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Journal Gynecol Oncol

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Sentinel lymph node isolated tumor cells in early staged endometrioid endometrial cancer: Utility or futility?

Travis T Sims, David M Boruta,

Gynecol Oncol (Gynecologic oncology)
[2021, 161(2):331-332]

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Gynecologic oncology treatment modifications or delays in response to the COVID-19 pandemic in a publicly funded versus privately funded North American tertiary cancer center.

Sabrina Piedimonte, Sue Li, Stephane Laframboise, Sarah E Ferguson, Marcus Q Bernardini, Genevieve Bouchard-Fortier, Liat Hogen, Paulina Cybulska, Michael J Worley, Taymaa May,

<h4>Objective</h4>To compare gynecologic oncology surgical treatment modifications and delays during the first wave of the COVID-19 pandemic between a publicly funded Canadian versus a privately funded American cancer center.<h4>Methods</h4>This is a retrospective cohort study of all planned gynecologic oncology surgeries at University Health Network (UHN) in Toronto, Canada and Brigham ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Gynecologic oncology treatment modifications or delays in response to the COVID-19 pandemic in a publicly funded versus privately funded North American tertiary cancer center

Sabrina Piedimonte, Sue Li, Stephane Laframboise, Sarah E. Ferguson, Marcus Q. Bernardini, Genevieve Bouchard-Fortier, Liat Hogen, Paulina Cybulska, Michael J. Worley, Taymaa May,

<h4>Objective</h4> To compare gynecologic oncology surgical treatment modifications and delays during the first wave of the COVID-19 pandemic between a publicly funded Canadian versus a privately funded American cancer center. <h4>Methods</h4> This is a retrospective cohort study of all planned gynecologic oncology surgeries at University Health Network (UHN) in Toronto, ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Gestational diabetes mellitus and risks of gynecologic cancers: Results from a nationwide Swedish twin study.

Zhuoyu Sun, Shuqi Wang, Rongrong Yang, Xuerui Li, Yumeng Yang, Xiuying Qi, Yaomei Ma, Weili Xu,

<h4>Background</h4>Type 2 diabetes has been associated with increased risk of gynecologic cancers, yet the effect of gestational diabetes mellitus (GDM) on gynecologic cancers is unclear.<h4>Objectives</h4>To examine associations between GDM history and subsequent gynecologic cancers in parous women, and to explore whether gestational hypertension (GH) plays a role in the associations.<h4>Study ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Uterine serous carcinoma.

Giorgio Bogani, Isabelle Ray-Coquard, Nicole Concin, Natalie Y L Ngoi, Philippe Morice, Takayuki Enomoto, Kazuhiro Takehara, Hannelore Denys, Remi A Nout, Domenica Lorusso, Michelle M Vaughan, Marta Bini, Masashi Takano, Diane Provencher, Alice Indini, Satoru Sagae, Pauline Wimberger, Robert Póka, Yakir Segev, Se Ik Kim, Francisco J Candido Dos Reis, Salvatore Lopez, Andrea Mariani, Mario M Leitao, Francesco Raspagliesi, Pieluigi Benedetti Panici, Violante Di Donato, Ludovico Muzii, Nicoletta Colombo, Giovanni Scambia, Sandro Pignata, Bradley J Monk,

Serous endometrial cancer represents a relative rare entity accounting for about 10% of all diagnosed endometrial cancer, but it is responsible for 40% of endometrial cancer-related deaths. Patients with serous endometrial cancer are often diagnosed at earlier disease stage, but remain at higher risk of recurrence and poorer prognosis when ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Continuity of care and receipt of aggressive end of life care among women dying of ovarian cancer.

Megan A Mullins, Julie J Ruterbusch, Philippa Clarke, Shitanshu Uppal, Michele L Cote, Lauren P Wallner,

<h4>Objective</h4>To evaluate the association between post-diagnosis continuity of care and receipt of aggressive end of life care among women dying of ovarian cancer.<h4>Methods</h4>This retrospective claims analysis included 6680 Medicare beneficiaries over age 66 with ovarian cancer who survived at least one year after diagnosis, had at least 4 outpatient evaluation ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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It's time to re-evaluate cervical Cancer screening after age 65.

