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Uptake of Biosimilar Infliximab in the UK, France, Japan, and Korea: Budget Savings or Market Expansion Across Countries?

Yujeong Kim, Hye-Young Kwon, Brian Godman, Evelien Moorkens, Steven Simoens, SeungJin Bae,

Objective:To compare the market dynamics of biosimilar infliximab among four Organization for Economic Cooperation and Development (OECD) countries (UK, France, Japan, and Korea) where supply-side and demand-side policies varied greatly, given high and growing expenditure on biological medicines to treat immunological diseases across countries. Methods:A quarterly dataset covering October 2012 ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:970]

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Shensong Yangxin Protects Against Metabolic Syndrome-Induced Ventricular Arrhythmias by Inhibiting Electrical Remodeling.

Hong-Jie Yang, Bin Kong, Wei Shuai, Jing-Jing Zhang, He Huang,

Shensong Yangxin (SSYX) is a traditional Chinese medicine, which has been proven to improve the clinical symptoms of arrhythmia. However, the role of SSYX in metabolic syndrome (MetS)-induced electrical remodeling remains to be fully elucidated. Here, we sought to clarify whether SSYX can alter the electrophysiological remodeling of cardiac myocytes ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:993]

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Glycosaminoglycans as Multifunctional Anti-Elastase and Anti-Inflammatory Drugs in Cystic Fibrosis Lung Disease.

Judith A Voynow, Shuo Zheng, Apparao B Kummarapurugu,

Neutrophil elastase (NE) is a major protease in the airways of patients with cystic fibrosis (CF) that activates airway inflammation by several mechanisms. NE stimulates epithelial toll like receptors (TLR) resulting in cytokine upregulation and release, upregulates MUC5AC, a major airway mucin, degrades both phagocytic receptors and opsonins resulting in ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:1011]

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Characterization of Corosolic Acid as a KPC-2 Inhibitor That Increases the Susceptibility of KPC-2-Positive Bacteria to Carbapenems.

Yonglin Zhou, Xiaohong Lv, Meishan Chen, Yan Guo, Rui Ding, Bin Liu, Xuming Deng, Jianfeng Wang,

The emergence of KPC-producing Gram-negative bacteria in clinical practice highlights the need to search for novel antimicrobials and new anti-infection strategies. In this study, we constructed a laboratory KPC-2-positive strain, E. coli BL21(DE3) (pET28a-KPC-2) and identified the activity of KPC-2 in this strain. Using enzyme inhibition assays, checkerboard MIC assays, ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:1047]

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The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer's Disease Pathophysiology.

Rita F Belo, Margarida L F Martins, Liana Shvachiy, Tiago Costa-Coelho, Carolina de Almeida-Borlido, João Fonseca-Gomes, Vera Neves, Hugo Vicente Miranda, Tiago F Outeiro, Joana E Coelho, Sara Xapelli, Cláudia A Valente, Montserrat Heras, Eduard Bardaji, Miguel A R B Castanho, Maria José Diógenes, Ana M Sebastião,

Kyotorphin (KTP, l-tyrosyl-l-arginine) is an endogenous dipeptide initially described to have analgesic properties. Recently, KTP was suggested to be an endogenous neuroprotective agent, namely for Alzheimer's disease (AD). In fact, KTP levels were shown to be decreased in the cerebrospinal fluid of patients with AD, and recent data showed that ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:985]

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Betulinic Acid Protects From Bone Loss in Ovariectomized Mice and Suppresses RANKL-Associated Osteoclastogenesis by Inhibiting the MAPK and NFATc1 Pathways.

Jiyong Wei, Yicheng Li, Qian Liu, Yanni Lan, Chengming Wei, Kun Tian, Liwei Wu, Chunbo Lin, Jiake Xu, Jinmin Zhao, Yuan Yang,

Osteoclasts with elevated bone resorption are commonly present in postmenopausal osteoporosis, and other osteolytic pathologies. Therefore, suppressing osteoclast generation and function has been the main focus of osteoporosis treatment. Betulinic acid (BA) represents a triterpenoid mainly purified from the bark of Betulaceae. BA shows multiple biological activities, including antitumor and ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:1025]

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Patients With Reflux Esophagitis Possess a Possible Different Oral Microbiota Compared With Healthy Controls.

