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Journal Gastroenterol Res Pract

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The Role of Active Inflammation and Surgical Therapy in Crohn's Disease Recurrence.

S Ingallinella, M Campanelli, A Antonelli, C Arcudi, V Bellato, A Divizia, M Franceschilli, L Petagna, B Sensi, S Sibio, L Siragusa, G S Sica,

An altered balance between effector and regulatory factors is supposed to sustain the tissue-damaging immune response in inflammatory bowel disease (IBD). Several studies demonstrate that severe active inflammation is a strong predictor for surgical complications and recurrence. Indeed, bowel resection in Crohn's disease (CD) patients has a high surgical recurrence ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:2845407]

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Routine Multiple Duodenal Biopsy during Endoscopy of Dyspeptic Patients Seems Unnecessary for Screening of Celiac Disease.

Amir Behforouz, Abbas Esmaeelzadeh, Homan Mosanan Mozaffari, Ali Mokhtarifar, Elham Faravani, Sakineh Amoueian, Alireza Khooei, Lida Jarahi, Ladan Goshayeshi,

<h4>Introduction</h4>Celiac disease (CD) is a chronic and common cause of dyspepsia with a rising prevalence worldwide. This study is aimed at investigating the prevalence of CD in dyspeptic patients based on serology and biopsy, determining the associated factors, and assessing the necessity of regular duodenal biopsies from normal mucosa in ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:6664741]

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The Impact of Sedation on Adenoma Detection Rate and Cecal Intubation Rate in Colonoscopy.

Qiongmei Zhang, Zhiyu Dong, Yuanxi Jiang, Tingting Zhan, Junwen Wang, Shuchang Xu,

<h4>Purpose</h4>To explore the effect of sedation on the quality of colonoscopy.<h4>Methods</h4>The data collected from the Digestive Endoscopy Center of Shanghai Tongji Hospital from March 2012 to June 2019 were retrospectively analyzed. The rate of sedation and quality metrics of colonoscopy such as adenoma detection rate (ADR) and cecal intubation rate ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:3089094]

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hsa_circRNA_000166 Facilitated Cell Growth and Limited Apoptosis through Targeting miR-326/LASP1 Axis in Colorectal Cancer.

Qin Hao, Zhongtao Zhang,

Circular RNAs (circRNAs) belong to noncoding RNAs and are widely expressed in a variety of cell species, including cancers. However, the function and mechanism of circRNAs in colorectal cancer (CRC) has not been well investigated. Here, we firstly downloaded and analyzed the circRNA expression profile of CRC from the Gene ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:8834359]

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Improved Survival Outcome and Access to Cancer Screening from Hemorrhoid in Patients with Rectal Cancer.

Qi Zou, Donglin Ren, Xiaolin Wang, Liangliang Bai, Guannan Tang, Meijin Huang, Yanxin Luo, Huichuan Yu,

<h4>Background</h4>The interventions for hemorrhoid increase access to rectal cancer screening and thus might reduce cancer death. We aimed to examine the impact of hemorrhoid on survival outcomes in rectal cancer.<h4>Methods</h4>We identified 510 patients with stage I to III rectal cancer from a prospectively collected database. Patients were divided into hemorrhoid ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:5045142]

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VSNL1 Promotes Gastric Cancer Cell Proliferation and Migration by Regulating P2X3/P2Y2 Receptors and Is a Clinical Indicator of Poor Prognosis in Gastric Cancer Patients.

Qiao-Qiong Dai, Yuan-Yu Wang, Yu-Peng Jiang, Li Li, Hui-Ju Wang,

<h4>Purpose</h4>The aim of this study was to investigate the role of Visinin Like 1 (VSNL1) in the proliferation and migration of gastric cancer (GC) cells as well as its clinical prognostic significance.<h4>Methods</h4>To this end, we evaluated VSNL1 expression in GC tissues and cell lines by real-time PCR and immunohistochemistry. To ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:7241942]

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Helicobacter pylori Prevalence in Laparoscopic Sleeve Gastrectomy Specimen.

