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Next-generation sequencing of bile cell-free DNA for the early detection of patients with malignant biliary strictures.

Maria Arechederra, María Rullán, Irene Amat, Daniel Oyon, Lucia Zabalza, Maria Elizalde, M Ujue Latasa, Maria R Mercado, David Ruiz-Clavijo, Cristina Saldaña, Ignacio Fernández-Urién, Juan Carrascosa, Vanesa Jusué, David Guerrero-Setas, Cruz Zazpe, Iranzu González-Borja, Bruno Sangro, Jose M Herranz, Ana Purroy, Isabel Gil, Leonard J Nelson, Juan J Vila, Marcin Krawczyk, Krzysztof Zieniewicz, Waldemar Patkowski, Piotr Milkiewicz, Francisco Javier Cubero, Gorka Alkorta-Aranburu, Maite G Fernandez-Barrena, Jesus M Urman, Carmen Berasain, Matias A Avila,

<h4>Objective</h4>Despite significant progresses in imaging and pathological evaluation, early differentiation between benign and malignant biliary strictures remains challenging. Endoscopic retrograde cholangiopancreatography (ERCP) is used to investigate biliary strictures, enabling the collection of bile. We tested the diagnostic potential of next-generation sequencing (NGS) mutational analysis of bile cell-free DNA (cfDNA).<h4>Design</h4>A prospective ... Read more >>

Gut (Gut)
[2021, :]

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COVID-19 in liver transplant candidates: pretransplant and post-transplant outcomes - an ELITA/ELTR multicentre cohort study.

Luca Saverio Belli, Christophe Duvoux, Paolo Angelo Cortesi, Rita Facchetti, Speranta Iacob, Giovanni Perricone, Sylvie Radenne, Sara Conti, Damiano Patrono, Gabriela Berlakovich, Angus Hann, Luisa Pasulo, Lluis Castells, Francois Faitot, Olivier Detry, Federica Invernizzi, Giulia Magini, Paolo De Simone, Ilias Kounis, Maria Cristina Morelli, Fernando Díaz Fontenla, Bo-Göran Ericzon, Carmelo Loinaz, Chris Johnston, Liliana Gheorghe, Mickael Lesurtel, Renato Romagnoli, Dagmar Kollmann, M Thamara Pr Perera, Stefano Fagiuoli, Darius Mirza, Audrey Coilly, Christian Toso, Krzysztof Zieniewicz, Laure Elkrief, Vincent Karam, Rene Adam, Caroline den Hoed, Marco Merli, Massimo Puoti, Luciano De Carlis, Gabriel C Oniscu, Salvatore Piano, Paolo Angeli, Constantino Fondevila, Wojciech G Polak, ,

<h4>Objective</h4>Explore the impact of COVID-19 on patients on the waiting list for liver transplantation (LT) and on their post-LT course.<h4>Design</h4>Data from consecutive adult LT candidates with COVID-19 were collected across Europe in a dedicated registry and were analysed.<h4>Results</h4>From 21 February to 20 November 2020, 136 adult cases with laboratory-confirmed SARS-CoV-2 ... Read more >>

Gut (Gut)
[2021, :]

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Sodium+/taurocholate cotransporting polypeptide as target therapy for liver fibrosis.

Ahmad Salhab, Johnny Amer, Yinying Lu, Rifaat Safadi,

<h4>Objective</h4>Sodium<sup>+</sup>/ taurocholate cotransporting polypeptide (NTCP) is a membrane transporter affecting the enterohepatic circulation of bile acids (BAs). We aimed to evaluate NTCP's roles in humans and animal models of liver fibrosis (LF).<h4>Design</h4>Primary hepatic stellate cells (pHSCs) isolated from livers biopsies of patients with LF with different fibrosis grading were stained ... Read more >>

Gut (Gut)
[2021, :]

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Proton pump inhibitors and gastric cancer: a population-based cohort study.

