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The potential involvement of JAK-STAT signaling pathway in the COVID-19 infection assisted by ACE2.

Jing Luo, Saisai Lu, Mengjiao Yu, Lixia Zhu, Chengwei Zhu, Chenlu Li, Jinxia Fang, Xiaochun Zhu, Xiaobing Wang,

COVID-19, a novel identified coronavirus disease due to Severe Acute Respiratory Syndrome coronaviruses 2 (SARS-Cov-2) infection, has posed a significant threat to public health worldwide. It has been reported COVID-19 keeps substantial nucleotide similarity and shares common receptor, Angiotensin-converting enzyme 2 (ACE2) with Severe Acute Respiratory Syndrome coronaviruses (SARS-Cov). Here, ... Read more >>

Gene (Gene)
[2020, :145325]

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Active ingredients and mechanisms of Phellinus linteus (grown on Rosa multiflora) for alleviation of Type 2 diabetes mellitus through network pharmacology.

Ki Kwang Oh, Md Adnan, Dong Ha Cho,

Phellinus linteus (mushroom) grown on Rosa multiflora ([email protected]), exposed beneficial effect and safety on Type 2 diabetes mellitus (T2DM) from Korean folk remedies. However, its active chemical constituents and mechanism(s) against T2DM have not been confirmed. Hence, we deciphered the active compounds and mechanism(s) of [email protected] against T2DM through network ... Read more >>

Gene (Gene)
[2020, :145320]

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Characterization of muscle development and gene expression in early embryos of chicken, quail, and their hybrids.

Mengting Zhu, Mingyuan Wang, Yanyan Shao, Ying Nan, Hugh T Blair, Stephen Todd Morris, Zongsheng Zhao, Hongmei Zhang,

Myogenesis is a complex, regulated process that involves myoblast proliferation, migration, adhesion, and fusion into myotubes. To investigate early development of embryonic muscles and the expression of regulatory genes during myogenesis in chicken, quail and their hybrids, meat-breeding cocks and egg-breeding cocks were selected as male parents, quails were used ... Read more >>

Gene (Gene)
[2020, :145319]

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Cloning and functional analysis of c/ebpα as negative regulator of dmrt1 in Chinese tongue sole (Cynoglossus semilaevis).

Qian Wang, Rui Wang, Bo Feng, Shuo Li, Shahid Mahboob, Changwei Shao,

c/ebpα is a member of the C/EBP family of transcription factors, which are involved in cell growth and differentiation and have a conserved basic leucine zipper (bZIP) domain. However, little is known about its function in sex determination and differentiation. In the present study, c/ebpα was cloned from the gonads ... Read more >>

Gene (Gene)
[2020, :145321]

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The mechanisms and functions of Circular RNAs in human diseases.

Xiaoling Weng, Xiao-Jie Lu,

Gene (Gene)
[2020, :145324]

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Emerging histone glutamine modifications mediated gene expression in cell differentiation and the VTA reward pathway.

Samir Kumar Patra,

Gene expression is the key to cellular functions and homeostasis. Histone modifications regulate chromatin dynamics and gene expression. Neuronal cell functions largely depend on fluxes of neurotransmitters for activation of chromatin and gene expression. New studies by Lepack et al. and Farrelly et al. recently demonstrated how tissue transglutaminase 2 ... Read more >>

Gene (Gene)
[2020, :145323]

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CRISPR/Cas9-mediated mutagenesis of Ago2 and Siwi in silkworm cultured cells.

Susumu Katsuma, Keisuke Shoji, Yutaka Suzuki, Takashi Kiuchi,

The BmN-4 cell line, originated from the silkworm Bombyx mori ovary, possesses endogenous small interfering RNA (siRNA) and PIWI-interacting RNA (piRNA) pathways. We performed CRISPR/Cas9-mediated genome editing of Ago2 and Siwi, which are the core factors for siRNA and piRNA pathways, respectively, to understand the importance of the two distinct ... Read more >>

Gene (Gene)
[2020, :145314]

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Whole exome sequencing for non-selective pediatric patients with hyperlipidemia.

Xuyun Hu, Lamei Chen, Chunxiu Gong, Jun Guo, Yuanying Chen, Quan Wang, Ruolan Guo, Wei Li, Chanjuan Hao,

BACKGROUND:Hyperlipidemia is a group of conditions with abnormally elevated levels of any or all lipids or lipoproteins in the blood. It is highly heterogeneous both genetically and clinically, which contributes to diagnostic challenges and results in many patients to be underdiagnosed and undertreated in China. Precise diagnosis and early management ... Read more >>

Gene (Gene)
[2020, :145310]

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Identification of Shaker K+ channel family members in sweetpotato and functional exploration of IbAKT1.