Baoyong Wang, Yu Zhang, Qiaofei Zhao, Yifan Yan, Tian Yang, Yanli Xia, Hongwei Chen,

Background and Aim:Reflux Esophagitis (RE) is caused by a variety of factors including anatomical and functional alterations involved in the pathogenesis. Oral microbiota is influenced by many factors such as heredity, nutrition, environments and host conditions, but little is known about relationship between oral microbiota and RE. The aim of this study was to explore whether the oral ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:1000]

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Traditional Use of Medicinal Plants in South-Eastern Serbia (Pčinja District): Ethnopharmacological Investigation on the Current Status and Comparison With Half a Century Old Data.

Jelena Živković, Milan Ilić, Katarina Šavikin, Gordana Zdunić, Aleksandra Ilić, Dejan Stojković,

Balkan Peninsula is one of the most important biodiversity centers in Europe. Despite that, the usage of plant species in the traditional medicine of some Balkan regions remained largely unexplored in the past. This study aimed to collect and document data on the traditional use of medicinal plants in Pčinja ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:1020]

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Advances in Molecular Mechanisms for Traditional Chinese Medicine Actions in Regulating Tumor Immune Responses.

Han Huang, Jiansong Fang, Xiude Fan, Tatsunori Miyata, Xiaoyue Hu, Lihe Zhang, Liangren Zhang, Yimin Cui, Zhenming Liu, Xiaoqin Wu,

Traditional Chinese medicine (TCM) has been developed for thousands of years with its various biological activities. The interest in TCM in tumor prevention and treatment is rising with its synergistic effect on tumor cells and tumor immunosuppressive microenvironment (TIM). Characteristic of TCM fits well within the whole system and multi-target ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:1009]

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Animal, Herb, and Microbial Toxins for Structural and Pharmacological Study of Acid-Sensing Ion Channels.

Dmitry I Osmakov, Timur A Khasanov, Yaroslav A Andreev, Ekaterina N Lyukmanova, Sergey A Kozlov,

Acid-sensing ion channels (ASICs) are of the most sensitive molecular sensors of extracellular pH change in mammals. Six isoforms of these channels are widely represented in membranes of neuronal and non-neuronal cells, where these molecules are involved in different important regulatory functions, such as synaptic plasticity, learning, memory, and nociception, ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:991]

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Phytotherapy for Cachexia: Where Do We Stand?

Kenny Kuchta, Silke Cameron,

Background:In contrast to Western medicine which currently offers no approved pharmacotherapy options for cachexia, in Japan multi-component extracts of medicinal plants are used with coverage by the national health insurance. This so called "Kampo" medicine is an example of the modern concept of multi-component/multi-target therapy. For the three traditional preparations ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:917]

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Editorial: Emerging Mechanisms in Purinergic Signaling: From Cell Biology to Therapeutic Perspectives.

Rosa Gomez-Villafuertes, Elena Adinolfi,

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:1022]

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Tuning Scorpion Toxin Selectivity: Switching From KV1.1 to KV1.3.

Andrei M Gigolaev, Alexey I Kuzmenkov, Steve Peigneur, Valentin M Tabakmakher, Ernesto L Pinheiro-Junior, Anton O Chugunov, Roman G Efremov, Jan Tytgat, Alexander A Vassilevski,

Voltage-gated potassium channels (KVs) perform vital physiological functions and are targets in different disorders ranging from ataxia and arrhythmia to autoimmune diseases. An important issue is the search for and production of selective ligands of these channels. Peptide toxins found in scorpion venom named KTx excel in both potency and ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:1010]

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Calcium Permeable Channels in Cancer Hallmarks.

