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Commentary: sVEGFR1 Is Enriched in Hepatic Vein Blood-Evidence for a Provisional Hepatic Factor Candidate?

Carolina Putotto, Bruno Marino, Paolo Versacci,

Front Pediatr (Frontiers in pediatrics)
[2021, 9:782779]

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A Machine Learning Model to Predict Intravenous Immunoglobulin-Resistant Kawasaki Disease Patients: A Retrospective Study Based on the Chongqing Population.

Jie Liu, Jian Zhang, Haodong Huang, Yunting Wang, Zuyue Zhang, Yunfeng Ma, Xiangqian He,

<b>Objective:</b> We explored the risk factors for intravenous immunoglobulin (IVIG) resistance in children with Kawasaki disease (KD) and constructed a prediction model based on machine learning algorithms. <b>Methods:</b> A retrospective study including 1,398 KD patients hospitalized in 7 affiliated hospitals of Chongqing Medical University from January 2015 to August 2020 ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:756095]

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Case Report: Potocki-Lupski Syndrome in Five Siblings.

Alina Grama, Claudia Sîrbe, Diana Miclea, Simona Sorana Cǎinap, Delia Huniadi, Bogdan Bulata, Tudor Lucian Pop,

Potocki-Lupski syndrome (PTLS) is a rare developmental disorder resulting from the partial duplication of the short arm of chromosome 17. Affected children may have hypotonia, facial dysmorphism, or neurological abnormalities. PTLS is also frequently associated with failure to thrive due to swallowing difficulties or growth hormone deficiency. We report the ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:698629]

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Intermittent Bi-Daily Sub-cutaneous Teriparatide Administration in Children With Hypoparathyroidism: A Single-Center Experience.

Julie Bernardor, Sacha Flammier, Sara Cabet, Sandrine Lemoine, Roland Chapurlat, Arnaud Molin, Aurélia Bertholet-Thomas, Justine Bacchetta,

<b>Introduction:</b> The use of teriparatide has been reported in children with hypoparathyroidism as an investigational physiologic replacement therapy. <b>Methods:</b> We aimed to retrospectively report our pediatric experience of bi-daily sub-cutaneous teriparatide. Results are presented as median (25th-75th quartile). As part of the routine follow-up of these patients with hypoparathyroidism, total ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:764040]

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Tocilizumab in Systemic Juvenile Idiopathic Arthritis: Response Differs by Disease Duration at Medication Initiation and by Phenotype of Disease.

Xin Yan, Wenjing Tang, Zhiyong Zhang, Yu Zhang, Chong Luo, Xuemei Tang,

<b>Objective:</b> We performed a single-center retrospective study to determine the different efficacy of tocilizumab (TCZ) in the early and late stages and in three phenotypic subgroups (monocyclic, polycyclic, and persistent) of systemic juvenile idiopathic arthritis (sJIA). <b>Methods:</b> Clinical and serological parameters of 77 sJIA patients treated by TCZ were collected ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:735846]

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Hip Involvement in Juvenile Idiopathic Arthritis: A Roadmap From Arthritis to Total Hip Arthroplasty or How Can We Prevent Hip Damage?

Lubov S Sorokina, Ilia S Avrusin, Rinat K Raupov, Natalia A Lubimova, Sergey V Khrypov, Mikhail M Kostik,

<b>Objectives:</b> To describe the clinical characteristics of hip involvement in juvenile idiopathic arthritis (JIA) from arthritis to hip osteoarthritis (HOA) and total hip arthroplasty (THA). <b>Study Design:</b> Seven hundred fifty-three patients aged 2-17 years with JIA were included in the study. The comparison analysis was performed between the following subgroups: ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:747779]

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Defective Toll-Like Receptors Driven B Cell Response in Hyper IgE Syndrome Patients With STAT3 Mutations.

Ruolan Gong, Jing Wu, Yingying Jin, Tongxin Chen,

Autosomal dominant hyper-IgE syndrome (AD-HIES) is a rare inherited primary immunodeficient disease (PIDs), which is caused by <i>STAT3</i> gene mutations. Previous studies indicated a defective Toll-like receptor (TLR) 9-induced B cell response in AD-HIES patients, including proliferation, and IgG production. However, the other TLRs-mediated B cell responses in AD-HIES patients ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:738799]

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Current and Future Uses of Continuous EEG in the NICU.

Amanda G Sandoval Karamian, Courtney J Wusthoff,

Continuous EEG (cEEG) is a fundamental neurodiagnostic tool in the care of critically ill neonates and is increasingly recommended. cEEG enhances prognostication <i>via</i> assessment of the background brain activity, plays a role in predicting which neonates are at risk for seizures when combined with clinical factors, and allows for accurate ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:768670]

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MIS-C Treatment: Is IVIG Always Necessary?

