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Apela gene therapy alleviates pulmonary hypertension in rats.

Yuexin Hu, Liangli Jin, Yang Pan, Jue Zou, Zhi Wang,

Pulmonary artery hypertension (PAH) is a common disease that threatens human health. At present, no treatment can cure PAH, and the prognosis is poor. Therefore, it is important to determine new targets for PAH treatment. Recently, a novel endogenous ligand Apela (ELABELA/Toddler/ELA32) of apelin peptide jejunum (APJ) receptor was identified ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2022, 36(7):e22431]

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High phosphate-induced progressive proximal tubular injury is associated with the activation of Stat3/Kim-1 signaling pathway and macrophage recruitment.

Beatrice Richter, Tamar Kapanadze, Nina Weingärtner, Stefanie Walter, Isabel Vogt, Andrea Grund, Jessica Schmitz, Jan Hinrich Bräsen, Florian P Limbourg, Dieter Haffner, Maren Leifheit-Nestler,

Dietary phosphate intake in the Western population greatly exceeds the recommended dietary allowance and is linked to enhanced cardiovascular and all-cause mortality. It is unclear whether a chronic high phosphate diet (HPD) causes kidney injury in healthy individuals. Here, we show that feeding a 2% HPD in C57BL/6N mice for ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2022, 36(7):e22407]

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