lam, Mufaddal T Moonim, David N Poller, Giovanni Tallini, R Michael Tuttle, Bin Xu, Anthony J Gill,

BACKGROUND AND OBJECTIVES:Thyroid cancer therapy is increasingly tailored to patients' risk of recurrence and death, placing renewed importance on pathologic parameters. The International Collaboration on Cancer Reporting (ICCR), an organization promoting evidence-based, internationally agreed upon standardized pathology data sets, is the ideal conduit for the development of a pathology reporting ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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c-MET Immunohistochemistry For Differentiating Malignant Mesothelioma from Benign Mesothelial Proliferations.

He Zhen Ren, Simon Cheung, Andrew Churg,

The separation of benign from malignant mesothelial proliferations can be a difficult problem for the surgical pathologist. c-MET is a receptor tyrosine kinase that is overexpressed and detectable by immunohistochemistry in many malignancies, including malignant mesothelioma. Whether c-MET is also expressed in benign mesothelial reactions is unclear from the literature. ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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Unique clinicopathologic and genetic alteration features in early onset colorectal carcinoma (CRC) compared to age-related CRC: large cohort next generation sequence analysis.

David Escobar, Ryan Jones, Juehua Gao, Leyu Sun, Jie Liao, Guang-Yu Yang,

Colorectal carcinoma (CRC) is the third most common cancer type in the United States. While the incidence of CRC is decreasing among an older population undergoing screening, the incidence of early-onset CRC is rising. There is a growing understanding that the molecular underpinnings of colorectal carcinoma vary by age. In ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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The potential utility of GATA3 for diagnosis of malignant pleural mesotheliomas.

Sarita Prabhakaran, Ashleigh Hocking, Chankyung Kim, Matthew Hussey, Sonja Klebe,

Malignant pleural mesothelioma is associated with asbestos exposure and poor outcomes. The usefulness of immunohistochemistry for diagnosis of sarcomatoid mesothelioma, especially the desmoplastic type, is limited and more effective markers are required. GATA3 has been suggested as a diagnostic marker for sarcomatoid mesothelioma. The potential usefulness of GATA3 for prognostication ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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Details of HER2 status in 454 cases of biliary tract cancer.

Nobuyoshi Hiraoka, Hiroaki Nitta, Akihiro Ohba, Hiroshi Yoshida, Chigusa Morizane, Takuji Okusaka, Satoshi Nara, Minoru Esaki, Yoji Kishi, Kazuaki Shimada,

Human epidermal growth factor receptor 2 (HER2)-targeted therapy has improved clinical outcomes in patients with HER2-positive breast and gastric cancers, although ineffective or recurrent cases are present. One reason for this is the heterogeneity of HER2 expression in cancer cells. The aim of this study was to investigate the clinicopathological ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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Comprehensive molecular genetic studies of EBV-negative aggressive NK-cell leukemia/lymphoma.

Juehua Gao, Yanming Zhang, Nabeel R Yaseen, Yuqiang Fang, Xinyan Lu, Madina Sukhanova, Qing Chen, Yi-Hua Chen,

EBV-negative aggressive NK-cell leukemia/lymphoma (ANKL) is a recently recognized, rare NK-cell neoplasm that preferentially affects non-Asians and has a fulminant clinical course. Little is known about the genetic alterations of this disease. In this study, we performed comprehensive molecular genetic studies, including chromosomal analysis, fluorescence in-situ hybridization (FISH), SNP microarray ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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Genetic basis of SMARCB1 protein loss in 22 sinonasal carcinomas.

Snjezana Dogan, Paolo Cotzia, Ryan N Ptashkin, Gouri J Nanjangud, Bin Xu, Amir Momeni Boroujeni, Marc A Cohen, David G Pfister, Manju L Prasad, Cristina R Antonescu, Yingbei Chen, Mrinal M Gounder,

SMARCB1-deficient sinonasal carcinoma (SNC) is an aggressive malignancy characterized by INI1 loss mostly owing to homozygous SMARCB1 deletion. With the exception of a few reported cases, these tumors have not been thoroughly studied by massive parallel sequencing (MPS). A retrospective cohort of 22 SMARCB1-deficient SNCs were studied by light microscopy, ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 104:105-116]

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Chromosomal microarray analysis of benign mesenchymal tumors with RB1 deletion.

Anna C Dusenbery, Jonathan J Davick, Robin D LeGallo, Eli S Williams,

Spindle cell lipomas/pleomorphic lipomas, mammary-type myofibroblastomas, and cellular angiofibromas are benign mesenchymal tumors that demonstrate histologically overlapping features but with varying anatomic locations and an uncertain etiologic relationship. These tumors have also been found to have an overlapping molecular profile with shared 13q14 deletions, which is the location of the ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 102:88-93]

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Primary round cell sarcomas of the urinary bladder with EWSR1 rearrangement: a multi-institutional study of thirteen cases with a review of the literature.

Manas R Baisakh, Ankit Tiwari, Jatin S Gandhi, Subhasini Naik, Shailendra K Sharma, Bonnie L Balzer, Shivani Sharma, Kamal Peddinti, Shilpy Jha, Pradeepa K Sahu, Dinesh Pradhan, Matthew Geller, Mahul B Amin, Jasreman Dhillon, Sambit K Mohanty,

Primary Ewing sarcoma (ES) of the urinary bladder is a rare and aggressive small blue round cell malignant neoplasm associated primarily with translocation involving EWSR1 and FLI1 genes located in the 22nd and 11th chromosomes, respectively. To date, 18 cases have been published in the literature as single-case reports, based chiefly ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 104:84-95]

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Acute myeloid leukemia with myelodysplasia-related changes diagnosed with multilineage dysplasia alone demonstrates a superior clinical outcome.

