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Journal Hum. Pathol.

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Appendageal Tumors and Tumor-Like Lesions of the Testis and Paratestis: A 32-Years of Experience at a Single Institution.

Khaleel I Al-Obaidy, Fatimah I Alruwaii, Thomas M Ulbright, Muhammad T Idrees,

The testicular hilum and paratestis contain several embryologically diverse anatomic structures, including the spermatic cord, tunica vaginalis, epididymis, rete testis, and several other embryonic remnants. Several benign and malignant lesions arise from these morphologically distinct structures, and, due to their proximity, it is challenging to classify and subsequently stage these ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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Immunophenotypic and Pathologic Heterogeneity of Unclassified Renal Cell Carcinoma: A Study of 300 Cases.

Mahmut Akgul, Liang Cheng,

Renal cell carcinoma, unclassified (RCC-U), is a heterogenous group of tumors that do not fit in any recognized histologic types. Immunohistochemical studies are frequently used to characterize these tumors. Herein, we sought to investigate the immunophenotypes of 300 cases of RCC-U. The cases were morphologically classified into three groups: oncocytoma/chromophobe ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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E-cadherin immunohistochemical expression in invasive lobular carcinoma of the breast: correlation with morphology and CDH1 somatic alterations.

Anne Grabenstetter, Abhinita S Mohanty, Satshil Rana, Ahmet Zehir, A Rose Brannon, Timothy M D'Alfonso, Deborah F DeLair, Lee K Tan, Dara S Ross,

E-cadherin (ECAD) immunohistochemical (IHC) expression is lost in ∼90% of invasive lobular carcinomas (ILC) due to genomic alterations of CDH1. We examined morphologic features and ECAD IHC expression in invasive breast carcinomas (BC) with known CDH1 alterations. Between 1/2014 - 5/2018, 202 cases of BC with a CDH1 somatic alteration ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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High Frequency of Triple Negative Breast Cancers Co-express p16 and SOX10 But Do Not Express AR.

Esther Yoon, Parker Wilson, Tao Zuo, Marguerite Pinto, Kimberly Cole, Malini Harigopal,

Triple negative breast cancers (TNBC) represent approximately 12-17% of all breast cancers and have distinctively aggressive clinical courses. Since routine biomarkers for breast cancer do not apply for TNBCs, it is essential to find novel prognostic markers and potential targets for therapeutic agents. p16 and SOX10 are emerging biomarkers with ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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Napsin A is a highly sensitive marker for nephrogenic adenoma: an immunohistochemical study with specificity test in genitourinary tumors.

Nima Sharifai, Brooj Abro, Jie-Fu Chen, Ming Zhao, Huiying He, Dengfeng Cao,

Nephrogenic adenomas are uncommon benign lesions that are typically cytologically bland, but degenerative and reactive changes may make it difficult to distinguish these lesions from malignant entities, such as urothelial carcinoma and prostatic adenocarcinoma. In this study, we explored whether napsin A, a sensitive marker for lung adenocarcinoma, may also ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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A Genomic Survey of Sarcomas on Sun-Exposed Skin Reveals Distinctive Candidate Drivers and Potentially Targetable Mutations.

Timothy I Miller, Nicholas A Zoumberos, Bryan Johnson, Daniel R Rhodes, Scott A Tomlins, May P Chan, Aleodor A Andea, David R Lucas, Jonathan B McHugh, Noah Smith, Kelly L Harms, Chad Brewer, Jasmine Saleh, Rajiv M Patel, Paul W Harms,

Sarcomas on photodamaged skin vary in prognosis and management, but can display overlapping microscopic and immunophenotypic features. Improved understanding of molecular alterations in these tumors may provide diagnostic and therapeutic insights. We characterized 111 cutaneous sarcomatoid malignancies and their counterparts, including primary cutaneous angiosarcoma (n=7), atypical fibroxanthoma (AFX)(n=21), pleomorphic dermal ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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Non-diffuse large B-cell lymphoma transformation from follicular lymphoma: a single-institution study of 19 cases.