Rong Jin, Aijun Zhang, Jian Sun, Xiaoguang Chen, Ming Liu, Peng Zhao, Wei Jiang, Zhonghou Tang,

The Shaker K<sup>+</sup> channel family plays a vital role in potassium absorption and stress resistance in plants. However little information on the genes family is available about sweetpotato. In the present study, eleven sweetpotato Shaker K<sup>+</sup> channel genes were identified and classified into five groups based on phylogenetic relationships, conserved ... Read more >>

Gene (Gene)
[2020, :145311]

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Low-intensity pulsed ultrasound promotes aggrecan expression via ZNT-9 in temporomandibular joint chondrocytes.

Dong He, Jing Wang, Yanhua Li, Gaoyi Wu, Guoxiong Zhu, Lei Chen,

Temporomandibular joint osteoarthritis (TMJ-OA) is one of the most common joint diseases. It causes severe pain and poor quality of life. One key feature of TMJ-OA is degeneration of the chondrocyte extracellular matrix (ECM). Low-intensity pulsed ultrasound (LIPUS) can promote the synthesis of ECM in cartilage. However, the exact mechanism ... Read more >>

Gene (Gene)
[2020, :145318]

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The functional roles of the non-coding RNAs in molluscs.

Zhang Hongkuan, Tan Karsoon, Li Shengkang, Ma Hongyu, Zheng Huaiping,

This review focus on the current knowledge of non-coding RNAs (ncRNAs) in molluscs. In this review, we provide an overview of long ncRNAs (lncRNA), microRNAs (miRNA) and piwi-interacting RNAs (piRNA), followed by evidence for the regulation of ncRNAs in variety of biological process in molluscs, including development, biomineralization and innate ... Read more >>

Gene (Gene)
[2020, :145300]

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Transcriptional regulation of human T-box 5 gene (TBX5) by bone- and cardiac-related transcription factors.

Débora Varela, Natércia Conceição, M Leonor Cancela,

T-box 5 (TBX5) protein belongs to the T-box family whose members play a crucial role in cell-type specification, morphogenesis and organogenesis. TBX5 is a transcription factor important for cardiac development and upper limbs formation and its haploinsufficiency causes Holt-Oram syndrome (HOS). An increase in TBX5 dosage also leads to HOS, ... Read more >>

Gene (Gene)
[2020, :145322]

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Bucky ball induces primordial germ cell increase in medaka.

Peng Song, Bingyan Sun, Yefei Zhu, Ying Zhong, Jing Guo, Lang Gui, Mingyou Li,

Balbaini body (Bb) plays a vital role in germ plasm (GP) assembly and dorsoventral pattern, which is of critical important in germline specification and development. Bucky ball (buc) is reported to be essential for boosting primordial germ cell (PGC) through Bb in previous research. In the present study, a buc ... Read more >>

Gene (Gene)
[2020, :145317]

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Identification and expression analysis of Langerhans cells marker Langerin/CD207 in grasscarp, Ctenopharyngodon idella.

Hui Wang, Xi Chen, Sisi Li, Chengchong Zhou, Lili Xu, Zhixin Wu, Xiaoxuan Chen,

Langerhans cells (LCs) play an essential role in the initiation of immune response and maintenance of immune tolerance. However, the function and the molecular markers of grass carp LCs remains unclear. The grass carp LCs were firstly identified by immunofluorescence (IF) using a commercial anti-human Langerin/CD207 polyclonal antibody (pAb) and ... Read more >>

Gene (Gene)
[2020, :145315]

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Structure, gene order, and nucleotide composition of mitochondrial genomes in parasitic lice from Amblycera.

Andrew D Sweet, Kevin P Johnson, Yanghui Cao, Robert S de Moya, Rachel K Skinner, Milton Tan, Stephany Virrueta Herrera, Stephen L Cameron,

Parasitic lice have unique mitochondrial (mt) genomes characterized by rearranged gene orders, variable genome structures, and less AT content compared to most other insects. However, relatively little is known about the mt genomes of Amblycera, the suborder sister to all other parasitic lice. Comparing among nine different genera (including representative ... Read more >>

Gene (Gene)
[2020, :145312]

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Trehalose protects motorneuron after brachial plexus root avulsion by activating autophagy and inhibiting apoptosis mediated by the AMPK signaling pathway.

Bohan Li, Ping Li, Ricong Weng, Zichao Wu, Bengang Qin, Jingtao Fang, Yuanyuan Wang, Shuai Qiu, Jiangtao Yang, Liqiang Gu,

Brachial plexus root avulsion (BPRA) is one of the most serious injuries of the upper extremity, which requires more effective treatment. Trehalose, a natural disaccharide, has reported to has a protective effect in neurodegenerative diseases. However, the effective effects and mechanism of trehalose on BPRA are still unclear. BPRA rat ... Read more >>

Gene (Gene)
[2020, :145307]

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Effect of vitamin D on malignant behavior of non-small cell lung cancer cells.