Nada A Sabbah, Carla Z Saoud, Mary Deeb, Selim M Nasser,

<h4>Introduction</h4>Laparoscopic sleeve gastrectomy (LSG) has become a common surgical procedure. The value of routine histopathologic examination of the LSG specimens remains, however, a controversial issue. Helicobacter pylori was the most prevalent finding in several previous studies, but the overall results were dissimilar. We aim to assess the prevalence of Helicobacter ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:8843696]

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Protective Role of Somatostatin in Sepsis-Induced Intestinal Barrier Dysfunction through Inhibiting the Activation of NF-κB Pathway.

Xin Xu, Quanli Zhu, Guoliang Li, Junjian Ma, Zhijian Pan, Wei Wu,

Somatostatin (SST) has a protective role in intestinal injury, inflammatory response, and intestinal mucosal barrier in rats with acute pancreatitis. However, its function in sepsis-induced intestinal barrier dysfunction remains largely unknown. A mouse sepsis model was constructed, and SST was injected into the tail vein. Then, hematoxylin and eosin staining ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:2549486]

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Clinicopathological Features and Prognostic Implication of Gastric Carcinoma with Lymphoid Stroma.

Jung-Soo Pyo, Nae Yu Kim, Byoung Kwan Son, Hyo Young Lee, Il Hwan Oh, Kwang Hyun Chung,

<h4>Methods</h4>This study included 34 eligible studies and 1757 GCLSs. The clinicopathologic characteristics of GCLS were investigated from eligible studies, and the meta-analysis was performed. In addition, we compared the survival rates between GCLS and non-GCLS.<h4>Results</h4>The estimated rate of GCLS was 0.062 (95% confidence interval (CI) 0.040-0.097). GCLS was significantly correlated ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:6628412]

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Histopathologic Parameters at Diagnosis as Early Predictors of Histologic Remission along the Course of Ulcerative Colitis.

Jesús K Yamamoto-Furusho, Braulio Martínez-Benítez, Germán E Sánchez-Morales,

<h4>Background</h4>Currently, the treatment goal in ulcerative colitis (UC) is to achieve clinical and endoscopic remission; nevertheless, histologic remission is a potential new treatment goal since it is associated with favorable long-term clinical outcome lower rates of hospitalization, complications, and colectomies.<h4>Aim</h4>Evaluate clinical and histopathologic characteristics at diagnosis as potential predictors of ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:8891937]

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Acupuncture for the Treatment of Liver Cirrhosis: A Meta-analysis.

Lu Qi, Shuang Li, Jun Xu, Jie Xu, Wangzouyang Lou, Liangbin Cheng, Chizhi Zhang,

Acupuncture is widely used in the clinical treatment of liver cirrhosis (LC) in China. However, the efficacy of acupuncture on LC has not been fully confirmed by systematic analysis. This current meta-analysis evaluated the impact effect of acupuncture on patients with LC. We conducted a systematic literature search of the ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:4054781]

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Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis.

Hong Lin, Jinpeng Yuan, Guoxi Liang, Yanxuan Wu, Liming Chen,

<h4>Background and aims</h4>Circular RNA (circRNA) demonstrates potential biological application in various solid tumors. We intended to evaluate the diagnostic, prognostic, and clinicopathological value of circRNA for esophageal cancer (EC).<h4>Methods</h4>We screened relative studies from Pubmed, Embase, Web of Science, and Cochrane Library. The diagnostic role of circRNAs was testified by pooled ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:8437250]

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Gastroenterologists Reveal More Digestive Symptoms in COVID-19 Patients than Nongastroenterologists in Fever Clinic.

