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Retraction: RBFOX3 Promotes Gastric Cancer Growth and Progression by Activating HTERT Signaling.

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[This retracts the article DOI: 10.3389/fonc.2020.01044.]. ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:738970]

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Carotenoid-Enriched Fractions From Spondias mombin Demonstrate HER2 ATP Kinase Domain Inhibition: Computational and In Vivo Animal Model of Breast Carcinoma Studies.

Damilohun Samuel Metibemu, Oluseyi Adeboye Akinloye, Idowu Olaposi Omotuyi, Jude Ogechukwu Okoye, Mustapha Ayodele Popoola, Adio Jamiu Akamo,

Human epidermal growth factor 2 (HER2) is overexpressed in about 20% of breast cancer and is associated with a poor prognosis. We report in this study that carotenoid-enriched fractions from <i>Spondias mombin</i> demonstrate HER2 ATP kinase domain inhibition. HER2 breast carcinoma was modeled in female Wistar rats and authenticated <i>via</i> ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:687190]

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Inhibition of MIR4435-2HG on Invasion, Migration, and EMT of Gastric Carcinoma Cells by Mediating MiR-138-5p/Sox4 Axis.

Li-Fei Gao, Wei Li, Ya-Gang Liu, Cui Zhang, Wei-Na Gao, Liang Wang,

<h4>Background</h4>The previous investigations have identified that long non-coding RNA (lncRNAs) act as crucial regulators in gastric carcinoma. However, the function of lncRNA MIR4435-2HG in the modulation of gastric carcinoma remains elusive. Here, we aimed to explore the role of MIR4435-2HG in gastric carcinoma.<h4>Method</h4>The Cancer Genome Atlas (TCGA) and Gene Expression ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:661288]

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Non-Small Cell Lung Cancer: Challenge and Improvement of Immune Drug Resistance.

Fanming Kong, Ziwei Wang, Dongying Liao, Jinhui Zuo, Hongxia Xie, Xiaojiang Li, Yingjie Jia,

Lung cancer is the leading cause of cancer deaths in the world. At present, immunotherapy has made a great breakthrough in lung cancer treatment. A variety of immune checkpoint inhibitors have been applied into clinical practice, including antibodies targeting the programmed cell death-1, programmed cell death-ligand 1, and cytotoxic T-lymphocyte ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:739191]

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Polymorphism of MUC1 Gene in Vietnamese Gastric Cancer Patients: A Multicenter Case-Control Study.

Ngoc-Lan Thi Nguyen, Ngoc-Dzung Thi Dang, Quang-Huy Dang, Van-Chuc Tran, Hoang-Long Vo, Masamitsu Yamaguchi, Thanh-Van Ta,

<h4>Background</h4>A few studies revealed that the polymorphisms of <i>Mucin 1</i> gene have a role and significance as a susceptible factor contributing to gastric cancer. To better understand the roles of two <i>MUC1</i> genotype polymorphisms of rs4072037 and rs2070803 in the development of gastric cancer in Vietnamese population, a multicenter, large-sample, ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:694977]

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miR-9-5p Mediates ABCC1 to Elevate the Sensitivity of Glioma Cells to Temozolomide.

Xiang-Rui Chen, Yan-Guo Zhang, Qiang Wang,

Chemotherapy combined with surgery is an important clinical treatment for glioma, but endogenous or acquired temozolomide (TMZ) resistance can lead to poor prognosis. microRNA (miR)-9-5p acts in biological function of glioma, but the drug resistance of miR-9-5p in glioma is under exploration. The study intended to test the molecular mechanism ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:661653]

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A Co-Expression Network Reveals the Potential Regulatory Mechanism of lncRNAs in Relapsed Hepatocellular Carcinoma.

Yuan Fang, Yang Yang, XiaoLi Zhang, Na Li, Bo Yuan, Li Jin, Sheng Bao, MengGe Li, Dan Zhao, LingRui Li, Zhong Zeng, HanFei Huang,

<h4>Background</h4>The mechanistic basis for relapsed hepatocellular carcinoma (HCC) remains poorly understood. Recent research has highlighted the important roles of long non-coding RNAs (lncRNAs) in HCC. However, there are only a few studies on the association between lncRNAs and HCC relapse.<h4>Methods</h4>Differentially expressed lncRNAs and mRNAs between a primary HCC group and ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:745166]

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MiR-199b-5p Promotes Gastric Cancer Progression by Regulating HHIP Expression.