Gina Jiang, Jose-Mario Capo-Chichi, Aijun Liu, Eshetu G Atenafu, Robert Guo, Ann Tierens, Mark D Minden, Hong Chang,

Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) generally confers poor prognosis; however, the clinical outcome remains heterogeneous. We sought to further stratify this subentity of AML by performing a retrospective analysis of 179 adult patients with AML-MRC diagnosed at our institution. Based on 2016 World Health Organization diagnostic criteria, 44 ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 104:117-126]

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Chromosome 3p loss of heterozygosity and reduced expression of H3K36me3 correlate with longer relapse-free survival in sacral conventional chordoma.

Guo Gord Zhu, Daniel Ramirez, Wen Chen, Chao Lu, Lu Wang, Denise Frosina, Achim Jungbluth, Peter Ntiamoah, Khedoudja Nafa, Patrick J Boland, Meera R Hameed,

Conventional chordoma is a rare slow-growing malignant tumor of notochordal origin primarily arising at the base of the skull and sacrococcygeal bones. Chordoma may arise from its benign counterpart, benign notochordal cell tumors, and can also undergo dedifferentiation progressing into dedifferentiated chordoma. No study has directly compared the genomic alterations ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 104:73-83]

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Concordance of breast cancer biomarker status between routine immunohistochemistry/in situ hybridization and Oncotype DX qRT-PCR with investigation of discordance, a study of 591 cases.

Haley Sechrist, Akisha Glasgow, Philip Bomeisl, Hannah Gilmore, Aparna Harbhajanka,

Patients with estrogen receptor (ER)+/human epidermal growth factor receptor (HER)2-, lymph node- breast cancer with high recurrence risk benefit from adjuvant chemotherapy in addition to hormonal therapy. This study compares ER, progesterone receptor (PR), and HER2 status between routine immunohistochemistry (IHC)/in situ hybridization (ISH) and Oncotype DX (ODX) in 591 ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 104:54-65]

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Well-differentiated rectal neuroendocrine tumors: analysis of histology, including insulinoma-associated protein 1 expression, and biologic behavior, involving a large cohort of 94 cases.

Ryan Sappenfield, Ivan A Gonzalez, Dengfeng Cao, Deyali Chatterjee,

Well-differentiated rectal neuroendocrine tumors (R-NETs) are increasingly being detected by screening colonoscopy, commonly manifesting as polyps. Chromogranin A is frequently negative in R-NETs. Insulinoma-associated protein 1 (INSM1) is a novel transcription factor that has recently shown excellent sensitivity and specificity for neuroendocrine (NE) differentiation in various anatomic sites but has ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 104:66-72]

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Urethral involvement is associated with higher mortality and local recurrence in vulvar melanoma: a single institutional experience.

Mitul B Modi, Phyllis A Gimotty, Michael E Ming, Neha Jariwala, Rosalie Elenitsas, Chris Miller, Emily Y Chu, Hanna Lindner, Ata S Moshiri, Lauren E Schwartz, Priti Lal, Maria C Reyes, David E Elder, Xiaowei Xu,

Vulvar malignant melanoma (VMM), although uncommon, comprises 5-10% of all vulvar malignancies. Local control is notoriously poor in VMM with recurrence rates of 30-50% compared with approximately 3% in cutaneous melanomas. We studied clinicopathologic features of 37 women with VMM, after reviewing three decades of clinical follow-up data in our ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 104:1-8]

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Carboxypeptidase A1 and regenerating islet-derived 1α as new markers for pancreatic acinar cell carcinoma.

Samar Said, Paul J Kurtin, Samih H Nasr, Rondell P Graham, Surendra Dasari, Julie A Vrana, Saba Yasir, Michael S Torbenson, Lizhi Zhang, Taofic Mounajjed, Zong-Ming Eric Chen, Hee Eun Lee, Tsung-Teh Wu,

Acinar cell carcinoma (ACC) is a rare tumor that differentiates toward pancreatic acinar cells and shows evidence of pancreatic enzyme production. Mixed acinar-neuroendocrine carcinoma (MANC) is defined as having more than 30% of both acinar and neuroendocrine cell types as per immunohistochemistry analysis. Trypsin is currently the most commonly used stain ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 103:120-126]

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A novel immunohistochemical scoring system reveals associations of C-terminal MET, ectodomain shedding, and loss of E-cadherin with poor prognosis in oral squamous cell carcinoma.

Maria J De Herdt, Senada Koljenović, Berdine van der Steen, Stefan M Willems, Marjan H Wieringa, Daan Nieboer, Jose A Hardillo, Aaron M Gruver, Wei Zeng, Ling Liu, Robert J Baatenburg de Jong, Leendert H J Looijenga,

Using tissue microarrays, it was shown that membranous C-terminal MET immunoreactivity and ectodomain (ECD) shedding are associated with poor prognosis in oral cancer. Seen the potential diagnostic value, extrapolation of these results to whole-tissue sections was investigated. Because MET orchestrates epithelial-to-mesenchymal transition (EMT), the results were benchmarked to loss of ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 104:42-53]

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Conjunctival nevi and melanoma: multiparametric immunohistochemical analysis, including p16, SOX10, HMB45, and Ki-67.

Tatyana Milman, Qiang Zhang, SuMae Ang, David Elder, Cristiane M Ida, Diva R Salomao, Sara E Lally, Jerry A Shields, Rose A Hamershock, Kareem Sioufi, Carol L Shields, Ralph C Eagle,

The role of p16 in the diagnosis and prognosis of conjunctival melanocytic lesions in the context of other clinical and immunohistochemical parameters has not been systematically explored. This study was conducted to determine whether p16 is a useful parameter in the diagnosis and prognosis of conjunctival melanocytic nevi and melanoma, ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 103:107-119]

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