Sendoa Tajada, Carlos Villalobos,

Cancer, the second cause of death worldwide, is characterized by several common criteria, known as the "cancer hallmarks" such as unrestrained cell proliferation, cell death resistance, angiogenesis, invasion and metastasis. Calcium permeable channels are proteins present in external and internal biological membranes, diffusing Ca2+ ions down their electrochemical gradient. Numerous ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:968]

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Tolerability, Safety, Pharmacokinetics and Drug Interaction of Cefotaxime Sodium-Tazobactam Sodium Injection (6:1) Following Single and Multiple Intravenous Doses in Chinese Healthy Subjects.

Ning Chen, Lu-Ning Sun, Wen-Hui Hu, Yi-Ya Wang, Li-Jun Xie, Juan Cheng, Hong-Wen Zhang, Yun Liu, Yong-Qing Wang, Li Ding,

Purpose:To evaluate the tolerability, safety, pharmacokinetics and drug interaction of cefotaxime sodium-tazobactam sodium injection (6:1) in Chinese healthy subjects. The results of the safety and pharmacokinetic studies supported further clinical trials. Method:A randomized, single-blind, ascending dose, placebo-controlled, single-center study was conducted. Sixty healthy subjects (38 males, 22 females) participated in ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:1033]

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Chijabyukpi-Tang Inhibits Pro-Inflammatory Cytokines and Chemokines via the Nrf2/HO-1 Signaling Pathway in TNF-α/IFN-γ-Stimulated HaCaT Cells and Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in Mice.

Ji-Hyun Lee, Ji-Ye Lim, Eun Hee Jo, Hyeon Min Noh, Sunggu Park, Min Cheol Park, Dae-Ki Kim,

Chijabyukpi-tang (CBT) is an oriental herbal formula consisting of three herbs (Gardeniae Fructus (Gardenia jasminoides J.Ellis.), Phellodendri Cortex (Phellodendron amurense Rupr.), Glycyrrhizae Radix (Glycyrrhiza uralensis Fisch. ex DC.) at the ratio of 2: 2: 1. CBT has traditionally been used to treat eczema with inflammation in Northeast Asia. The components ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:1018]

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Characterization of PF-6142, a Novel, Non-Catecholamine Dopamine Receptor D1 Agonist, in Murine and Nonhuman Primate Models of Dopaminergic Activation.

Rouba Kozak, Tamás Kiss, Keith Dlugolenski, David E Johnson, Roxanne R Gorczyca, Kyle Kuszpit, Brian D Harvey, Polina Stolyar, Stacey J Sukoff Rizzo, William E Hoffmann, Dmitri Volfson, Mihaly Hajós, Jennifer E Davoren, Amanda L Abbott, Graham V Williams, Stacy A Castner, David L Gray,

Selective activation of dopamine D1 receptors remains a promising pro-cognitive therapeutic strategy awaiting robust clinical investigation. PF-6142 is a key example from a recently disclosed novel series of non-catechol agonists and partial agonists of the dopamine D1/5 receptors (D1R) that exhibit pharmacokinetic (PK) properties suitable for oral delivery. Given their ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:1005]

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Caffeic Acid Phenethyl Ester Ameliorates Calcification by Inhibiting Activation of the AKT/NF-κB/NLRP3 Inflammasome Pathway in Human Aortic Valve Interstitial Cells.

Ming Liu, Fei Li, Yuming Huang, Tingwen Zhou, Si Chen, Geng Li, Jiawei Shi, Nianguo Dong, Kang Xu,

Calcific aortic valve disease (CAVD) occurs via a pathophysiological process that includes inflammation-induced osteoblastic differentiation of aortic valvular interstitial cells (AVICs). Here, we investigated the role of the anti-inflammatory compound caffeic acid phenethyl ester (CAPE) in inhibiting CAVD. Human AVICs were isolated and cultured in osteogenic induction medium (OM) with ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:826]

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Advance in Drug Delivery for Ageing Skeletal Muscle.

