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Decreased Vacuolar Ca2+ Storage and Disrupted Vesicle Trafficking Underlie Alpha-Synuclein-Induced Ca2+ Dysregulation in S. cerevisiae.

Geert Callewaert, Petra D'hooge, Tien-Yang Ma, Mara Del Vecchio, Vincent Van Eyck, Vanessa Franssens, Joris Winderickx,

The yeast Saccharomyces cerevisiae is a powerful model to study the molecular mechanisms underlying α-synuclein (α-syn) cytotoxicity. This is due to the high degree of conservation of cellular processes with higher eukaryotes and the fact that yeast does not endogenously express α-synuclein. In this work, we focused specifically on the ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:266]

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Detection of Rare Methyl-CpG Binding Protein 2 Gene Missense Mutations in Patients With Schizophrenia.

Chia-Hsiang Chen, Min-Chih Cheng, Ailing Huang, Tsung-Ming Hu, Lieh-Yung Ping, Yu-Syuan Chang,

Deleterious mutations of MECP2 are responsible for Rett syndrome, a severe X-linked childhood neurodevelopmental disorder predominates in females, male patients are considered fatal. However, increasing reports indicate that some MECP2 mutations may also present various neuropsychiatric phenotypes, including intellectual disability, autism spectrum disorder, depression, cocaine addiction, and schizophrenia in both ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:]

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Using Genetic Risk Score Approaches to Infer Whether an Environmental Factor Attenuates or Exacerbates the Adverse Influence of a Candidate Gene.

Wan-Yu Lin, Yu-Shun Lin, Chang-Chuan Chan, Yu-Li Liu, Shih-Jen Tsai, Po-Hsiu Kuo,

Some candidate genes have been robustly reported to be associated with complex traits, such as the fat mass and obesity-associated (FTO) gene on body mass index (BMI), and the fibroblast growth factor 5 (FGF5) gene on blood pressure levels. It is of interest to know whether an environmental factor (E) ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:]

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How Can We Not Waste Legacy Genomic Research Data?

Susan E. Wallace, Emily Kirby, Bartha Maria Knoppers,

Enabling genomic and biomedical data to be shared for secondary research purposes is not always straightforward for existing “legacy” data sets. Researchers may not know whether their data meet ethical and regulatory requirements for sharing. As a result, these data, collected using public funds and the good will and efforts ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:]

Cited: 0 times

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Detection of Rare Methyl-CpG Binding Protein 2 Gene Missense Mutations in Patients With Schizophrenia.

Chia-Hsiang Chen, Min-Chih Cheng, Ailing Huang, Tsung-Ming Hu, Lieh-Yung Ping, Yu-Syuan Chang,

Deleterious mutations of MECP2 are responsible for Rett syndrome, a severe X-linked childhood neurodevelopmental disorder predominates in females, male patients are considered fatal. However, increasing reports indicate that some MECP2 mutations may also present various neuropsychiatric phenotypes, including intellectual disability, autism spectrum disorder, depression, cocaine addiction, and schizophrenia in both ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:476]

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The Whole-Genome Sequencing and Hybrid Assembly of Mytilus coruscus.

Ronghua Li, Weijia Zhang, Junkai Lu, Zhouyi Zhang, Changkao Mu, Weiwei Song, Herve Migaud, Chunlin Wang, Michaël Bekaert,

The hard-shelled mussel (Mytilus coruscus) is an economically important shellfish that has been cultivated for the last decade. Due to over-exploitation, most mussel stocks have dramatically declined. Efforts to study this species' natural distribution, genetics, breeding, and cultivation have been hindered by the lack of a high-quality reference genome. To ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:440]

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Immune-Related Prognostic Model in Colon Cancer: A Gene Expression-Based Study.

Haojie Yang, Wei Jin, Hua Liu, Dan Gan, Can Cui, Changpeng Han, Zhenyi Wang,

Mounting evidence supports that the malignant phenotypes of cancers are defined not only by the intrinsic activity of tumor cells but also by immune cells that are recruited and activated in tumor-related microenvironment. Here, we developed a diagnostic and prognostic model for colon cancer, based on expression profiles of immune-related ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:401]

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Identification and Analysis of Dysfunctional Genes and Pathways in CD8+ T Cells of Non-Small Cell Lung Cancer Based on RNA Sequencing.

Xuefang Tao, Xiaotang Wu, Tao Huang, Deguang Mu,

Lung cancer, the most common of malignant tumors, is typically of the non-small cell (NSCLC) type. T-cell-based immunotherapies are a promising and powerful approach to treating NSCLCs. To characterize the CD8+ T cells of non-small cell lung cancer, we re-analyzed the published RNA-Seq gene expression profiles of 36 CD8+ T ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:352]

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De novo Transcriptome Assembly, Gene Annotation and SSR Marker Development in the Moon Seed Genus Menispermum (Menispermaceae).

