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Structural insights into the ligand recognition and catalysis of the key aminobutanoyltransferase CntL in staphylopine biosynthesis.

Zhiteng Luo, Siting Luo, Yingchen Ju, Peng Ding, Jun Xu, Qiong Gu, Huihao Zhou,

Staphylopine (StP) and other nicotianamine-like metallophores are crucial for many pathogens to acquire the transition metals from hosts during invasion. CntL from Staphylococcus aureus (SaCntL) catalyzes the condensation of the 2-aminobutyrate (Ab) moiety of S-adenosylmethionine (SAM) with D-histidine in the biosynthesis of StP. Here, we report the crystal structures of ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21575]

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Cardiomyocyte-specific Srsf3 deletion reveals a mitochondrial regulatory role.

Audrey-Ann Dumont, Lauralyne Dumont, Delong Zhou, Hugo Giguère, Chantal Pileggi, Mary-Ellen Harper, Denis P Blondin, Michelle S Scott, Mannix Auger-Messier,

Serine-rich splicing factor 3 (SRSF3) was recently reported as being necessary to preserve RNA stability via an mTOR mechanism in a cardiac mouse model in adulthood. Here, we demonstrate the link between Srsf3 and mitochondrial integrity in an embryonic cardiomyocyte-specific Srsf3 conditional knockout (cKO) mouse model. Fifteen-day-old Srsf3 cKO mice ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21544]

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Cell-type specific analysis of physiological action of estrogen in mouse oviducts.

Emily A McGlade, Gerardo G Herrera, Kalli K Stephens, Sierra L W Olsen, Sarayut Winuthayanon, Joie Guner, Sylvia C Hewitt, Kenneth S Korach, Francesco J DeMayo, John P Lydon, Diana Monsivais, Wipawee Winuthayanon,

One of the endogenous estrogens, 17β-estradiol (E<sub>2</sub> ) is a female steroid hormone secreted from the ovary. It is well established that E<sub>2</sub> causes biochemical and histological changes in the uterus. However, it is not completely understood how E<sub>2</sub> regulates the oviductal environment in vivo. In this study, we assessed ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21563]

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Slack K+ channels attenuate NMDA-induced excitotoxic brain damage and neuronal cell death.

Rebekka Ehinger, Anna Kuret, Lucas Matt, Nadine Frank, Katharina Wild, Clement Kabagema-Bilan, Helmut Bischof, Roland Malli, Peter Ruth, Anne E Bausch, Robert Lukowski,

The neuronal Na<sup>+</sup> -activated K<sup>+</sup> channel Slack (aka Slo2.2, K<sub>Na</sub> 1.1, or Kcnt1) has been implicated in setting and maintaining the resting membrane potential and defining excitability and firing patterns, as well as in the generation of the slow afterhyperpolarization following bursts of action potentials. Slack activity increases significantly under ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21568]

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Glutathionylation chemistry promotes interleukin-1 beta-mediated glycolytic reprogramming and pro-inflammatory signaling in lung epithelial cells.

Reem Aboushousha, Evan Elko, Shi B Chia, Allison M Manuel, Cheryl van de Wetering, Jos van der Velden, Maximilian MacPherson, Cuixia Erickson, Julie A Reisz, Angelo D'Alessandro, Emiel F M Wouters, Niki L Reynaert, Ying-Wai Lam, Vikas Anathy, Albert van der Vliet, David J Seward, Yvonne M W Janssen-Heininger,

Glycolysis is a well-known process by which metabolically active cells, such as tumor or immune cells meet their high metabolic demands. Previously, our laboratory has demonstrated that in airway epithelial cells, the pleiotropic cytokine, interleukin-1 beta (IL1B) induces glycolysis and that this contributes to allergic airway inflammation and remodeling. Activation ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21525]

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Clustering of adenosine A2B receptors with ectonucleotidases in caveolin-rich lipid rafts underlies immunomodulation by Leishmania amazonensis.

