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Galectin-9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin-dependent manner.

Asif J Iqbal, Franziska Krautter, Isobel A Blacksell, Rachael D Wright, Shani N Austin-Williams, Mathieu Benoit-Voisin, Mohammed T Hussain, Hannah L Law, Toshiro Niki, Mitsuomi Hirashima, Michele Bombardieri, Costantino Pitzalis, Alok Tiwari, Gerard B Nash, Lucy V Norling, Dianne Cooper,

Neutrophil trafficking is a key component of the inflammatory response. Here, we have investigated the role of the immunomodulatory lectin Galectin-9 (Gal-9) on neutrophil recruitment. Our data indicate that Gal-9 is upregulated in the inflamed vasculature of RA synovial biopsies and report the release of Gal-9 into the extracellular environment ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2022, 36(1):e22065]

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Eph signaling is regulated by miRNA-210: Implications for corneal epithelial repair.

Nihal Kaplan, Min Liu, Junyi Wang, Wending Yang, Elaina Fiolek, Han Peng, Robert M Lavker,

A distinct boundary exists between the progenitor cells in the basal limbal epithelium and the more differentiated corneal epithelial basal cells. We have shown that reciprocal expression patterns of EphA2 and Ephrin-A1 are likely to contribute to normal limbal-corneal epithelial compartmentalization as well as play a role in response to ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2022, 36(1):e22076]

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Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 1.

Stefanie Ruhs, Bruno Griesler, Ralf Huebschmann, Katharina Stroedecke, Nicole Straetz, Christian Ihling, Andrea Sinz, Antonia Masch, Mike Schutkowski, Michael Gekle, Claudia Grossmann,

The mineralocorticoid receptor (MR) with its ligand aldosterone (aldo) physiologically regulates electrolyte homeostasis and blood pressure but it can also lead to pathophysiological effects in the cardiovascular system. Previous results show that posttranslational modifications (PTM) can influence MR signaling and function. Based on in silico and in vitro data, casein ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2022, 36(1):e22059]

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A newly intervention strategy in preeclampsia: Targeting PD-1/Tim-3 signaling pathways to modulate the polarization of decidual macrophages.

Xiao-Hui Hu, Zhi-Hui Li, Kahindo P Muyayalo, Li-Ling Wang, Chun-Yan Liu, Gil Mor, Ai-Hua Liao,

Programmed cell death-1 (PD-1) and T-cell immunoglobulin mucin-3 (Tim-3) are important immune checkpoint receptors that prevent an overreacted maternal immune response to fetal antigens during pregnancy. Disruption of complex immune regulation mechanisms is associated with adverse pregnancy outcomes, including preeclampsia (PE). Our recent study showed that the Tim-3 pathway was ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2022, 36(1):e22073]

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Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice.

Yalan Zhang, Imran H Quraishi, Heather McClure, Luis A Williams, YungChih Cheng, Siddharth Kale, Graham T Dempsey, Sudhir Agrawal, David J Gerber, Owen B McManus, Leonard K Kaczmarek,

Mutations in KCNC3, the gene that encodes the Kv3.3 voltage dependent potassium channel, cause Spinocerebellar Ataxia type 13 (SCA13), a disease associated with disrupted motor behaviors, progressive cerebellar degeneration, and abnormal auditory processing. The Kv3.3 channel directly binds Hax-1, a cell survival protein. A disease-causing mutation, Kv3.3-G592R, causes overstimulation of ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22053]

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A novel smaller β-defensin-derived peptide is active against multidrug-resistant bacterial strains.

Roberta Colicchio, Ersilia Nigro, Irene Colavita, Chiara Pagliuca, Salvatore Di Maro, Stefano Tomassi, Elena Scaglione, Fortunata Carbone, Maria Vincenza Carriero, Giuseppe Matarese, Aurora Daniele, Sandro Cosconati, Antonello Pessi, Francesco Salvatore, Paola Salvatore,

Antibiotic resistance is becoming a severe obstacle in the fight against acute and chronic infectious diseases that accompany most degenerative illnesses from neoplasia to osteo-arthritis and obesity. Currently, the race is on to identify pharmaceutical molecules or combinations of molecules able to prevent or reduce the insurgence and/or progression of ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22026]

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Melatonin ameliorates cerebral ischemia-reperfusion injury in diabetic mice by enhancing autophagy via the SIRT1-BMAL1 pathway.

Lian Liu, Quan Cao, Wenwei Gao, Bing-Yu Li, Cheng Zeng, Zhongyuan Xia, Bo Zhao,

Diabetic brains are more vulnerable to ischemia-reperfusion injury. Previous studies have proved that melatonin could protect against cerebral ischemia-reperfusion (CIR) injury in non-diabetic stroke models; however, its roles and the underlying mechanisms against CIR injury in diabetic mice remain unknown. Streptozotocin-induced diabetic mice and high-glucose-cultured HT22 cells were exposed to ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22040]

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Mechanical and chemical cues synergistically promote human venous smooth muscle cell osteogenesis through integrin β1-ERK1/2 signaling: A cell model of hemodialysis fistula calcification.

