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Journal Front Oncol

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Video-Mosaicked Handheld Dual-Axis Confocal Microscopy of Gliomas: An ex vivo Feasibility Study in Humans.

Yoko Fujita, Linpeng Wei, Patrick J Cimino, Jonathan T C Liu, Nader Sanai,

Background:Intraoperative confocal microscopy can enable high-resolution cross-sectional imaging of intact tissues as a non-invasive real-time alternative to gold-standard histology. However, all current means of intraoperative confocal microscopy are hindered by a limited field of view (FOV), presenting a challenge for evaluating gliomas, which are highly heterogeneous. Objective:This study explored the ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1674]

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A Radiomics Nomogram for the Preoperative Prediction of Lymph Node Metastasis in Pancreatic Ductal Adenocarcinoma.

Jiahao Gao, Fang Han, Yingying Jin, Xiaoshuang Wang, Jiawen Zhang,

Purpose:To construct and verify a CT-based multidimensional nomogram for the evaluation of lymph node (LN) status in pancreatic ductal adenocarcinoma (PDAC). Materials and Methods:We retrospectively assessed data from 172 patients with clinicopathologically confirmed PDAC surgically resected between February 2014 and November 2016. Patients were assigned to either a training cohort ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1654]

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Comprehending Meningioma Signaling Cascades Using Multipronged Proteomics Approaches & Targeted Validation of Potential Markers.

Shuvolina Mukherjee, Deeptarup Biswas, Rucha Gadre, Pooja Jain, Nelofer Syed, Julianna Stylianou, Qingyu Zeng, Anita Mahadevan, Sridhar Epari, Prakash Shetty, Aliasgar Moiyadi, Graham Roy Ball, Sanjeeva Srivastava,

Meningiomas are one of the most prevalent primary brain tumors. Our study aims to obtain mechanistic insights of meningioma pathobiology using mass spectrometry-based label-free quantitative proteome analysis to identifying druggable targets and perturbed pathways for therapeutic intervention. Label-free based proteomics study was done from peptide samples of 21 patients and ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1600]

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Establishment of a Jaw Fibrosarcoma Patient-Derived Xenograft and Evaluation of the Tumor Suppression Efficacy of Plumbagin Against Jaw Fibrosarcoma.

Yuqi Xin, Shiya Li, Qingkun Jiang, Fangling Hu, Yuanqiao He, Jie Zhang,

Background: Head and neck fibrosarcoma is a rare malignant tumor, accounting for about 1% of all head and neck tumors. It can also occur in the jaw bone, for which surgical resection is the main treatment but the recurrence rate is high and the prognosis is usually poor. Due to ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1479]

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Score for the Survival Probability of Patients With Orbital Rhabdomyosarcoma After Surgery: A Long-Term and Large Cohort Study.

Yu Zhang, Chaobin He, Yu Lian, Huiming Xiao,

Orbital rhabdomyosarcoma (RMS) is a relatively rare primary malignancy occurring in children. The objective of this study was to evaluate the cumulative incidence of cancer-specific death and competing risk of death among RMS patients after surgery and to build nomograms to predict overall survival (OS) and cancer-specific survival (CSS) based ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1590]

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Case Report: Concomitant Diagnosis of Plasma Cell Leukemia in Patient With JAK2 Positive Myeloproliferative Neoplasm.

Christine J Kurian, Colin Thomas, Sarah Houtmann, Thomas Klumpp, Adam Finn Binder,

Plasma cell dyscrasias and myeloproliferative neoplasms (MPN) are hematologic malignancies arising from two distinct hematopoietic cell lineages. They rarely occur concomitantly. Here, we report a case of a patient with a recent diagnosis of a JAK2 V617F positive MPN who presented with a new diagnosis of plasma cell leukemia. The ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1497]

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Establishment of a 3D Co-culture With MDA-MB-231 Breast Cancer Cell Line and Patient-Derived Immune Cells for Application in the Development of Immunotherapies.