Yiyan Songyang, Tianbao Song, Zhan Shi, Wen Li, Songyisha Yang, Dejia Li,

OBJECTIVE:To investigate the effects of vitamin D on the malignant behavior of A549 and NCI-H1975 tumor cells (proliferation, apoptosis, invasion, metastasis and drug resistance-related proteins) and the activation of the PI3K/AKT/mTOR signaling pathway, in order to evaluate the effect of vitamin D on the therapeutic action of cisplatin. METHOD:In vitro ... Read more >>

Gene (Gene)
[2020, :145309]

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Retraction notice to "Identification of FOXN4 as a tumor suppressor of breast carcinogenesis via the activation of TP53 and deactivation of Notch signaling" [Gene 722 (2020) 144057].

Xiao Wang, Dan Su, Zhiquan Qin, Zheling Chen,

Gene (Gene)
[2020, :145161]

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Integrated gene-based and pathway analyses using UK Biobank data identify novel genes for chronic respiratory diseases.

Lijuan Wang, Rui Fang, Meng Zhu, Na Qin, Yuzhuo Wang, Jingyi Fan, Qi Sun, Mengmeng Ji, Xikang Fan, Junxing Xie, Hongxia Ma, Juncheng Dai,

BACKGROUND:Chronic respiratory diseases have become a non-negligible cause of death globally. Although smoking and environmental exposures are primary risk factors for chronic respiratory diseases, genetic factors also play an important role in determining individual's susceptibility to diseases. Here we performed integrated gene-based and pathway analyses to systematically illuminate the heritable ... Read more >>

Gene (Gene)
[2020, :145287]

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Nbnrp1 mediates Verticillium dahliae effector PevD1-triggered defense responses by regulating sesquiterpenoid phytoalexins biosynthesis pathway in Nicotiana benthamiana.

Yingbo Liang, Ze Li, Yi Zhang, Fanlu Meng, Dewen Qiu, Hongmei Zeng, Guangyue Li, Xiufen Yang,

PevD1, a fungal effector secreted by Verticillium dahliae, could induce hypersensitive responses-like necrosis and systemic acquired resistance (SAR) in cotton and tobacco plants. PevD1 could drastically induce the expression of Nbnrp1, which is an asparagine-rich protein (NRP) of Nicotiana benthamiana. Our previous research indicated that Nbnrp1 positively regulated PevD1-induced cell ... Read more >>

Gene (Gene)
[2020, :145280]

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Retraction notice to "Linc-ROR targets FGF2 to regulate HASMC proliferation and migration via sponging miR-195-5p" [Gene 725 (2020) 144143].

Zheng Ji, Jufang Chi, He Sun, Ao Ru, Tingjuan Ni, Jie Zhang, Fengchun Jiang, Haitao Lv, Fang Peng, Hangyuan Guo, Yi Chen,

Gene (Gene)
[2020, :145160]

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RcsB-dependent regulation of type VI secretion system in porcine extra-intestinal pathogenic Escherichia coli.

Linlin Hu, Feifei Yu, Manli Liu, Jing Chen, Bingbing Zong, Yanyan Zhang, Tumei Chen, Chenchen Wang, Tongchao Zhang, Junli Zhang, Yongwei Zhu, Xiangru Wang, Huanchun Chen, Chen Tan,

Signal transduction system and specialized secretory devices are crucial for bacteria to sense and adequately adapt in adverse environmental conditions. Therefore, it's crucial for microbes to detect and respond to lethal attacks when envelope is perturbed so as to minimize and fix the damage in milieu. We investigated the adaptive ... Read more >>

Gene (Gene)
[2020, :145289]

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Corrigendum to "Correlation study between ADA and IFN-γ gene polymorphisms and the risk of developing tuberculous pericarditis" [Gene 676 (2018) 214-218/https://doi.org/10.1016/j.gene.2018.07.032].

Fangming Zhong, Tao Dai, Yu Sheng,

Gene (Gene)
[2020, :145230]

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DNA repair pathways important for the survival of Escherichia coli to hydrogen peroxide mediated killing.

Amruta Dhawale, Gargi Bindal, Devashish Rath, Archana Rath,

Escherichia coli exposed to 1-3 mM hydrogen peroxide undergo killing which is designated as the mode-one killing which is a result of oxidative DNA damage. Oxidative stress mediated DNA damage can be repaired by various DNA repair pathways like base excision repair, nucleotide excision repair and homologous recombination repair. In this ... Read more >>

Gene (Gene)
[2020, :145297]

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Dynamics of HOX gene expression and regulation in adipocyte development.

Vinod Kumar, Mouliganesh Sekar, Priyanka Sarkar, Kshitish K Acharya, Kavitha Thirumurugan,

HOX proteins are homeodomain-containing transcription factors that play a central role in development. We have applied genome-wide approaches to develop time-dependent profile of differentially expressed genes in early and mature adipocytes. The list of differentially expressed HOX genes were developed by analyzing the microarray datasets of murine adipocyte samples at ... Read more >>

Gene (Gene)
[2020, :145308]

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