Sarah Dilley, Warner Huh, Batel Blechter, Anne F Rositch,

Cervical cancer screening guidelines currently recommend cessation of cervical cancer screening after age 65, despite 20% of new cervical cancer cases occurring in this age group. The US population is aging, research methodology that examines cervical cancer incidence and mortality rates has changed, and sexual behaviors and the rates at ... Read more >>

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[2021, :]

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Management of pregnancy after radical trachelectomy.

Yoshifumi Kasuga, Satoru Ikenoue, Mamoru Tanaka, Daigo Ochiai,

Radical trachelectomy (RT) is a surgery for early-stage cervical cancer treatment that preserves the childbearing ability, and its use has become increasingly common worldwide. Thus, the rate of conception in women who have undergone RT is increasing. However, pregnancy after RT is associated with a higher risk of several obstetric ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Cervical re-injection of indocyanine green to improve sentinel lymph node detection in endometrial cancer.

M Maramai, M T Achilarre, A Aloisi, I Betella, S Bogliolo, A Garbi, M Maruccio, C Quatrale, G D Aletti, A Mariani, N Colombo, A Maggioni, F Multinu, V Zanagnolo,

<h4>Objectives</h4>To evaluate the role of cervical re-injection of indocyanine green (ICG) to increase the detection rate of sentinel lymph node (SLN) in patients with endometrial cancer (EC) who underwent robotic-assisted surgical staging.<h4>Methods</h4>We retrospectively identified consecutive EC patients undergoing robotic-assisted staging with SLN biopsy at our Institution between June 2016 and ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Hypersensitivity to platinum salts according to BRCA status in ovarian cancer: A retrospective analysis of clinical outcomes and systematic review of literature.

G Giannone, G Scotto, D Katsaros, U De Giorgi, A Farolfi, F Borella, S Cosma, A Ferrero, S Mangiacotti, M Villa, V Tuninetti, E Ghisoni, M Turinetto, G Mittica, S Gemmiti, L Zavallone, M Aglietta, B Pasini, M Di Maio, G Valabrega,

<h4>Background</h4>Hypersensitivity reactions (HSRs) to platinum are an important issue in the treatment of patients (pts) with ovarian cancer (OC). Germline BRCA mutations have been proposed as a risk factor. We aimed at evaluating the incidence and severity of HSRs to platinum in OC pts. with known BRCA status.<h4>Patients and methods</h4>We ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Epithelial ovarian cancer and the use of circulating tumor DNA: A systematic review.

Christine Fribert Thusgaard, Malene Korsholm, Kristina Magaard Koldby, Torben A Kruse, Mads Thomassen, Kirsten Marie Jochumsen,

<h4>Objective</h4>One way to improve the survival rate of epithelial Ovarian Cancer (EOC) is by identifying effective biomarkers useful at different stages and time points of the disease. A potential biomarker is circulating tumor DNA (ctDNA) in plasma or serum. In this systematic review, we provide an overview of applications of ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Bevacizumab in advanced endometrial cancer.

Maria M Rubinstein, Shannan Dickinson, Priyanka Narayan, Qin Zhou, Alexia Iasonos, Weining Ma, Yulia Lakhman, Vicky Makker,

<h4>Objective</h4>Prospective data have demonstrated the efficacy of bevacizumab monotherapy in the treatment of advanced endometrial cancer. Bevacizumab is used off-label, and real-world data regarding the role of bevacizumab in endometrial cancer treatment are scant. In this largest single-institution retrospective study of its kind, we report our experience with bevacizumab monotherapy ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Characteristics and outcome of BRCA mutated epithelial ovarian cancer patients in Italy: A retrospective multicenter study (MITO 21).

