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Journal Front Cell Neurosci

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Codon Optimization of Insect Odorant Receptor Genes May Increase Their Stable Expression for Functional Characterization in HEK293 Cells.

Rebecca E Roberts, Jothi Kumar Yuvaraj, Martin N Andersson,

Insect odorant receptor (OR) genes are routinely expressed in Human Embryonic Kidney (HEK) 293 cells for functional characterization ("de-orphanization") using transient or stable expression. However, progress in this research field has been hampered because some insect ORs are not functional in this system, which may be due to insufficient protein ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:744401]

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Glypican 4 Regulates Aβ Internalization in Neural Stem Cells Partly via Low-Density Lipoprotein Receptor-Related Protein 1.

Kaige Ma, Shan Xing, Yan Luan, Chenglin Zhang, Yingfei Liu, Yulang Fei, Zhichao Zhang, Yong Liu, Xinlin Chen,

Neural stem cell (NSC) damage has been reported in patients with Alzheimer's disease. Intracellular Aβ plays a vital role in NSC damage. Heparan sulfate proteoglycans are potent mediators of Aβ enrichment in the brain. We hypothesized the heparan sulfate proteoglycan glypican 4 (Gpc4) regulates Aβ internalization by NSCs. We evaluated ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:732429]

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She Doesn't Even Go Here: The Role of Inflammatory Astrocytes in CNS Disorders.

Jacqueline Kelsey Reid, Hedwich Fardau Kuipers,

Astrocyte heterogeneity is a rapidly evolving field driven by innovative techniques. Inflammatory astrocytes, one of the first described subtypes of reactive astrocytes, are present in a variety of neurodegenerative diseases and may play a role in their pathogenesis. Moreover, genetic and therapeutic targeting of these astrocytes ameliorates disease in several ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:704884]

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Use of Radical Oxygen Species Scavenger Nitrones to Treat Oxidative Stress-Mediated Hearing Loss: State of the Art and Challenges.

Isabel Varela-Nieto, Silvia Murillo-Cuesta, Lourdes Rodríguez-de la Rosa, María Jesús Oset-Gasque, José Marco-Contelles,

Nitrones are potent antioxidant molecules able to reduce oxidative stress by trapping reactive oxygen and nitrogen species. The antioxidant potential of nitrones has been extensively tested in multiple models of human diseases. Sensorineural hearing loss has a heterogeneous etiology, genetic alterations, aging, toxins or exposure to noise can cause damage ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:711269]

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Compensatory Hippocampal Neurogenesis in the Absence of Cognitive Impairment Following Experimental Hippocampectomy in Adult Rats.

Giuliana T M Cardoso, Walace Gomes-Leal, Edna C S Franco, Antonio Pereira, Francinaldo L Gomes, Ana Leda F Brino, Silene M A Lima,

Temporal lobe epilepsy (TLE) is the commonest type of focal epilepsy in adult humans, and hippocampal sclerosis (HS) is the main pathological finding in this type of epilepsy. In refractory TLE, patients are indicated for unilateral resection of the affected hippocampus by a surgical procedure called hippocampectomy which generally does ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:709291]

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Sparsely Distributed, Pre-synaptic Kv3 K+ Channels Control Spontaneous Firing and Cross-Unit Synchrony via the Regulation of Synaptic Noise in an Auditory Brainstem Circuit.

Timothy OIsen, Alberto Capurro, Maša Švent, Nadia Pilati, Charles Large, Nick Hartell, Martine Hamann,

Spontaneous subthreshold activity in the central nervous system is fundamental to information processing and transmission, as it amplifies and optimizes sub-threshold signals, thereby improving action potential initiation and maintaining reliable firing. This form of spontaneous activity, which is frequently considered noise, is particularly important at auditory synapses where acoustic information ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:721371]

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Transcranial Laser Photobiomodulation Improves Intracellular Signaling Linked to Cell Survival, Memory and Glucose Metabolism in the Aged Brain: A Preliminary Study.

Fabrízio Dos Santos Cardoso, Fernanda Cristina Borini Mansur, Rodrigo Álvaro Brandão Lopes-Martins, Francisco Gonzalez-Lima, Sérgio Gomes da Silva,

Aging is often accompanied by exacerbated activation of cell death-related signaling pathways and decreased energy metabolism. We hypothesized that transcranial near-infrared laser may increase intracellular signaling pathways beneficial to aging brains, such as those that regulate brain cell proliferation, apoptosis, and energy metabolism. To test this hypothesis, we investigated the ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:683127]

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Anatomical Organization of the Rat Subfornical Organ.

Amirah-Iman Hicks, Simona Kobrinsky, Suijian Zhou, Jieyi Yang, Masha Prager-Khoutorsky,

The subfornical organ (SFO) is a sensory circumventricular organ located along the anterodorsal wall of the third ventricle. SFO lacks a complete blood-brain barrier (BBB), and thus peripherally-circulating factors can penetrate the SFO parenchyma. These signals are detected by local neurons providing the brain with information from the periphery to ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:691711]

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The Role of the UPR Pathway in the Pathophysiology and Treatment of Bipolar Disorder.

