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Journal Front Physiol

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Corrigendum: Psychophysiological Patterns Related to Success in a Special Operation Selection Course.

Alberto J Hormeño-Holgado, Pantelis T Nikolaidis, Vicente J Clemente-Suárez,

[This corrects the article DOI: 10.3389/fphys.2019.00867.]. ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:614969]

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Exercise-Induced Autophagy Suppresses Sarcopenia Through Akt/mTOR and Akt/FoxO3a Signal Pathways and AMPK-Mediated Mitochondrial Quality Control.

Zhengzhong Zeng, Jiling Liang, Liangwen Wu, Hu Zhang, Jun Lv, Ning Chen,

Exercise training is one of the most effective interventional strategies for sarcopenia in aged people. Nevertheless, the underlying mechanisms are not well recognized. Increasing studies have reported abnormal regulation of autophagy in aged skeletal muscle. Our current study aims to explore the efficiency of exercise interventions, including treadmill exercise, resistance ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:583478]

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Biliary-Atresia-Associated Mannosidase-1-Alpha-2 Gene Regulates Biliary and Ciliary Morphogenesis and Laterality.

Juhoon So, Mylarappa Ningappa, Joseph Glessner, Jun Min, Chethan Ashokkumar, Sarangarajan Ranganathan, Brandon W Higgs, Dong Li, Qing Sun, Lori Schmitt, Amy C Biery, Steven Dobrowolski, Christine Trautz, Leah Fuhrman, Molly Christine Schwartz, Nikolai Thomas Klena, Joseph Fusco, Krishna Prasadan, Morayooluwa Adenuga, Nada Mohamed, Qi Yan, Wei Chen, William Horne, Anil Dhawan, Khalid Sharif, Deirdre Kelly, Robert H Squires, George K Gittes, Hakon Hakonarson, Victor Morell, Cecilia Lo, Shankar Subramaniam, Donghun Shin, Rakesh Sindhi,

Background/Aims:Infectious and genetic factors are invoked, respectively in isolated biliary atresia (BA), or syndromic BA, with major extrahepatic anomalies. However, isolated BA is also associated with minor extrahepatic gut and cardiovascular anomalies and multiple susceptibility genes, suggesting common origins. Methods:We investigated novel susceptibility genes with genome-wide association, targeted sequencing and ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:538701]

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Transcriptome Analysis and Knockdown of the Juvenile Hormone Esterase Gene Reveal Abnormal Feeding Behavior in the Sugarcane Giant Borer.

Daniel D Noriega, Fabricio B M Arraes, José Dijair Antonino, Leonardo L P Macedo, Fernando C A Fonseca, Roberto C Togawa, Priscila Grynberg, Maria C M Silva, Aldomario S Negrisoli, Maria F Grossi-de-Sa,

The sugarcane giant borer (SGB), Telchin licus licus, is a pest that has strong economic relevance for sugarcane producers. Due to the endophytic behavior of the larva, current methods of management are inefficient. A promising biotechnological management option has been proposed based on RNA interference (RNAi), a process that uses ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:588450]

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Editorial: Gastronomic Science.

Suzanne Devkota, Leon G Fine,

Front Physiol (Frontiers in physiology)
[2020, 11:612921]

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Antioxidative Potency of Dolphin Serum Albumin Is Stronger Than That of Human Serum Albumin Irrespective of Substitution of 34Cysteine With Serine.

Miwa Suzuki, Makoto Anraku, Wataru Hakamata, Takushi Kishida, Keiichi Ueda, Tomoko Endoh,

Serum albumin (SA), the most abundant protein in circulation, functions as a carrier protein, osmoregulator, and antioxidant. Generally, SA exerts its antioxidative effects by scavenging reactive oxygen species. Because marine mammals are superior divers, they are intermittently exposed to oxidative stress induced by rapid reperfusion of oxygen to ischemic tissues ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:598451]

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Extracellular Vesicles From High Glucose-Treated Podocytes Induce Apoptosis of Proximal Tubular Epithelial Cells.

Ying Huang, Ruizhao Li, Li Zhang, Yuanhan Chen, Wei Dong, Xingchen Zhao, Huan Yang, Shu Zhang, Zhiyong Xie, Zhiming Ye, Weidong Wang, Chunling Li, Zhilian Li, Shuangxin Liu, Zheng Dong, Xueqing Yu, Xinling Liang,

Diabetic kidney disease (DKD) is a serious and common complication of diabetes. Extracellular vesicles (EVs) have emerged as crucial vectors in cell-to-cell communication during the development of DKD. EVs may mediate intercellular communication between podocytes and proximal tubules. In this study, EVs were isolated from podocyte culture supernatants under high ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:579296]

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Blockade of Acid-Sensing Ion Channels Increases Urinary Bladder Capacity With or Without Intravesical Irritation in Mice.