Grazia Artioli, Gaia Giannone, Giorgio Valabrega, Furio Maggiorotto, Sofia Genta, Sandro Pignata, Domenica Lorusso, Gennaro Cormio, Simona Scalone, Maria Ornella Nicoletto, Filippo Greco, Emanuela Rossi, Ilaria Spagnoletti, Ugo De Giorgi, Michele Orditura, Anna Maria Mosconi, Anila Kardhashi, Stefano Bogliolo, Lucia Borgato,

<h4>Objective</h4>Around 15% of epithelial ovarian cancer (EOC) patients (pts) harbor a germline BRCA1 or 2 mutation, showing different features than BRCA wild-type pts. The clinical and pathological features of an Italian BRCA mutated EOC cohort were described.<h4>Methods</h4>We retrospectively analyzed clinical, pathological and mutational data from a cohort of Italian BRCA ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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The next generation sequencing of cancer-related genes in small cell neuroendocrine carcinoma of the cervix.

Xuan Pei, Libing Xiang, Wei Chen, Wei Jiang, Lina Yin, Xuxia Shen, Xiaoyan Zhou, Huijuan Yang,

<h4>Objective</h4>Small cell neuroendocrine carcinoma of the cervix (SCNEC) is a lethal malignancy and little treatment progress has been made for decades. We sought to map its genetic profiles, and identify whether SCNEC harbor mutations and potential targets for therapeutic interventions.<h4>Methods</h4>Primary tumor tissue and blood samples were obtained from 51 patients ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Updates on conservative management of endometrial cancer in patients younger than 45 years.

Sergio M Lucchini, Agustin Esteban, Mariana A Nigra, Ana T Palacios, Juan P Alzate-Granados, Hernan F Borla,

Endometrial cancer is the most common gynecologic malignancy in developed country. Women under the age of 40 represent 5% of all endometrial cancer and the majority are nulliparous at the time of diagnosis. The aim of this review was to compare oncologic and fertility outcomes among different fertility-preserving therapies in ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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The impact of expanding gynecologic oncology care to ovarian cancer patients in small cities and rural communities.

Emma Jane Swayze, Lauren Strzyzewski, Pooja Avula, Aaron L Zebolsky, Anna V Hoekstra,

<h4>Objective</h4>Patients with ovarian cancer from smaller cities and rural communities face unique challenges in accessing comprehensive care. This study compares management strategies, outcomes, and access to care for patients in a small city and surrounding rural communities before and after establishing a full-time gynecologic oncology (GO) office.<h4>Methods</h4>A local tumor registry ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Understanding the effect of mechanical forces on ovarian cancer progression.

A Martinez, M Buckley, C B Scalise, A A Katre, J J Dholakia, D Crossman, M J Birrer, J L Berry, R C Arend,

<h4>Objective</h4>Mechanical forces including tension, compression, and shear stress are increasingly implicated in tumor progression and metastasis. Understanding the mechanisms behind epithelial ovarian cancer (EOC) progression and metastasis is critical, and this study aimed to elucidate the effect of oscillatory and constant tension on EOC.<h4>Methods</h4>SKOV-3 and OVCAR-8 EOC cell lines were ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Optimal duration of fertility-sparing hormonal treatment for early-stage endometrioid endometrial cancer.

Seung-Hyuk Shim, Su Hyun Chae, Kyeong A So, Sun Joo Lee, Ji Young Lee, Tae Jin Kim, Ernest S Han, Soon-Beom Kang,

<h4>Objectives</h4>To analyze the oncologic outcomes of long-term fertility-sparing treatment (FST) in patients with early-stage endometrial cancer (EC) and to determine the optimal duration of FST that would not hamper survival outcomes.<h4>Methods</h4>Patients undergoing FST for presumed stage IA, grade 1 EC between 2005 and 2008 were retrospectively analyzed. Oncologic outcomes were ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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MiR-29c downregulates tumor-expressed B7-H3 to mediate the antitumor NK-cell functions in ovarian cancer.