Diana P Saraiva, Ana T Matias, Sofia Braga, António Jacinto, M Guadalupe Cabral,

3D cell culture including different cell types, such as immune cells, is a representative platform that mimics the tumor microenvironment. Here we disclose an easy-to-handle 3D co-culture protocol using a scaffold-free technique with the breast cancer cell line MDA-MB-231 and breast cancer patient-derived immune cells from peripheral blood. The method ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1543]

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Radiomics Analysis Based on Diffusion Kurtosis Imaging and T2 Weighted Imaging for Differentiation of Pancreatic Neuroendocrine Tumors From Solid Pseudopapillary Tumors.

Yan-Jie Shi, Hai-Tao Zhu, Yu-Liang Liu, Yi-Yuan Wei, Xiu-Bo Qin, Xiao-Yan Zhang, Xiao-Ting Li, Ying-Shi Sun,

Objective:To develop and validate a radiomics model of diffusion kurtosis imaging (DKI) and T2 weighted imaging for discriminating pancreatic neuroendocrine tumors (PNETs) from solid pseudopapillary tumors (SPTs). Materials and Methods:Sixty-six patients with histopathological confirmed PNETs (n = 31) and SPTs (n = 35) were enrolled in this study. ROIs of ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1624]

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Corrigendum: The Emerging Role of the c-MET-HGF Axis in Non-small Cell Lung Cancer Tumor Immunology and Immunotherapy.

Helen F Titmarsh, Richard O'Connor, Kevin Dhaliwal, Ahsan R Akram,

[This corrects the article DOI: 10.3389/fonc.2020.00054.]. ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1516]

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Comparison of Early T-Cell Precursor and Non-ETP Subtypes Among 122 Chinese Adults With Acute Lymphoblastic Leukemia.

Yi Zhang, Jie-Jing Qian, Yi-Le Zhou, Xin Huang, Jian-Hu Li, Xue-Ying Li, Chen-Ying Li, Huan-Ping Wang, Yin-Jun Lou, Hai-Tao Meng, Wen-Juan Yu, Hong-Yan Tong, Jie Jin, Hong-Hu Zhu,

Background: Adult T-cell acute lymphoblastic leukemia (T-ALL) is a rare hematological malignancy and significantly linked to poor outcomes. Early T-cell precursor (ETP) leukemia is a unique subtype of T-ALL. The aim of this study is to compare the differences between ETP and non-ETP ALLs in China. Methods: We retrospectively analyzed ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1423]

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The Preferred Locations of Meningioma According to Different Biological Characteristics Based on Voxel-Wise Analysis.

Chongran Sun, Zhangqi Dou, Jiawei Wu, Biao Jiang, Yasaman Iranmanesh, Xiaobo Yu, Jianru Li, Hang Zhou, Chen Zhong, Yucong Peng, Jianfeng Zhuang, Qian Yu, Xinyan Wu, Feng Yan, Qi Xie, Gao Chen,

Objective: Meningiomas presented preferred intracranial distribution, which may reflect potential biological natures. This study aimed to analyze the preferred locations of meningioma according to different biological characteristics. Method: A total of 1,107 patients pathologically diagnosed with meningiomas between January 2012 and December 2016 were retrospectively analyzed. Preoperative MRI were normalized, ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1412]

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Is Invagination Anastomosis More Effective in Reducing Clinically Relevant Pancreatic Fistula for Soft Pancreas After Pancreaticoduodenectomy Under Novel Fistula Criteria: A Systematic Review and Meta-Analysis.

Zhe Cao, Wenhao Luo, Jiangdong Qiu, Yueze Liu, Lianfang Zheng, Taiping Zhang,

Objective: To define the effectiveness of different anastomosis on clinically relevant postoperative fistula in patients with soft pancreas using the newest version of the fistula definition and criteria. Background: Different criteria of clinically relevant postoperative pancreatic fistula (POPF) result in the optimal anastomosis technique remaining controversial. Methods: PubMed, Embase, Web ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1637]

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EI24 Inhibits Cell Proliferation and Drug Resistance of Esophageal Squamous Cell Carcinoma.

Lili Duan, Jiaojiao Ma, Wanli Yang, Lu Cao, Xiaoqian Wang, Liaoran Niu, Yiding Li, Wei Zhou, Yujie Zhang, Jinqiang Liu, Hongwei Zhang, Qingchuan Zhao, Liu Hong, Daiming Fan,

Drug resistance, whether intrinsic or acquired, often leads to treatment failure in esophageal squamous cell carcinoma (ESCC). Clarifying the mechanism of drug resistance in ESCC has great significance for reversing drug resistance, as well as improving the prognosis of patients. Previously, we demonstrated that etoposide-induced 2.4-kb mRNA (EI24) is the ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1570]

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Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy.