Mitsuharu Yoshiyama, Hideki Kobayashi, Masayuki Takeda, Isao Araki,

We conducted this study to examine whether acid-sensing ion channels (ASICs) are involved in the modulation of urinary bladder activity with or without intravesical irritation induced by acetic acid. All in vivo evaluations were conducted during continuous infusion cystometry in decerebrated unanesthetized female mice. During cystometry with a pH 6.3 ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:592867]

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No Change - No Gain; The Effect of Age, Sex, Selected Genes and Training on Physiological and Performance Adaptations in Cross-Country Skiing.

Jan-Michael Johansen, Sannija Goleva-Fjellet, Arnstein Sunde, Lars Erik Gjerløw, Lars Arne Skeimo, Baard I Freberg, Mona Sæbø, Jan Helgerud, Øyvind Støren,

The aim was to investigate the effect of training, sex, age and selected genes on physiological and performance variables and adaptations before, and during 6 months of training in well-trained cross-country skiers. National-level cross-country skiers were recruited for a 6 months observational study (pre - post 1 - post 2 ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:581339]

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Editorial: Extra-Oral Taste Receptors: Function, Disease and Evolution.

Ronghua ZhuGe, Eugeni Roura, Maik Behrens,

Front Physiol (Frontiers in physiology)
[2020, 11:607134]

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Adipokines: New Potential Therapeutic Target for Obesity and Metabolic, Rheumatic, and Cardiovascular Diseases.

Lucia Recinella, Giustino Orlando, Claudio Ferrante, Annalisa Chiavaroli, Luigi Brunetti, Sheila Leone,

Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic and complex endocrine organ, which produces and secretes several adipokines, including hormones, cytokines, extracellular matrix (ECM) proteins, and growth and vasoactive factors. A wide body of evidence showed that adipokines play a critical role ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:578966]

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Transcriptomic Analyses Reveal the Protective Immune Regulation of Conjugated Linoleic Acids in Sheep Ruminal Epithelial Cells.

Chunlei Yang, Wei Lan, Shijie Ye, Binna Zhu, Zhengwei Fu,

The ruminal epithelium is continuously challenged by antigens released by the lysis of dead microbial cells within the rumen. However, the innate immune system of the ruminal epithelium can almost always actively respond to these challenges. The cross talk between the ruminal microbiota and innate immune cells in the ruminal ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:588082]

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Optimizing the Use of Phase Change Material Vests Worn During Explosives Ordnance Disposal Operations in Hot Conditions.

Sarah Lee Davey, Ben James Lee, Mark Smith, Mark Oldroyd, Charles Doug Thake,

Phase change material (PCM) cooling garments' efficacy is limited by the duration of cooling provided. The purpose of this study was to evaluate the effect of replacing a PCM vest during a rest period on physiological and perceptual responses during explosive ordnance disposal (EOD) related activity. Six non-heat acclimated males ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:573521]

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The Dunkin Hartley Guinea Pig Is a Model of Primary Osteoarthritis That Also Exhibits Early Onset Myofiber Remodeling That Resembles Human Musculoskeletal Aging.

Robert V Musci, Maureen A Walsh, Adam R Konopka, Christopher A Wolff, Frederick F Peelor, Raoul F Reiser, Kelly S Santangelo, Karyn L Hamilton,

Skeletal muscle dysfunction, articular cartilage degeneration, and bone loss occur essentially in parallel during aging. Mechanisms contributing to this systemic musculoskeletal decline remain incompletely understood, limiting progress toward developing effective therapeutics. Because the progression of human musculoskeletal aging is slow, researchers rely on rodent models to identify mechanisms and test ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:571372]

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Biological Impact and Enzyme Activities of Spodoptera litura (Lepidoptera: Noctuidae) in Response to Synergistic Action of Matrine and Beauveria brongniartii.

Jianhui Wu, Jiaying Li, Can Zhang, Xintong Yu, Andrew G S Cuthbertson, Shaukat Ali,

Matrine, a naturally occurring heterocyclic compound, has been shown to enhance the pathogenicity of the entomopathogenic fungus Beauveria brongniartii against Spodoptera litura. In the current study, the biological impacts and synergism activities of these two agents on nutritional efficiency and antioxidant enzymes in S. litura were explored. Our results showed ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:584405]

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Aspirin Eugenol Ester Attenuates Paraquat-Induced Hepatotoxicity by Inhibiting Oxidative Stress.

Zhen-Dong Zhang, Mei-Zhou Huang, Ya-Jun Yang, Xi-Wang Liu, Zhe Qin, Shi-Hong Li, Jian-Yong Li,

Aspirin eugenol ester (AEE) is a new potential drug with anti-inflammatory and antioxidant stress pharmacological activity. Paraquat (PQ) is an effective and commercially important herbicide that is widely used worldwide. However, paraquat is highly toxic and can cause various complications and acute organ damage, such as liver, kidney and lung ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:582801]

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Disruption of STAT6 Signal Promotes Cardiac Fibrosis Through the Mobilization and Transformation of CD11b+ Immature Myeloid Cells.

