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Corrigendum: Incidence and Prognostic Significance of PD-L1 Expression in High-Grade Salivary Gland Carcinoma.

Qigen Fang, Yao Wu, Wei Du, Xu Zhang, Defeng Chen,

[This corrects the article DOI: 10.3389/fonc.2021.701181.]. ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:836903]

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Rectraction: miRNA-193a-3p Regulates the AKT2 Pathway to Inhibit the Growth and Promote the Apoptosis of Glioma Cells by Targeting ALKBH5.

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[This retracts the article DOI: 10.3389/fonc.2021.600451.]. ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:840650]

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Retraction: LncRNA DLX6-AS1 Promotes Malignant Phenotype and Lymph Node Metastasis in Prostate Cancer by Inducing LARGE Methylation.

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[This retracts the article DOI: 10.3389/fonc.2020.01172.]. ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:840152]

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Erratum: Metformin Downregulates PD-L1 Expression in Esophageal Squamous Cell Carcinoma by Inhibiting IL-6 Signaling Pathway.

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[This corrects the article DOI: 10.3389/fonc.2021.762523.]. ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:832786]

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Retraction: LINC00337 Regulates KLF5 and Maintains Stem-Cell Like Traits of Cervical Cancer Cells by Modulating miR-145.

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[This retracts the article DOI: 10.3389/fonc.2020.01433.]. ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:840051]

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Discriminative Localized Sparse Approximations for Mass Characterization in Mammograms.

Sokratis Makrogiannis, Keni Zheng, Chelsea Harris,

The most common form of cancer among women in both developed and developing countries is breast cancer. The early detection and diagnosis of this disease is significant because it may reduce the number of deaths caused by breast cancer and improve the quality of life of those effected. Computer-aided detection ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:725320]

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Retraction: lncRNA-XLOC_012370 Promotes the Development of Pancreatic Cancer and Inactivates the NF-κB Pathway Through miR-140-5p.

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[This retracts the article DOI: 10.3389/fonc.2020.620550.]. ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:841478]

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Retraction: MicroRNA-27 Inhibits Autophagy and Promotes Proliferation of Multiple Myeloma Cells by Targeting the NEDD4/Notch1 Axis.

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[This retracts the article DOI: 10.3389/fonc.2020.571914.]. ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:840086]

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Patient-Derived Organoids in Precision Medicine: Drug Screening, Organoid-on-a-Chip and Living Organoid Biobank.

Zilong Zhou, Lele Cong, Xianling Cong,

Organoids are <i>in vitro</i> self-assembling, organ-like, three-dimensional cellular structures that stably retain key characteristics of the respective organs. Organoids can be generated from healthy or pathological tissues derived from patients. Cancer organoid culture platforms have several advantages, including conservation of the cellular composition that captures the heterogeneity and pharmacotypic signatures ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:762184]

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Retraction: Exosomal MicroRNA-221-3p Confers Adriamycin Resistance in Breast Cancer Cells by Targeting PIK3R1.

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[This retracts the article DOI: 10.3389/fonc.2020.00441.]. ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:839904]

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Glycosylation Changes in Prostate Cancer Progression.

William Butler, Jiaoti Huang,

Prostate Cancer (PCa) is the most commonly diagnosed malignancy and second leading cause of cancer-related mortality in men. With the use of next generation sequencing and proteomic platforms, new biomarkers are constantly being developed to both improve diagnostic sensitivity and specificity and help stratify patients into different risk groups for ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:809170]

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A Postsurgical Prognostic Nomogram for Locally Advanced Rectosigmoid Cancer to Assist in Patient Selection for Adjuvant Chemotherapy.

Chao Zhang, Shutao Zhao, Xudong Wang,

<h4>Background</h4>The perioperative treatment model for locally advanced rectosigmoid junction cancer (LARSC) has not been finalized; whether this model should refer to the treatment model for rectal cancer remains controversial.<h4>Methods</h4>We screened 10,188 patients with stage II/III rectosigmoid junction adenocarcinoma who underwent surgery between 2004 and 2016 from the National Cancer Institute ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:772482]

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Case Report: Tumor Microenvironment Characteristics in a Patient With HER2 Mutant Lung Squamous Cell Carcinoma Harboring High PD-L1 Expression Who Presented Hyperprogressive Disease.