Jigar Patel, Ivan Berezowski, Rajesh Naidu Janapala, Ali Pourmand,

Gut (Gut)
[2021, :]

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Optimal timing of cholecystectomy after necrotising biliary pancreatitis.

Nora D Hallensleben, Hester C Timmerhuis, Robbert A Hollemans, Sabrina Pocornie, Janneke van Grinsven, Sandra van Brunschot, Olaf J Bakker, Rogier van der Sluijs, Matthijs P Schwartz, Peter van Duijvendijk, Tessa Römkens, Martijn W J Stommel, Robert C Verdonk, Marc G Besselink, Stefan A W Bouwense, Thomas L Bollen, Hjalmar C van Santvoort, Marco J Bruno, ,

<h4>Objective</h4>Following an episode of acute biliary pancreatitis, cholecystectomy is advised to prevent recurrent biliary events. There is limited evidence regarding the optimal timing and safety of cholecystectomy in patients with necrotising biliary pancreatitis.<h4>Design</h4>A post hoc analysis of a multicentre prospective cohort. Patients with biliary pancreatitis and a CT severity score ... Read more >>

Gut (Gut)
[2021, :]

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Recent advances in clinical practice: epidemiology of autoimmune liver diseases.

Palak J Trivedi, Gideon M Hirschfield,

Autoimmune liver diseases are chronic inflammatory hepatobiliary disorders that when classically defined encompass three distinctive clinical presentations; primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH). Meaningful changes in disease epidemiology are reported, with increasing incidence and prevalence of AIH and PSC in Europe, and rising prevalence ... Read more >>

Gut (Gut)
[2021, :]

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Automated sizing of colorectal polyps using computer vision.

Mohamed Abdelrahim, Hiroyasu Saiga, Naoto Maeda, Ejaz Hossain, Hitoshi Ikeda, Pradeep Bhandari,

Gut (Gut)
[2021, :]

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Incorrectly analysing stratified and minimised trials may lead to wrongfully rejecting superiority of interventions.

Reinier Cornelis Anthonius van Linschoten, Rachel West, Desirée van Noord, Nikki van Leeuwen,

Gut (Gut)
[2021, :]

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Reverse translation approach generates a signature of penetrating fibrosis in Crohn's disease that is associated with anti-TNF response.

Shanshan Xiong, Charles E Whitehurst, Li Li, Gyu Seong Heo, Chin-Wen Lai, Umang Jain, Brian D Muegge, Scott T Espenschied, Ryan J Musich, Minhu Chen, Yongjian Liu, Ta-Chiang Liu, Thaddeus S Stappenbeck,

<h4>Objective</h4>Fibrosis is a common feature of Crohn's disease (CD) which can involve the mesenteric fat. However, the molecular signature of this process remains unclear. Our goal was to define the transcriptional signature of mesenteric fibrosis in CD subjects and to model mesenteric fibrosis in mice to improve our understanding of ... Read more >>

Gut (Gut)
[2021, :]

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Topological analysis of hepatocellular carcinoma tumour microenvironment based on imaging mass cytometry reveals cellular neighbourhood regulated reversely by macrophages with different ontogeny.

Jianpeng Sheng, Junlei Zhang, Lin Wang, Vincent Tano, Jianghui Tang, Xun Wang, Jiangchao Wu, Jinyuan Song, Yaxing Zhao, Jingxia Rong, Fei Cheng, Jianfeng Wang, Yinan Shen, Liang Wen, Junjun He, Hui Zhang, Taohong Li, Qi Zhang, Xueli Bai, Zhimin Lu, Tingbo Liang,

<h4>Objective</h4>Hepatocellular carcinoma (HCC) tumour microenvironment (TME) is highly complex with diverse cellular components organising into various functional units, cellular neighbourhoods (CNs). And we wanted to define CN of HCC while preserving the TME architecture, based on which, potential targets for novel immunotherapy could be identified.<h4>Design</h4>A highly multiplexed imaging mass cytometry ... Read more >>

Gut (Gut)
[2021, :]

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Helicobacter pylori infection has a detrimental impact on the efficacy of cancer immunotherapies.

