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Meis1, Hi1α, and GATA1 are integrated into a hierarchical regulatory network to mediate primitive erythropoiesis.

Hsin-Yu Chung, Bo-An Lin, Yi-Xuan Lin, Chen-Wei Chang, Wen-Shyong Tzou, Tun-Wen Pei, Chin-Hwa Hu,

During development, erythroid cells are generated by two waves of hematopoiesis. In zebrafish, primitive erythropoiesis takes place in the intermediate cell mass region, and definitive erythropoiesis arises from the aorta-gonad mesonephros. TALE-homeoproteins Meis1 and Pbx1 function upstream of GATA1 to specify the erythroid lineage. Embryos lacking Meis1 or Pbx1 have ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21915]

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Polycystin-1 dependent regulation of polycystin-2 via GRP94, a member of HSP90 family that resides in the endoplasmic reticulum.

Qin Yao, Patricia Outeda, Hangxue Xu, Rebecca Walker, Denis Basquin, Feng Qian, Liudmila Cebotaru, Terry Watnick, Valeriu Cebotaru,

Autosomal dominant polycystic kidney disease is a common inherited renal disorder that results from mutations in either PKD1 or PKD2, encoding polycystin-1 (PC1) and polycystin-2 (PC2), respectively. Downregulation or overexpression of PKD1 or PKD2 in mouse models results in renal cyst formation, suggesting that the quantity of PC1 and PC2 ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21865]

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Fusion and beyond: Satellite cell contributions to loading-induced skeletal muscle adaptation.

Kevin A Murach, Christopher S Fry, Esther E Dupont-Versteegden, John J McCarthy, Charlotte A Peterson,

Satellite cells support adult skeletal muscle fiber adaptations to loading in numerous ways. The fusion of satellite cells, driven by cell-autonomous and/or extrinsic factors, contributes new myonuclei to muscle fibers, associates with load-induced hypertrophy, and may support focal membrane damage repair and long-term myonuclear transcriptional output. Recent studies have also ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21893]

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Zoledronate alters natural progression of tissue-engineered vascular grafts.

Yu-Chun Chang, Junlang Li, Gabriel Mirhaidari, Jacob Zbinden, Jenny Barker, Kevin Blum, James Reinhardt, Cameron Best, John Kelly, Toshihiro Shoji, Tai Yi, Christopher Breuer,

Macrophages are a critical driver of neovessel formation in tissue-engineered vascular grafts (TEVGs), but also contribute to graft stenosis, a leading clinical trial complication. Macrophage depletion via liposomal delivery of clodronate, a first-generation bisphosphonate, mitigates stenosis, but simultaneously leads to a complete lack of tissue development in TEVGs. This result ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21849]

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Novel approaches to intervene gut microbiota in the treatment of chronic liver diseases.

Chang Liu, Yu-Li Wang, Yong-Yu Yang, Ning-Ping Zhang, Chen Niu, Xi-Zhong Shen, Jian Wu,

Recent investigations of gut microbiota have contributed to understanding of the critical role of microbial community in pathophysiology. Dysbiosis not only causes disturbance directly to the gastrointestinal tract but also affects the liver through gut-liver axis. Various types of dysbiosis have been documented in alcoholic liver disease (ALD), nonalcoholic fatty ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21871]

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X-ray microtomography reveals a lattice-like network within aortic elastic lamellae.

Aïcha Ben Zemzem, Aline Genevaux, Amandine Wahart, Andrew J Bodey, Sébastien Blaise, Béatrice Romier-Crouzet, Jessica Jonquet, Camille Bour, Rémi Cogranne, Pierre Beauseroy, Manuel Dauchez, Michael J Sherratt, Laurent Debelle, Sébastien Almagro,

The arterial wall consists of three concentric layers: intima, media, and adventitia. Beyond their resident cells, these layers are characterized by an extracellular matrix (ECM), which provides both biochemical and mechanical support. Elastin, the major component of arterial ECM, is present in the medial layer and organized in concentric elastic ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21844]

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The 2021 FASEB Virtual Science Research Conference on Protein Aggregation: Function, Dysfunction, and Disease, June 23-25, 2021.

Danny M Hatters, Randal Halfmann, Jean Baum,

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21884]

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US companies' COVID patents: Will "the saints go marching in"?

Thoru Pederson,

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21879]

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Group IIA secreted phospholipase A2 (PLA2G2A) augments adipose tissue thermogenesis.

Michael S Kuefner, Erin Stephenson, Mladen Savikj, Heather S Smallwood, Qingming Dong, Christine Payré, Gérard Lambeau, Edwards A Park,

Group IIA secreted phospholipase A2 (PLA2G2A) hydrolyzes glycerophospholipids at the sn-2 position resulting in the release of fatty acids and lysophospholipids. C57BL/6 mice do not express Pla2g2a due to a frameshift mutation (wild-type [WT] mice). We previously reported that transgenic expression of human PLA2G2A in C57BL/6 mice (IIA+ mice) protects ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21881]

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Plasma extracellular vesicles tau and β-amyloid as biomarkers of cognitive dysfunction of Parkinson's disease.