Mahmoud Suliman, Michael W Schmidtke, Miriam L Greenberg,

Bipolar disorder (BD) is a mood disorder that affects millions worldwide and is associated with severe mood swings between mania and depression. The mood stabilizers valproate (VPA) and lithium (Li) are among the main drugs that are used to treat BD patients. However, these drugs are not effective for all ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:735622]

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Tetris in the Nervous System: What Principles of Neuronal Tiling Can Tell Us About How Glia Play the Game.

Dana F DeSantis, Cody J Smith,

The precise organization and arrangement of neural cells is essential for nervous system functionality. Cellular tiling is an evolutionarily conserved phenomenon that organizes neural cells, ensuring non-redundant coverage of receptive fields in the nervous system. First recorded in the drawings of Ramon y Cajal more than a century ago, we ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:734938]

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Modulation of Glial Function in Health, Aging, and Neurodegenerative Disease.

Kendra L Hanslik, Kaitlyn M Marino, Tyler K Ulland,

In the central nervous system (CNS), glial cells, such as microglia and astrocytes, are normally associated with support roles including contributions to energy metabolism, synaptic plasticity, and ion homeostasis. In addition to providing support for neurons, microglia and astrocytes function as the resident immune cells in the brain. The glial ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:718324]

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Plasma Membrane Ca2+ Pump PMCA4z Is More Active Than Splicing Variant PMCA4x.

Gerardo R Corradi, Luciana R Mazzitelli, Guido D Petrovich, Felicitas de Tezanos Pinto, Lucia Rochi, Hugo P Adamo,

The plasma membrane Ca<sup>2+</sup> pumps (PMCA) are P-ATPases that control Ca<sup>2+</sup> signaling and homeostasis by transporting Ca<sup>2+</sup> out of the eukaryotic cell. Humans have four genes that code for PMCA isoforms (PMCA1-4). A large diversity of PMCA isoforms is generated by alternative mRNA splicing at sites A and C. The ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:668371]

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Deletion of C1ql1 Causes Hearing Loss and Abnormal Auditory Nerve Fibers in the Mouse Cochlea.

Yue Qi, Wei Xiong, Shukui Yu, Zhengde Du, Tengfei Qu, Lu He, Wei Wei, Lingjun Zhang, Ke Liu, Yi Li, David Z He, Shusheng Gong,

Complement C1q Like 1 (C1QL1), a secreted component of C1Q-related protein, is known to play an important role in synaptic maturation, regulation, and maintenance in the central nervous system. <i>C1ql1</i> is expressed in adult cochlear inner and outer hair cells (IHCs and OHCs) with preferential expression in OHCs. We generated ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:713651]

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Review and Hypothesis: A Potential Common Link Between Glial Cells, Calcium Changes, Modulation of Synaptic Transmission, Spreading Depression, Migraine, and Epilepsy-H.

Robert Paul Malchow, Boriana K Tchernookova, Ji-In Vivien Choi, Peter J S Smith, Richard H Kramer, Matthew A Kreitzer,

There is significant evidence to support the notion that glial cells can modulate the strength of synaptic connections between nerve cells, and it has further been suggested that alterations in intracellular calcium are likely to play a key role in this process. However, the molecular mechanism(s) by which glial cells ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:693095]

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Isobaric Tags for Relative and Absolute Quantitation-Based Quantitative Serum Proteomics Analysis in Ischemic Stroke Patients With Hemorrhagic Transformation.

Zhifeng Qi, Shuhua Yuan, Xixi Zhou, Xunming Ji, Ke Jian Liu,

Hemorrhagic transformation (HT), which occurs with or without reperfusion treatments (thrombolysis and/or thrombectomy), deteriorates the outcomes of ischemic stroke patients. It is essential to find clinically reliable biomarkers that can predict HT. In this study, we screened for potential serum biomarkers from an existing blood bank and database with 243 ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:710129]

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Corrigendum: Overexpression of mGluR7 in the Prefrontal Cortex Attenuates Autistic Behaviors in Mice.

Xiaona Wang, Chao Gao, Yaodong Zhang, Shunan Hu, Yidan Qiao, Zhengqin Zhao, Lingshan Gou, Jijun Song, Qi Wang,

[This corrects the article DOI: 10.3389/fncel.2021.689611.]. ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:747696]

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Neuronal and Astrocytic Regulations in Schizophrenia: A Computational Modelling Study.

Lea Fritschi, Johanna Hedlund Lindmar, Florian Scheidl, Kerstin Lenk,

According to the tripartite synapse model, astrocytes have a modulatory effect on neuronal signal transmission. More recently, astrocyte malfunction has been associated with psychiatric diseases such as schizophrenia. Several hypotheses have been proposed on the pathological mechanisms of astrocytes in schizophrenia. For example, post-mortem examinations have revealed a reduced astrocytic ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:718459]

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Prolonged Amphetamine Exposures Increase the Endogenous Human Dopamine Receptors 2 at the Cellular Membrane in Cells Lacking the Dopamine Transporter.

