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Journal Front Mol Neurosci

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Period 2: A Regulator of Multiple Tissue-Specific Circadian Functions.

Gennaro Ruggiero, Zohar Ben-Moshe Livne, Yair Wexler, Nathalie Geyer, Daniela Vallone, Yoav Gothilf, Nicholas S Foulkes,

The zebrafish represents a powerful model for exploring how light regulates the circadian clock due to the direct light sensitivity of its peripheral clocks, a property that is retained even in organ cultures as well as zebrafish-derived cell lines. Light-inducible expression of the <i>per2</i> clock gene has been predicted to ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:718387]

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Pharmacological Rescue of the Brain Cortex Phenotype of Tbx1 Mouse Mutants: Significance for 22q11.2 Deletion Syndrome.

Ilaria Favicchia, Gemma Flore, Sara Cioffi, Gabriella Lania, Antonio Baldini, Elizabeth Illingworth,

<h4>Objectives</h4><i>Tbx1</i> mutant mice are a widely used model of 22q11.2 deletion syndrome (22q11.2DS) because they manifest a broad spectrum of physical and behavioral abnormalities that is similar to that found in 22q11.2DS patients. In <i>Tbx1</i> mutants, brain abnormalities include changes in cortical cytoarchitecture, hypothesized to be caused by the precocious ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:663598]

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Activation of Rac1 Has an Opposing Effect on Induction and Maintenance of Long-Term Potentiation in Hippocampus by Acting on Different Kinases.

Dongyang Cui, Xiaodong Jiang, Ming Chen, Huan Sheng, Da Shao, Li Yang, Xinli Guo, Yingqi Wang, Bin Lai, Ping Zheng,

Rac1 is a small GTPase of the Rho family. A previous study showed that the activation of Rac1 had an opposing effect on induction and maintenance of long-term potentiation (LTP) in the hippocampus. However, the molecular mechanism underlying this opposing effect remains to be addressed. In the present work, we ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:720371]

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L-Serine, an Endogenous Amino Acid, Is a Potential Neuroprotective Agent for Neurological Disease and Injury.

Lisha Ye, Yechao Sun, Zhenglin Jiang, Guohua Wang,

Central nervous system (CNS) lesions are major causes of human death and disability worldwide, and they cause different extents of motor and sensory dysfunction in patients. Thus, it is crucial to develop new effective neuroprotective drugs and approaches targeted to the heterogeneous nature of CNS injury and disease. L-serine is ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:726665]

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Development of Tinnitus and Hyperacusis in a Mouse Model of Tobramycin Cochleotoxicity.

Ryan J Longenecker, Rende Gu, Jennifer Homan, Jonathan Kil,

Aminoglycosides (AG) antibiotics are a common treatment for recurrent infections in cystic fibrosis (CF) patients. AGs are highly ototoxic, resulting in a range of auditory dysfunctions. It was recently shown that the acoustic startle reflex (ASR) can assess behavioral evidence of hyperacusis and tinnitus in an amikacin cochleotoxicity mouse model. ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:715952]

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Estrogen Receptor β as a Candidate Regulator of Sex Differences in the Maternal Immune Activation Model of ASD.

Madeline L Arnold, Kaoru Saijo,

Interestingly, more males are diagnosed with autism spectrum disorder (ASD) than females, yet the mechanism behind this difference is unclear. Genes on the sex chromosomes and differential regulation by sex steroid hormones and their receptors are both candidate mechanisms to explain this sex-dependent phenotype. Nuclear receptors (NRs) are a large ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:717411]

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Distinctive Regulation of Emotional Behaviors and Fear-Related Gene Expression Responses in Two Extended Amygdala Subnuclei With Similar Molecular Profiles.

Shuhei Ueda, Masahito Hosokawa, Koji Arikawa, Kiyofumi Takahashi, Mao Fujiwara, Manami Kakita, Taro Fukada, Hiroaki Koyama, Shin-Ichiro Horigane, Keiichi Itoi, Masaki Kakeyama, Hiroko Matsunaga, Haruko Takeyama, Haruhiko Bito, Sayaka Takemoto-Kimura,

The central nucleus of the amygdala (CeA) and the lateral division of the bed nucleus of the stria terminalis (BNST) are the two major nuclei of the central extended amygdala that plays essential roles in threat processing, responsible for emotional states such as fear and anxiety. While some studies suggested ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:741895]

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Ketone Bodies in the Brain Beyond Fuel Metabolism: From Excitability to Gene Expression and Cell Signaling.

Darío García-Rodríguez, Alfredo Giménez-Cassina,

Ketone bodies are metabolites that replace glucose as the main fuel of the brain in situations of glucose scarcity, including prolonged fasting, extenuating exercise, or pathological conditions such as diabetes. Beyond their role as an alternative fuel for the brain, the impact of ketone bodies on neuronal physiology has been ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:732120]

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HDAC6: A Key Link Between Mitochondria and Development of Peripheral Neuropathy.