Francesco Licciardi, Letizia Baldini, Marta Dellepiane, Carlotta Covizzi, Roberta Mogni, Giulia Pruccoli, Cecilia Orsi, Ivana Rabbone, Emilia Parodi, Federica Mignone, Davide Montin,

<b>Background:</b> MIS-C is a potentially severe inflammatory syndrome associated with SARS-CoV-2 exposure. Intravenous immunoglobulin (IVIG) is considered the first-tier therapy, but it implies infusion of large fluid volumes that may worsen cardiac function. <b>Patients and Methods:</b> Since April 2020, we have developed a treatment protocol that avoids the infusion of ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:753123]

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Maternal-Fetal Pharmacology of Drugs: A Review of Current Status of the Application of Physiologically Based Pharmacokinetic Models.

Nupur Chaphekar, Prerna Dodeja, Imam H Shaik, Steve Caritis, Raman Venkataramanan,

Pregnancy and the postpartum period are associated with several physiological changes that can alter the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs. For certain drugs, dosing changes may be required during pregnancy and postpartum to achieve drug exposures comparable to what is observed in non-pregnant subjects. There is very limited ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:733823]

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Intracranial Metastases Tend to Be Overt and Predict Poor Prognosis in Children With Neuroblastoma.

Ying Liu, Liang Huo, Jinhua Zhang, Ying Liu,

<b>Background:</b> Neuroblastoma (NB) is the most common pediatric extracranial solid neoplasm after leukemia. Intracranial metastases (IM) rarely occur in patients with NB. The present study aimed to review the clinical characteristics of NB patients from a single center presenting with IM. <b>Methods:</b> Two hundred children (aged 3-91 months) with NB ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:716880]

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The Association Between Placental Residual Blood Volume and Two Placental Transfusion Methods After Delivery at Term.

Tai-Ho Hung, Ya-Chun Chuang, Lulu Huang,

<b>Background:</b> Despite reports of the beneficial effects, such as increasing hemoglobin level and iron store in the neonatal period, of delayed cord clamping, or umbilical cord milking after delivery in healthy term-born infants, the duration of delayed clamping or rounds of milking in most previous reports were determined arbitrarily and ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:768075]

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Predicting Flow Rate Escalation for Pediatric Patients on High Flow Nasal Cannula Using Machine Learning.

Joshua A Krachman, Jessica A Patricoski, Christopher T Le, Jina Park, Ruijing Zhang, Kirby D Gong, Indranuj Gangan, Raimond L Winslow, Joseph L Greenstein, James Fackler, Anthony A Sochet, Jules P Bergmann,

<b>Background:</b> High flow nasal cannula (HFNC) is commonly used as non-invasive respiratory support in critically ill children. There are limited data to inform consensus on optimal device parameters, determinants of successful patient response, and indications for escalation of support. Clinical scores, such as the respiratory rate-oxygenation (ROX) index, have been ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:734753]

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Feasibility and Safety of a Simple Non-cystoscopic Double-J Tube Removal Technique in Children.

Qiao Bao, Weihua Lao, Tong Shi, Keyu Ouyang, Sai Ma, Wen Zhang, Yankun Lin,

<b>Objective:</b> Double-J tube placement is an important procedure during upper urinary tract surgery. A primary drawback is the requirement of a second double-J tube removal under a cystoscope. Therefore, a simple and feasible alternative is required to remove the double-J tube without cystoscopy. The present study reported the feasibility and ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:761903]

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Point Prevalence and Associated Factors of Hip Displacement in Pediatric Patients With Mitochondrial Disease.

Sungmin Kim, Young-Mock Lee, Kun-Bo Park, Minsu Lee, Hoon Park,

<b>Objective:</b> Mitochondrial disease is a multisystem disorder resulting from mitochondrial dysfunction. Although musculoskeletal system is vulnerable to mitochondrial dysfunction, little information is available on orthopedic issues such as hip displacement and scoliosis in patients with mitochondrial disease. We aimed to examine the point prevalence of hip displacement and investigate the ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:637240]

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Minimal Residual Disease Prior to and After Haematopoietic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia: What Level of Negativity Is Relevant?

Pietro Merli, Marianne Ifversen, Tony H Truong, Hanne V Marquart, Jochen Buechner, Matthias Wölfl, Peter Bader,

Minimal residual disease (MRD) assessment plays a central role in risk stratification and treatment guidance in paediatric patients with acute lymphoblastic leukaemia (ALL). As such, MRD prior to haematopoietic stem cell transplantation (HSCT) is a major factor that is independently correlated with outcome. High burden of MRD is negatively correlated ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:777108]

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Outcomes of High-Flow Nasal Cannula Vs. Nasal Continuous Positive Airway Pressure in Young Children With Respiratory Distress: A Systematic Review and Meta-Analysis.

Xueqin Zhao, Qiaozhi Qin, Xian Zhang,

<b>Background:</b> Continuous positive airway pressure (CPAP) has been associated with a lower risk of treatment failure than high-flow nasal cannula (HFNC) in pediatric patients with respiratory distress and severe hypoxemia. However, the publication of new trials on children younger than 2 years warrants a review and updated meta-analysis of the ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:759297]

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Floating-Harbor Syndrome Treated With Recombinant Human Growth Hormone: A Case Report and Literature Review.