Akiko Miyagi Maeshima, Hirokazu Taniguchi, Hanae Ida, Rika Hosoba, Takahiro Fujino, Yo Saito, Sayako Yuda, Shinichi Makita, Suguru Fukuhara, Wataru Munakata, Tatsuya Suzuki, Dai Maruyama, Koji Izutsu,

Diffuse large B-cell lymphoma (DLBCL) is the most common histological transformation (HT) of follicular lymphoma (FL). Other types of HT are very rare, and their incidence, histopathology, and patient outcomes have not been sufficiently described. Here, we assessed the clinicopathological characteristics of 19 cases of non-DLBCL HT of FL in ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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Histopathologic features of non-infectious granulomatous disorders involving the skin.

Julia S Lehman, Olayemi Sokumbi, Margot S Peters, Alina G Bridges, Nneka I Comfere, Lawrence E Gibson, Carilyn N Wieland,

Granulomatous dermatoses may represent primary skin inflammation or can serve as the harbinger of a multitude of underlying systemic disorders or drug reactions. Taken together with clinical findings, the microscopic features from skin biopsy can allow recognition of various patterns and facilitate a precise diagnosis. Accurate classification of entities in ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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A Suggested Immunohistochemical Algorithm for the Classification of T Cell Lymphomas Involving Lymph Node.

Francisco Vega, L Jeffrey Medeiros,

T cell lymphomas are a heterogeneous group of neoplasms derived from mature T lymphocytes. These neoplasms are uncommon and usually diagnostically challenging. The focus of this paper is to suggest an immunohistochemistry-based, practical approach to assist in the diagnosis of nodal T-cell lymphomas. These neoplasms fall into two major groups: ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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Significance of Paneth cell-like differentiation in prostatic adenocarcinoma: a retrospective cohort study of 80 cases.

Daniela C Salles, Douglas A Mata, Jonathan I Epstein,

The grading and prognosis of prostatic adenocarcinoma with Paneth cell-like differentiation (PanEC) is controversial with limited available data. We identified 80 cases, not previously published, of PanEC first identified on biopsy (n = 69), transurethral resection of the prostate (n = 1), and radical prostatectomy (RP) (n = 10). Of 69 biopsies, 22 did not have ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 102:7-12]

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Genetic alterations and their association with clinicopathologic characteristics in advanced breast carcinomas: focusing on clinically actionable genetic alterations.

Cody Eric Freitag, Ping Mei, Lai Wei, Anil V Parwani, Zaibo Li,

Breast carcinomas (BCs) are genetically heterogeneous and associated with numerous mutations which can be used to predict outcomes and initiate targeted therapies. We investigated clinicopathologic characteristics associated with gene mutations detected using the FoundationOne CDx assay in a cohort of 223 clinically advanced BCs (66 locally recurrent and 157 metastatic) ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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NOR-1 distinguishes acinic cell carcinoma from its mimics on fine-needle aspiration biopsy specimens.

Luan Nguyen, Shefali Chopra, Derek B Laskar, Jianyu Rao, David Lieu, Fai Chung, Evelyn D Kim, Mariza de Peralta-Venturina, Shikha Bose, Bonnie Balzer,

Acinic cell carcinoma of the salivary gland (ACC-SG) is characterized by a recurrent chromosomal rearrangement (t(4; 9)(q13; q31)) that upregulates the transcription factor NR4A3. Studies conducted on formalin-fixed paraffin-embedded (FFPE) tissue have found that nuclear expression of a monoclonal antibody NR4A3 (NOR-1) is a sensitive and specific diagnostic marker for ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 102:1-6]

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A subset of sinonasal undifferentiated carcinoma is associated with transcriptionally active high-risk human papillomavirus by in situ hybridization: a clinical and pathologic analysis.

