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Journal Front Physiol

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A Bitter Taste in Your Heart.

Conor J Bloxham, Simon R Foster, Walter G Thomas,

The human genome contains ∼29 bitter taste receptors (T2Rs), which are responsible for detecting thousands of bitter ligands, including toxic and aversive compounds. This sentinel function varies between individuals and is underpinned by naturally occurring T2R polymorphisms, which have also been associated with disease. Recent studies have reported the expression ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:431]

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Exploring the Factors Contributing to the High Ultimate pH of Broiler Pectoralis Major Muscles Affected by Wooden Breast Condition.

Giulia Baldi, Con-Ning Yen, Morgan R Daughtry, Jocelyn Bodmer, Brian C Bowker, Hong Zhuang, Massimiliano Petracci, David E Gerrard,

The elevated ultimate pH (pH u ) found in wooden breast (WB) meat suggests an altered muscular energetic status in WB but also could be related to a prematurely terminated post-mortem pH decline. The aims of this study were to explore the factors contributing to the elevated pH u and ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:343]

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A Bitter Taste in Your Heart.

Conor J. Bloxham, Simon R. Foster, Walter G. Thomas,

The human genome contains ∼29 bitter taste receptors (T2Rs), which are responsible for detecting thousands of bitter ligands, including toxic and aversive compounds. This sentinel function varies between individuals and is underpinned by naturally occurring T2R polymorphisms, which have also been associated with disease. Recent studies have reported the expression ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:]

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iTRAQ-Based Comparative Proteomic Analysis of Larval Midgut From the Beet Armyworm, Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae) Challenged With the Entomopathogenic Bacteria Serratia marcescens.

Surajit De Mandal, Boda Lin, Miaojun Shi, Yapeng Li, Xiaoxia Xu, Fengliang Jin,

Entomopathogenic bacteria Serratia marcescens is widely used as an environmentally friendly biocontrol agent against various pests, including Spodoptera exigua. Understanding the immune defense mechanism of S. exigua through comparative proteomic analysis can identify the key proteins expressed in response to the microbial infection. Here, we employed the as isobaric tags ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:]

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Targeting the Multiple Physiologic Roles of VDAC With Steroids and Hydrophobic Drugs.

Tatiana K Rostovtseva, María Queralt-Martín, William M Rosencrans, Sergey M Bezrukov,

There is accumulating evidence that endogenous steroids and non-polar drugs are involved in the regulation of mitochondrial physiology. Many of these hydrophobic compounds interact with the Voltage Dependent Anion Channel (VDAC). This major metabolite channel in the mitochondrial outer membrane (MOM) regulates the exchange of ions and water-soluble metabolites, such ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:446]

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Heterogeneity of Red Blood Cells: Causes and Consequences.

Anna Bogdanova, Lars Kaestner, Greta Simionato, Amittha Wickrema, Asya Makhro,

Mean values of hematological parameters are currently used in the clinical laboratory settings to characterize red blood cell properties. Those include red blood cell indices, osmotic fragility test, eosin 5-maleimide (EMA) test, and deformability assessment using ektacytometry to name a few. Diagnosis of hereditary red blood cell disorders is complemented ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:392]

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Identification and Validation of Reference Genes for Quantitative Gene Expression Analysis in Ophraella communa.

Yan Zhang, Jiqiang Chen, Guangmei Chen, Chao Ma, Hongsong Chen, Xuyuan Gao, Zhenqi Tian, Shaowei Cui, Zhenya Tian, Jianying Guo, Fanghao Wan, Zhongshi Zhou,

Ophraella communa is an effective bio-control agent of the invasive common weed. By now, the reference genes in O. communa have not yet been screened and validated. The aim of this study was to screen for the most stable reference genes in different backgrounds, such as different developmental stages, sexes, ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:]

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The Effect of Exercise Training During Pregnancy to Improve Maternal Vascular Health: Focus on Gestational Hypertensive Disorders.

Isabel Witvrouwen, Dominique Mannaerts, An M Van Berendoncks, Yves Jacquemyn, Emeline M Van Craenenbroeck,

Hypertensive disorders of pregnancy, including gestational hypertension and pre-eclampsia, occur in up to 10% of pregnancies and are associated with increased life-long cardiovascular risk. Physical activity improves cardiovascular health in pregnancy and may lower the risk of developing hypertensive disorders of pregnancy. However, a minority of pregnant women comply with ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:450]

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Post-exercise Endothelium-Dependent Vasodilation Is Dependent on Training Status.

L V Kapilevich, V V Kologrivova, A N Zakharova, Laurent Mourot,

The effect of training status on post-exercise flow-mediated dilation (FMD) is not well characterized. We tested the hypothesis that the more trained the subjects, the lower the reduction in FMD after an acute bout of aerobic exercise. Forty-seven men (mean ± SD, age: 20.1 ± 1.2 years, body mass: 75.5 ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:348]

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Brain Network Modularity During a Sustained Working-Memory Task.