Chen-Chih Chung, Lung Chan, Jia-Hung Chen, Oluwaseun Adebayo Bamodu, Hung-Wen Chiu, Chien-Tai Hong,

The contribution of circulatory tau and β-amyloid in Parkinson's disease (PD), especially the cognitive function, remains inconclusive. Extracellular vesicles (EVs) cargo these proteins throughout the bloodstream after they are directly secreted from many cells, including neurons. The present study aims to investigate the role of the plasma EV-borne tau and ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21895]

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Tryptophan-derived serotonin-kynurenine balance in immune activation and intestinal inflammation.

Sabah Haq, Jensine A Grondin, Waliul I Khan,

Endogenous tryptophan metabolism pathways lead to the production of serotonin (5-hydroxytryptamine; 5-HT), kynurenine, and several downstream metabolites which are involved in a multitude of immunological functions in both health and disease states. Ingested tryptophan is largely shunted to the kynurenine pathway (95%) while only minor portions (1%-2%) are sequestered for ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21888]

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Neuromyelitis optica (NMO)-IgG-driven organelle reorganization in human iPSC-derived astrocytes.

Sukhee Cho, Hyein Lee, Minkyo Jung, Kirim Hong, Seung-Hwa Woo, Young-Sam Lee, Byoung Joon Kim, Mi Young Jeon, Jinsoo Seo, Ji Young Mun,

Neuromyelitis optica (NMO) is an autoimmune disease that primarily targets astrocytes. Autoantibodies (NMO-IgG) against the water channel protein, aquaporin 4 (AQP4), are a serologic marker in NMO patients, and they are known to be responsible for the pathophysiology of the disease. In the brain, AQP4 is mainly expressed in astrocytes, ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21894]

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Alterations in mitochondrial biogenesis and respiratory activity, inflammation of the senescence-associated secretory phenotype, and lipolysis in the perirenal fat and liver of rats following lifelong exercise and detraining.

Lei Sun, Fang-Hui Li, Chong Han, Zhuang-Zhi Wang, Ke-Ke Gao, Yi-Bo Qiao, Song Ma, Tian Xie, Jing Wang,

The primary aims of this study were to determine the effects of lifelong exercise and detraining on age-related alterations in mitochondrial function, inflammation associated with senescence-associated secretory phenotype (SASP), and lipolysis in the perirenal fat and liver of rats. Female Sprague-Dawley rats were randomly assigned to four groups: young control ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21890]

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Feeding intervention potentiates the effect of mechanical loading to induce new bone formation in mice.

Hasmik Jasmine Samvelyan, John Cummings Mathers, Timothy Michael Skerry,

The benefits of increased human lifespan depend upon duration of healthy, independent living; the healthspan. Bone-wasting disorders contribute significantly to loss of independence, frailty, and morbidity in older people. Therefore, there is an unmet need globally for lifestyle interventions to reduce the likelihood of bone fractures with age. Although many ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21792]

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Expression, regulation, and function of exosome-derived miRNAs in cancer progression and therapy.

Bowen Li, Yu Cao, Mingjun Sun, Hui Feng,

Exosomes are a novel class of intercellular signal modulators that contain a wide range of molecules and deliver information between cells and tissues. MicroRNAs (miRNAs), a type of regulatory non-coding RNA, are often incorporated into exosomes as signaling molecules. In this review, we discuss the expression of exosomal miRNAs from ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21916]

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Longitudinal peripheral tissue RNA-Seq transcriptomic profiling, hyperalgesia, and wound healing in the rat plantar surgical incision model.

Taichi Goto, Matthew R Sapio, Dragan Maric, Jeffrey M Robinson, Anthony F Domenichiello, Leorey N Saligan, Andrew J Mannes, Michael J Iadarola,

Postoperative pain and delayed healing in surgical wounds, which require complex management strategies have understudied complicated mechanisms. Here we investigated temporal changes in behavior, tissue structure, and transcriptomic profiles in a rat model of a surgical incision, using hyperalgesic behavioral tests, histological analyses, and next-generation RNA sequencing, respectively. The most ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21852]

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Low lysophosphatidylcholine induces skeletal muscle myopathy that is aggravated by high-fat diet feeding.

Patrick J Ferrara, Anthony R P Verkerke, J Alan Maschek, Justin L Shahtout, Piyarat Siripoksup, Hiroaki Eshima, Jordan M Johnson, Jonathan J Petrocelli, Ziad S Mahmassani, Thomas D Green, Joseph M McClung, James E Cox, Micah J Drummond, Katsuhiko Funai,

Obesity alters skeletal muscle lipidome and promotes myopathy, but it is unknown whether aberrant muscle lipidome contributes to the reduction in skeletal muscle contractile force-generating capacity. Comprehensive lipidomic analyses of mouse skeletal muscle revealed a very strong positive correlation between the abundance of lysophosphatidylcholine (lyso-PC), a class of lipids that ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21867]

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Retraction fibers produced by fibronectin-integrin α5β1 interaction promote motility of brain tumor cells.