Chih-Yu Yang, Pu-Yuan Chang, Bo-Sheng Wu, Der-Cherng Tarng, Oscar Kuang-Sheng Lee,

Arteriovenous fistula (AVF) is the vascular access of choice for renal replacement therapy. However, AVF is susceptible to calcification with a high prevalence of 40%-65% in chronic hemodialysis patients. Repeated needle puncture for hemodialysis cannulation results in intimal denudation of AVF. We hypothesized that exposure to blood shear stress in ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22042]

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Quantitative analysis of neuronal mitochondrial movement reveals patterns resulting from neurotoxicity of rotenone and 6-hydroxydopamine.

Rui F Simões, Rute Pino, Maurício Moreira-Soares, Jaromira Kovarova, Jiri Neuzil, Rui Travasso, Paulo J Oliveira, Teresa Cunha-Oliveira, Francisco B Pereira,

Alterations in mitochondrial dynamics, including their intracellular trafficking, are common early manifestations of neuronal degeneration. However, current methodologies used to study mitochondrial trafficking events rely on parameters that are primarily altered in later stages of neurodegeneration. Our objective was to establish a reliable applied statistical analysis to detect early alterations ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22024]

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Mechanical loading alleviated the inhibition of β2-adrenergic receptor agonist terbutaline on bone regeneration.

Ziyan Wang, Yang Liu, Jianing Zhang, Minmin Lin, Chufan Xiao, Haoying Bai, Chao Liu,

The long-term use of adrenergic medication in treating various conditions, such as asthma, increases the chances of bone fracture. Dynamic mechanical loading at a specific time is a method for improving bone quality and promoting healing. Therefore, we hypothesized that precisely controlling the mechanical environment can contribute to the alleviation ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22033]

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SMAD2 and SMAD3 differentially regulate adiposity and the growth of subcutaneous white adipose tissue.

Roshan Kumari, Maria Johnson Irudayam, Qusai Al Abdallah, Tamekia L Jones, Tahliyah S Mims, Michelle A Puchowicz, Joseph F Pierre, Chester W Brown,

Adipose tissue is the primary site of energy storage, playing important roles in health. While adipose research largely focuses on obesity, fat also has other critical functions, producing adipocytokines and contributing to normal nutrient metabolism, which in turn play important roles in satiety and total energy homeostasis. SMAD2/3 proteins are ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22018]

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Suppression of Plasmodium MIF-CD74 signaling protects against severe malaria.

Alvaro Baeza Garcia, Edwin Siu, Xin Du, Lin Leng, Blandine Franke-Fayard, Chris J Janse, Shanshan W Howland, Laurent Rénia, Elias Lolis, Richard Bucala,

The deadliest complication of infection by Plasmodium parasites, cerebral malaria, accounts for the majority of malarial fatalities. Although our understanding of the cellular and molecular mechanisms underlying the pathology remains incomplete, recent studies support the contribution of systemic and neuroinflammation as the cause of cerebral edema and blood-brain barrier (BBB) ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e21997]

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Relevance of VEGF and CD147 in different SARS-CoV-2 positive digestive tracts characterized by thrombotic damage.

Daria Bortolotti, Carolina Simioni, Luca Maria Neri, Roberta Rizzo, Chiara Marina Semprini, Savino Occhionorelli, Ilaria Laface, Juana Maria Sanz, Giovanna Schiuma, Sabrina Rizzo, Gabriele Varano, Silvia Beltrami, Valentina Gentili, Roberta Gafà, Angelina Passaro,

Several evidence suggests that, in addition to the respiratory tract, also the gastrointestinal tract is a main site of severe acute respiratory syndrome CoronaVirus 2 (SARS-CoV-2) infection, as an example of a multi-organ vascular damage, likely associated with poor prognosis. To assess mechanisms SARS-CoV-2 responsible of tissue infection and vascular ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e21969]

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LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia.

Sohta Ishihama, Satoya Yoshida, Tatsuya Yoshida, Yu Mori, Noriyuki Ouchi, Shunsuke Eguchi, Teruhiro Sakaguchi, Takuma Tsuda, Katsuhiro Kato, Yuuki Shimizu, Koji Ohashi, Takahiro Okumura, Yasuko K Bando, Hiroaki Yagyu, Nina Wettschureck, Naoto Kubota, Stefan Offermanns, Takashi Kadowaki, Toyoaki Murohara, Mikito Takefuji,

In the heart, fatty acid is a major energy substrate to fuel contraction under aerobic conditions. Ischemia downregulates fatty acid metabolism to adapt to the limited oxygen supply, making glucose the preferred substrate. However, the mechanism underlying the myocardial metabolic shift during ischemia remains unknown. Here, we show that lipoprotein ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22048]

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OTUB1 regulates lung development, adult lung tissue homeostasis, and respiratory control.