Lixia Xia, Yinghui Yu, Fen Lan, Junrong Yan, Jinfan Li, Wen Li, Yang Xia,

<h4>Background</h4>High PD-L1 expression in non-small cell lung cancer (NSCLC) is evident to predict elevated immunotherapy efficacy, to which NSCLC with onco-driver gene mutations is probed with poor responsiveness. Thus, it is of great interest to investigate how effective immune monotherapy is in the presence of concurrent high PD-L1 expression and ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:760703]

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Retraction: Downregulation of hsa_circ_0001836 Induces Pyroptosis Cell Death in Glioma Cells via Epigenetically Upregulating NLRP1.

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[This retracts the article DOI: 10.3389/fonc.2021.622727.]. ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:840877]

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CDKN2A Deletion Leading to Hematogenous Metastasis of Human Gastric Carcinoma.

Juanli Qiao, Yuan Tian, Xiaojing Cheng, Zhaojun Liu, Jing Zhou, Liankun Gu, Baozhen Zhang, Lianhai Zhang, Jiafu Ji, Rui Xing, Dajun Deng,

<h4>Introduction</h4>Somatic copy number deletion (SCND) of <i>CDKN2A</i> gene is the most frequent event in cancer genomes. Whether <i>CDKN2A</i> SCND drives human cancer metastasis is far from clear. Hematogenous metastasis is the main reason of human gastric carcinoma (GC) death. Thus, prediction GC metastasis is eagerly awaited.<h4>Method</h4>GC patients (<i>n</i>=408) enrolled in ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:801219]

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Nomograms Combining Ultrasonic Features With Clinical and Pathological Features for Estimation of Delphian Lymph Node Metastasis Risk in Papillary Thyroid Carcinoma.

Qi Qi, Pan Xu, Cheng Zhang, Suping Guo, Xingzhi Huang, Songli Chen, Yaohui Li, Aiyun Zhou,

<h4>Background</h4>This work explores the clinical significance of Delphian lymph nodes (DLN) in thyroid papillary carcinoma (PTC). At the same time, a nomogram is constructed based on clinical, pathological, and ultrasonic (US) features to evaluate the possibility of DLN metastasis (DLNM) in PTC patients. This is the first study to predict ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:792347]

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The Application of Artificial Intelligence and Machine Learning in Pituitary Adenomas.

Congxin Dai, Bowen Sun, Renzhi Wang, Jun Kang,

Pituitary adenomas (PAs) are a group of tumors with complex and heterogeneous clinical manifestations. Early accurate diagnosis, individualized management, and precise prediction of the treatment response and prognosis of patients with PA are urgently needed. Artificial intelligence (AI) and machine learning (ML) have garnered increasing attention to quantitatively analyze complex ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:784819]

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Pancreatic Serous Cystic Neoplasms and Mucinous Cystic Neoplasms: Differential Diagnosis by Combining Imaging Features and Enhanced CT Texture Analysis.

Hai-Yan Chen, Xue-Ying Deng, Yao Pan, Jie-Yu Chen, Yun-Ying Liu, Wu-Jie Chen, Hong Yang, Yao Zheng, Yong-Bo Yang, Cheng Liu, Guo-Liang Shao, Ri-Sheng Yu,

<h4>Objective</h4>To establish a diagnostic model by combining imaging features with enhanced CT texture analysis to differentiate pancreatic serous cystadenomas (SCNs) from pancreatic mucinous cystadenomas (MCNs).<h4>Materials and methods</h4>Fifty-seven and 43 patients with pathology-confirmed SCNs and MCNs, respectively, from one center were analyzed and divided into a training cohort (n = 72) ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:745001]

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Alterations in Intestinal Microbiota Composition in Mice Treated With Vitamin D3 or Cathelicidin.

Yu Jiang, Yue Wan, Jing Li, Yueshui Zhao, Yongshun Ma, Jing Yu, Donghong Yuan, Shixin Xiang, Fukuan Du, Xu Wu, Mingxing Li, Yu Chen, Zhangang Xiao, Qinglian Wen, Wei Hu, Jing Shen,

Gut microbiota is a complex aggregation of microbial organisms, which offers diverse protective benefits to the host. Dysbiosis of intestinal microbiota is frequently associated with many diseases. Vitamin D3 (VD), which was originally associated with bone health, also possesses antimicrobial activities and can act through antimicrobial peptide. Cathelicidin is a ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:700038]

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Evaluation of Serum miR-17-92 Cluster as Noninvasive Biomarkers for Bladder Cancer Diagnosis.

