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4th ISCB Latin American Student Council Symposium: a virtual and inclusive experience during COVID-19 times.

Camila Castillo-Vilcahuaman, Catalina Valdivia, Cleidy Osorio-Mogollón, Claudia Silva-Andrade, Rafael Puche, Sebastián Ayala-Ruano, Yesid Cuesta-Astroz, R Gonzalo Parra,

Since 2014, the ISCB Latin American Student Council Symposium (LA-SCS) serves as the main biannual activity where students from all levels, postdocs and early researchers from the entire Latin American region can gather to discuss recent advances in the fields of bioinformatics and computational biology. This time we faced a ... Read more >>

F1000Res (F1000Research)
[2020, 9:]

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Case Report: A rare presentation and diagnosis of gingival melanoacanthoma caused by teeth whitening strips.

Hamad Albagieh, Ashwag Aloyouny, Shatha Alharthi,

Background: Oral melanoacanthoma is not common. It occurs mostly on the buccal mucosa. Since it happens suddenly and progresses rapidly, it clinically resembles melanoma. Melanoacanthoma occurs in regions susceptible to trauma. The clinical presentation of the lesion is not enough to diagnose it; therefore, tissue biopsy is necessary to exclude ... Read more >>

F1000Res (F1000Research)
[2020, 9:1452]

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The role of exogenous epidermal growth factor on Ki-67 proliferation marker expression in the submandibular salivary gland of albino rats receiving doxorubicin.

Mohamed Mansy, Malak Soliman, Rabab Mubarak, Mohamed Shamel,

<b>Background:</b> This study was conducted to evaluate the role of exogenous epidermal growth factor (EGF) injection on the Ki-67 immuno-expression in submandibular salivary gland tissue of rats receiving doxorubicin (DXR). <b>Methods:</b> A total of 21 two-month-old male albino rats, of 200 g body weight, were divided into three groups: control ... Read more >>

F1000Res (F1000Research)
[2020, 9:1393]

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'The long tail of Covid-19' - The detection of a prolonged inflammatory response after a SARS-CoV-2 infection in asymptomatic and mildly affected patients.

Ivan Doykov, Jenny Hällqvist, Kimberly C Gilmour, Louis Grandjean, Kevin Mills, Wendy E Heywood,

'Long Covid', or medical complications associated with post SARS-CoV-2 infection, is a significant post-viral complication that is being more and more commonly reported in patients. Therefore, there is an increasing need to understand the disease mechanisms, identify drug targets and inflammatory processes associated with a SARS-CoV-2 infection. To address this ... Read more >>

F1000Res (F1000Research)
[2020, 9:1349]

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On the transformation of MinHash-based uncorrected distances into proper evolutionary distances for phylogenetic inference.

Alexis Criscuolo,

Recently developed MinHash-based techniques were proven successful in quickly estimating the level of similarity between large nucleotide sequences. This article discusses their usage and limitations in practice to approximating uncorrected distances between genomes, and transforming these pairwise dissimilarities into proper evolutionary distances. It is notably shown that complex distance measures can ... Read more >>

F1000Res (F1000Research)
[2020, 9:1309]

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Creating and sustaining collaborative multi-institutional industry site visit programs: a toolkit.

Tammy R L Collins, Kiri Hoff, Molly Starback, Patrick D Brandt, Christopher E Holmquist, Rebekah L Layton,

<b>Background:</b> As more early career scientists enter into diverse career pathways, visiting local companies or organizations can support their exploration of these paths. As an efficient way to facilitate this, we developed a collaborative regional site visit program: the Enhancing Local Industry Transitions through Exploration (ELITE) Consortium.  Consortium members arrange ... Read more >>

F1000Res (F1000Research)
[2020, 9:1317]

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Psychological burden of the COVID-19 pandemic and its associated factors among frontline doctors of Bangladesh: a cross-sectional study.

Lingkan Barua, Muhammed Shahriar Zaman, Fardina Rahman Omi, Mithila Faruque,

<b>Background:</b> Frontline doctors are the most vulnerable and high-risk population to get the novel coronavirus disease 2019 (COVID-19) infection. Hence, we aimed to evaluate the anxiety, depression, sleep disturbance and fear of COVID-19 among frontline doctors of Bangladesh during the pandemic, and the associated factors for these psychological symptoms. <b>Methods:</b> ... Read more >>

F1000Res (F1000Research)
[2020, 9:1304]

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Cancer T-cell therapy: building the foundation for a cure.

Alexander Kamb, William Y Go,

T-cell cancer therapy is a clinical field flush with opportunity.  It is part of the revolution in immuno-oncology, most apparent in the dramatic clinical success of PD-1/CTLA-4 antibodies and chimeric antigen receptor T-cells (CAR-Ts) to cure certain melanomas and lymphomas, respectively.  Therapeutics based on T cells ultimately hold more promise ... Read more >>

F1000Res (F1000Research)
[2020, 9:1295]

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Activation of the Keap1-Nrf2 pathway by specioside and the n-butanol extract from the inner bark of Tabebuia rosea (Bertol) DC.