Faiza Hina, Gulbar Yisilam, Shenyi Wang, Pan Li, Chengxin Fu,

The moonseed genus Menispermum L. (Menispermaceae) is disjunctly distributed in East Asia and eastern North America. Although Menispermum has important medicinal value, genetic and genomic information is scarce, with very few available molecular markers. In the current study, we used Illumina transcriptome sequencing and de novo assembly of the two ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:]

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Heavy Metal Stress-Associated Proteins in Rice and Arabidopsis: Genome-Wide Identification, Phylogenetics, Duplication, and Expression Profiles Analysis.

Jiaming Li, Minghui Zhang, Jian Sun, Xinrui Mao, Jingguo Wang, Hualong Liu, Hongliang Zheng, Xianwei Li, Hongwei Zhao, Detang Zou,

Heavy metal exposure is a serious environmental stress in plants. However, plants have evolved several strategies to improve their heavy metal tolerance. Heavy metal-associated proteins (HMPs) participate in heavy metal detoxification. Here, we identified 46 and 55 HMPs in rice and Arabidopsis, respectively, and named them OsHMP 1–46 and AtHMP ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:]

Cited: 0 times

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Decreased Vacuolar Ca2+ Storage and Disrupted Vesicle Trafficking Underlie Alpha-Synuclein-Induced Ca2+ Dysregulation in S. cerevisiae.

Geert Callewaert, Petra D’hooge, Tien-Yang Ma, Mara Del Vecchio, Vincent Van Eyck, Vanessa Franssens, Joris Winderickx,

The yeast Saccharomyces cerevisiae is a powerful model to study the molecular mechanisms underlying α-synuclein (α-syn) cytotoxicity. This is due to the high degree of conservation of cellular processes with higher eukaryotes and the fact that yeast does not endogenously express α-synuclein. In this work, we focused specifically on the ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:]

Cited: 0 times

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Heavy Metal Stress-Associated Proteins in Rice and Arabidopsis: Genome-Wide Identification, Phylogenetics, Duplication, and Expression Profiles Analysis.

Jiaming Li, Minghui Zhang, Jian Sun, Xinrui Mao, Jingguo Wang, Hualong Liu, Hongliang Zheng, Xianwei Li, Hongwei Zhao, Detang Zou,

Heavy metal exposure is a serious environmental stress in plants. However, plants have evolved several strategies to improve their heavy metal tolerance. Heavy metal-associated proteins (HMPs) participate in heavy metal detoxification. Here, we identified 46 and 55 HMPs in rice and Arabidopsis, respectively, and named them OsHMP 1-46 and AtHMP ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:477]

Cited: 0 times

View full text PDF listing >>



How Can We Not Waste Legacy Genomic Research Data?

Susan E Wallace, Emily Kirby, Bartha Maria Knoppers,

Enabling genomic and biomedical data to be shared for secondary research purposes is not always straightforward for existing "legacy" data sets. Researchers may not know whether their data meet ethical and regulatory requirements for sharing. As a result, these data, collected using public funds and the good will and efforts ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:446]

Cited: 0 times

View full text PDF listing >>



The Whole-Genome Sequencing and Hybrid Assembly of Mytilus coruscus.

Ronghua Li, Weijia Zhang, Junkai Lu, Zhouyi Zhang, Changkao Mu, Weiwei Song, Herve Migaud, Chunlin Wang, Michaël Bekaert,

The hard-shelled mussel (Mytilus coruscus) is an economically important shellfish that has been cultivated for the last decade. Due to over-exploitation, most mussel stocks have dramatically declined. Efforts to study this species' natural distribution, genetics, breeding, and cultivation have been hindered by the lack of a high-quality reference genome. To ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:]

Cited: 0 times

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“Mitochondrial Toolbox” – A Review of Online Resources to Explore Mitochondrial Genomics.

Ruaidhri Cappa, Cassio de Campos, Alexander P. Maxwell, Amy J. McKnight,

Mitochondria play a significant role in many biological systems. There is emerging evidence that differences in the mitochondrial genome may contribute to multiple common diseases, leading to an increasing number of studies exploring mitochondrial genomics. There is often a large amount of complex data generated (for example via next generation ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:]

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The Draft Genome Dataset of the Asian Cricket Teleogryllus occipitalis for Molecular Research Toward Entomophagy.

Kosuke Kataoka, Ryuhei Minei, Keigo Ide, Atsushi Ogura, Haruko Takeyama, Makio Takeda, Takeshi Suzuki, Kei Yura, Toru Asahi,

Front Genet (Frontiers in genetics)
[2020, 11:]

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Construction and Analysis of a ceRNA Network Reveals Potential Prognostic Markers in Colorectal Cancer.