Amanda Braga Figueiredo, Renata Alves de Oliveira E Castro, Nívia Carolina Nogueira-Paiva, Filipa Moreira, Francisco Queiroz Gonçalves, Rodrigo Pedro Soares, William Castro-Borges, Gustavo Gonçalves Silva, Rodrigo Antunes Cunha, Teresa Gonçalves, Luís Carlos Crocco Afonso,

Extracellular adenosine plays important roles in modulating the immune responses. We have previously demonstrated that infection of dendritic cells (DC) by Leishmania amazonensis leads to increased expression of CD39 and CD73 and to the selective activation of the low affinity A<sub>2B</sub> receptors (A<sub>2B</sub> R), which contributes to DC inhibition, without ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21509]

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Unique metabolic phenotype and its transition during maturation of juvenile male germ cells.

Anna Laura Voigt, Douglas Andrew Kondro, Diana Powell, Hanna Valli-Pulaski, Mark Ungrin, Jan-Bernd Stukenborg, Claudia Klein, Ian A Lewis, Kyle E Orwig, Ina Dobrinski,

Human male reproductive development has a prolonged prepubertal period characterized by juvenile quiescence of germ cells with immature spermatogonial stem cell (SSC) precursors (gonocytes) present in the testis for an extended period of time. The metabolism of gonocytes is not defined. We demonstrate with mitochondrial ultrastructure studies via TEM and ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21513]

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Cochlear protection against noise exposure requires serotonin type 3A receptor via the medial olivocochlear system.

Kazuya Ohata, Makoto Kondo, Yoshiyuki Ozono, Yukiko Hanada, Takashi Sato, Hidenori Inohara, Shoichi Shimada,

The cochlear efferent feedback system plays important roles in auditory processing, including regulation of the dynamic range of hearing, and provides protection against acoustic trauma. These functions are performed through medial olivocochlear (MOC) neurons. However, the underlying cellular and molecular mechanisms are not fully understood. The serotonin type 3A (5-HT3A) ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21486]

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Extracellular vesicles regulate purinergic signaling and epithelial sodium channel expression in renal collecting duct cells.

Eric R Barros Lamus, Valentina Carotti, Christine R S de Vries, Femke Witsel, Onno J Arntz, Fons A J van de Loo, Cristian A Carvajal, René J M Bindels, Joost G J Hoenderop, Juan P Rigalli,

Purinergic signaling regulates several renal physiological and pathophysiological processes. Extracellular vesicles (EVs) are nanoparticles released by most cell types, which, in non-renal tissues, modulate purinergic signaling. The aim of this study was to investigate the effect of EVs from renal proximal tubule (HK2) and collecting duct cells (HCD) on intra- ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21506]

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Alpha-1-antitrypsin reduces inflammation and exerts chondroprotection in arthritis.

Magdalena K Kaneva, Milind M Muley, Eugene Krustev, Allison R Reid, Patricia R Souza, Francesco Dell'Accio, Jason J McDougall, Mauro Perretti,

While new treatments have been developed to control joint disease in rheumatoid arthritis, they are partially effective and do not promote structural repair of cartilage. Following an initial identification of α-1-Antitrypsin (AAT) during the resolution phase of acute inflammation, we report here the properties of this protein in the context ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21472]

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RNAi prodrugs decrease elevated mRNA levels of Polo-like kinase 1 in ex vivo cultured primary cells from pediatric acute myeloid leukemia patients.

Iryna Kolosenko, Oksana Goroshchuk, Linda Vidarsdottir, Ann-Charlotte Björklund, Steven F Dowdy, Caroline Palm-Apergi,

Polo-like kinase 1 (Plk1) is an important regulator of the cell cycle and it is frequently overexpressed in cancer cells. Several small molecule inhibitors have been developed to target Plk1 and some of them have reached clinical trials in adults with acute myeloid leukemia (AML). Pediatric AML patients have a ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21476]

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Role of epigenetic m6 A RNA methylation in vascular development: mettl3 regulates vascular development through PHLPP2/mTOR-AKT signaling.

Ramendu Parial, Hui Li, Jia Li, Stephen Archacki, Zhongcheng Yang, Isabel Z Wang, Qiuyun Chen, Chengqi Xu, Qing K Wang,

N<sup>6</sup> -methyladenosine (m6A) methylation is the most prevalent RNA modification, and it emerges as an important regulatory mechanism of gene expression involved in many cellular and biological processes. However, the role of m<sup>6</sup> A methylation in vascular development is not clear. The m<sup>6</sup> A RNA methylation is regulated by dynamic ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21465]

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Estrogen-related receptor α is involved in angiogenesis and skeletal muscle revascularization in hindlimb ischemia.