Sandra Catalina Garzón-Castaño, Francisco Javier Jiménez-González, Luz Angela Veloza, Juan Carlos Sepúlveda-Arias,

<b>Background:</b> A large number of chemical compounds exert their antioxidant effects by activation of key transcriptional regulatory mechanisms, such as the transcription factor Nrf2. The aim of this study was to evaluate the activation of the Keap1-Nrf2 pathway by both the <i>n</i>-butanol extract obtained from the inner bark of <i>Tabebuia ... Read more >>

F1000Res (F1000Research)
[2020, 9:1262]

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The evaluation of feeding, mortality and oviposition of poultry red mite ( Dermanyssus gallinae) on aging hens using a high welfare on-hen feeding device.

Francesca Nunn, Kathryn Bartley, Javier Palarea-Albaladejo, Alasdair J Nisbet,

A study was performed to examine any effect of hen age on the feeding ability and mortality of different life-stages of <i>Dermanyssus gallinae</i> [Poultry Red Mite (PRM)] when fed using a high welfare, on-hen mite feeding device. Mite feeding assays were carried out every two weeks on a cohort of ... Read more >>

F1000Res (F1000Research)
[2020, 9:1266]

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Nutritional value of the Middle Eastern diet: analysis of total sugar, salt, and iron in Lebanese traditional dishes.

Maha Hoteit, Edwina Zoghbi, Mohamad Al Iskandarani, Alissar Rady, Iman Shankiti, Joseph Matta, Ayoub Al-Jawaldeh,

<b>Background:</b> The expanding burden of diet-related non-communicable diseases in the Eastern Mediterranean Countries requires urgent public health vigilance and actions. This study aimed at establishing a database analysis of total sugar, salt and iron content in Lebanese foods, focusing on traditional dishes. <b>Methods:</b> The collection of food samples was done ... Read more >>

F1000Res (F1000Research)
[2020, 9:1254]

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Protocol for a proof-of-concept observational study evaluating the potential utility and acceptability of a telemedicine solution for the post-anesthesia care unit.

Thaddeus P Budelier, Christopher Ryan King, Shreya Goswami, Anchal Bansal, Stephen H Gregory, Troy S Wildes, Joanna Abraham, Sherry L McKinnon, Amy Cooper, Ivan Kangrga, Jackie L Martin, Melissa Milbrandt, Alex S Evers, Michael S Avidan,

<b>Introduction:</b> The post-anesthesia care unit (PACU) is a clinical area designated for patients recovering from invasive procedures. There are typically several geographically dispersed PACUs within hospitals. Patients in the PACU can be unstable and at risk for complications. However, clinician coverage and patient monitoring in PACUs is not well regulated ... Read more >>

F1000Res (F1000Research)
[2020, 9:1261]

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TreeSummarizedExperiment: a S4 class for data with hierarchical structure.

Ruizhu Huang, Charlotte Soneson, Felix G M Ernst, Kevin C Rue-Albrecht, Guangchuang Yu, Stephanie C Hicks, Mark D Robinson,

Data organized into hierarchical structures (e.g., phylogenies or cell types) arises in several biological fields. It is therefore of interest to have data containers that store the hierarchical structure together with the biological profile data, and provide functions to easily access or manipulate data at different resolutions. Here, we present ... Read more >>

F1000Res (F1000Research)
[2020, 9:1246]

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Case Report: Complete heart block as a manifestation of cardiac metastasis of oral cancer.

Andrianto Andrianto, Eka Prasetya Budi Mulia, Denny Suwanto, Dita Aulia Rachmi, Mohammad Yogiarto,

Metastatic tumors of the heart presenting with complete heart block (CHB) is an extremely uncommon case. There are no available guidelines in managing CHB in terminal cancer. Permanent pacemaker implantation in such cases is a challenge in terms of clinical utility and palliative care. We report a case of a ... Read more >>

F1000Res (F1000Research)
[2020, 9:1243]

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Cross-sectional study of Facebook addiction in a sample of Nepalese population.

Alok Atreya, Samata Nepal, Prakash Thapa,

Background: Facebook addiction is said to occur when an individual spends an excessive amount of time on Facebook, disrupting one's daily activities and social life. The present study aimed to find out the level of Facebook addiction in the Nepalese context and briefly discuss the issues associated with its unintended ... Read more >>

F1000Res (F1000Research)
[2020, 9:1237]

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Retrospective evaluation of two-year results with a filtering trabeculotomy in comparison to conventional trabeculectomy by exact matching.

