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Journal Genes Dev.

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RNA-activated DNA cleavage by the Type III-B CRISPR-Cas effector complex.

Michael A Estrella, Fang-Ting Kuo, Scott Bailey,

The CRISPR (clustered regularly interspaced short palindromic repeat) system is an RNA-guided immune system that protects prokaryotes from invading genetic elements. This system represents an inheritable and adaptable immune system that is mediated by multisubunit effector complexes. In the Type III-B system, the Cmr effector complex has been found to ... Read more >>

Genes Dev. (Genes & development)
[2016, 30(4):460-470]

Cited: 59 times

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Sister acts: coordinating DNA replication and cohesion establishment.

Rebecca Sherwood, Tatsuro S Takahashi, Prasad V Jallepalli,

The ring-shaped cohesin complex links sister chromatids and plays crucial roles in homologous recombination and mitotic chromosome segregation. In cycling cells, cohesin's ability to generate cohesive linkages is restricted to S phase and depends on loading and establishment factors that are intimately connected to DNA replication. Here we review how ... Read more >>

Genes Dev. (Genes & development)
[2010, 24(24):2723-2731]

Cited: 45 times

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Expanded roles of the Fanconi anemia pathway in preserving genomic stability.

Younghoon Kee, Alan D D'Andrea,

Studying rare human genetic diseases often leads to a better understanding of normal cellular functions. Fanconi anemia (FA), for example, has elucidated a novel DNA repair mechanism required for maintaining genomic stability and preventing cancer. The FA pathway, an essential tumor-suppressive pathway, is required for protecting the human genome from ... Read more >>

Genes Dev. (Genes & development)
[2010, 24(16):1680-1694]

Cited: 198 times

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KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development.

Yu-ichi Tsukada, Tohru Ishitani, Keiichi I Nakayama,

Methylation of histone H3 Lys 9 and Lys 27 (H3K9 and H3K27) is associated with transcriptional silencing. Here we show that KDM7, a JmjC domain-containing protein, catalyzes demethylation of both mono- or dimethylated H3K9 and H3K27. Inhibition of KDM7 orthologs in zebrafish resulted in developmental brain defects. KDM7 interacts with ... Read more >>

Genes Dev. (Genes & development)
[2010, 24(5):432-437]

Cited: 70 times

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Epigenetic control of skull morphogenesis by histone deacetylase 8.

Michael Haberland, Mayssa H Mokalled, Rusty L Montgomery, Eric N Olson,

Histone deacetylases (Hdacs) are transcriptional repressors with crucial roles in mammalian development. Here we provide evidence that Hdac8 specifically controls patterning of the skull by repressing a subset of transcription factors in cranial neural crest cells. Global deletion of Hdac8 in mice leads to perinatal lethality due to skull instability, ... Read more >>

Genes Dev. (Genes & development)
[2009, 23(14):1625-1630]

Cited: 100 times

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Eating to exit: autophagy-enabled senescence revealed.

Eileen White, Scott W Lowe,

Autophagy and senescence are two distinct cellular responses to stress that are also tumor suppression mechanisms. In this issue of Genes & Development, Young and colleagues (pp. 798-803) discovered that autophagy is induced during and facilitates the process of senescence. Knowing now that these two pathways are functionally intertwined sets ... Read more >>

Genes Dev. (Genes & development)
[2009, 23(7):784-787]

Cited: 56 times

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TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth.

X Gao, D Pan,

Tuberous sclerosis is a human disease caused by mutations in the TSC1 or the TSC2 tumor suppressor gene. Previous studies of a Drosophila TSC2 homolog suggested a role for the TSC genes in maintaining DNA content, with loss of TSC2 leading to polyploidy and increased cell size. We have isolated ... Read more >>

Genes Dev. (Genes & development)
[2001, 15(11):1383-1392]

Cited: 252 times

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Malignant glioma: genetics and biology of a grave matter.

Maher, Furnari, Bachoo, Rowitch, Louis, Cavenee, DePinho,

Genes Dev. (Genes & development)
[2001, 15(11):1311-1333]

Cited: 683 times

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KNOX homeodomain protein directly suppresses the expression of a gibberellin biosynthetic gene in the tobacco shoot apical meristem.

Sakamoto, Kamiya, Ueguchi-Tanaka, Iwahori, Matsuoka,

To identify genes targeted by the tobacco KNOX homeodomain protein, Nicotiana tabacum homeobox 15 (NTH15), we have generated an inducible system using the human glucocorticoid receptor. In this system, steroid treatment strictly induced NTH15 function and immediately suppressed the expression of a gibberellin (GA) biosynthetic gene encoding GA 20-oxidase (Ntc12) ... Read more >>

Genes Dev. (Genes & development)
[2001, 15(5):581-590]

Cited: 224 times

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Ataxia telangiectasia mutated is essential during adult neurogenesis.