Mengqi Deng, Di Wu, Yanqin Zhang, Zhaoyu Jin, Jinwei Miao,

<h4>Objective</h4>B7-H3 is a member of the B7 family of immune checkpoint molecule. Although B7-H3 has been shown to regulate T cell-mediated peripheral immune response, whether it also correlated with NK cell exhaustion in ovarian cancer remains unclear. The purpose of this study was to explore the mechanism of B7-H3 regulating ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Erratum to 'A state-wide population-based evaluation of cervical cancers arising during opportunistic screening in the United States' [Gynecologic Oncology 159 (2020) 344-353].

Rebecca Landy, Christopher Mathews, Michael Robertson, Charles L Wiggins, Yolanda J McDonald, Daniel W Goldberg, Isabel C Scarinci, Jack Cuzick, Peter D Sasieni, Cosette M Wheeler, ,

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Timing of surgery in patients with partial response or stable disease after neoadjuvant chemotherapy for advanced ovarian cancer.

Roni Nitecki, Nicole D Fleming, Bryan M Fellman, Larissa A Meyer, Anil K Sood, Karen H Lu, J Alejandro Rauh-Hain,

<h4>Objective</h4>The ideal number of neoadjuvant chemotherapy (NACT) cycles prior to interval tumor-reductive surgery (iTRS) for advanced ovarian cancer is poorly defined. We sought to assess survival stratified by number of NACT cycles and residual disease following iTRS in patients with advanced ovarian cancer with partial response (PR) or stable disease ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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PP2A and E3 ubiquitin ligase deficiencies: Seminal biological drivers in endometrial cancer.

Jesus Gonzalez-Bosquet, Jamie N Bakkum-Gamez, Amy L Weaver, Michaela E McGree, Sean C Dowdy, Abimbola O Famuyide, Benjamin R Kipp, Kevin C Halling, Fergus J Couch, Karl C Podratz,

<h4>Objective</h4>PI3K-AKT pathway mutations initiate a kinase cascade that characterizes endometrial cancer (EC). As kinases seldom cause oncogenic transformation without dysregulation of antagonistic phosphatases, pivotal interactions governing this pathway were explored and correlated with clinical outcomes.<h4>Methods</h4>After exclusion of patients with POLE mutations from The Cancer Genome Atlas EC cohort with endometrioid ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Stereotactic body radiotherapy for the treatment of gynecologic malignancies: Passing fancy or here to stay?

Ryan J Hutten, Y Jessica Huang, David K Gaffney,

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Using rADioMIcs and machine learning with ultrasonography for the differential diagnosis of myometRiAL tumors (the ADMIRAL pilot study). Radiomics and differential diagnosis of myometrial tumors.

V Chiappa, M Interlenghi, C Salvatore, F Bertolina, G Bogani, A Ditto, F Martinelli, I Castiglioni, F Raspagliesi,

<h4>Objective</h4>To develop and evaluate the performance of a radiomics and machine learning model applied to ultrasound (US) images in predicting the risk of malignancy of a uterine mesenchymal lesion.<h4>Methods</h4>Single-center retrospective evaluation of consecutive patients who underwent surgery for a malignant uterine mesenchymal lesion (sarcoma) and a control group of patients ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Entinostat, a selective HDAC1/2 inhibitor, potentiates the effects of olaparib in homologous recombination proficient ovarian cancer.

Vijayalaxmi G Gupta, Jeff Hirst, Shariska Petersen, Katherine F Roby, Meghan Kusch, Helen Zhou, Makena L Clive, Andrea Jewell, Harsh B Pathak, Andrew K Godwin, Andrew J Wilson, Marta A Crispens, Emily Cybulla, Alessandro Vindigni, Katherine C Fuh, Dineo Khabele,

<h4>Objective</h4>Poly ADP ribose polymerase inhibitors (PARPi) are most effective in BRCA1/2 mutated ovarian tumors. Better treatments are needed for homologous recombination HR-proficient cancer, including CCNE1 amplified subtypes. We have showndhown that histone deacetylase inhibitors (HDACi) sensitize HR-proficient ovarian cancer to PARPi. In this study, we provide complementary preclinical data for ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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