Yi Li, Ming Chen, Yanpeng Zhao, Ming Li, Yong Qin, Shi Cheng, Yanyu Yang, Pengbin Yin, Licheng Zhang, Peifu Tang,

The age-related loss of skeletal muscle, sarcopenia, is characterized by progressive loss of muscle mass, reduction in muscle strength, and dysfunction of physical performance. It has become a global health problem leading to several adverse outcomes in the ageing population. Research on skeletal muscle loss prevention and treatment is developing ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:1016]

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O-1602, an Agonist of Atypical Cannabinoid Receptors GPR55, Reverses the Symptoms of Depression and Detrusor Overactivity in Rats Subjected to Corticosterone Treatment.

Andrzej Wróbel, Anna Serefko, Aleksandra Szopa, Daniela Ulrich, Ewa Poleszak, Tomasz Rechberger,

In view of the fact that GPR55 receptors are localized in brain areas implicated in the pathophysiology of depression, GPR55 gene expression is reduced in the dorsolateral prefrontal cortex of suicide victims, and GPR55 receptor agonism exerts an anxiolytic-like effect, GPR55 receptors have drawn our attention as a potential target ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:1002]

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Homoharringtonine Inhibits Allergic Inflammations by Regulating NF-κB-miR-183-5p-BTG1 Axis.

Misun Kim, Hyein Jo, Yoojung Kwon, Youngmi Kim, Hyun Suk Jung, Dooil Jeoung,

Homoharringtonine (HHT) is a drug for treatment of chronic myeloid leukemia. However, the role of HHT in allergic inflammations remains unknown. Mouse model of atopic dermatitis (AD) induced by 2, 4,-dinitroflurobenzene (DNFB) and anaphylaxis employing 2,4-dinitropheny-human serum albumin (DNP-HSA) were used to examine the role of HHT in allergic inflammations. ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:1032]

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Traditional Asian Herbs in Skin Whitening: The Current Development and Limitations.

Yibo Hu, Hongliang Zeng, Jinhua Huang, Ling Jiang, Jing Chen, Qinghai Zeng,

In Asia, the market for whitening cosmetics is expanding rapidly, more and more people prefer to use natural products. Driven by natural product demand and technical advances, herbal research is also developing fast. Lots of studies reported that Asian herbal reagents can reduce melanogenesis, these findings provide evidence for the ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:982]

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Retinoic Acid Alleviates Cisplatin-Induced Acute Kidney Injury Through Activation of Autophagy.

Junxia Wu, Canbin Zheng, Xin Wan, Mingjun Shi, Kathryn McMillan, Jenny Maique, Changchun Cao,

Cisplatin-induced acute kidney injury (CIAKI) is a common complication in patients receiving cisplatin-based chemotherapy. But the effective therapies for CIAKI are not available. Retinoic acid (RA), the main derivative of vitamin A, has the potential to reduce inflammation and fibrosis in renal injury. However, the effect and mechanism of RA ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:987]

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Pharmacogenetic Testing for Prevention of Severe Cutaneous Adverse Drug Reactions.

Chih-Jung Chang, Chun-Bing Chen, Shuen-Iu Hung, Chao Ji, Wen-Hung Chung,

Severe cutaneous adverse reactions (SCAR), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS), are idiosyncratic and unpredictable drug-hypersensitivity reactions with a high-mortality rate ranging from 10% to over 30%, thus causing a major burden on the healthcare system. Recent pharmacogenomic ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:969]

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Effect of Sishen Pill on Memory T Cells From Experimental Colitis Induced by Dextran Sulfate Sodium.

Wei Ge, Hai-Yan Wang, Hai-Mei Zhao, Xue-Ke Liu, You-Bao Zhong, Jian Long, Zheng-Yun Zuo, Duan-Yong Liu,

Immune memory has a protective effect on the human body, but abnormal immune memory is closely related to the occurrence and development of autoimmune diseases including inflammatory bowel disease (IBD). Sishen Pill (SSP) is a classic prescription of traditional Chinese medicine, which is often used to treat chronic colitis, but ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:908]

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