Marta Moraschi, Daniele Mascali, Silvia Tommasin, Tommaso Gili, Ibrahim Eid Hassan, Michela Fratini, Mauro DiNuzzo, Richard G. Wise, Silvia Mangia, Emiliano Macaluso, Federico Giove,

Spontaneous oscillations of the blood oxygenation level-dependent (BOLD) signal are spatially synchronized within specific brain networks and are thought to reflect synchronized brain activity. Networks are modulated by the performance of a task, even if the exact features and degree of such modulations are still elusive. The presence of networks ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:]

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The Effect of Exercise Training During Pregnancy to Improve Maternal Vascular Health: Focus on Gestational Hypertensive Disorders.

Isabel Witvrouwen, Dominique Mannaerts, An M. Van Berendoncks, Yves Jacquemyn, Emeline M. Van Craenenbroeck,

Hypertensive disorders of pregnancy, including gestational hypertension and pre-eclampsia, occur in up to 10% of pregnancies and are associated with increased life-long cardiovascular risk. Physical activity improves cardiovascular health in pregnancy and may lower the risk of developing hypertensive disorders of pregnancy. However, a minority of pregnant women comply with ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:]

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Vascular Signaling in Allogenic Solid Organ Transplantation – The Role of Endothelial Cells.

Laura Kummer, Marcin Zaradzki, Vijith Vijayan, Rawa Arif, Markus A. Weigand, Stephan Immenschuh, Andreas H. Wagner, Jan Larmann,

Graft rejection remains the major obstacle after vascularized solid organ transplantation. Endothelial cells, which form the interface between the transplanted graft and the host’s immunity, are the first target for host immune cells. During acute cellular rejection endothelial cells are directly attacked by HLA I and II-recognizing NK cells, macrophages, ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:]

Cited: 0 times

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Exploring the Factors Contributing to the High Ultimate pH of Broiler Pectoralis Major Muscles Affected by Wooden Breast Condition.

Giulia Baldi, Con-Ning Yen, Morgan R. Daughtry, Jocelyn Bodmer, Brian C. Bowker, Hong Zhuang, Massimiliano Petracci, David E. Gerrard,

The elevated ultimate pH (pHu) found in wooden breast (WB) meat suggests an altered muscular energetic status in WB but also could be related to a prematurely terminated post-mortem pH decline. The aims of this study were to explore the factors contributing to the elevated pHu and establish whether the ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:]

Cited: 0 times

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Evidence of a Role for the TRPC Subfamily in Mediating Oxidative Stress in Parkinson’s Disease.

Daniele Maria-Ferreira, Natalia Mulinari Turin de Oliveira, Liziane Cristine Malaquias da Silva, Elizabeth Soares Fernandes,

Parkinson’s disease (PD) represents one of the most common multifactorial neurodegenerative disorders affecting the elderly population. It is associated with the aggregation of α-synuclein protein and the loss of dopaminergic neurons in the substantia nigra pars compacta of the brain. The disease is mainly represented by motor symptoms, such as ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:]

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Photoperiod Affects Harderian Gland Morphology and Secretion in Female Cricetulus barabensis: Autophagy, Apoptosis, and Mitochondria.

Zhe Wang, Jin-Hui Xu, Jun-Jie Mou, Xiao-Tong Kong, Ming Wu, Hui-Liang Xue, Lai-Xiang Xu,

Photoperiod is an important factor of mammalian seasonal rhythm. The Harderian gland (HG) appears to act as a "standby" structure of the retinal-pineal axis, mediating light signals in vitro and neuroendocrine regulation in vivo; however, the effect of photoperiod on the HG is not clear. Here, we studied morphological differences ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:408]

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2-Chlorofatty Aldehyde Elicits Endothelial Cell Activation.

Jane McHowat, Shubha Shakya, David A Ford,

Endothelial activation and dysfunction are hallmarks of inflammation. Neutrophil-vascular endothelium interactions have significant effects on vascular wall physiology and pathology. Myeloperoxidase (MPO)-derived products released from activated neutrophils can mediate the inflammatory response and contribute to endothelial dysfunction. 2-Chlorofatty aldehyde (2-ClFALD) is the direct oxidation product of MPO-derived hypochlorous acid (HOCl) ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:460]

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Post-exercise Endothelium-Dependent Vasodilation Is Dependent on Training Status.

L. V. Kapilevich, V. V. Kologrivova, A. N. Zakharova, Laurent Mourot,

The effect of training status on post-exercise flow-mediated dilation (FMD) is not well characterized. We tested the hypothesis that the more trained the subjects, the lower the reduction in FMD after an acute bout of aerobic exercise. Forty-seven men (mean ± SD, age: 20.1 ± 1.2 years, body mass: 75.5 ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:]

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Gravity Deprivation: Is It Ethical for Optimal Physiology?

