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Oxidative stress-induced lncRNA CYLD-AS1 promotes RPE inflammation via Nrf2/miR-134-5p/NF-κB signaling pathway.

Han Du, Zixin Huang, Xin Zhou, Xielan Kuang, Chongde Long, Han Tang, Jingshu Zeng, Hao Huang, Huijun Liu, Binbin Zhu, Licheng Fu, Ke Hu, ShuiBin Lin, Hua Wang, Qingjiong Zhang, Jianhua Yan, Huangxuan Shen,

Oxidative stress-induced damage to and dysfunction of retinal pigment epithelium (RPE) cells are important pathogenetic factors of age-related macular degeneration (AMD); however, the underlying molecular mechanism is not fully understood. Long noncoding RNAs (lncRNAs) have important roles in various biological processes. In this study, using an oxidative damage model in ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2022, 36(10):e22577]

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Novel pathophysiological roles of α-synuclein in age-related vascular endothelial dysfunction.

Yoichi Takami, Cheng Wang, Hironori Nakagami, Koichi Yamamoto, Yoichi Nozato, Yuki Imaizumi, Motonori Nagasawa, Hikari Takeshita, Tsuneo Nakajima, Shuko Takeda, Yasushi Takeya, Yasufumi Kaneda, Hiromi Rakugi,

Although α-synuclein (SNCA) is a well-known pathological molecule involved in synucleinopathy in neurons, its physiological roles remain largely unknown. We reported that serum SNCA levels have a close inverse correlation with blood pressure and age, which indicates the involvement of SNCA in age-related endothelial dysfunction. Therefore, this study aimed to ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2022, 36(10):e22555]

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