Ezra Baraban, Charles C L Tong, Nithin D Adappa, Kumarasen Cooper,

Sinonasal undifferentiated carcinoma (SNUC) is an aggressive malignancy with a poor prognosis, and pathologically, it is a diagnosis of exclusion. Rendering this diagnosis can be challenging in practice because of the large number of diverse entities in the differential diagnosis. We encountered an index case of a sinonasal carcinoma otherwise ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 101:64-69]

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Dysplastic lipoma: potential diagnostic pitfall of using MDM2 RNA in situ hybridization to distinguish between lipoma and atypical lipomatous tumor.

Yin P Hung, Michael Michal, Adrian M Dubuc, Andrew E Rosenberg, G Petur Nielsen,

The distinction between lipoma and atypical lipomatous tumor can be challenging in some cases. While detection of MDM2 gene amplification via fluorescence in situ hybridization (FISH) has been well established as a diagnostic tool to distinguish atypical lipomatous tumor and well-differentiated liposarcoma from benign mimics, MDM2 RNA in situ hybridization ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 101:53-57]

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Cicatricial organizing pneumonia: a clinicopathologic and radiologic study on a cohort diagnosed by surgical lung biopsy at a single institution.

Matthew J Woge, Jay H Ryu, Brian J Bartholmai, Eunhee S Yi,

Cicatricial organizing pneumonia (CiOP) refers to intraluminal collagen deposition in a background of otherwise classic appearing organizing pneumonia (OP), sometimes with formation of peculiar fibrous nodules or densely fibrotic linear bands. Dendriform ossification has been also described in CiOP cases. This study is to evaluate the clinicopathologic and radiologic characteristics ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 101:58-63]

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Evolution of severe acute respiratory syndrome coronavirus 2 RNA test results in a patient with fatal coronavirus disease 2019: a case report.

Chen Shao, Hui Liu, Lingjia Meng, Lin Sun, Yankun Wang, Zhujun Yue, Heli Kong, Hongjun Li, Honglei Weng, Fudong Lv, Ronghua Jin,

A 65-year-old man was hospitalized owing to fever (38.6 °C) and dry cough since 4 days. He visited Wuhan 8 days ago. At admission, nasopharyngeal swab samples were taken, and polymerase chain reaction analysis confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA positivity. On day 9, after admission, the chest ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 101:82-88]

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Dataset for the Reporting of Pheochromocytoma and Paraganglioma: Explanations and Recommendations of the Guidelines from the International Collaboration on Cancer Reporting (ICCR).

Lester D R Thompson, Anthony J Gill, Sylvia L Asa, Roderick J Clifton-Bligh, Ronald R de Krijger, Noriko Kimura, Paul Komminoth, Ernest E Lack, Jacques W M Lenders, Ricardo V Lloyd, Thomas G Papathomas, Peter M Sadow, Arthur S Tischler,

BACKGROUND AND OBJECTIVES:The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organized to develop evidence-based, internationally agreed upon standardized datasets for each anatomic site, to be used throughout the world. Providing global standardization of pathology tumor classification, staging, and other reporting elements will lead to improved patient management and ... Read more >>

Hum. Pathol. (Human pathology)
[2020, :]

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Heterogeneity of ARID1A expression in gastric cancer may affect patient survival and therapeutic efficacy.

Motonobu Saito, Takashi Kohno, Koji Kono,

Hum. Pathol. (Human pathology)
[2020, 101:80-81]

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p57-discordant villi in hydropic products of conception: a clinicopathological study of 70 cases.

Lucie Gaillot-Durand, Sophie Patrier, Jacqueline Aziza, Louise Devisme, Anne-Claude Riera, Pascale Marcorelles, Fanny Pelluard, Bernard Gasser, Claire Mauduit, Touria Hajri, Jérôme Massardier, Pierre-Adrien Bolze, François Golfier, Mojgan Devouassoux-Shisheboran, Fabienne Allias,

p57 immunostaining is performed on hydropic products of conception to diagnose hydatidiform moles (HMs), which can progress to gestational trophoblastic neoplasia. Partial hydatidiform mole (PHM) and hydropic abortion (HA) display positive staining in stromal and cytotrophoblastic cells, whereas complete hydatidiform mole (CHM) is characterized by loss of p57 expression in ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 101:18-30]

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Tumor mutation burden and checkpoint immunotherapy markers in primary and metastatic synovial sarcoma.