Paul Oster, Laurie Vaillant, Erika Riva, Brynn McMillan, Christina Begka, Caroline Truntzer, Corentin Richard, Marine M Leblond, Meriem Messaoudene, Elisavet Machremi, Emeric Limagne, Francois Ghiringhelli, Bertrand Routy, Gregory Verdeil, Dominique Velin,

<h4>Objective</h4>In this study, we determined whether <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection dampens the efficacy of cancer immunotherapies.<h4>Design</h4>Using mouse models, we evaluated whether immune checkpoint inhibitors or vaccine-based immunotherapies are effective in reducing tumour volumes of <i>H. pylori</i>-infected mice. In humans, we evaluated the correlation between <i>H. pylori</i> seropositivity and the ... Read more >>

Gut (Gut)
[2021, :]

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Hidden link in gut-joint axis: gut microbes promote rheumatoid arthritis at early stage by enhancing ascorbate degradation.

Yan Zhao, Mingyue Cheng, Liang Zou, Luxu Yin, Chaofang Zhong, Yuguo Zha, Xue Zhu, Lei Zhang, Kang Ning, Jinxiang Han,

Gut (Gut)
[2021, :]

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Rapid resolution of COVID-19 after faecal microbiota transplantation.

Jarosław Biliński, Katarzyna Winter, Marcin Jasiński, Anna Szczęś, Natalia Bilinska, Benjamin H Mullish, Ewa Małecka-Panas, Grzegorz W Basak,

Gut (Gut)
[2021, :]

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Braf mutation induces rapid neoplastic transformation in the aged and aberrantly methylated intestinal epithelium.

Lochlan Fennell, Alexandra Kane, Cheng Liu, Diane McKeone, Gunter Hartel, Chang Su, Catherine Bond, Mark Bettington, Barbara Leggett, Vicki Whitehall,

<h4>Objective</h4>Sessile serrated lesions (SSLs) are common across the age spectrum, but the <i>BRAF</i> mutant cancers arising occur predominantly in the elderly. Aberrant DNA methylation is uncommon in SSL from young patients. Here, we interrogate the role of ageing and DNA methylation in SSL initiation and progression.<h4>Design</h4>We used an inducible model ... Read more >>

Gut (Gut)
[2021, :]

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Proton pump inhibitors and risk of gastric cancer: population-based cohort study.

Devin Abrahami, Emily Gibson McDonald, Mireille E Schnitzer, Alan N Barkun, Samy Suissa, Laurent Azoulay,

<h4>Objective</h4>To determine whether new users of proton pump inhibitors (PPIs) are at an increased risk of gastric cancer compared with new users of histamine-2 receptor antagonists (H2RAs).<h4>Design</h4>Using the UK Clinical Practice Research Datalink, we conducted a population-based cohort study using a new-user active comparator design. From 1 January 1990 to ... Read more >>

Gut (Gut)
[2021, :]

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Proton pump inhibitors and risk of colorectal cancer.

Devin Abrahami, Emily Gibson McDonald, Mireille E Schnitzer, Alan N Barkun, Samy Suissa, Laurent Azoulay,

<h4>Objective</h4>To determine whether proton pump inhibitors (PPIs) are associated with an increased risk of colorectal cancer, compared with histamine-2 receptor antagonists (H2RAs).<h4>Design</h4>The United Kingdom Clinical Practice Research Datalink was used to identify initiators of PPIs and H2RA from 1990 to 2018, with follow-up until 2019. Cox proportional hazards models were ... Read more >>

Gut (Gut)
[2021, :]

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Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.