Seon Yong Lee, Sang-Hun Choi, Min Seok Lee, Amanzhol Kurmashev, Hae Nim Lee, Young-Gyu Ko, Kanghun Lee, Sohee Jeong, Jihye Seong, Joo H Kang, Hyunggee Kim,

Glioblastoma (GBM) is a refractory disease that has a highly infiltrative characteristic. Over the past decade, GBM perivascular niche (PVN) has been described as a route of dissemination. Here, we investigated that trailed membrane structures, namely retraction fibers (RFs), are formed by perivascular extracellular matrix (ECM) proteins. By using the ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21906]

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Potential role of epicardial adipose tissue in coronary artery endothelial cell dysfunction in type 2 diabetes.

Noura N Ballasy, Anshul S Jadli, Pariya Edalat, Sean Kang, Ali Fatehi Hassanabad, Karina P Gomes, Paul W M Fedak, Vaibhav B Patel,

Cardiovascular disease is the most prevalent cause of morbidity and mortality in diabetes. Epicardial adipose tissue (EAT) lies in direct contact with the myocardium and coronary arteries and can influence cardiac (patho) physiology through paracrine signaling pathways. This study hypothesized that the proteins released from EAT represent a critical molecular ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21878]

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Neuronal calcium sensor 1 (NCS1) dependent modulation of neuronal morphology and development.

Tom T Fischer, Lien D Nguyen, Barbara E Ehrlich,

Calcium (Ca<sup>2+</sup> ) signaling is critical for neuronal functioning and requires the concerted interplay of numerous Ca<sup>2+</sup> -binding proteins, including neuronal calcium sensor 1 (NCS1). Although an important role of NCS1 in neuronal processes and in neurodevelopmental and neurodegenerative diseases has been established, the underlying mechanisms remain enigmatic. Here, we ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21873]

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Molecular basis of Period 1 regulation by adrenergic signaling in the heart.

Itamar C G Jesus, Flávia M Araújo, Thássio Mesquita, Nilton N S Júnior, Mário M Silva, Henrique J N Morgan, Kaoma S C Silva, Cleide L A Silva, Alexander Birbrair, Flávio A Amaral, Luiz C Navegantes, Helio C Salgado, Raphael E Szawka, Maristela O Poletini, Silvia Guatimosim,

The cardiac circadian clock is responsible for the modulation of different myocardial processes, and its dysregulation has been linked to disease development. How this clock machinery is regulated in the heart remains an open question. Because noradrenaline (NE) can act as a zeitgeber in cardiomyocytes, we tested the hypothesis that ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21886]

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Late adolescence mortality in mice with brain-specific deletion of the volume-regulated anion channel subunit LRRC8A.

Corinne S Wilson, Preeti Dohare, Shaina Orbeta, Julia W Nalwalk, Yunfei Huang, Russell J Ferland, Rajan Sah, Annalisa Scimemi, Alexander A Mongin,

The leucine-rich repeat-containing family 8 member A (LRRC8A) is an essential subunit of the volume-regulated anion channel (VRAC). VRAC is critical for cell volume control, but its broader physiological functions remain under investigation. Recent studies in the field indicate that Lrrc8a disruption in the brain astrocytes reduces neuronal excitability, impairs ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21869]

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Apela inhibits systemic and renal inflammatory reactions in mice with type I cardiorenal syndrome.

Liangli Jin, Quanyi Li, Jing Li, Yang Pan, Jue Zou, Xiaoyuan Wu, Zhi Wang,

This study investigated the effect of apela on renal function and anti-inflammatory effect on whole body and kidney tissue in mice with type I cardiorenal syndrome (CRS). The murine type I CRS model was established and apela was subcutaneously infused for two weeks. Cardiac and renal functions were evaluated by ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21907]

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Pre-clinical evaluation of dual targeting of the GPCRs CaSR and V2R as therapeutic strategy for autosomal dominant polycystic kidney disease.

Annarita Di Mise, Xiaofang Wang, Hong Ye, Lorenzo Pellegrini, Vicente E Torres, Giovanna Valenti,

Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations of PKD1 or PKD2 genes, is characterized by development and growth of cysts causing progressive kidney enlargement. Reduced resting cytosolic calcium and increased cAMP levels associated with the tonic action of vasopressin are two central biochemical defects in ADPKD. Here we ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21874]

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Gemcitabine synergizes with cisplatin to inhibit nasopharyngeal carcinoma cell proliferation and tumor growth.

Shi-Wei He, Yuan Zhang, Lei Chen, Wei-Jie Luo, Xiao-Min Li, Yang Chen, Sheng-Yan Huang, Qing-Mei He, Xiao-Jing Yang, Ying-Qin Li, Na Liu, Yin Zhao, Jun Ma,

In a recently published phase III clinical trial, gemcitabine (GEM) plus cisplatin (DDP) induction chemotherapy significantly improved recurrence-free survival and overall survival and became the standard of care among patients with locoregionally advanced NPC. However, the molecular mechanisms of GEM synergized with DPP in NPC cells remain elucidated. These findings ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21885]

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