Linyuan Xue, Hongyu Qi, He Zhang, Lu Ding, Qingxia Huang, Daqing Zhao, Boyang Jason Wu, Xiangyan Li,

Recently, targeting metabolic reprogramming has emerged as a potential therapeutic approach for fighting cancer. Sterol regulatory element binding protein-2 (SREBP-2), a basic helix-loop-helix leucine zipper transcription factor, mainly regulates genes involved in cholesterol biosynthesis and homeostasis. SREBP-2 binds to the sterol regulatory elements (SREs) in the promoters of its target ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1510]

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RB1 Germline Variant Predisposing to a Rare Ovarian Germ Cell Tumor: A Case Report.

Elisa Gelli, Chiara Fallerini, Floriana Valentino, Annarita Giliberti, Francesca Castiglione, Lucrezia Laschi, Maria Palmieri, Alessandra Fabbiani, Rossella Tita, Maria Antonietta Mencarelli, Alessandra Renieri, Francesca Ariani,

Malignant ovarian germ cell tumors (MOGCTs) are neoplasms of the ovary, of which, due to their rarity and heterogeneity, few is reported about genetic background and development. Here, we report a 18-years old patient diagnosed with an ovarian mixed germ cell tumor, without any previous history of malignancies, who has ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1467]

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Immune Cells Combined With NLRP3 Inflammasome Inhibitor Exert Better Antitumor Effect on Pancreatic Ductal Adenocarcinoma.

Hailiang Liu, Yong Xu, Kai Liang, Rong Liu,

Pancreatic cancer is among the most aggressive malignancies associated with chronic inflammation. Moreover, cellular immunity can be inhibited by inflammation induced by nucleotide-binding domain, leucine-rich family, pyrin-containing 3 (NLRP3) inflammasome. Accordingly, NLRP3 inhibition combining cytokine-induced killer (CIK) cells may improve antitumor efficacy. 3,4-Methylenedioxy-β-nitrostyrene (MNS) was selected as a specific NLRP3 ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1378]

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p53 Affects PGC1α Stability Through AKT/GSK-3β to Enhance Cisplatin Sensitivity in Non-Small Cell Lung Cancer.

Xinyue Deng, Yang Li, Shuang Gu, Yingying Chen, Bingbing Yu, Jing Su, Liankun Sun, Yanan Liu,

Drug resistance greatly limits the therapeutic efficacy of treatment of non-small cell lung cancer (NSCLC). One of the important factors is the dysfunction of tumor suppressor p53. Recent studies have suggested that p53 suppresses tumors by regulating number of mitochondrial proteins, including peroxisome proliferator-activated receptor coactivator (PGC1α). Although several studies ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1252]

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Matrix Metallopeptidase 14: A Candidate Prognostic Biomarker for Diffuse Large B-Cell Lymphoma.

Chengliang Yin, Junyan Zhang, Ming Shen, Zhenyang Gu, Yan Li, Wanguo Xue, Jinlong Shi, Wenrong Huang,

Background:Matrix metallopeptidase 14 (MMP14) is an important gene in the regulation of T-cell function. However, the correlation between MMP14 expression, prognosis, and immune cell infiltration in diffuse large B-cell lymphoma (DLBCL) remains unclear. Methods:We investigated the influence of MMP14 on clinical prognosis using data obtained from three Gene Expression Omnibus ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1520]

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Impact of Radiation Dose on Survival for Esophageal Squamous Cell Carcinoma Treated With Neoadjuvant Chemoradiotherapy.

Yang Yang, Xiaofang Xu, Xia Zhou, Wuan Bao, Danhong Zhang, Feiying Gu, Xianghui Du, Qixun Chen, Guoqin Qiu,

Purpose: Radiation dose used in the neoadjuvant chemoradiotherapy (NCRT) for patients with locally advanced esophageal squamous cell carcinoma (ESCC) varies in different trials and clinical practice. Methods and Materials: Data from patients diagnosed with ESCC receiving NCRT followed by esophagectomy were retrospectively collected from February 2013 to December 2017. Lower ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1431]

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Radiomics Analysis of Multiparametric MRI for the Preoperative Prediction of Lymph Node Metastasis in Cervical Cancer.