D M Allen, H van Praag, J Ray, Z Weaver, C J Winrow, T A Carter, R Braquet, E Harrington, T Ried, K D Brown, F H Gage, C Barlow,

Ataxia telangiectasia (A-T) is an autosomal recessive disease characterized by normal brain development followed by progressive neurodegeneration. The gene mutated in A-T (ATM) is a serine protein kinase implicated in cell cycle regulation and DNA repair. The role of ATM in the brain and the consequences of its loss on ... Read more >>

Genes Dev. (Genes & development)
[2001, 15(5):554-566]

Cited: 95 times

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The transcription factor Sox10 is a key regulator of peripheral glial development.

S Britsch, D E Goerich, D Riethmacher, R I Peirano, M Rossner, K A Nave, C Birchmeier, M Wegner,

The molecular mechanisms that determine glial cell fate in the vertebrate nervous system have not been elucidated. Peripheral glial cells differentiate from pluripotent neural crest cells. We show here that the transcription factor Sox10 is a key regulator in differentiation of peripheral glial cells. In mice that carry a spontaneous ... Read more >>

Genes Dev. (Genes & development)
[2001, 15(1):66-78]

Cited: 508 times

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Bridging cytoskeletal intersections.

E Fuchs, I Karakesisoglou,

Genes Dev. (Genes & development)
[2001, 15(1):1-14]

Cited: 92 times

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Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.

D Rudolph, W C Yeh, A Wakeham, B Rudolph, D Nallainathan, J Potter, A J Elia, T W Mak,

Phosphorylation of IkappaB, an inhibitor of NF-kappaB, is an important step in the activation of the transcription factor NF-kappaB. Phosphorylation is mediated by the IkappaB kinase (IKK) complex, known to contain two catalytic subunits: IKKalpha and IKKbeta. A novel, noncatalytic component of this kinase complex called NEMO (NF-kappaB essential modulator)/IKKgamma ... Read more >>

Genes Dev. (Genes & development)
[2000, 14(7):854-862]

Cited: 319 times

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T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification.

T P Yamaguchi, S Takada, Y Yoshikawa, N Wu, A P McMahon,

Wnt3a encodes a signal that is expressed in the primitive streak of the gastrulating mouse embryo and is required for paraxial mesoderm development. In its absence cells adopt ectopic neural fates. Embryos lacking the T-box-containing transcription factors, Brachyury or Tbx6, also lack paraxial mesoderm. Here we show that Brachyury is ... Read more >>

Genes Dev. (Genes & development)
[1999, 13(24):3185-3190]

Cited: 247 times

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A cis-acting element in the 3'-untranslated region of human TNF-alpha mRNA renders splicing dependent on the activation of protein kinase PKR.

F Osman, N Jarrous, Y Ben-Asouli, R Kaempfer,

We report a role for the 3'-untranslated region in control of mRNA splicing and show that human TNF-alpha 3' UTR harbors a cis-acting element that renders splicing of precursor transcripts dependent on activation of PKR, the RNA-activated protein kinase that phosphorylates eukaryotic initiation factor 2 (eIF2). When this element, designated ... Read more >>

Genes Dev. (Genes & development)
[1999, 13(24):3280-3293]

Cited: 69 times

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

M Kaeberlein, M McVey, L Guarente,

The SIR genes are determinants of life span in yeast mother cells. Here we show that life span regulation by the Sir proteins is independent of their role in nonhomologous end joining. The short life span of a sir3 or sir4 mutant is due to the simultaneous expression of a ... Read more >>

Genes Dev. (Genes & development)
[1999, 13(19):2570-2580]

Cited: 1147 times

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Multilineage embryonic hematopoiesis requires hypoxic ARNT activity.

D M Adelman, E Maltepe, M C Simon,

Although most cells undergo growth arrest during hypoxia, endothelial cells and placental cytotrophoblasts proliferate in response to low O(2). We demonstrate that proliferation of embryonic multilineage hematopoietic progenitors is also regulated by a hypoxia-mediated signaling pathway. This pathway requires HIF-1 (HIF-1alpha/ARNT heterodimers) because Arnt(-/-) embryoid bodies fail to exhibit hypoxia-mediated ... Read more >>

Genes Dev. (Genes & development)
[1999, 13(19):2478-2483]

Cited: 110 times

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XRCC3 promotes homology-directed repair of DNA damage in mammalian cells.

