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Functional lipidomics of vascular endothelial cells in response to laminar shear stress.

Tsuyoshi Hirata, Kimiko Yamamoto, Kazutaka Ikeda, Makoto Arita,

Laminar shear stress generated by blood flow stimulates endothelial cells and activates signal transduction, which plays an important role in vascular homeostasis. Several lines of evidence indicate that membrane and intracellular lipids are involved in the signal transduction of biomechanical stresses. In this study, we performed global profiling of cellular ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21301]

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Multidrug resistance-associated protein 4 (Mrp4) is a novel genetic factor in the pathogenesis of obesity and diabetes.

Ajay C Donepudi, Yoojin Lee, Ji-Young Lee, John D Schuetz, José E Manautou,

Multidrug resistance protein 4 (Mrp4) is an efflux transporter known to transport several xenobiotics and endogenous molecules. We recently identified that the lack of Mrp4 increases adipose tissue and body weights in mice. However, the role of Mrp4 in adipose tissue physiology are unknown. The current study aimed at characterizing ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21304]

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Myelination defects in the medial prefrontal cortex of Fkbp5 knockout mice.

Koeul Choi, Joonhee Lee, Hyo Jung Kang,

The hypothalamic-pituitary-adrenal (HPA) axis plays a principal role in stress response regulation and has been implicated in the etiology of stress-related disorders. The HPA axis regulates the normal synthesis and release of glucocorticoids; dysregulation of the HPA axis causes abnormal responses to stress. FK506-binding protein 5 (FKBP5), a co-chaperone of ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21297]

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Ceramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells.

Xuewei Zhang, Wataru Sakamoto, Daniel Canals, Masumi Ishibashi, Masaya Matsuda, Kentaro Nishida, Masafumi Toyoshima, Shogo Shigeta, Makoto Taniguchi, Can E Senkal, Toshiro Okazaki, Nobuo Yaegashi, Yusuf A Hannun, Takeshi Nabe, Kazuyuki Kitatani,

Regulation of sphingolipid metabolism plays a role in cellular homeostasis, and dysregulation of these pathways is involved in cancer progression. Previously, our reports identified ceramide as an anti-metastatic lipid. In the present study, we investigated the biochemical alterations in ceramide-centered metabolism of sphingolipids that were associated with metastatic potential. We ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21287]

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Lipocalin-2 mediates the rejection of neural transplants.

Yi-Chinn Weng, Yu-Ting Huang, I-Chen Chiang, Pei-Ju Tsai, Yu-Wen Su, Wen-Hai Chou,

Lipocalin-2 (LCN2) has been implicated in promoting apoptosis and neuroinflammation in neurological disorders; however, its role in neural transplantation remains unknown. In this study, we cultured and differentiated Lund human mesencephalic (LUHMES) cells into human dopaminergic-like neurons and found that LCN2 mRNA was progressively induced in mouse brain after the ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21317]

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Butyrate drives the acetylation of histone H3K9 to activate steroidogenesis through PPARγ and PGC1α pathways in ovarian granulosa cells.

Qianhong Ye, Xiangfang Zeng, Shuai Wang, Xiangzhou Zeng, Guangxin Yang, Changchuan Ye, Shuang Cai, Meixia Chen, Siyu Li, Shiyan Qiao,

Maintaining ovarian steroidogenesis is of critical importance, considering that steroid hormones are required for successful establishment and maintenance of pregnancy and proper development of embryos and fetuses. Investigating the mechanism that butyrate modulates the ovarian steroidogenesis is beneficial for understanding the impact of lipid nutrition on steroidogenesis. Herein, we identified ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21316]

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Sex-based differences after a single bout of exercise on PGC1α isoforms in skeletal muscle: A pilot study.

Daniela D'Amico, Antonella Marino Gammazza, Filippo Macaluso, Letizia Paladino, Federica Scalia, Giulio Spinoso, Ivan Dimauro, Daniela Caporossi, Francesco Cappello, Valentina Di Felice, Rosario Barone,

To date, there are limited and incomplete data on possible sex-based differences in fiber-types of skeletal muscle and their response to physical exercise. Adult healthy male and female mice completed a single bout of endurance exercise to examine the sex-based differences of the peroxisome proliferator-activated receptor gamma coactivator 1 alpha ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21328]

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Women, opioid use and addiction.

Teddy G Goetz, Jill B Becker, Carolyn M Mazure,

In the midst of the current coronavirus pandemic, the United States continues to struggle with an ongoing opioid epidemic, initially fueled by widespread prescribing of opioid medications during the 1990s. The primary reason for prescribing opioids is to treat pain. Women have more acute and chronic pain and have been ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21303]

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Mss51 deletion increases endurance and ameliorates histopathology in the mdx mouse model of Duchenne muscular dystrophy.

