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Journal Exp. Dermatol.

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Lower proximal cup and outer root sheath cells regenerate hair bulbs during anagen hair follicle repair after chemotherapeutic injury.

Wen-Yen Huang, Jin-Bon Hong, Michael Chang, Shih-Yi Wang, Shih-Fan Lai, Hsiung-Fei Chien, Sung-Jan Lin,

The cell dynamics and cell origin for anagen hair follicle (HF) repair following chemotherapeutic injury are unclear. We first mapped the HF response to cyclophosphamide (CYP) at natural anagen VI in mice. We found that 30 to 60 mg/kg of CYP lead to dose-dependent HF dystrophy that was spontaneously repaired ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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Targeting the α7 nicotinic acetylcholine receptor -a novel road towards the future treatment of skin diseases.

Agatha Stegemann, Markus Böhm,

Nicotinic acetylcholine receptors (nAChRs) are members of the superfamily of neurotransmitter-gated ion channels. The natural ligand for nAChRs is the endogenous neurotransmitter acetylcholine. Among the nAChRs is the α7nAChR. It is not only expressed by neural tissues but also in the skin. A number of different resident cutaneous cell types ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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COVID-19 and Vitamin D: A lesson from the skin.

Radomir M Slominski, Joanna Stefan, Mohamad Athar, Michael F Holick, Anton M Jetten, Chander Raman, Andrzej T Slominski,

The negative outcomes of COVID-19 diseases respiratory distress (ARDS) and the damage to other organs are secondary to a "cytokine storm" and to the attendant oxidative stress. Active hydroxyl-forms of vitamin D are anti-inflammatory, induce anti-oxidative responses, and stimulate innate immunity against infectious agents. These properties are shared by calcitriol ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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Biomarker function of HMGA2 in ultraviolet-induced skin cancer development.

Wootae Ha, Amanda Hinde, Lillian Xie, Megan H Trager, Liang Liu,

The high mobility group AT-hook 2 (HMGA2) gene encodes a transcription factor that is expressed during embryonic development but down-regulated in adult tissues. Its re-expression in adult tissues is often associated with tumorigenesis. In this study, we found that HMGA2 is highly expressed in human cutaneous squamous cell carcinoma (SCC) ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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IL6R is a target of miR-197 in human keratinocytes.

Moamen Masalha, Devorah Gur-Wahnon, Talal Meningher, Iddoddo Z Ben-Dov, Riad Kassem, Yechezkel Sidi, Drorror Avni,

BACKGROUND:Psoriasis is a chronic inflammatory disorder with cutaneous and systemic manifestations and substantial negative effects on patients' quality of life. MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play a role in the pathogenesis of psoriasis. Previously studies, from others and by us, highlighted specific miRNAs that are dysregulated ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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Acne as an altered dermato-endocrine response problem.

Stefania Briganti, Enrica Flori, Arianna Mastrofrancesco, Monica Ottaviani,

Acne is the most common skin disease in adolescent Westernized populations. Several data support the involvement of the mammalian target of rapamycin complex 1 (mTORC1) signaling in the interplay between androgens, insulin, insulin-like growth factor (IGF1), and high glycemic index diet in acne. The Peroxisome Proliferator Activated Receptor γ (PPARγ) ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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Quantifying Cellular Forces: Practical Considerations of Traction Force Microscopy for Dermal Fibroblasts.

Abigail De La Pena, Marah Mukhtar, Ryosuke Yokosawa, Santiago Carrasquilla, Chelsey S Simmons,

Traction force microscopy (TFM) is a well-established technique traditionally used by biophysicists to quantify the forces adherent biological cells exert on their microenvironment. As image processing software becomes increasingly user-friendly, TFM is being adopted by broader audiences to quantify contractility of (myo)fibroblasts. While many technical reviews of TFM's computational mechanics ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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In-vivo confocal microscopy: the role of comparative approach in patients with multiple atypical nevi.

Sabrina Longhitano, Riccardo Pampena, Stefania Guida, Barbara De Pace, Silvana Ciardo, Johanna Chester, Caterina Longo, Francesca Farnetani, Giovanni Pellacani,

BACKGROUND:In-vivo reflectance confocal microscopy (RCM) increases diagnostic accuracy for melanoma diagnosis when combined with dermoscopy. In patients with multiple atypical nevi a comparative dermoscopic approach improves melanoma recognition and saves unnecessary excision. The performance of a comparative approach combining dermoscopy and RCM has not been yet investigated. OBJECTIVE:To validate a ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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Generalized pustular psoriasis - dawn of a new era in targeted immunotherapy.