Li Guo, Guowei Yang, Yihao Kang, Sunjing Li, Rui Duan, Lulu Shen, Wenwen Jiang, Bowen Qian, Zibo Yin, Tingming Liang,

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide and is derived from an accumulation of genetic and epigenetic changes. This study explored potential prognostic markers in CRC via the construction and in-depth analysis of a competing endogenous RNA (ceRNA) network, which was generated through a ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:418]

Cited: 0 times

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De novo Transcriptome Assembly, Gene Annotation and SSR Marker Development in the Moon Seed Genus Menispermum (Menispermaceae).

Faiza Hina, Gulbar Yisilam, Shenyi Wang, Pan Li, Chengxin Fu,

The moonseed genus Menispermum L. (Menispermaceae) is disjunctly distributed in East Asia and eastern North America. Although Menispermum has important medicinal value, genetic and genomic information is scarce, with very few available molecular markers. In the current study, we used Illumina transcriptome sequencing and de novo assembly of the two ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:380]

Cited: 0 times

View full text PDF listing >>



Using Genetic Risk Score Approaches to Infer Whether an Environmental Factor Attenuates or Exacerbates the Adverse Influence of a Candidate Gene.

Wan-Yu Lin, Yu-Shun Lin, Chang-Chuan Chan, Yu-Li Liu, Shih-Jen Tsai, Po-Hsiu Kuo,

Some candidate genes have been robustly reported to be associated with complex traits, such as the fat mass and obesity-associated (FTO) gene on body mass index (BMI), and the fibroblast growth factor 5 (FGF5) gene on blood pressure levels. It is of interest to know whether an environmental factor (E) ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:331]

Cited: 0 times

View full text PDF listing >>



Immune-Related Prognostic Model in Colon Cancer: A Gene Expression-Based Study.

Haojie Yang, Wei Jin, Hua Liu, Dan Gan, Can Cui, Changpeng Han, Zhenyi Wang,

Mounting evidence supports that the malignant phenotypes of cancers are defined not only by the intrinsic activity of tumor cells but also by immune cells that are recruited and activated in tumor-related microenvironment. Here, we developed a diagnostic and prognostic model for colon cancer, based on expression profiles of immune-related ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:]

Cited: 0 times

View full text PDF listing >>



Construction and Analysis of a ceRNA Network Reveals Potential Prognostic Markers in Colorectal Cancer.

Li Guo, Guowei Yang, Yihao Kang, Sunjing Li, Rui Duan, Lulu Shen, Wenwen Jiang, Bowen Qian, Zibo Yin, Tingming Liang,

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide and is derived from an accumulation of genetic and epigenetic changes. This study explored potential prognostic markers in CRC via the construction and in-depth analysis of a competing endogenous RNA (ceRNA) network, which was generated through a ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:]

Cited: 0 times

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Genome-Wide Identification and Evolutionary Analysis of NBS-LRR Genes From Dioscorea rotundata.

Yan-Mei Zhang, Min Chen, Ling Sun, Yue Wang, Jianmei Yin, Jia Liu, Xiao-Qin Sun, Yue-Yu Hang,

Dioscorea rotundata is an important food crop that is mainly cultivated in subtropical regions of the world. D. rotundata is frequently infected by various pathogens during its lifespan, which results in a substantial economic loss in terms of yield and quality. The disease resistance gene (R gene) profile of D. ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:484]

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Causal Attributions in an Australian Aboriginal Family With Marfan Syndrome: A Qualitative Study.

Aideen M McInerney-Leo, Jennifer West, Bettina Meiser, Malcolm West, Matthew A Brown, Emma Duncan,

Causal attributions are important determinants of how health threats are processed and affect health-related behaviors. To date, there has been no research on causal attributions in genetic conditions in Aboriginal Australians. Forty members of a large Aboriginal Australian family with Marfan syndrome (MFS) were invited to participate in an ethically ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:461]

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Analysis of the Mouse Y Chromosome by Single-Molecule Sequencing With Y Chromosome Enrichment.

Yuki Yano, Tomoki Chiba, Hiroshi Asahara,

Since human and mouse Y chromosomes contain repeated sequences, it is difficult to determine the precise sequences and analyze the function of individual Y chromosome genes. Therefore, the causes of many diseases and abnormalities related to Y chromosome genes, such as male infertility, remain unclear. In this study, to elucidate ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:406]

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Novel Missense Variant in Heterozygous State in the BRPF1 Gene Leading to Intellectual Developmental Disorder With Dysmorphic Facies and Ptosis.

Muhammad Imran Naseer, Angham Abdulrahman Abdulkareem, Francisco J Guzmán-Vega, Stefan T Arold, Peter Natesan Pushparaj, Adeel G Chaudhary, Mohammad H AlQahtani,

Intellectual developmental disorder with dysmorphic facies and ptosis is an autosomal dominant condition characterized by delayed psychomotor development, intellectual disability, delayed speech, and dysmorphic facial features, mostly ptosis. Heterozygous mutations in bromodomain and plant homeodomain (PHD) finger containing one (BRPF1) gene have been reported. In this study, whole exome sequencing ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:368]

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