Amalia Ruiz-Serrano, Josep M Monné Rodríguez, Julia Günter, Samantha P M Sherman, Agnieszka E Jucht, Pascal Fluechter, Yulia L Volkova, Svende Pfundstein, Giovanni Pellegrini, Carsten A Wagner, Christoph Schneider, Roland H Wenger, Carsten C Scholz,

OTUB1 is one of the most highly expressed deubiquitinases, counter-regulating the two most abundant ubiquitin chain types. OTUB1 expression is linked to the development and progression of lung cancer and idiopathic pulmonary fibrosis in humans. However, the physiological function of OTUB1 is unknown. Here, we show that constitutive whole-body Otub1 ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22039]

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Dysregulated retinoic acid signaling in airway smooth muscle cells in asthma.

Amy E Defnet, Sushrut D Shah, Weiliang Huang, Paul Shapiro, Deepak A Deshpande, Maureen A Kane,

Vitamin A deficiency has been shown to exacerbate allergic asthma. Previous studies have postulated that retinoic acid (RA), an active metabolite of vitamin A and high-affinity ligand for RA receptor (RAR), is reduced in airway inflammatory condition and contributes to multiple features of asthma including airway hyperresponsiveness and excessive accumulation ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22016]

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Erratum.

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22064]

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Francis S. Collins: Transformer and translator for NIH.

Thoru Pederson,

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22022]

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Erratum.

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22050]

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Transcription factor SOX4 facilitates BMP2-regulated gene expression during invasive trophoblast differentiation.

Yuyin Yi, Hua Zhu, Christian Klausen, Peter C K Leung,

The interplay between growth factors, signaling pathways and transcription factors during placental development is key to controlling trophoblast differentiation. Bone morphogenetic protein 2 (BMP2) has been implicated in trophoblast invasion and spiral artery remodeling during early placental development. However, the molecular mechanisms by which these are accomplished have not been ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22028]

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The effects of maturation and aging on the rotator cuff tendon-to-bone interface.

Xiping Jiang, Melinda Wojtkiewicz, Chinmay Patwardhan, Sydney Greer, Yunfan Kong, Mitchell Kuss, Xi Huang, Jun Liao, Yongfeng Lu, Andrew Dudley, Rebekah L Gundry, Matthias Fuchs, Philipp Streubel, Bin Duan,

Rotator cuff tendon injuries often occur at the tendon-to-bone interface (i.e., enthesis) area, with a high prevalence for the elderly population, but the underlying reason for this phenomenon is still unknown. The objective of this study is to identify the histological, molecular, and biomechanical alterations of the rotator cuff enthesis ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22066]

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Choline metabolome response to prenatal choline supplementation across pregnancy: A randomized controlled trial.

Siraphat Taesuwan, Melissa Q McDougall, Olga V Malysheva, Erica Bender, Julie E H Nevins, Srisatish Devapatla, Ramesh Vidavalur, Marie A Caudill, Kevin C Klatt,

Pregnancy places a unique stress upon choline metabolism, requiring adaptations to support both maternal and fetal requirements. The impact of pregnancy and prenatal choline supplementation on choline and its metabolome in free-living, healthy adults is relatively uncharacterized. This study investigated the effect of prenatal choline supplementation on maternal and fetal ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22063]

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The LPS induced pyroptosis exacerbates BMPR2 signaling deficiency to potentiate SLE-PAH.

Yanjiang Xing, Jiuliang Zhao, Meijun Zhou, Shuliang Jing, Xin Zhao, Pei Mao, Junyan Qian, Can Huang, Zhuang Tian, Qian Wang, Xiaofeng Zeng, Mengtao Li, Jun Yang,

Pulmonary arterial hypertension (PAH) is a common and fatal complication of systemic lupus erythematosus (SLE). Whether the BMP receptor deficiency found in the genetic form of PAH is also involved in SLE-PAH patients remains to be identified. In this study, we employed patient-derived samples from SLE-associated PAH (SLE-PAH) and established ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22044]

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Science tikkun: Science for humanity in an age of aggression.

Peter Hotez,

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e22047]

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The role of the electron transport chain in immunity.

Maureen Yin, Luke A J O'Neill,

The electron transport chain (ETC) couples oxidative phosphorylation (OXPHOS) with ATP synthase to drive the generation of ATP. In immune cells, research surrounding the ETC has drifted away from bioenergetics since the discovery of cytochrome c (Cyt c) release as a signal for programmed cell death. Complex I has been ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(12):e21974]

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