Yudong Jiang, Chaoqun Han, Tao Bai, Shengyan Zhang, Jun Song, Xiaohua Hou,

The incidence of digestive symptoms may vary depending on doctors' professional backgrounds when they inquired suspected COVID-19 patients in a fever clinic. We sought to understand the characteristics of inquiries about digestive symptoms by doctors in different specialties; therefore, inquiry records of 2 gastroenterologists and 6 nongastroenterologists were reviewed. We ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:8853922]

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Methanolic Extract of Distemonanthus benthamianus (Caesalpiniaceae) Stem Bark Suppresses Ethanol/Indomethacin-Induced Chronic Gastric Injury in Rats.

Vanessa Mba Matah Marte, Gilbert Ateufack, Marius Mbiantcha, Albert Donatien Atsamo, Carine Flore Adjouzem, Stéphanie Flore Djuichou Nguemnang, Eric Gonzal Tsafack, William Yousseu Nana, Yacine Karelle Madjo Kouam, Elvira Ngoufack Azanze,

<i>Distemonanthus benthamianus</i> (Caesalpiniaceae) is a plant from the Cameroon pharmacopoeia very widely used in the treatment of many pathologies among which are gastrointestinal disorders. The main purpose of this study was to assess the healing properties of gastric ulcer from the methanolic extract of <i>Distemonanthus benthamianus</i> and its mechanisms of ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:8180323]

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Prognostic Value of the Pretreatment Systemic Immune-Inflammation Index in Patients with Colorectal Cancer.

Jing Li, Jingjing Shao, Xunlei Zhang, Xin Chen, Wenjing Zhao, Hongyan Qian, Xiaopeng Cui, Xiaohui Jiang,

<h4>Background</h4>Multiple studies have reported the significance of the systemic immune-inflammation index (SII) in the prognosis of colorectal cancer (CRC), but no consensus has yet been reached. The purpose of this study was to systematically assess the prognostic value of SII in patients with CRC.<h4>Materials and methods</h4>We performed a systematic literature ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:8781674]

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Corrigendum to "Acute-on-Chronic Liver Failure in Pregnant Patients with Chronic Hepatitis B: A Retrospective Observational Case Series Study".

Shiwei Wang, Haofeng Xiong, Changling Luo, Hong Zhao, Ying Fan, Ting Zhang, Lili Wang, Qi Wang, Wen Xie,

[This corrects the article DOI: 10.1155/2020/9831687.]. ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:2603491]

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The Efficacy of Short-Duration Polyethylene Glycol plus Electrolytes for Improving Bowel Preparation of Colonoscopy in Patients with Chronic Constipation.

Naohisa Yoshida, Yoshikazu Inagaki, Kohei Fukumoto, Hiroyuki Yoriki, Yutaka Inada, Takaaki Murakami, Yuri Tomita, Hikaru Hashimoto, Satoshi Sugino, Ryohei Hirose, Osamu Dohi, Ken Inoue, Yoshito Itoh,

<h4>Materials and methods</h4>This multicenter retrospective study was conducted from September 2019 to September 2020 at 5 related institutions among patients ≥ 20 years old diagnosed with chronic constipation whose previous colonoscopic BP had had a fair or poor Aronchick score. Two or four sachets of PEG+E (13.7 or 27.4 g/day) were ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:8886073]

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The Presence of Ascites Affects the Predictive Value of HVPG on Early Rebleeding in Patients with Cirrhosis.

Chuan Liu, Ruoyang Shao, Sining Wang, Guangchuan Wang, Lifen Wang, Mingyan Zhang, Yanna Liu, Mingkai Liang, Xiaoguo Li, Ning Kang, Jitao Wang, Dan Xu, Hua Mao, Chunqing Zhang, Xiaolong Qi,

<h4>Background and aims</h4>Gastroesophageal variceal bleeding is a serious complication of portal hypertension in cirrhotic patients and could be predicted by hepatic venous pressure gradient (HVPG). However, whether the presence of ascites affects the prognostic value of HVPG for patients with acute variceal bleeding is still unknown. This retrospective study is ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:1329857]

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Utilization of an Intraoperative Grading Scale in Laparoscopic Cholecystectomy: A Nepalese Perspective.