Krystal English, Michelle Craig Barton,

Peripheral neuropathy, which is the result of nerve damage from lesions or disease, continues to be a major health concern due to the common manifestation of neuropathic pain. Most investigations into the development of peripheral neuropathy focus on key players such as voltage-gated ion channels or glutamate receptors. However, emerging ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:684714]

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Elevated Expression and Activity of Sodium Leak Channel Contributes to Neuronal Sensitization of Inflammatory Pain in Rats.

Jia Li, Yali Chen, Jin Liu, Donghang Zhang, Peng Liang, Peilin Lu, Jiefei Shen, Changhong Miao, Yunxia Zuo, Cheng Zhou,

Inflammatory pain encompasses many clinical symptoms, and there is no satisfactory therapeutic target. Neuronal hyperexcitability and/or sensitization of the primary nociceptive neurons in the dorsal root ganglion (DRG) and spinal dorsal horn are critical to the development and maintenance of inflammatory pain. The sodium leak channel (NALCN), a non-selective cation ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:723395]

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Plasma Lipolysis and Changes in Plasma and Cerebrospinal Fluid Signaling Lipids Reveal Abnormal Lipid Metabolism in Chronic Migraine.

Katherine Castor, Jessica Dawlaty, Xianghong Arakaki, Noah Gross, Yohannes W Woldeamanuel, Michael G Harrington, Robert P Cowan, Alfred N Fonteh,

<h4>Background</h4>Lipids are a primary storage form of energy and the source of inflammatory and pain signaling molecules, yet knowledge of their importance in chronic migraine (CM) pathology is incomplete. We aim to determine if plasma and cerebrospinal fluid (CSF) lipid metabolism are associated with CM pathology.<h4>Methods</h4>We obtained plasma and CSF ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:691733]

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Presenilin-1 Mutations Are a Cause of Primary Lateral Sclerosis-Like Syndrome.

Juan Francisco Vázquez-Costa, María Payá-Montes, Marina Martínez-Molina, Teresa Jaijo, Jazek Szymanski, Miguel Mazón, Pablo Sopena-Novales, , Jordi Pérez-Tur, Teresa Sevilla,

<h4>Background and purpose</h4>Primary lateral sclerosis (PLS) is a progressive upper motor neuron (UMN) disorder. It is debated whether PLS is part of the amyotrophic lateral sclerosis (ALS) spectrum, or a syndrome encompassing different neurodegenerative diseases. Recently, new diagnostic criteria for PLS have been proposed. We describe four patients of two ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:721047]

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Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons.

Ali Harb, Nils Vogel, Ali Shaib, Ute Becherer, Dieter Bruns, Ralf Mohrmann,

Different families of auxiliary subunits regulate the function and trafficking of native α<i>-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid</i> (AMPA) receptors in the central nervous system. While a facilitatory role of auxiliary subunits in ER export and forward trafficking of newly synthesized AMPA receptors is firmly established, it is unclear whether auxiliary subunits also control ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:728498]

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Dynamic Changes in the Levels of Amyloid-β42 Species in the Brain and Periphery of APP/PS1 Mice and Their Significance for Alzheimer's Disease.

Liding Zhang, Changwen Yang, Yanqing Li, Shiqi Niu, Xiaohan Liang, Zhihong Zhang, Qingming Luo, Haiming Luo,

Although amyloid-β<sub>42</sub> (Aβ<sub>42</sub>) has been used as one of the core biomarkers for Alzheimer's disease (AD) diagnosis, the dynamic changes of its different forms in the brain, blood, and even intestines and its correlation with the progression of AD disease remain obscure. Herein, we screened Aβ<sub>42</sub>-specific preferred antibody pairs 1F12/1F12 ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:723317]

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Novel Therapies for Parkinsonian Syndromes-Recent Progress and Future Perspectives.

Dominika Przewodowska, Weronika Marzec, Natalia Madetko,

<b>Background:</b> Atypical parkinsonian syndromes are rare, fatal neurodegenerative diseases associated with abnormal protein accumulation in the brain. Examples of these syndromes include progressive supranuclear palsy, multiple system atrophy, and corticobasal degeneration. A common clinical feature in parkinsonism is a limited improvement with levodopa. So far, there are no disease-modifying treatments ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:720220]

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Physical Exercise Modulates Brain Physiology Through a Network of Long- and Short-Range Cellular Interactions.

Alan Consorti, Irene Di Marco, Gabriele Sansevero,

In the last decades, the effects of sedentary lifestyles have emerged as a critical aspect of modern society. Interestingly, recent evidence demonstrated that physical exercise plays an important role not only in maintaining peripheral health but also in the regulation of central nervous system function. Many studies have shown that ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:710303]

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Application of Trio-Whole Exome Sequencing in Genetic Diagnosis and Therapy in Chinese Children With Epilepsy.

