Full Text Journal Articles in
Journal Exp. Cell Res.

Advertisement

Find full text journal articles






Heterogeneity of telomerase reverse transcriptase mutation and expression, telomerase activity and telomere length across human cancer cell lines cultured in vitro.

Marta Dratwa, Barbara Wysoczanska, Eliza Turlej, Artur Anisiewicz, Magdalena Maciejewska, Joanna Wietrzyk, Katarzyna Bogunia-Kubik,

Promoter region of the telomerase reverse transcriptase gene (TERTp) constitutes a regulatory element capable to affect TERT expression (TE), telomerase activity (TA) and telomere length (TL). TERTp mutation status, TL, TA and TE were assessed in 27 in vitro cultured human cell lines, including 11 solid tumour, 13 haematological and ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, :112298]

Cited: 0 times

View full text PDF listing >>



PRC1 catalytic unit RING1B regulates early neural differentiation of human pluripotent stem cells.

Divya Desai, Aparna Khanna, Prasad Pethe,

BACKGROUND:Polycomb group (PcG) proteins are histone modifiers which control gene expression by assembling into large repressive complexes termed - Polycomb repressive complex (PRC); RING1B, core catalytic subunit of PRC1 that performs H2AK119 monoubiquitination leading to gene repression. The role of PRC1 complex during early neural specification in humans is unclear; ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, :112294]

Cited: 0 times

View full text PDF listing >>



Advertisement

Bleomycin induced apical-basal polarity loss in alveolar epithelial cell contributes to experimental pulmonary fibrosis.

Yu-Zhi Lu, Xin-Liang He, Fei Liu, Pei-Pei Cheng, Li-Mei Liang, Meng Wang, Shuai-Jun Chen, Yi Huang, Fan Yu, Jian-Bao Xin, Hong Ye, Lin-Jie Song, Wan-Li Ma,

Idiopathic pulmonary fibrosis (IPF) is a fatal fibrosing interstitial lung disease with limited therapeutic options and a median survival of 3 years after diagnosis. Dysregulated epithelial regeneration is key event involved in initiating and sustaining IPF. The type II alveolar epithelial cells (AECIIs) play a crucial role for epithelial regeneration ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, :112295]

Cited: 0 times

View full text PDF listing >>



Dysregulation of LncRNA ANRIL mediated by miR-411-3p inhibits the malignant proliferation and tumor stem cell like property of multiple myeloma via hypoxia-inducible factor 1α.

Meng Wang, Hua-Yan Zhao, Jing-Lan Zhang, Ding-Ming Wan, Ying-Mei Li, Zhong-Xing Jiang,

Long non-coding RNA (lncRNA) ANRIL has been reported to be closely related to the relapse of multiple myeloma patients. However, the functional role and underlying mechanism of lncRNA ANRIL in multiple myeloma are not known. This study aims to investigate the biological function of lncRNA ANRIL in multiple myeloma. In ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, :112280]

Cited: 0 times

View full text PDF listing >>



lncRNA Eif4g2 improves palmitate-induced dysfunction of mouse β-cells via modulation of Nrf2 activation.

Jing Wang, Zijing Lin, Zhuowen Yang, Xiaomin Liu,

Chronic oxidative stress resulting from hyperlipidemia is thought to be a key pathogenic driver of pancreatic β-cell dysfunction in leading to the onset of type 2 diabetes mellitus (T2DM). Long non-coding RNAs (lncRNAs) have been increasingly recognized to regulate dysfunction within pancreatic β-cells in the context of T2DM. In the ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, :112291]

Cited: 0 times

View full text PDF listing >>



CiRS-7 functions as a ceRNA of RAF-1/PIK3CD to promote metastatic progression of oral squamous cell carcinoma via MAPK/AKT signaling pathways.