Jue-Sheng Ong, Jiyuan An, Xikun Han, Matthew H Law, Priyanka Nandakumar, , , Johannes Schumacher, Ines Gockel, Anne Bohmer, Janusz Jankowski, Claire Palles, Catherine M Olsen, Rachel E Neale, Rebecca Fitzgerald, Aaron P Thrift, Thomas L Vaughan, Matthew F Buas, David A Hinds, Puya Gharahkhani, Bradley J Kendall, Stuart MacGregor,

<h4>Objective</h4>Gastro-oesophageal reflux disease (GERD) has heterogeneous aetiology primarily attributable to its symptom-based definitions. GERD genome-wide association studies (GWASs) have shown strong genetic overlaps with established risk factors such as obesity and depression. We hypothesised that the shared genetic architecture between GERD and these risk factors can be leveraged to (1) ... Read more >>

Gut (Gut)
[2021, :]

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Artificial intelligence and colonoscopy experience: lessons from two randomised trials.

Alessandro Repici, Marco Spadaccini, Giulio Antonelli, Loredana Correale, Roberta Maselli, Piera Alessia Galtieri, Gaia Pellegatta, Antonio Capogreco, Sebastian Manuel Milluzzo, Gianluca Lollo, Dhanai Di Paolo, Matteo Badalamenti, Elisa Ferrara, Alessandro Fugazza, Silvia Carrara, Andrea Anderloni, Emanuele Rondonotti, Arnaldo Amato, Andrea De Gottardi, Cristiano Spada, Franco Radaelli, Victor Savevski, Michael B Wallace, Prateek Sharma, Thomas Rösch, Cesare Hassan,

<h4>Background and aims</h4>Artificial intelligence has been shown to increase adenoma detection rate (ADR) as the main surrogate outcome parameter of colonoscopy quality. To which extent this effect may be related to physician experience is not known. We performed a randomised trial with colonoscopists in their qualification period (AID-2) and compared ... Read more >>

Gut (Gut)
[2021, :]

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Histopathological effects of electrosurgical interventions in an in vivo porcine model of colonic endoscopic mucosal resection.

Anthony M Whitfield, Nicholas G Burgess, Farzan F Bahin, Sharir Kabir, María Pellisé, Rebecca Sonson, Vishnu Subramanian, Hema Mahajan, Duncan McLeod, Karen Byth, Michael J Bourke,

<h4>Objective</h4>Endoscopic mucosal resection (EMR) in the colon has been widely adopted, but there is limited data on the histopathological effects of the differing electrosurgical currents (ESCs) used. We used an in vivo porcine model to compare the tissue effects of ESCs for snare resection and adjuvant margin ablation techniques.<h4>Design</h4>Standardised EMR ... Read more >>

Gut (Gut)
[2021, :]

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Should you trust the radiologist?

Sun Mi Ha, Donal Sheehan, Ahmed Shalabi, Malcolm A West, Rajapandian Ilangovan, Morgan Moorghen, John T Jenkins, Siwan Thomas-Gibson,

Gut (Gut)
[2021, :]

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Calprotectin: from biomarker to biological function.

Almina Jukic, Latifa Bakiri, Erwin F Wagner, Herbert Tilg, Timon E Adolph,

The incidence of inflammatory bowel diseases (IBD) emerged with Westernisation of dietary habits worldwide. Crohn's disease and ulcerative colitis are chronic debilitating conditions that afflict individuals with substantial morbidity and challenge healthcare systems across the globe. Since identification and characterisation of calprotectin (CP) in the 1980s, faecal CP emerged as ... Read more >>

Gut (Gut)
[2021, :]

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Pancreatic cancer surveillance and its ongoing challenges: is it time to refine our eligibility criteria?

Thomas P Potjer,

Gut (Gut)
[2021, :]

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Guts UK 50 years old: onwards and upwards.

Julie Harrington, John McLaughlin, Jonathan M Rhodes,

Gut (Gut)
[2021, :]

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Duality of the association between COVID-19 and acute pancreatitis.

Xiu-He Lv, Kai Deng, Jin-Lin Yang,

Gut (Gut)
[2021, :]

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Diabetes is the strongest risk factor of hepatic fibrosis in lean patients with non-alcoholic fatty liver disease.

Huiyul Park, Eileen L Yoon, Seon Cho, Dae Won Jun, Eun-Hee Nah,

Gut (Gut)
[2021, :]

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