Ruth Neuhauser, Kilian Eyerich, Alexander Boehner,

Generalized pustular psoriasis (GPP) is a rare, inflammatory skin disease characterized by recurrent flares of pustulation accompanied by systemic symptoms. Due to its acuteness, sufficient diagnosis and treatment is essential, but often faces challenges. We recently overviewed various treatment options of GPP utilizing established therapies in psoriasis vulgaris (PsO). Although ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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EZH2 Polymorphisms in melanoma skin cancer risk.

Belpinati Francesca, Malerba Giovanni, Dal Toè Melissa, Ceccuzzi Laura, Rodolfo Monica, Poli Albino, Turco Alberto, Vergani Elisabetta, Sangalli Antonella, Gomez-Lira Macarena,

BACKGROUND:Melanoma is the most deadly skin cancer and its incidence is growing. EZH2, a member of the Polycomb Group (PcGs) proteins family, plays an important biological role in the occurrence and development of melanoma. EZH2 germline genetic polymorphisms have not been yet evaluated in melanoma predisposition. METHODS:330 sporadic Italian melanoma ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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Heterogeneity in Amount of Growth Factors Secreted by Platelets in Platelet-Rich Plasma Samples from Alopecia Patients.

Javed A Shaik, Nima Estharabadi, Ronda S Farah, Maria K Hordinsky,

Platelet α-granules release growth factors (GFs) that promote healing and tissue regeneration. Platelet-rich plasma (PRP) is shown to be beneficial in treating alopecia, however, clinical response can be inconsistent. Due to several fold enrichment of platelets secreting large quantities of GFs following PRP injections, heterogeneity in amounts of GFs secreted ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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in vivo Quantitative Analysis of Advanced Glycation End Products in Atopic Dermatitis - Possible Culprit for the Comorbidities?

Ji Yeon Hong, Min Jeong Kim, Jun Ki Hong, Hyun Ha Noh, Kui Young Park, Mi Kyung Lee, Seong Jun Seo,

Advanced glycation end products (AGEs) interact with the membrane-bound receptor for AGEs (RAGE), consequently amplifying the inflammatory response. Soluble receptor for AGE (sRAGE) and endogenous secretory RAGE (esRAGE) act as decoys for AGE and competitively sequester RAGE ligands, thereby serving a cytoprotective role. Our objective was to investigate AGE expression ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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Endocrinology and immunology of acne: Two sides of the same coin.

Christos C Zouboulis,

Current experimental research on acne pathophysiology has revealed a more complicated template than the classically reported four factor etiology. Cells of the pilosebaceous unit, which represent the template for the developments of acne lesions seem to be parallelly affected by endocrinological/metabolic factors as well as inflammatory/immunological ones, which influence cooperate ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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Skin microbiota analysis in human 3D skin models - "Free your mice".

Hila Emmert, Franziska Rademacher, Regine Gläser, Jürgen Harder,

In the May issue of Experimental Dermatology 2018 we published a review article focusing on human 3D skin models in the context of microbiota research.[1] The principal intention was to provide an overview of present and future concepts to use skin models in microbiota analyses. With the present viewpoint we ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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Identification of putative phenotype-modifying genetic factors associated with phenotypic diversity in Brooke-Spiegler syndrome.

Éva Melinda Pap, Katalin Farkas, Márta Széll, Gábor Németh, Neil Rajan, Nikoletta Nagy,

Brooke-Spiegler syndrome (BSS, OMIM 605041) is a rare monogenic skin disease characterized by the development of skin appendage tumors caused by mutations in the cylindromatosis gene. We recently investigated a Hungarian and an Anglo-Saxon pedigrees affected by Brooke-Spiegler syndrome. Despite carrying the same disease-causing mutation (c.2806C>T, p.Arg936X) of the cylindromatosis ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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Development and characterization of a human Th17-driven ex vivo skin inflammation model.

Jardet Claire, David Anthony, Braun Emilie, Descargues Pascal, Grolleau Jean-Louis, Hebsgaard Josephine, Norsgaard Hanne, Lovato Paola,

Skin models mimicking features of psoriasis-related inflammation are needed to support the development of new drugs in dermatology. Reconstructed skin models lack tissue complexity, including a fully competent skin barrier, and presence and/or diversity of immune cells. Here we describe InflammaSkin®, a novel human Th17-driven ex vivo skin inflammation model. ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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The Role of the Renin-Angiotensin System in Skin Physiology and Pathophysiology.

Igor Maciel Souza Silva, Kasper Bostlund Assersen, Natalie Nanette Willadsen, Julie Jepsen, Metin Artuc, Ulrike Muscha Steckelings,

Since its first description around the year 2000, the local renin angiotensin system (RAS) in skin has been subject of an increasing number of studies with many additions over the last two to three years. A focus of research has been investigations on the role of cutaneous angiotensin receptors and ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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Hair follicle immune privilege and its collapse in alopecia areata.