Yazmin I Rovira Gonzalez, Adam L Moyer, Nicolas J LeTexier, August D Bratti, Siyuan Feng, Vanessa Peña, Congshan Sun, Hannah Pulcastro, Ting Liu, Shama R Iyer, Richard M Lovering, Brian O'Rourke, Kathryn R Wagner,

Mitochondrial derangement is an important contributor to the pathophysiology of muscular dystrophies and may be among the earliest cellular deficits. We have previously shown that disruption of Mss51, a mammalian skeletal muscle protein that localizes to the mitochondria, results in enhanced muscle oxygen consumption rate, increased endurance capacity, and improved ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21276]

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Regulation of the nuclear speckle localization and function of Rac1.

Abdalla Abdrabou, Zhixiang Wang,

Despite significant evidence that Rac1 is localized to the nucleus, little is known regarding the function and biological significance of nuclear Rac1. Here, we showed that in response to EGF Rac1 was translocated to nuclear speckles and co-localized with the nuclear speckle marker Serine/arginine-rich splicing factor 2 (SRSF2) in Cos-7 ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21235]

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Antagonistic effects of finerenone and spironolactone on the aldosterone-regulated transcriptome of human kidney cells.

Florian Le Billan, Julie Perrot, Elena Carceller, Simon Travers, Say Viengchareun, Peter Kolkhof, Marc Lombès, Jérôme Fagart,

Aldosterone, the main mineralocorticoid hormone in humans, plays a pivotal role in the control of water and salt reabsorption via activation of the mineralocorticoid receptor (MR). Alterations in MR signaling pathway lead to renal dysfunction, including chronic kidney disease and renal fibrosis, that can be prevented or treated with mineralocorticoid ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21314]

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Endothelial cell secreted metalloproteinase-2 enhances neural stem cell N-cadherin expression, clustering, and migration.

Rita Matta, Muhammad Sulaiman Yousafzai, Michael Murrell, Anjelica L Gonzalez,

Neuroblasts have a clustered phenotype critical for their unidirectional migration, which in part is dependent on signaling from microvascular endothelial cells (EC) and pericytes (PC). Diffusible signals secreted by vascular cells have been demonstrated to increase survival, proliferation, and differentiation of subventricular zone resident neural stem cells (NSC); however, the ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21311]

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Temporal regulation of tumor growth in nocturnal mammals: In vivo studies and chemotherapeutical potential.

Paula M Wagner, César G Prucca, Fabiola N Velazquez, Lucas G Sosa Alderete, Beatriz L Caputto, Mario E Guido,

Tumors of the nervous system including glioblastoma multiforme (GBM) are the most frequent and aggressive form of brain tumors; however, little is known about the impact of the circadian timing system on the formation, growth, and treatment of these tumors. We investigated day/night differences in tumor growth after injection of ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21231]

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Novel immortalized human vocal fold epithelial cell line: In vitro tool for mucosal biology.

Xia Chen, Vlasta Lungova, Haiyan Zhang, Chitrasen Mohanty, Christina Kendziorski, Susan L Thibeault,

Study of vocal fold (VF) mucosal biology requires essential human vocal fold epithelial cell (hVFE) lines for use in appropriate model systems. We steadily transfected a retroviral construct containing human telomerase reverse transcriptase (hTERT) into primary normal hVFE to establish a continuously replicating hVFE cell line. Immortalized hVFE across passages ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21243]

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Protective role of IL33 signaling in negative pregnancy outcomes associated with lipopolysaccharide exposure.

Keisuke Kozai, Khursheed Iqbal, Ayelen Moreno-Irusta, Regan L Scott, Mikaela E Simon, Pramod Dhakal, Patrick E Fields, Michael J Soares,

Interleukin 33 (IL33) signaling has been implicated in the establishment and maintenance of pregnancy and in pregnancy disorders. The goal of this project was to evaluate the role of IL33 signaling in rat pregnancy. The rat possesses hemochorial placentation with deep intrauterine trophoblast invasion; features also characteristic of human placentation. ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21272]

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CircARID1A regulates mouse skeletal muscle regeneration by functioning as a sponge of miR-6368.

Jia Liu, MengLu Li, LingHao Kong, MengWen Cao, MoLan Zhang, YanHong Wang, ChengChuang Song, XingTang Fang, Hong Chen, ChunLei Zhang,

The noncoding RNAs play important role in growth and development of mammalian skeletal muscle. Recent work has shown that circRNAs are abundant in skeletal muscle tissue, with significant changes in their expression patterns during muscle development and aging. We identified a novel circRNA called circARID1A that is highly expressed in ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21324]

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A general strategy to inhibit serine protease by targeting its autolysis loop.

Longguang Jiang, Cai Yuan, Mingdong Huang,

Serine proteases are a large family of enzymes critical for multiple physiological processes, and proven diagnostic and therapeutic targets in several clinical indications. The high similarity of active sites among different serine proteases posts a challenge to reach high selectivity for inhibitors of serine proteases targeting at the active site. ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21259]

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p53-mediated regulation of mitochondrial dynamics plays a pivotal role in the senescence of various normal cells as well as cancer cells.

Young Yeon Kim, Jee-Hyun Um, Dong Jin Shin, Dae Jin Jeong, Young Bin Hong, Jeanho Yun,

The tumor suppressor p53 is known as a critical mediator of many cellular processes, including cellular senescence, but its role in mitochondrial dynamics is not fully understood. We have previously shown that p53 regulates mitochondrial dynamics via the PKA-Drp1 pathway to induce cellular senescence. In this study, to further understand ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21319]

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Deficiency of circadian gene cryptochromes in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice.