Lina Hou, Wei Zhou, Jialiang Ren, Xiaosong Du, Lei Xin, Xin Zhao, Yanfen Cui, Ruiping Zhang,

Objective: To develop and validate a radiomics predictive model based on multiparameter MR imaging features and clinical features to predict lymph node metastasis (LNM) in patients with cervical cancer. Material and Methods: A total of 168 consecutive patients with cervical cancer from two centers were enrolled in our retrospective study. ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1393]

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Co-incidence of Human Papillomaviruses and Epstein-Barr Virus Is Associated With High to Intermediate Tumor Grade in Human Head and Neck Cancer in Syria.

Ishita Gupta, Lina Ghabreau, Hamda Al-Thawadi, Amber Yasmeen, Semir Vranic, Ala-Eddin Al Moustafa, Mohammed I Malki,

High-risk human papillomaviruses (high-risk HPVs) have been recently reported to be co-present with Epstein-Barr virus (EBV) in different types of human cancers including head and neck (HN), where they can cooperate in the initiation and/or progression of this cancer. Accordingly, we herein explored the prevalence of high-risk HPVs and EBV ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1016]

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Mutational Landscape of Esophageal Squamous Cell Carcinoma in an Indian Cohort.

Kiran K Mangalaparthi, Krishna Patel, Aafaque A Khan, Malini Manoharan, Coral Karunakaran, Sakthivel Murugan, Ravi Gupta, Rohit Gupta, Arati Khanna-Gupta, Amitabha Chaudhuri, Prashant Kumar, Bipin Nair, Rekha V Kumar, T S Keshava Prasad, Aditi Chatterjee, Akhilesh Pandey, Harsha Gowda,

Esophageal squamous cell carcinoma (ESCC) is the most common histological subtype of esophageal cancer in India. Cigarette smoking and chewing tobacco are known risk factors associated with ESCC. However, genomic alterations associated with ESCC in India are not well-characterized. In this study, we carried out exome sequencing to characterize the ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1457]

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Long Non-Coding RNA Profile Study Identifies an Immune-Related lncRNA Prognostic Signature for Kidney Renal Clear Cell Carcinoma.

Zhuolun Sun, Changying Jing, Chutian Xiao, Tengcheng Li,

Kidney renal clear cell carcinoma (KIRC) is the predominant pathological subtype of renal cell carcinoma (RCC) in adults. Long non-coding RNAs (lncRNAs) are an important class of gene expression regulators and serve fundamental roles in immune regulation. The intent of this study is to develop a novel immune-related lncRNA signature ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1430]

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SARS-CoV-2 Infection in Cancer Patients: A Picture of an Italian Onco-Covid Unit.

Maria Lucia Reale, Paolo Bironzo, Valentina Bertaglia, Erica Palesandro, Gianmarco Leone, Fabrizio Tabbò, Maristella Bungaro, Marco Audisio, Annapaola Mariniello, Simonetta G Rapetti, Rosario F Di Stefano, Elisa Artusio, Enrica Capelletto, Paola Sperone, Adriana Boccuzzi, Marco Calandri, Alberto Perboni, Umberto Malapelle, Francesco Passiglia, Silvia Novello,

Background: The world, and Italy on the front lines, has experienced a major medical emergency due to the novel coronavirus outbreak. Cancer patients are one of the potentially most vulnerable cohorts of people, but data about their management are still few. Patients and Methods: In this monocentric retrospective study we ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1722]

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Chronic Stress Promotes Cancer Development.

Shirui Dai, Yongzhen Mo, Yumin Wang, Bo Xiang, Qianjin Liao, Ming Zhou, Xiaoling Li, Yong Li, Wei Xiong, Guiyuan Li, Can Guo, Zhaoyang Zeng,

Stress is an inevitable part of life. Chronic stress on account of reasons like adversity, depression, anxiety, or loneliness/social isolation can endanger human health. Recent studies have shown that chronic stress can induce tumorigenesis and promote cancer development. This review describes the latest progress of research on the molecular mechanisms ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1492]

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