Zhichao Dou, Ling Gao, Wenhao Ren, Hao Zhang, Xiaofei Wang, Shaoming Li, Jingjing Zheng, Xinjuan Kong, Peng Chi, Keqian Zhi,

PURPOSE:Recent findings have shown that circRNA dysregulation was involved in the development of many types of cancer. However, our knowledge of circRNA in oral squamous cell carcinoma (OSCC) remains elusive. METHODS:Here, we explored whether ciRS-7 could function as a ceRNA in promoting metastasis of OSCC via regulating miR-7 activity. The ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, :112290]

Cited: 0 times

View full text PDF listing >>



Lipopolysaccharide-induced DC-SIGN/TLR4 crosstalk activates NLRP3 inflammasomes via MyD88-independent signaling in gastric epithelial cells.

Yufan Chen, Jiebin Huang, Chundi Xu,

Abnormal pattern recognition receptor (PRR) signaling plays an important role in gastric mucosal damage caused by stomach microbiota; however, the underlying molecular mechanisms remain obscure. Here, we show that DC-SIGN, a surface phenotype marker of dendritic cells, is overexpressed in gastric epithelial cells facing LPS stimulation. NLRP3 expression in gastric ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, :112292]

Cited: 0 times

View full text PDF listing >>



Endoplasmic reticulum stress related factor IRE1α regulates TXNIP/NLRP3-mediated pyroptosis in diabetic nephropathy.

Ruiqiong Ke, Yan Wang, Shihua Hong, Lixia Xiao,

The nod-like receptor protein-3 (NLRP3)-mediated pyroptosis is involved in kidney diseases. Thioredoxin interacting protein (TXNIP) directly interacts with NLRP3. This study aimed to probe the mechanism of TXNIP and NLRP3 pathway in diabetic nephropathy (DN). Marker detection and histological staining indicated that in DN rats, the renal function was destroyed, ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, :112293]

Cited: 0 times

View full text PDF listing >>



Tp0136 targets fibronectin (RGD)/Integrin β1 interactions promoting human microvascular endothelial cell migration.

Xi Luo, Shu-Wen Lin, Qiu-Yan Xu, Wu-Jian Ke, Zheng-Xiang Gao, Man-Li Tong, Li-Li Liu, Li-Rong Lin, Hui-Lin Zhang, Tian-Ci Yang,

Lesion healing without treatment is a unique clinical characteristic of the early stages of syphilis infection. Angiogenesis, which involves endothelial cell migration, is an important process in wound healing. Tp0136, an outer membrane protein of T. pallidum, has the ability to bind host fibronectin-producing cells, which plays a crucial role ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, :112289]

Cited: 0 times

View full text PDF listing >>



Corrigendum to "Glucose impairs angiogenesis and promotes ventricular remodelling following myocardial infarction via upregulation of microRNA-17" [Exp. Cell Res. 381 (2019) 191-200].

Meiling Yan, Kankai Chen, Rong Sun, Kaibin Lin, Xiaolin Qian, Minjie Yuan, Yanpeng Wang, Jian Ma, Yanwei Qing, Jun Xu, Meng Wei, Dong Huang, Jingbo Li,

Exp. Cell Res. (Experimental cell research)
[2020, :112287]

Cited: 0 times

View full text PDF listing >>



Aryl hydrocarbon receptor mediates Jak2/STAT3 signaling for non-small cell lung cancer stem cell maintenance.

Jie Xiong, Xinxin Zhang, Yong Zhang, Bin Wu, Liang Fang, Ning Wang, Hongyu Yi, Ning Chang, Lihua Chen, Jian Zhang,

Cancer stem cells (CSCs) play an important role in shaping the invasive cancer phenotype by contributing to tumor initiation, metastasis, relapse, and therapeutic resistance in non-small cell lung cancer (NSCLC). The Aryl hydrocarbon receptor (AhR), a ligand activated transcription factor, which is well known for mediating the toxicity and tumorigenesis ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, 396(1):112288]

Cited: 0 times

View full text PDF listing >>



M2 macrophage-derived exosomes carry microRNA-370 to alleviate asthma progression through inhibiting the FGF1/MAPK/STAT1 axis.