Yu-Sheng Lin, Ming-Lung Tsai, I-Chang Hsieh, Ming-Shien Wen, Chao-Yung Wang,

Cryptochromes are photoreceptors that mediate the circadian entrainment by light in plants and animals. They are also involved in magnetic field sensing in some animals. Recent studies suggest that cryptochromes play an essential role in metabolism and cardiovascular disease. However, the tissue-specific function of cryptochromes in atherosclerosis is unknown. We ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21309]

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Silencing of circIgf1r plays a protective role in neuronal injury via regulating astrocyte polarization during epilepsy.

Lin Shao, Guang-Tong Jiang, Xing-Liang Yang, Meng-Liu Zeng, Jing-Jing Cheng, Shuo Kong, Xin Dong, Tao-Xiang Chen, Song Han, Jun Yin, Wan-Hong Liu, Xiao-Hua He, Chunjiang He, Bi-Wen Peng,

Epilepsy is a common brain disorder, repeated seizures of epilepsy may lead to a series of brain pathological changes such as neuronal or glial damage. However, whether circular RNAs are involved in neuronal injury during epilepsy is not fully understood. Here, we screened circIgf1r in the status epilepticus model through ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21330]

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Nanoparticle-encapsulated antioxidant improves placental mitochondrial function in a sexually dimorphic manner in a rat model of prenatal hypoxia.

Esha Ganguly, Raven Kirschenman, Floor Spaans, Claudia D Holody, Thomas E J Phillips, C Patrick Case, Christy-Lynn M Cooke, Michael P Murphy, Hélène Lemieux, Sandra T Davidge,

Pregnancy complications associated with prenatal hypoxia lead to increased placental oxidative stress. Previous studies suggest that prenatal hypoxia can reduce mitochondrial respiratory capacity and mitochondrial fusion, which could lead to placental dysfunction and impaired fetal development. We developed a placenta-targeted treatment strategy using a mitochondrial antioxidant, MitoQ, encapsulated into nanoparticles ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, :e21338]

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The tumor suppressor LATS2 reduces v-Src-induced membrane blebs in a kinase activity-independent manner.

Masayoshi Ikeuchi, Ryuzaburo Yuki, Youhei Saito, Yuji Nakayama,

When cells with excess DNA, such as tetraploid cells, undergo cell division, it can contribute to cellular transformation via asymmetrical chromosome segregation-generated genetic diversity. Cell cycle progression of tetraploid cells is suppressed by large tumor suppressor 2 (LATS2) kinase-induced inhibitory phosphorylation of the transcriptional coactivator Yes-associated protein (YAP). We recently ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(1):e21242]

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Stimulation of endogenous pulsatile growth hormone secretion by activation of growth hormone secretagogue receptor reduces the fat accumulation and improves the insulin sensitivity in obese mice.

Zhengxiang Huang, Xuehan Lu, Lili Huang, Chunhong Zhang, Johannes D Veldhuis, Michael A Cowley, Chen Chen,

Obese individuals often show low growth hormone (GH) secretion, which leads to reduced lipid mobilization and further fat accumulation. Pharmacological approaches to increase GH levels in obese individuals by GH injection or GH-releasing hormone receptor agonist showed promising effects on fat reduction. However, side effects on glucose metabolism and the ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(1):e21269]

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Spatial and temporal roles of SARS-CoV PLpro -A snapshot.

Shaomin Yan, Guang Wu,

SARS-CoV and SARS-CoV-2 encode four structural and accessory proteins (spike, envelope, membrane and nucleocapsid proteins) and two polyproteins (pp1a and pp1ab). The polyproteins are further cleaved by 3C-like cysteine protease (3CL<sup>pro</sup> ) and papain-like protease (PL<sup>pro</sup> ) into 16 nonstructural proteins (nsps). PL<sup>pro</sup> is released from nsp3 through autocleavage, and ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(1):e21197]

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27-Hydroxycholesterol regulates human SLC22A12 gene expression through estrogen receptor action.

Masaya Matsubayashi, Yoshihiko M Sakaguchi, Yoshiki Sahara, Hitoki Nanaura, Sotaro Kikuchi, Arvand Asghari, Linh Bui, Shinko Kobashigawa, Mari Nakanishi, Riko Nagata, Takeshi K Matsui, Genro Kashino, Masatoshi Hasegawa, Shin Takasawa, Masahiro Eriguchi, Kazuhiko Tsuruya, Shushi Nagamori, Kazuma Sugie, Takahiko Nakagawa, Minoru Takasato, Michihisa Umetani, Eiichiro Mori,

The excretion and reabsorption of uric acid both to and from urine are tightly regulated by uric acid transporters. Metabolic syndrome conditions, such as obesity, hypercholesterolemia, and insulin resistance, are believed to regulate the expression of uric acid transporters and decrease the excretion of uric acid. However, the mechanisms driving ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(1):e21262]

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