Hui Bo, Lihong Jiang, Jiaqi Zheng, Jie Sun,

<b>Introduction:</b> We aimed to summarize the clinical characteristics of Floating-Harbor syndrome (FHS) and the effect of recombinant human growth hormone (rhGH) to increase height. <b>Methods:</b> The clinical manifestations, gene sequencing results, treatment, and regression of one child with FHS were reported at the Department of Pediatrics, General Hospital of Tianjin ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:747353]

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Case Report: Retroaortic Innominate Vein With Supracardiac Total Anomalous Pulmonary Venous Connection.

Toshinobu Ifuku, Ayako Kuraoka, Tomoko Ohhira, Koichi Sagawa, Toshihide Nakano, Hideaki Kado,

A retroaortic innominate vein (RAIV) is a rare anomaly that passes posterior to the ascending aorta to join the superior vena cava and is associated with congenital heart disease (CHD). The RAIV and normal left innominate vein (LIV) rarely duplicate. The etiology of the RAIV and its relationship with CHD ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:734567]

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Occupational Performance Coaching With Parents to Promote Community Participation of Young Children With Developmental Disabilities: Protocol for a Feasibility and Pilot Randomized Control Trial.

Chi-Wen Chien, Yuen Yi Cynthia Lai, Chung-Ying Lin, Fiona Graham,

<b>Background:</b> High rates of restricted community participation have been reported in young children with developmental disabilities. Occupational performance coaching (OPC), grounded in self-determination theory, aims to facilitate children's participation in life situations through coaching parents. However, there have been limited randomized controlled trials demonstrating the efficacy of OPC, especially with ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:720885]

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Long-Term Outcomes and Prognosticators of Pediatric Primary Dilated Cardiomyopathy in an Asian Cohort.

Po-Yuan Wang, Wei-Chieh Tseng, Chun-Min Fu, Mei-Hwan Wu, Jou-Kou Wang, Yih-Sharng Chen, Nai-Kuan Chou, Shoei-Shen Wang, Shuenn-Nan Chiu, Ming-Tai Lin, Chun-Wei Lu, Chun-An Chen,

<b>Background:</b> Dilated cardiomyopathy (DCM) is the most common childhood cardiomyopathy. The epidemiological profiles and prognosticators of clinical outcomes in Asian populations are not well elucidated. <b>Methods:</b> Data of 104 children aged <18 years with a diagnosis of primary DCM from January 1990 to December 2019 in our institutional database were ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:771283]

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Case Report: Two Cases of Pediatric Thrombotic Thrombocytopenic Purpura Treated With Combined Therapy.

Costanza Tripiciano, Paola Zangari, Mauro Montanari, Giovanna Leone, Laura Massella, Lucia Garaboldi, Michela Massoud, Stefano Lancellotti, Luisa Strocchio, Emma Concetta Manno, Paolo Palma, Tiziana Corsetti, Matteo Luciani,

Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy caused by a severely reduced activity of the von Willebrand factor-cleaving protease ADAMTS13. Over 95% of TTPs are acquired, due to autoantibody inhibitors. In children, acquired TTP is a very rare, life-threatening disease. To date, no consensus exists on the treatment strategy ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:743206]

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An Unexpected Hepatic Hydrothorax After a Successful Kasai Portoenterostomy: A Case Report.

Giulia Ranucci, Fabiola Di Dato, Daniela Liccardo, Marco Spada, Giuseppe Maggiore, Raffaele Iorio,

Hepatic hydrothorax (HH) represents a rare complication of portal hypertension among adult cirrhotic patients. Here, we describe a pediatric case of HH, observed in a biliary atresia infant. The child presented with recurrent right-sided pleural effusion, after a successful Kasai portoenterostomy with restoration of bile flow and without overt signs ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:766187]

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Tubuloglomerular Disease With Cone-Shaped Epiphyses Associated With Hypomorphic Variant and a Novel p.Cys14Arg in the TTC21B Gene: A Case Report.

Martin Bezdíčka, Dana Zemková, Sylva Skálová, Eva Hovorková, Miroslav Podhola, Jan Burkert, Jakub Zieg,

Monogenic nephrotic syndrome (NS) is associated with a resistance to initial glucocorticoid therapy and causative variants, which may be found in several genes influencing podocyte stability and kidney development. The <i>TTC21B</i> gene, which encodes the retrograde intraflagellar transport protein IFT139, is found mostly in association with ciliopathies in humans. The ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:752878]

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Evaluation of Caspase-1, Interleukin-1β, and Interleukin-18, in the Middle Ear Effusion in Children With Otitis Media With Effusion.

Shanshan Liu, Lining Guo, Min Chen, Wei Liu, Yanhong Li, Xiaoxu Wang, Shilan Li, Jie Zhang, Xin Ni,

<b>Objectives:</b> The present study aimed to assess the expression of caspase-1 and caspase-1-dependent processing of cytokines, such as interleukin (IL)-1β and IL-18, in the middle ear effusion of children with otitis media with effusion (OME) in order to identify the potential role of inflammasomes in OME. <b>Methods:</b> This study included ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:732973]

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