Weiwei Zhang, Baoling Zhu, Suling Ding, Xiangfei Wang, Jian Wu, Xiaowei Zhu, Yunzeng Zou, Junbo Ge, Minghong Tong, Xiangdong Yang,

Cardiac fibrosis is an important pathological basis of various cardiovascular diseases. The roles of STAT6 signal in allergy, immune regulation, tumorigenesis, and renal fibrosis have been documented. However, the function and mechanism of STAT6 signal in sympathetic overactivation-induced cardiac fibrosis have not been fully elucidated. This study explores the novel ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:579712]

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Transient Receptor Potential Ankyrin 1 Mediates Hypoxic Responses in Mice.

Sichong Chen, Nobuaki Takahashi, Changping Chen, Jordan L Pauli, Chiharu Kuroki, Jun Kaminosono, Hideki Kashiwadani, Yuichi Kanmura, Yasuo Mori, Shaowu Ou, Liying Hao, Tomoyuki Kuwaki,

Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel that is broadly expressed in sensory pathways, such as the trigeminal and vagus nerves. It is capable of detecting various irritants in inspired gasses and is activated during hypoxia. In this study, the role of TRPA1 in hypoxia-induced behavioral, ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:576209]

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Remodeling of Rat M. Gastrocnemius Medialis During Recovery From Aponeurotomy.

Cintia Rivares, Reinald Brunner, Johan J M Pel, Guus C Baan, Peter A Huijing, Richard T Jaspers,

Aponeurotomy is a surgical intervention by which the aponeurosis is transsected perpendicularly to its longitudinal direction, halfway along its length. This surgical principle of aponeurotomy has been applied also to intramuscular lengthening and fibrotomia. In clinics, this intervention is performed in patients with cerebral palsy in order to lengthen or ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:541302]

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Pdgfra and Pdgfrb Genetically Interact in the Murine Neural Crest Cell Lineage to Regulate Migration and Proliferation.

Julia Mo, Robert Long, Katherine A Fantauzzo,

Cranial neural crest cells (cNCCs) are migratory, multipotent cells that originate from the forebrain to the hindbrain and eventually give rise to the cartilage and bone of the frontonasal skeleton, among other derivatives. Signaling through the two members of the platelet-derived growth factor receptor (PDGFR) family of receptor tyrosine kinases, ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:588901]

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A Temporal Examination of Cytoplasmic Ca2 + Levels, Sarcoplasmic Reticulum Ca2 + Levels, and Ca2 + -Handling-Related Proteins in Different Skeletal Muscles of Hibernating Daurian Ground Squirrels.

Zhe Wang, Jie Zhang, Xiu-Feng Ma, Hui Chang, Xin Peng, Shen-Hui Xu, Hui-Ping Wang, Yun-Fang Gao,

To explore the possible mechanism of the sarcoplasmic reticulum (SR) in the maintenance of cytoplasmic calcium (Ca2+) homeostasis, we studied changes in cytoplasmic Ca2+, SR Ca2+, and Ca2+-handling proteins of slow-twitch muscle (soleus, SOL), fast-twitch muscle (extensor digitorum longus, EDL), and mixed muscle (gastrocnemius, GAS) in different stages in hibernating ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:562080]

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USP22 Protects Against Myocardial Ischemia-Reperfusion Injury via the SIRT1-p53/SLC7A11-Dependent Inhibition of Ferroptosis-Induced Cardiomyocyte Death.

Shuxian Ma, Linyan Sun, Wenhao Wu, Jiangli Wu, Zhangnan Sun, Jianjun Ren,

Myocardial ischemia-reperfusion (MI/R) injury is characterized by iron deposition and reactive oxygen species production, which can induce ferroptosis. Ferroptosis has also been proposed to promote cardiomyocyte death. The current study sought to define the mechanism governing cardiomyocyte death in MI/R injury. An animal model of MI/R was established by ligation ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:551318]

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Female Sex Hormone Effects on the Vasculature: Considering the Validity of Restricting Study Inclusion to Low-Hormone Phases.

Casey G Turner, Anna E Stanhewicz, Brett J Wong,

Many studies of vascular function limit the testing of premenopausal female participants to periods when female sex hormones, either endogenous or exogenous, are at their lowest concentration. This practice, when not part of the specific research question, may limit data surrounding the predominant physiological state of premenopausal females and pose ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:596507]

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Corrigendum: Current Knowledge on the Vascular Effects of Menthol.

Henrique Silva,

[This corrects the article DOI: 10.3389/fphys.2020.00298.]. ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:602231]

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Physiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/OSR1 Kinase Signaling Pathway and the Cation-Coupled Chloride Cotransporters.

Adrián Rafael Murillo-de-Ozores, María Chávez-Canales, Paola de Los Heros, Gerardo Gamba, María Castañeda-Bueno,

The role of Cl- as an intracellular signaling ion has been increasingly recognized in recent years. One of the currently best described roles of Cl- in signaling is the modulation of the With-No-Lysine (K) (WNK) - STE20-Proline Alanine rich Kinase (SPAK)/Oxidative Stress Responsive Kinase 1 (OSR1) - Cation-Coupled Cl- Cotransporters ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:585907]

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