Mai He, Brooj Abro, Madhurima Kaushal, Ling Chen, Tiffany Chen, Mercia Gondim, Weisi Yan, Julie Neidich, Louis P Dehner, John D Pfeifer,

Synovial sarcoma (SS) is a soft-tissue malignancy that most often affects patients aged between 15 and 40 years, and the prognosis for patients with metastatic disease is generally poor. This study was performed to evaluate checkpoint blockade immunotherapy markers in SS, including tumor mutational burden (TMB), DNA mismatch repair (MMR) ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 100:15-23]

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Telomere lengths differ significantly between small-cell neuroendocrine prostate carcinoma and adenocarcinoma of the prostate.

Christopher M Heaphy, Michael C Haffner, Mindy K Graham, David Lim, Christine Davis, Eva Corey, Jonathan I Epstein, Mario A Eisenberger, Hao Wang, Angelo M De Marzo, Alan K Meeker, Tamara L Lotan,

Small-cell neuroendocrine carcinoma (SCNC) of the prostate is an aggressive subtype with frequent TP53 mutation and RB1 inactivation; however, the molecular phenotype remains an area of investigation. Here, we compared telomere lengths in prostatic SCNC and usual-type prostatic adenocarcinoma (AdCa). We studied 32 cases of prostatic SCNC (including 11 cases ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 101:70-79]

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Simple mucinous cysts of the pancreas have heterogeneous somatic mutations.

Marc Attiyeh, Lance Zhang, Christine Iacobuzio-Donahue, Peter Allen, Rami Imam, Olca Basturk, David S Klimstra, Carlie S Sigel,

Simple mucinous cysts of the pancreas have an epithelial lining resembling pancreatic intraepithelial neoplasia but may have a clinical presentation similar to premalignant mucinous neoplasms such as intraductal papillary mucinous neoplasms. Whether the epithelial lining shares genomic alterations with other pancreatic preinvasive neoplasms such as PanIN and intraductal papillary mucinous ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 101:1-9]

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Revisiting the distinct histomorphologic features of inflammatory bowel disease-associated neoplastic precursor lesions in the SCENIC and post-DALM Era.

Xianyong Gui, Marietta Iacucci, Subrata Ghosh, Jose G P Ferraz, Scott Lee,

Distinct histomorphologic features of colitis-associated dysplasia (CAD) or neoplastic precursors in inflammatory bowel disease (IBD) have never been clearly identified. In this study, we tried to further explore the differentiating morphologic features of CAD by retrospectively reviewing the lesions that were clearly associated with carcinomas (carcinoma-related lesions) and by comparing ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 100:24-37]

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Lymphocytic colitis pattern of injury presenting as endoscopic polyps: a case series.

Zhiyan Fu, Mahmoud Aldyab, Mustafa Erdem Arslan, Ann Boguniewicz, Dipti M Karamchandani, Hwajeong Lee,

Lymphocytic colitis (LC) is characterized by chronic watery diarrhea and unremarkable endoscopic findings. Only one case of LC presenting as multiple colonic polyps has been reported. We report a case series of histologic LC pattern of injury (LCPI), presenting as endoscopic polyps, and compare them with typical LC cases. Eighteen ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 101:10-17]

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Programmed death ligand 1/indoleamine 2,3-dioxygenase 1 expression and tumor-infiltrating lymphocyte status in renal cell carcinoma with sarcomatoid changes and rhabdoid features.

Daisuke Kiyozawa, Dai Takamatsu, Kenichi Kohashi, Fumio Kinoshita, Shin Ishihara, Yu Toda, Masatoshi Eto, Yoshinao Oda,

Renal cell carcinoma (RCC) with sarcomatoid changes and rhabdoid features has shown poor outcomes. Several immune checkpoint inhibitors including programmed cell death protein 1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitors have been approved for the treatment of RCC. Combination therapy using PD-1/PD-L1 and indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors has also been ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 101:31-39]

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