Songda Chen, Huijie Wu, Lingyu Zhu, Mengjie Jiang, Shuli Wei, Jinhua Luo, Aiqun Liu,

<h4>Objectives</h4>Gastric cancer (GC) is one of the most common malignant tumors. More and more evidences support the role of microRNAs (miRNAs) in tumor progression. However, the role of miRNAs in human GC remains largely unknown.<h4>Methods</h4>Based on the published gastric cancer expression profile data, combined with bioinformatics analysis, potential miRNAs in ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:728393]

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Immune Modulatory Short Noncoding RNAs Targeting the Glioblastoma Microenvironment.

Jun Wei, Eli Gilboa, George A Calin, Amy B Heimberger,

Glioblastomas are heterogeneous and have a poor prognosis. Glioblastoma cells interact with their neighbors to form a tumor-permissive and immunosuppressive microenvironment. Short noncoding RNAs are relevant mediators of the dynamic crosstalk among cancer, stromal, and immune cells in establishing the glioblastoma microenvironment. In addition to the ease of combinatorial strategies ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:682129]

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Comprehensive Analysis of E2F Family Members in Human Gastric Cancer.

Shengbo Li, Xiaofan Yang, Wenqing Li, Zhenbing Chen,

Gastric cancer (GC) is the second most common cancer and the third most frequent cause of cancer-related deaths in China. E2Fs are a family of transcription factors reported to be involved in the tumor progression of various cancer types; however, the roles of individual E2Fs are still not known exactly ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:625257]

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Small Extracellular Vesicles in the Development, Diagnosis, and Possible Therapeutic Application of Esophageal Squamous Cell Carcinoma.

Zheng Zhao, Shuyue Yang, Anni Zhou, Xiao Li, Rui Fang, Shutian Zhang, Guiping Zhao, Peng Li,

Esophageal squamous cell carcinoma (ESCC) persists among the most lethal and broad-spreading malignancies in China. The exosome is a kind of extracellular vesicle (EV) from about 30 to 200 nm in diameter, contributing to the transfer of specific functional molecules, such as metabolites, proteins, lipids, and nucleic acids. The paramount ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:732702]

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Validating HMMR Expression and Its Prognostic Significance in Lung Adenocarcinoma Based on Data Mining and Bioinformatics Methods.

Xia Li, Haiwei Zuo, Li Zhang, Qiuwen Sun, Yong Xin, Longzhen Zhang,

Hyaluronic acid-mediated motility receptor (<i>HMMR</i>), a tumor-related gene, plays a vital role in the occurrence and progression of various cancers. This research is aimed to reveal the effect of <i>HMMR</i> in lung adenocarcinoma (LUAD). We first obtained the gene expression profiles and clinical data of patients with LUAD from The ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:720302]

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CXCL9 Is a Potential Biomarker of Immune Infiltration Associated With Favorable Prognosis in ER-Negative Breast Cancer.

Yuan-Ke Liang, Ze-Kun- Deng, Mu-Tong Chen, Si-Qi Qiu, Ying-Sheng Xiao, Yu-Zhu Qi, Qin Xie, Zheng-Hao Wang, Shi-Cheng Jia, De Zeng, Hao-Yu Lin,

The chemokine CXCL9 (C-X-C motif chemokine ligand 9) has been reported to be required for antitumour immune responses following immune checkpoint blockade. In this study, we sought to investigate the potential value of CXCL9 according to immune responses in patients with breast cancer (BC). A variety of open-source databases and ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:710286]

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Case Report and Literature Review: Primary Pulmonary NUT-Midline Carcinoma.