Jingyao Wang, Xiqi Peng, Rongkang Li, Kaihao Liu, Chunduo Zhang, Xuan Chen, Guocheng Huang, Liwen Zhao, Zebo Chen, Yongqing Lai,

Previous studies have shown that the miR-17-92 cluster is involved in the occurrence and development of bladder cancer. However, the role of serum miR-17-92 cluster in the diagnosis of bladder cancer has not been studied. In the present study, we evaluated the expression of miR-17-92 cluster members in bladder cancer ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:795837]

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Case Report: Combination of Olaparib With Chemotherapy in a Patient With ATM-Deficient Colorectal Cancer.

Georgios I Papageorgiou, Evangelos Fergadis, Nikos Skouteris, Evridiki Christakos, Sergios A Tsakatikas, Evangelos Lianos, Christos Kosmas,

Poly-ADP ribose polymerase (PARP) inhibitors are constantly increasing in their indications for use as anti-cancer treatment in various neoplasms, the majority of which are linked with BRCA deficiency. Preclinical data support the investigation of PARP inhibitors in other neoplasms exhibiting "BRCAness" or homologous recombination deficiency (HRD) as monotherapy as well ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:788809]

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Importance of Normalization of Carbohydrate Antigen 19-9 in Patients With Intrahepatic Cholangiocarcinoma.

Hui Li, Yuan Feng, Chang Liu, Jiawang Li, Jiaxin Li, Hong Wu, Genshu Wang, Dewei Li,

<h4>Background</h4>Although carbohydrate antigen 19-9 (CA19-9) is an established prognostic marker for intrahepatic cholangiocarcinoma (ICC) patients, the significance of elevated preoperative CA19-9 that normalized after resection remains unknown. This study aimed to investigate whether elevated preoperative CA19-9 that normalized after curative resection had an impact on prognosis among patients with ICC.<h4>Methods</h4>Patients ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:780455]

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Clinical Complete Remission of An Advanced Gastric Adenocarcinoma After Camrelizumab Plus Chemotherapy Followed by Camrelizumab Plus Capecitabine: A Case Report.

Jieheng Lin, Jianying Yang, Wenping Wang, Xiaotong Lin, Yang Cao,

We report a rare case of PDL1-negative advanced gastric adenocarcinoma that improved significantly after camrelizumab plus chemotherapy followed by camrelizumab plus capecitabine as first-line therapy. A 65-year-old woman was diagnosed with a gastric adenocarcinoma in 2017 <i>via</i> contrast-enhanced computed tomography (CT) and endoscopic biopsy. She stabilised after preoperative neoadjuvant chemotherapy, ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:775147]

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The Relationship Between Body Mass Index and Different Regional Patterns of Lymph Node Involvement in Papillary Thyroid Cancers.

Changlin Li, Gianlorenzo Dionigi, Nan Liang, Haixia Guan, Hui Sun,

<h4>Introduction</h4>Lymph node (LN) metastasis is the first site of metastasis of papillary thyroid cancer (PTC). LN status influences clinical management and the prognosis of patients. We explored the relationship between patient obesity and regional patterns of LN involvement in PTC.<h4>Materials and methods</h4>This study retrospectively analyzed the data from 12,772 PTC ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:767245]

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Adipose-Derived Stem Cells Facilitate Ovarian Tumor Growth and Metastasis by Promoting Epithelial to Mesenchymal Transition Through Activating the TGF-β Pathway.

Xiaowu Liu, Guannan Zhao, Xueyun Huo, Yaohong Wang, Gabor Tigyi, Bing-Mei Zhu, Junming Yue, Wenjing Zhang,

Adipose-derived stem cells (ADSC) are multipotent mesenchymal stem cells derived from adipose tissues and are capable of differentiating into multiple cell types in the tumor microenvironment (TME). The roles of ADSC in ovarian cancer (OC) metastasis are still not well defined. To understand whether ADSC contributes to ovarian tumor metastasis, ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:756011]

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