Tiejia Jiang, Jia Gao, Lihua Jiang, Lu Xu, Congying Zhao, Xiaojun Su, Yaping Shen, Weiyue Gu, Xiaohong Kong, Ying Yang, Feng Gao,

Epilepsy is one of the most common neurological disorders in pediatric patients with other underlying neurological defects. Identifying the underlying etiology is crucial for better management of the disorder. We performed trio-whole exome sequencing in 221 pediatric patients with epilepsy. Probands were divided into seizures with developmental delay/intellectual disability (DD/ID) ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:699574]

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Potential Therapeutic Role of HDAC Inhibitors in FUS-ALS.

Clara Tejido, Donya Pakravan, Ludo Van Den Bosch,

Mutations in the <i>FUS</i> gene cause amyotrophic lateral sclerosis (ALS-FUS). However, the exact pathogenic mechanism of mutant fused in sarcoma (FUS) protein is not completely understood. FUS is an RNA binding protein (RBP) localized predominantly in the nucleus, but ALS-linked FUS mutations can affect its nuclear localization signal impairing its ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:686995]

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Miro1 Impairment in a Parkinson's At-Risk Cohort.

David Nguyen, Vinita Bharat, Devon M Conradson, Pawan Nandakishore, Xinnan Wang,

There is a lack of reliable molecular markers for Parkinson's disease (PD) patients and at-risk individuals. The detection of the pre-symptomatic population of PD will empower more effective clinical intervention to delay or prevent disease onset. We have previously found that the mitochondrial protein Miro1 is resistant to mitochondrial depolarization-induced ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:734273]

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Nitric Oxide Deficiency in Mitochondrial Disorders: The Utility of Arginine and Citrulline.

Mohammed Almannai, Ayman W El-Hattab,

Mitochondrial diseases represent a growing list of clinically heterogeneous disorders that are associated with dysfunctional mitochondria and multisystemic manifestations. In spite of a better understanding of the underlying pathophysiological basis of mitochondrial disorders, treatment options remain limited. Over the past two decades, there is growing evidence that patients with mitochondrial ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:682780]

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Altered Cerebrospinal Fluid Clearance and Increased Intracranial Pressure in Rats 18 h After Experimental Cortical Ischaemia.

Steven W Bothwell, Daniel Omileke, Rebecca J Hood, Debbie-Gai Pepperall, Sara Azarpeykan, Adjanie Patabendige, Neil J Spratt,

Oedema-independent intracranial pressure (ICP) rise peaks 20-22-h post-stroke in rats and may explain early neurological deterioration. Cerebrospinal fluid (CSF) volume changes may be involved. Cranial CSF clearance primarily occurs <i>via</i> the cervical lymphatics and movement into the spinal portion of the cranio-spinal compartment. We explored whether impaired CSF clearance at ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:712779]

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Pharmacological Manipulation of Wnt/β-Catenin Signaling Pathway in Human Neural Precursor Cells Alters Their Differentiation Potential and Neuronal Yield.

Michael Telias, Dalit Ben-Yosef,

The canonical Wnt/β-catenin pathway is a master-regulator of cell fate during embryonic and adult neurogenesis and is therefore a major pharmacological target in basic and clinical research. Chemical manipulation of Wnt signaling during <i>in vitro</i> neuronal differentiation of stem cells can alter both the quantity and the quality of the ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:680018]

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Long Noncoding RNAs in Neurodegenerative Diseases: Pathogenesis and Potential Implications as Clinical Biomarkers.

Meng Zhang, Ping He, Zhigang Bian,

Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), are progressive and ultimately fatal. NDD onset is influenced by several factors including heredity and environmental cues. Long noncoding RNAs (lncRNAs) are a class of noncoding RNA molecules with: (i) lengths greater ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:685143]

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SNARE Regulatory Proteins in Synaptic Vesicle Fusion and Recycling.

Chad W Sauvola, J Troy Littleton,

Membrane fusion is a universal feature of eukaryotic protein trafficking and is mediated by the soluble <i>N</i>-ethylmaleimide sensitive factor attachment protein receptor (SNARE) family. SNARE proteins embedded in opposing membranes spontaneously assemble to drive membrane fusion and cargo exchange <i>in vitro</i>. Evolution has generated a diverse complement of SNARE regulatory ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:733138]

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The Role of Calmodulin vs. Synaptotagmin in Exocytosis.

Renhao Xue, Hao Meng, Jiaxiang Yin, Jingyao Xia, Zhitao Hu, Huisheng Liu,

Exocytosis is a Ca<sup>2+</sup>-regulated process that requires the participation of Ca<sup>2+</sup> sensors. In the 1980s, two classes of Ca<sup>2+</sup>-binding proteins were proposed as putative Ca<sup>2+</sup> sensors: EF-hand protein calmodulin, and the C2 domain protein synaptotagmin. In the next few decades, numerous studies determined that in the final stage of membrane ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2021, 14:691363]

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