Yunxiang Zhang, Kai Han, Xiaotong Dong, Qian Hou, Tianbao Li, Li Li, Gengyin Zhou, Xia Liu, Guifeng Zhao, Wei Li,

Nuclear protein of the testis (NUT) carcinoma is a very rare and aggressive carcinoma characterized by chromosomal rearrangement. NUT-midline carcinoma (NMC) can occur anywhere in the body, but most of the tumors are found in the midline anatomic structure or mediastinum. Pulmonary-originated NMC is extremely rare and often difficult to ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:700781]

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RNA Sequencing for Personalized Treatment of Metastatic Leiomyosarcoma: Case Report.

Alexander Seryakov, Zaynab Magomedova, Maria Suntsova, Anastasia Prokofieva, Elizaveta Rabushko, Alexander Glusker, Lyudmila Makovskaia, Marianna Zolotovskaia, Anton Buzdin, Maxim Sorokin,

Uterine leiomyosarcoma (UL) is a rare malignant tumor that develops from the uterine smooth muscle tissue. Due to the low frequency and lack of sufficient data from clinical trials there is currently no effective treatment that is routinely accepted for UL. Here we report a case of a 65-years-old female ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:666001]

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An Integrated Radiomics Model Incorporating Diffusion-Weighted Imaging and 18F-FDG PET Imaging Improves the Performance of Differentiating Glioblastoma From Solitary Brain Metastases.

Liqiang Zhang, Rui Yao, Jueni Gao, Duo Tan, Xinyi Yang, Ming Wen, Jie Wang, Xiangxian Xie, Ruikun Liao, Yao Tang, Shanxiong Chen, Yongmei Li,

<h4>Background</h4>The effectiveness of conventional MRI (cMRI)-based radiomics in differentiating glioblastoma (GBM) from solitary brain metastases (SBM) is not satisfactory enough. Therefore, we aimed to develop an integrated radiomics model to improve the performance of differentiating GBM from SBM.<h4>Methods</h4>One hundred patients with solitary brain tumors (50 with GBM, 50 with SBM) ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:732704]

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The Oncogenic Role of APC/C Activator Protein Cdc20 by an Integrated Pan-Cancer Analysis in Human Tumors.

Fei Wu, Yang Sun, Jie Chen, Hongyun Li, Kang Yao, Yongjun Liu, Qingyong Liu, Jiaju Lu,

The landscape of <i>CDC20</i> gene expression and its biological impacts across different types of cancers remains largely unknown. Here, a pan-cancer analysis was performed to analyze the role of Cdc20 in various human cancers. Our results indicated that the expression levels of the <i>CDC20</i> gene were significantly elevated in bladder ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:721797]

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Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and Prospects.

Cuicui Lu, Duncan Wei, Yahui Zhang, Peng Wang, Wen Zhang,

Breast cancer is the most common malignancy among women worldwide, excluding non-melanoma skin cancer. It is now well understood that breast cancer is a heterogeneous entity that exhibits distinctive histological and biological features, treatment responses and prognostic patterns. Therefore, the identification of novel ideal diagnostic and prognostic biomarkers is of ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:710538]

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Comparison of Multiple Clinical Testing Modalities for Assessment of NPM1-Mutant AML.

Amanda Lopez, Sanjay Patel, Julia T Geyer, Joelle Racchumi, Amy Chadburn, Paul Simonson, Madhu M Ouseph, Giorgio Inghirami, Nuria Mencia-Trinchant, Monica L Guzman, Alexandra Gomez-Arteaga, Sangmin Lee, Pinkal Desai, Ellen K Ritchie, Gail J Roboz, Wayne Tam, Michael J Kluk,

<h4>Background</h4><i>NPM1</i> mutation status can influence prognosis and management in AML. Accordingly, clinical testing (i.e., RT-PCR, NGS and IHC) for mutant <i>NPM1</i> is increasing in order to detect residual disease in AML, alongside flow cytometry (FC). However, the relationship of the results from RT-PCR to traditional NGS, IHC and FC is ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:701318]

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Spatiotemporal Patterns of Loco-Regional Recurrence After Breast-Conserving Surgery.