A J Pierce, R D Johnson, L H Thompson, M Jasin,

Homology-directed repair of DNA damage has recently emerged as a major mechanism for the maintenance of genomic integrity in mammalian cells. The highly conserved strand transferase, Rad51, is expected to be critical for this process. XRCC3 possesses a limited sequence similarity to Rad51 and interacts with it. Using a novel ... Read more >>

Genes Dev. (Genes & development)
[1999, 13(20):2633-2638]

Cited: 709 times

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Mice lacking both presenilin genes exhibit early embryonic patterning defects.

D B Donoviel, A K Hadjantonakis, M Ikeda, H Zheng, P S Hyslop, A Bernstein,

Genetic studies in worms, flies, and humans have implicated the presenilins in the regulation of the Notch signaling pathway and in the pathogenesis of Alzheimer's Disease. There are two highly homologous presenilin genes in mammals, presenilin 1 (PS1) and presenilin 2 (PS2). In mice, inactivation of PS1 leads to developmental ... Read more >>

Genes Dev. (Genes & development)
[1999, 13(21):2801-2810]

Cited: 281 times

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Nuclear events in ethylene signaling: a transcriptional cascade mediated by ETHYLENE-INSENSITIVE3 and ETHYLENE-RESPONSE-FACTOR1.

R Solano, A Stepanova, Q Chao, J R Ecker,

Response to the gaseous plant hormone ethylene in Arabidopsis requires the EIN3/EIL family of nuclear proteins. The biochemical function(s) of EIN3/EIL proteins, however, has remained unknown. In this study, we show that EIN3 and EILs comprise a family of novel sequence-specific DNA-binding proteins that regulate gene expression by binding directly ... Read more >>

Genes Dev. (Genes & development)
[1998, 12(23):3703-3714]

Cited: 571 times

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A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice.

E C Holland, W P Hively, R A DePinho, H E Varmus,

The epidermal growth factor receptor (EGFR) gene is amplified or mutated in 30%-50% of human gliobastoma multiforme (GBM). These mutations are associated usually with deletions of the INK4a-ARF locus, which encodes two gene products (p16(INK4a) and p19(ARF)) involved in cell-cycle arrest and apoptosis. We have investigated the role of EGFR ... Read more >>

Genes Dev. (Genes & development)
[1998, 12(23):3675-3685]

Cited: 292 times

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Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation.

E M McInerney, D W Rose, S E Flynn, S Westin, T M Mullen, A Krones, J Inostroza, J Torchia, R T Nolte, N Assa-Munt, M V Milburn, C K Glass, M G Rosenfeld,

Ligand-dependent activation of gene transcription by nuclear receptors is dependent on the recruitment of coactivators, including a family of related NCoA/SRC factors, via a region containing three helical domains sharing an LXXLL core consensus sequence, referred to as LXDs. In this manuscript, we report receptor-specific differential utilization of LXXLL-containing motifs ... Read more >>

Genes Dev. (Genes & development)
[1998, 12(21):3357-3368]

Cited: 286 times

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The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development.

H Tian, R E Hammer, A M Matsumoto, D W Russell, S L McKnight,

Mice lacking the hypoxia-inducible transcription factor EPAS1 die at mid-gestation. Despite normal morphological development of the circulatory system, EPAS1-deficient mice display pronounced bradycardia. In addition to the vascular endothelium, EPAS1 is expressed intensively in the organ of Zuckerkandl (OZ), the principle source of catecholamine production in mammalian embryos. EPAS1-deficient embryos ... Read more >>

Genes Dev. (Genes & development)
[1998, 12(21):3320-3324]

Cited: 344 times

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mRNA stabilization by poly(A) binding protein is independent of poly(A) and requires translation.

J M Coller, N K Gray, M P Wickens,

Translation and mRNA stability are enhanced by the presence of a poly(A) tail. In vivo, the tail interacts with a conserved polypeptide, poly(A) binding protein (Pab1p). To examine Pab1p function in vivo, we have tethered Pab1p to the 3' UTR of reporter mRNAs by fusing it to MS2 coat protein ... Read more >>

Genes Dev. (Genes & development)
[1998, 12(20):3226-3235]

Cited: 119 times

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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling.

A W Lin, M Barradas, J C Stone, L van Aelst, M Serrano, S W Lowe,

Oncogenic Ras transforms immortal rodent cells to a tumorigenic state, in part, by constitutively transmitting mitogenic signals through the mitogen-activated protein kinase (MAPK) cascade. In primary cells, Ras is initially mitogenic but eventually induces premature senescence involving the p53 and p16(INK4a) tumor suppressors. Constitutive activation of MEK (a component of ... Read more >>

Genes Dev. (Genes & development)
[1998, 12(19):3008-3019]

Cited: 507 times

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