Danesh H Sopariwala, Neah Likhite, Gungsheng Pei, Fnu Haroon, Lisa Lin, Vikas Yadav, Zhongming Zhao, Vihang A Narkar,

Skeletal muscle ischemia is a major consequence of peripheral arterial disease (PAD) or critical limb ischemia (CLI). Although therapeutic options for resolving muscle ischemia in PAD/CLI are limited, the issue is compounded by poor understanding of the mechanisms driving muscle vascularization. We found that nuclear receptor estrogen-related receptor alpha (ERRα) ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21480]

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Therapeutic implications of inflammasome in inflammatory bowel disease.

Vishal Khatri, Ramaswamy Kalyanasundaram,

Inflammatory bowel disease (IBD) remains a persistent health problem with a global burden surging over 6.8 million cases currently. Clinical pathology of IBD is complicated; however, hyperactive inflammatory and immune responses in the gut is shown to be one of the persistent causes of the disease. Human gut inflammasome, the ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21439]

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Diacylglycerol kinase δ functions as a proliferation suppressor in pancreatic β-cells.

Taiji Sato, Chihiro Ishiwatari, Yukiko K Kaneko, Yoko Ishikawa, Yuki Kimura, Naoya Watanabe, Ikumi Aoshima, Yukari Matsuda, Takahiro Nakayama, Rina Chiba, Takahiro Fujinuki, Kai Iwata, Qiang Lu, Takako Usuki, Fumio Sakane, Tomohisa Ishikawa,

Although an aberrant reduction in pancreatic β-cell mass contributes to the pathogenesis of diabetes, the mechanism underlying the regulation of β-cell mass is poorly understood. Here, we show that diacylglycerol kinase δ (DGKδ) is a key enzyme in the regulation of β-cell mass. DGKδ expression was detected in the nucleus ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21420]

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A novel universal algorithm for filament network tracing and cytoskeleton analysis.

Daniel A D Flormann, Moritz Schu, Emmanuel Terriac, Divyendu Thalla, Lucina Kainka, Marcus Koch, Annica K B Gad, Franziska Lautenschläger,

The rapid development of advanced microscopy techniques over recent decades has significantly increased the quality of imaging and our understanding of subcellular structures, such as the organization of the filaments of the cytoskeleton using fluorescence and electron microscopy. However, these recent improvements in imaging techniques have not been matched by ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21582]

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Endothelial cell, myeloid, and adaptive immune responses in SARS-CoV-2 infection.

Nicolas Degauque, Alain Haziot, Sophie Brouard, Nuala Mooney,

SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is an emerging respiratory pathogen that has rapidly spread in human populations. Severe forms of infection associate cytokine release syndrome and acute lung injury due to hyperinflammatory responses even though virus clearance is achieved. Key components of inflammation include immune cell recruitment in ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21577]

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Quinomycin A reduces cyst progression in polycystic kidney disease.

Priyanka S Radadiya, Mackenzie M Thornton, Emily A Daniel, Jessica Y Idowu, Wei Wang, Brenda Magenheimer, Dharmalingam Subramaniam, Pamela V Tran, James P Calvet, Darren P Wallace, Madhulika Sharma,

Polycystic kidney disease (PKD) is a genetic disorder characterized by aberrant renal epithelial cell proliferation and formation and progressive growth of numerous fluid-filled cysts within the kidneys. Previously, we showed that there is elevated Notch signaling compared to normal renal epithelial cells and that Notch signaling contributes to the proliferation ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21533]

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Fibroblast growth factor induced Ucp1 expression in preadipocytes requires PGE2 biosynthesis and glycolytic flux.