Fei-Lin Qu, Rui Mao, Zhe-Bin Liu, Cai-Jin Lin, A-Yong Cao, Jiong Wu, Guang-Yu Liu, Ke-Da Yu, Gen-Hong Di, Jun-Jie Li, Zhi-Ming Shao,

<h4>Background</h4>Loco-regional recurrences (LRR) following breast-conserving surgery (BCS) remain a heterogeneous class of disease that has significant variation in its biological behavior and prognosis.<h4>Methods</h4>To delineate the spatiotemporal patterns of LRR after BCS, we analyzed the data of 4325 patients treated with BCS from 2006 to 2016. Clinico-pathological and treatment specific factors ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:690658]

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Corrigendum: TFEB Promotes Prostate Cancer Progression via Regulating ABCA2-Dependent Lysosomal Biogenesis.

Xuejin Zhu, Yangjia Zhuo, Shulin Wu, Yanfei Chen, Jianheng Ye, Yulin Deng, Yuanfa Feng, Ren Liu, Shanghua Cai, Zhihao Zou, Bin Wang, Chin-Lee Wu, Guohua Zeng, Weide Zhong,

[This corrects the article DOI: 10.3389/fonc.2021.632524.]. ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:750277]

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Development and Validation of an Esophageal Squamous Cell Carcinoma Risk Prediction Model for Rural Chinese: Multicenter Cohort Study.

Junming Han, Lijie Wang, Huan Zhang, Siqi Ma, Yan Li, Zhongli Wang, Gaopei Zhu, Deli Zhao, Jialin Wang, Fuzhong Xue,

<h4>Background</h4>There are rare prediction models for esophageal squamous cell carcinoma (ESCC) for rural Chinese population. We aimed to develop and validate a prediction model for ESCC based on a cohort study for the population.<h4>Methods</h4>Data of 115,686 participants were collected from esophageal cancer (EC) early diagnosis and treatment of cancer program ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:729471]

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Diagnostic Value of Delayed PET/MR in Liver Metastasis in Comparison With PET/CT.

Nina Zhou, Xiangxi Meng, Yan Zhang, Boqi Yu, Jianmin Yuan, Jiangyuan Yu, Hua Zhu, Zhi Yang,

<h4>Objectives</h4>The aim of this study was to evaluate the value of a delayed positron emission tomography/magnetic resonance (PET/MR) scan relative to a single positron emission tomography/computed tomography (PET/CT) scan for liver metastasis detection.<h4>Methods</h4>In this study, 70 patients with solid malignancies and suspicious liver lesions undergoing 2-deoxy-2-[<sup>18</sup>F]fluoro-<i>D</i>-glucose [(<sup>18</sup>F)FDG] PET/CT and subsequent ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:717687]

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Use of F-18 FDG PET/CT Through Delayed Diuretic Imaging for Preoperative Evaluation of Upper Urinary Tract-Occupying Lesions.

Jun Wang, Liang Zhang, Jian Guo Wu, Ruohua Chen, Jia Lin Shen,

<h4>Purpose</h4>To evaluate the value of F-18 FDG PET/CT in the differentiation of malignant and benign upper urinary tract-occupying lesions.<h4>Patients and methods</h4>64 patients with upper urinary tract-occupying lesions underwent F-18 FDG PET/CT at RenJi Hospital from January 2015 to February 2019 in this retrospective study. Of the 64 patients, 50 patients ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:699801]

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Pulmonary Neuroendocrine Neoplasms Overexpressing Epithelial-Mesenchymal Transition Mechanical Barriers Genes Lack Immune-Suppressive Response and Present an Increased Risk of Metastasis.

Tabatha Gutierrez Prieto, Camila Machado Baldavira, Juliana Machado-Rugolo, Cecília Farhat, Eloisa Helena Ribeiro Olivieri, Vanessa Karen de Sá, Eduardo Caetano Abilio da Silva, Marcelo Luiz Balancin, Alexandre Muxfeldt Ab Saber, Teresa Yae Takagaki, Vladmir Cláudio Cordeiro de Lima, Vera Luiza Capelozzi,

Typical carcinoids (TC), atypical carcinoids (AC), large cell neuroendocrine carcinomas (LCNEC), and small cell lung carcinomas (SCLC) encompass a bimodal spectrum of metastatic tumors with morphological, histological and histogenesis differences, The hierarchical structure reveals high cohesiveness between neoplastic cells by mechanical desmosomes barrier assembly in carcinoid tumors and LCNEC, while ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:645623]

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