Alicja Strzalkowska, Peter Strzalkowski, Yousef Al Yousef, Jost Hillenkamp, Franz Grehn, Nils A Loewen,

<b>Background:</b> To compare two-year results of a filtering trabeculotomy (FTO) to conventional trabeculectomy (TE) in open-angle glaucoma by exact matching. <b>Methods:</b> 110 patients received an FTO and 86 a TE. FTO avoided the need for an iridectomy due to a preserved trabeculo-descemet window anterior to the scleral flap. TE employed ... Read more >>

F1000Res (F1000Research)
[2020, 9:1245]

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Career planning courses increase career readiness of graduate and postdoctoral trainees.

Rebekah L Layton, V Scott H Solberg, Arthee E Jahangir, Joshua D Hall, Christine A Ponder, Keith J Micoli, Nathan L Vanderford,

<b>Background:</b> Given national calls for intentional career development during graduate and post-graduate scientific training, this study assessed career readiness development within the context of academic career courses. The current study evaluated the effects of academic career courses offered at two institutions that were specifically designed to increase career awareness, interest, ... Read more >>

F1000Res (F1000Research)
[2020, 9:1230]

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BioSounds: an open-source, online platform for ecoacoustics.

Kevin Darras, Noemí Pérez, Mauladi -, Tara Hanf-Dressler,

Passive acoustic monitoring of soundscapes and biodiversity produces vast amounts of audio recordings. However, the management of these raw data presents technical challenges and their analysis suffers from bottlenecks. A multitude of software solutions exist, but none can perform all the data processing needed by ecologists for analysing large acoustic ... Read more >>

F1000Res (F1000Research)
[2020, 9:1224]

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Recent advances in understanding, diagnosing and treating venous thrombosis.

Noel C Chan, Jeffrey I Weitz,

Focusing on the current state of the art, this article (a) describes recent advances in the understanding of the pathogenesis of venous thromboembolism (VTE), (b) discusses current approaches for the prevention, diagnosis and treatment of VTE, (c) outlines the role of aspirin for VTE prevention and treatment, and (d) highlights ... Read more >>

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[2020, 9:]

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Climate change is a major stressor causing poor pregnancy outcomes and child development.

David M Olson, Gerlinde A S Metz,

The climate crisis is the existential threat of our times and for generations to come. This is no longer a threat but a reality affecting us, our children, and the generations that follow. Pregnant mothers, their fetuses, and their children are among those at greatest risk in every population and ... Read more >>

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[2020, 9:]

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Potential therapeutic manipulations of the CXCR3 chemokine axis for the treatment of inflammatory fibrosing diseases.

Morgan K Groover, Jillian M Richmond,

Chemokines play important roles in homeostasis and inflammatory processes. While their roles in leukocyte recruitment are well-appreciated, chemokines play additional roles in the body, including mediating or regulating angiogenesis, tumor metastasis and wound healing. In this opinion article, we focus on the role of CXCR3 and its ligands in fibrotic ... Read more >>

F1000Res (F1000Research)
[2020, 9:1197]

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Journal- or article-based citation measure? A study of academic promotion at a Swiss university.

Nicole Steck, Lukas Stalder, Matthias Egger,

In academia, decisions on promotions are influenced by the citation impact of the works published by the candidates. The Medical Faculty of the University of Bern used a measure based on the journal impact factor (JIF) for this purpose: the JIF of the papers submitted for promotion should rank in ... Read more >>

F1000Res (F1000Research)
[2020, 9:1188]

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Bioinformatic study to discover natural molecules with activity against COVID-19.

Sweta Singh, Hector Florez,

<b>Background:</b> In 2020, the world has struggled to deal with coronavirus disease 2019 (COVID-19), which started in 2019 in China and has spread throughout the globe, affecting at least 31,175,835 humans globally and claiming 962,634 lives reported till 22nd September, 2020 by the World Health Organization. The main causative agent ... Read more >>

F1000Res (F1000Research)
[2020, 9:1203]

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Multi-parametric characterization of drug effects on cells.

Yael Paran, Yuvalal Liron, Sarit Batsir, Nicola Mabjeesh, Benjamin Geiger, Zvi Kam,

We present here a novel multi-parametric approach for the characterization of multiple cellular features, using images acquired by high-throughput and high-definition light microscopy. We specifically used this approach for deep and unbiased analysis of the effects of a drug library on five cultured cell lines. The presented method enables the ... Read more >>

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[2020, 9:]

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Nurse practitioners and physician assistants working in ambulance care: A systematic review.

Risco van Vliet, Remco Ebben, Nicolette Diets, Thomas Pelgrim, Jorik Loef, Lilian Vloet,

<b>Background</b>: This review aims to describe the activities of nurse practitioners (NPs) and physician assistants (PAs) working in ambulance care, and the effect of these activities on patient outcomes, process of care, provider outcomes, and costs. <b>Methods</b>: PubMed, MEDLINE (EBSCO), EMBASE (OVID), Web of Science, the Cochrane Library (Cochrane Database ... Read more >>

F1000Res (F1000Research)
[2020, 9:1182]

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