Jack J W A van Loon, Patrick Cras, Willem H A C M Bouwens, Willemijn Roozendaal, Joan Vernikos,

Front Physiol (Frontiers in physiology)
[2020, 11:470]

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Vascular Signaling in Allogenic Solid Organ Transplantation - The Role of Endothelial Cells.

Laura Kummer, Marcin Zaradzki, Vijith Vijayan, Rawa Arif, Markus A Weigand, Stephan Immenschuh, Andreas H Wagner, Jan Larmann,

Graft rejection remains the major obstacle after vascularized solid organ transplantation. Endothelial cells, which form the interface between the transplanted graft and the host's immunity, are the first target for host immune cells. During acute cellular rejection endothelial cells are directly attacked by HLA I and II-recognizing NK cells, macrophages, ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:443]

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Cerebral Metabolic Changes During Visuomotor Adaptation Assessed Using Quantitative fMRI.

Catherine Foster, Jessica J Steventon, Daniel Helme, Valentina Tomassini, Richard G Wise,

The brain retains a lifelong ability to adapt through learning and in response to injury or disease-related damage, a process known as functional neuroplasticity. The neural energetics underlying functional brain plasticity have not been thoroughly investigated experimentally in the healthy human brain. A better understanding of the blood flow and ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:428]

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Pro12Ala Polymorphism on the PPARγ2 Gene and Weight Loss After Aerobic Training: A Randomized Controlled Trial.

Glêbia Alexa Cardoso, Darlene Camati Persuhn, Mateus Duarte Ribeiro, Bruno Rafael Virgínio de Sousa, Klécia de Farias Sena, Antônio Eduardo Monteiro de Almeida, João Modesto-Filho, Raquel Suelen Brito da Silva, Alexandre Sérgio Silva,

The objective of this study was to verify the influence of the Pro12Ala polymorphism of the PPARγ2 gene in response of a training program on the body composition. Sixty-nine previously inactive men and women (32.8 ± 8.2 years) were genotyped and underwent a 12-week aerobic (running/walking) training program (3-5 sessions, ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:385]

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Evidence of a Role for the TRPC Subfamily in Mediating Oxidative Stress in Parkinson's Disease.

Daniele Maria-Ferreira, Natalia Mulinari Turin de Oliveira, Liziane Cristine Malaquias da Silva, Elizabeth Soares Fernandes,

Parkinson's disease (PD) represents one of the most common multifactorial neurodegenerative disorders affecting the elderly population. It is associated with the aggregation of α-synuclein protein and the loss of dopaminergic neurons in the substantia nigra pars compacta of the brain. The disease is mainly represented by motor symptoms, such as ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:332]

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Dietary Copper Plays an Important Role in Maintaining Intestinal Barrier Integrity During Alcohol-Induced Liver Disease Through Regulation of the Intestinal HIF-1α Signaling Pathway and Oxidative Stress.

Hongwei Lin, Dazhi Chen, Qianjing Du, Tongtong Pan, Hanxiao Tu, Yuedong Xu, Teng Teng, Jingjing Tu, Ji Li, Zhuo Lin, Xiaodong Wang, Lanman Xu, Yong-Ping Chen,

Impaired intestinal barrier function and oxidative stress injury play critical roles in the pathogenesis of alcoholic liver disease (ALD), and recent investigations have revealed a role for dietary copper in the liver and intestinal barrier function. Therefore, the current study investigates the mechanisms and role of dietary copper in alcohol ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:]

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2-Chlorofatty Aldehyde Elicits Endothelial Cell Activation.

Jane McHowat, Shubha Shakya, David A. Ford,

Endothelial activation and dysfunction are hallmarks of inflammation. Neutrophil-vascular endothelium interactions have significant effects on vascular wall physiology and pathology. Myeloperoxidase (MPO)-derived products released from activated neutrophils can mediate the inflammatory response and contribute to endothelial dysfunction. 2-Chlorofatty aldehyde (2-ClFALD) is the direct oxidation product of MPO-derived hypochlorous acid (HOCl) ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:]

Cited: 0 times

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A Comprehensive Engineering Analysis of Left Heart Dynamics After MitraClip in a Functional Mitral Regurgitation Patient.

Andrés Caballero, Wenbin Mao, Raymond McKay, Rebecca T Hahn, Wei Sun,

Percutaneous edge-to-edge mitral valve (MV) repair using MitraClip has been recently established as a treatment option for patients with heart failure and functional mitral regurgitation (MR), which significantly expands the number of patients that can be treated with this device. This study aimed to quantify the morphologic, hemodynamic and structural ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:432]

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