Suman Baral, Raj Kumar Chhetri, Neeraj Thapa,

<h4>Introduction</h4>Difficult geographic diversity and late presentation to medical attention often make the laparoscopic cholecystectomy difficult and chances of conversion and complication remains. Various preoperative grading scales have been developed for predicting the difficulty of surgery in cholecystitis patients; however, intraoperative assessment of anatomical status and inflammation of the gall bladder ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:8954572]

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Retracted: Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-Analysis.

Gastroenterology Research And Practice,

[This retracts the article DOI: 10.1155/2014/827989.]. ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:9470819]

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Comparison of a Novel Herbal Medicine and Omeprazole in the Treatment of Functional Dyspepsia: A Randomized Double-Blinded Clinical Trial.

Ghasem Bordbar, Mohammad Bagher Miri, Mahmoud Omidi, Saeed Shoja, Malihe Akhavan,

<h4>Background</h4>The <i>Trachyspermum ammi</i> L. (TA), <i>Anethum graveolens</i> L. (AG), and <i>Zataria multiflora</i> Boiss (ZM) herbal oils are among the most used herbal products in traditional medicine as the antiseptic, anesthetic, carminative, and antispasmodic. However, there are no clinical studies to evaluate the efficacy of the herbs mentioned in the treatment ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:5152736]

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Clinical Characterization of Ulcerative Colitis in Patients with Primary Sclerosing Cholangitis.

Shun Murasugi, Ayumi Ito, Teppei Omori, Shinichi Nakamura, Katsutoshi Tokushige,

<h4>Objectives</h4>The clinical/colonoscopic features of ulcerative colitis (UC) associated with primary sclerosing cholangitis (PSC), the prognostic impact of UC, and the utility of UC screening in PSC patients are unknown. We characterized UC associated with PSC and assessed UC's impact on the prognosis of PSC and the importance of colonoscopic UC ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:7969628]

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Circulating Irisin Levels in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.

Jie Hu, Yani Ke, Fangping Wu, Shan Liu, Conghua Ji, Xiaohong Zhu, Ying Zhang,

<h4>Background and aims</h4>Previous studies have revealed the close relation of irisin with the occurrence and development of nonalcoholic fatty liver disease (NAFLD). A systematic review and meta-analysis were conducted to evaluate the association of circulating irisin levels and NAFLD.<h4>Methods</h4>A systematic literature search of PubMed, Embase, Cochrane Library, Clinicaltrials.gov, WANFANG, CNKI, ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:8818191]

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In Vitro Antioxidant, Anti-inflammatory, and In Vivo Anticolitis Effects of Combretin A and Combretin B on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice.

Mbiantcha Marius, Dawe Amadou, Atsamo Albert Donatien, Ateufack Gilbert, Yousseu Nana William, Khalid Rauf, Mehreen Arif, Fanta Yadang Sabine Adeline, Njoku Isaac Saint, Hamza Dar, Naeem Ur Rehman, Izhar Ahmad,

<i>Combretum fragrans</i> (Combretaceae) is a Cameroonian medicinal plant containing various secondary metabolites and traditionally used for the treatment of several pathologies. Two cycloartane-type triterpenes, Combretin A and Combretin B, were isolated from this plant. This study was aimed at evaluating the anti-inflammatory, antioxidant, and anticolitis effects of these compounds. <i>In ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:4253174]

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The Psychosocial Burden of HCV Infection and the Impact of Antiviral Therapy on the Quality of Life in Liver and Kidney Transplant Recipients: A Pilot Study.

Antonella Santonicola, Giancarlo Bilancio, Fabiana Zingone, Laura Donnarumma, Cesare Caputo, Carolina Ciacci,

<h4>Background</h4>Therapy with direct-acting antivirals (DAA) for HCV is safe and effective in the liver (LT) and kidney transplant (KT) recipients; however, data on the quality of life (QoL) of patients are scanty. This pilot study is aimed at prospectively evaluating the QoL in LT and KT recipients before and after ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:8754247]

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