Thomas Gantert, Fiona Henkel, Christine Wurmser, Josef Oeckl, Lena Fischer, Mark Haid, Jerzy Adamski, Julia Esser-von Bieren, Martin Klingenspor, Tobias Fromme,

High uncoupling protein 1 (Ucp1) expression is a characteristic of differentiated brown adipocytes and is linked to adipogenic differentiation. Paracrine fibroblast growth factor 8b (FGF8b) strongly induces Ucp1 transcription in white adipocytes independent of adipogenesis. Here, we report that FGF8b and other paracrine FGFs act on brown and white preadipocytes ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21572]

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Cystathionine gamma-lyase/H2 S signaling facilitates myogenesis under aging and injury condition.

Yanjie Zhang, Laura Masters, Yuehong Wang, Lingyun Wu, Yanxi Pei, Baoqing Guo, Amadeo Parissenti, Simon J Lees, Rui Wang, Guangdong Yang,

Hydrogen sulfide (H<sub>2</sub> S) can be endogenously produced and belongs to the class of signaling molecules known as gasotransmitters. Cystathionine gamma-lyase (CSE)-derived H<sub>2</sub> S is implicated in the regulation of cell differentiation and the aging process, but the involvements of the CSE/H<sub>2</sub> S system in myogenesis upon aging and injury ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21511]

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Postnatal deletion of Bmal1 in mice protects against obstructive renal fibrosis via suppressing Gli2 transcription.

Jiayang Zhang, Chengcheng Liu, Qing Liang, Feng Zheng, Youfei Guan, Guangrui Yang, Lihong Chen,

Circadian clock is involved in regulating most renal physiological functions, including water and electrolyte balance and blood pressure homeostasis, however, the role of circadian clock in renal pathophysiology remains largely unknown. Here we aimed to investigate the role of Bmal1, a core clock component, in the development of renal fibrosis, ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21530]

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Tetrandrine attenuates intestinal epithelial barrier defects caused by colitis through promoting the expression of Occludin via the AhR-miR-429 pathway.

Yuyao Chu, Yanrong Zhu, Yajing Zhang, Xiaojing Liu, Yilei Guo, Lan Chang, Xinming Yun, Zhifeng Wei, Yufeng Xia, Yue Dai,

The elevated intestinal permeability due to mucosal barrier defects is not only secondary to inflammatory bowel disease but also precedes enteritis. Tetrandrine, a bisbenzyl isoquinoline alkaloid isolated from the dried roots of Stephamis tetlandra S. Moor, was previously demonstrated to ameliorate colitis induced by dextran sulfate sodium (DSS) in mice. ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21502]

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E-selectin negatively regulates polymorphonuclear neutrophil transmigration through altered endothelial junction integrity.

Dandan Huang, Qihan Ding, Shenbao Chen, Shouqin Lü, Yan Zhang, Mian Long,

Transendothelial migration (TEM) of neutrophils under blood flow is critical in the inflammatory cascade. However, the role of endothelial plasticity in this process is not fully understood. Therefore, we used an in vitro model to test the dynamics of human polymorphonuclear neutrophil (PMN) TEM across lipopolysaccharide-treated human umbilical vein endothelial ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21521]

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Reduced RECK levels accelerate skeletal muscle differentiation, improve muscle regeneration, and decrease fibrosis.

Jaime Gutiérrez, David Gonzalez, Rodrigo Escalona-Rivano, Chiaki Takahashi, Enrique Brandan,

The muscle regeneration process requires a properly assembled extracellular matrix (ECM). Its homeostasis depends on the activity of different matrix-metalloproteinases (MMPs). The reversion-inducing-cysteine-rich protein with kazal motifs (RECK) is a membrane-anchored protein that negatively regulates the activity of different MMPs. However, the role of RECK in the process of skeletal ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21503]

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The sodium leak channel NALCN regulates cell excitability of pituitary endocrine cells.

Hathaichanok Impheng, Céline Lemmers, Malik Bouasse, Christian Legros, Narawut Pakaprot, Nathalie C Guérineau, Philippe Lory, Arnaud Monteil,

Anterior pituitary endocrine cells that release hormones such as growth hormone and prolactin are excitable and fire action potentials. In these cells, several studies previously showed that extracellular sodium (Na<sup>+</sup> ) removal resulted in a negative shift of the resting membrane potential (RMP) and a subsequent inhibition of the spontaneous ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21400]

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