Marta Bertolini, Kevin McElwee, Amos Gilhar, Silvia Bulfone-Paus, Ralf Paus,

Anagen stage hair follicles (HFs) exhibit "immune privilege (IP)" from the level of the bulge downwards to the bulb. Both passive and active IP mechanisms protect HFs from physiologically undesired immune responses and limit immune surveillance. IP is relative, not absolute, and is primarily based on absent, or greatly reduced, ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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Decreased suppression of CD8+ and CD4+ T cells by peripheral regulatory T cells in generalized vitiligo due to reduced NFATC1 and FOXP3 proteins.

Prashant S Giri, Mitesh Dwivedi, Rasheedunnisa Begum,

Regulatory T cells (Tregs) are involved in the suppression of activated T cells in generalized vitiligo (GV). The study was aimed to investigate Tregs functional defects in Treg:CD8+ and Treg:CD4+ T cells' co-culture systems of 55 GV patients and 45 controls. CD8+ and CD4+ T-cell proliferation was assessed by BrdU ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?

Ralf Paus, Yuval Ramot, Robert S Kirsner, Marjana Tomic-Canic,

Topical hormone therapy with natural or synthetic ligands of nuclear hormone receptors such as glucocorticoids, vitamin D analogues and retinoids has a long and highly successful tradition in dermatology. Yet the dermatological potential of thyroid hormone receptor (TR) agonists has been widely ignored, despite abundant clinical, cell and molecular biology, ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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Dialog between skin and its microbiota: Emergence of "Cutaneous Bacterial Endocrinology".

Pierre-Jean Racine, Xavier Janvier, Maximilien Clabaut, Chloe Catovic, Djouhar Souak, Amine M Boukerb, Anne Groboillot, Yoan Konto-Ghiorghi, Cécile Duclairoir-Poc, Olivier Lesouhaitier, Nicole Orange, Sylvie Chevalier, Marc G J Feuilloley,

Microbial endocrinology is studying the response of microorganisms to hormones and neurohormones and the microbiota production of hormones-like molecules. Until now, it was mainly applied to the gut and revealed that the intestinal microbiota should be considered as a real organ in constant and bilateral interactions with the whole human ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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The renin-angiotensin system in cutaneous hypertrophic scar and keloid formation.

Keshvad Hedayatyanfard, Nazgol-Sadat Haddadi, Seyed Ali Ziai, Hossein Karim, Feizollah Niazi, Ulrike Muscha Steckelings, Behnam Habibi, Ali Modarressi, Ahmad-Reza Dehpour,

Hypertrophic scar and keloid are two types of fibroproliferative conditions that result from excessive extracellular matrix production. The underlying pathological mechanism is not entirely clear. Activation of the renin-angiotensin system (RAS) is associated with fibrosis in various organs. RAS components including angiotensin II (Ang II), angiotensin AT1 and AT2 receptors, ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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How can nanoparticle-based technologies revolutionize the topical therapy in psoriasis?

Anca Sindrilaru, Adriana Filip, Karin Scharffetter-Kochanek, Diana Crisan,

Psoriasis is one of the most common dermatoses with a heterogeneous pathogenesis which can be successfully exploited therapeutically as it is increasingly well understood. Topical therapy is the gold standard for psoriasis patients with mild disease courses and for complementary and maintenance treatment in moderate and severe forms. However, while ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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Can melatonin and its metabolites boost the efficacy of targeted therapy in patients with advanced melanoma?

Konrad Kleszczyński, Markus Böhm,

Despite groundbreaking new treatments such as checkpoint inhibition and targeted therapy, the overall response and survival rates are limited in patients with metastatic melanoma. Here, we hypothesize that melatonin and its metabolites could be promising boosters of the efficacy of BRAF/MEK inhibitors in patients with advanced melanoma. Melatonin, a well-known ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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Terminal keratinocyte differentiation in vitro is associated with a stable DNA methylome.

Jos P H Smits, René A M Dirks, Jieqiong Qu, Merel A W Oortveld, Arie B Brinkman, Patrick L J M Zeeuwen, Joost Schalkwijk, Huiqing Zhou, Hendrik Marks, Ellen H van den Bogaard,

The epidermal compartment of the skin is regenerated constantly by proliferation of epidermal keratinocytes. Differentiation of a subset of these keratinocytes allows the epidermis to retain its barrier properties. Regulation of keratinocyte fate-whether to remain proliferative or terminally differentiate-is complex and not fully understood. The objective of our study was ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2020, :]

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