Vindhya Nawaratne, Sean P McLaughlin, Felix P Mayer, Zayna Gichi, Alyssa Mastriano, Lucia Carvelli,

The dopamine 2 receptors (D2R) are G-protein coupled receptors expressed both in pre- and post-synaptic terminals that play an important role in mediating the physiological and behavioral effects of amphetamine (Amph). Previous studies have indicated that the effects of Amph at the D2R mainly rely on the ability of Amph ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:681539]

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Fibrotic Scar After Spinal Cord Injury: Crosstalk With Other Cells, Cellular Origin, Function, and Mechanism.

Ziyu Li, Shuisheng Yu, Xuyang Hu, Yiteng Li, Xingyu You, Dasheng Tian, Li Cheng, Meige Zheng, Juehua Jing,

The failure of axonal regeneration after spinal cord injury (SCI) results in permanent loss of sensorimotor function. The persistent presence of scar tissue, mainly fibrotic scar and astrocytic scar, is a critical cause of axonal regeneration failure and is widely accepted as a treatment target for SCI. Astrocytic scar has ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:720938]

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Electrophysiological Characterization of Regular and Burst Firing Pyramidal Neurons of the Dorsal Subiculum in an Angelman Syndrome Mouse Model.

Prudhvi Raj Rayi, Hanoch Kaphzan,

Angelman syndrome (AS) is a debilitating neurogenetic disorder characterized by severe developmental delay, speech impairment, gait ataxia, sleep disturbances, epilepsy, and a unique behavioral phenotype. AS is caused by a microdeletion or mutation in the maternal 15q11-q13 chromosome region containing <i>UBE3A</i> gene. The hippocampus is one of the important brain ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:670998]

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Implications of FBXW7 in Neurodevelopment and Neurodegeneration: Molecular Mechanisms and Therapeutic Potential.

Yu Yang, Xuan Zhou, Xinpeng Liu, Ruying Song, Yiming Gao, Shuai Wang,

The ubiquitin-proteasome system (UPS) mediated protein degradation is crucial to maintain quantitive and functional homeostasis of diverse proteins. Balanced cellular protein homeostasis controlled by UPS is fundamental to normal neurological functions while impairment of UPS can also lead to some neurodevelopmental and neurodegenerative disorders. Functioning as the substrate recognition component ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:736008]

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GABA B Receptor-Mediated Regulation of Dendro-Somatic Synergy in Layer 5 Pyramidal Neurons.

Jan M Schulz, Jim W Kay, Josef Bischofberger, Matthew E Larkum,

Synergistic interactions between independent synaptic input streams may fundamentally change the action potential (AP) output. Using partial information decomposition, we demonstrate here a substantial contribution of synergy between somatic and apical dendritic inputs to the information in the AP output of L5b pyramidal neurons. Activation of dendritic GABA <sub><i>B</i></sub> receptors ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:718413]

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Research Progress on the Mechanism of Cochlear Hair Cell Regeneration.

Shan Xu, Ning Yang,

Mammalian inner ear hair cells do not have the ability to spontaneously regenerate, so their irreversible damage is the main cause of sensorineural hearing loss. The damage and loss of hair cells are mainly caused by factors such as aging, infection, genetic factors, hypoxia, autoimmune diseases, ototoxic drugs, or noise ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:732507]

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Experimental Social Stress: Dopaminergic Receptors, Oxidative Stress, and c-Fos Protein Are Involved in Highly Aggressive Behavior.

Renata M Felippe, Gabriel M Oliveira, Rafaela S Barbosa, Betina D Esteves, Beatriz M S Gonzaga, Samuel I M Horita, Luciana R Garzoni, Daniela G Beghini, Tânia C Araújo-Jorge, Viviane M S Fragoso,

Aggression is defined as hostile behavior that results in psychological damage, injury and even death among individuals. When aggression presents itself in an exacerbated and constant way, it can be considered escalating or pathological. The association between social stress and the emergence of exacerbated aggressiveness is common and is suggested ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:696834]

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Contralateral Axon Sprouting but Not Ipsilateral Regeneration Is Responsible for Spontaneous Locomotor Recovery Post Spinal Cord Hemisection.

Yudong Cao, Ya Shi, Zhifeng Xiao, Xi Chen, Bing Chen, Bin Yang, Muya Shu, Yanyun Yin, Shuyu Wu, Wen Yin, Xianyong Fu, Jun Tan, Quanwei Zhou, Zhaoping Wu, Xingjun Jiang, Jianwu Dai,

Spinal cord injury (SCI) usually results in permanent functional impairment and is considered a worldwide medical problem. However, both motor and sensory functions can spontaneously recover to varying extents in humans and animals with incomplete SCI. This study observed a significant spontaneous hindlimb locomotor recovery in Sprague-Dawley rats at four ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:730348]

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