Chunlu Li, Bing Dai, Jiapeng Hu, Yunxiao Shang,

PURPOSE:Emerging evidence has suggested the functions of exosomes in allergic diseases including asthma. This work aimed to study the roles of M2 macrophage-derived exosomes (M2Φ-Exos) in pediatric asthma progression and the potential molecules. METHODS:A mouse model with asthma was induced by ovalbumin (OVA) and treated with M2Φ-Exos. The secretion of ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, :112285]

Cited: 0 times

View full text PDF listing >>



Human papillomavirus type 16 E7 oncoprotein-induced upregulation of lysine-specific demethylase 5A promotes cervical cancer progression by regulating the microRNA-424-5p/suppressor of zeste 12 pathway.

Jia Liu, Hongqin Zhao, Qian Zhang, Zhengzheng Shi, Yuyang Zhang, Liang Zhao, Yi Ren, Rongying Ou, Yunsheng Xu,

Human papillomavirus (HPV) infection and viral protein expression cause several epigenetic alterations that lead to cervical carcinogenesis. Our previous study identified that upregulated lysine-specific demethylase (KDM) 2 A promotes cervical cancer progression by inhibiting mircoRNA (miR)-132 function. However, the roles of histone methylation modifiers in HPV-related cervical cancer remain unclear. In ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, 396(1):112277]

Cited: 0 times

View full text PDF listing >>



The hidden world of non-canonical ORFs.

Exp. Cell Res. (Experimental cell research)
[2020, :112267]

Cited: 0 times

View full text PDF listing >>



Eating the unknown: Xenophagy and ER-phagy are cytoprotective defenses against pathogens.

Alessio Reggio, Viviana Buonomo, Paolo Grumati,

Autophagy is an evolutionary conserved catabolic process devoted to the removal of unnecessary and harmful cellular components. In its general form, autophagy governs cellular lifecycle through the formation of double membrane vesicles, termed autophagosomes, that enwrap and deliver unwanted intracellular components to lysosomes. In addition to this omniscient role, forms ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, 396(1):112276]

Cited: 0 times

View full text PDF listing >>



Prognostic and therapeutic relevance of phosphofructokinase platelet-type (PFKP) in breast cancer.

Sheikh Mohammad Umar, Akanksha Kashyap, Shruti Kahol, Sandeep Mathur, Ajay Gogia, S V S Deo, Chandra Prakash Prasad,

In the present study, we have explored the prognostic value of the Phosphofructokinase Platelet-type (PFKP) expression and its therapeutic relevance in metastatic breast cancer. PFKP immunohistochemistry was performed on Invasive ductal carcinomas (IDCs; n = 87) of breast, and its association with clinicopathological parameters were evaluated. Using online meta-analysis tools, PFKP's prognostic ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, :112282]

Cited: 0 times

View full text PDF listing >>



Anti-tumor effect of single-chain antibody to Reg3a in colorectal cancer.

Pei Du, Xiaonan Wang, Tianqi Yin, Xueqing Zhang, Zhiyuan Zhang, Weihong Yu, Min Wang, Chen Luo, Luting Yu,

BACKGROUND:Regenerating protein 3a (Reg3a) is a trophic factor that functions as a stimulus in cell proliferation and neogenesis. Previous studies showed that Reg3a is ectopically upregulated in a majority of colorectal cancers (CRC) and detectable in the serum. METHODS:Single-chain variable fragment targeting Reg3a (scFv-Reg3a) was screened from a phage library. ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, 396(1):112278]

Cited: 0 times

View full text PDF listing >>



Platycodin D (PD) regulates LncRNA-XIST/miR-335 axis to slow down bladder cancer progression in vitro and in vivo.

Dayin Chen, Tingyu Chen, Yingxue Guo, Chennan Wang, Longxin Dong, Chunfeng Lu,

Recently, increasing evidences indicated that Platycodin D (PD) served as an effective anti-tumor drug for cancer treatment in clinic. However, the molecular mechanisms are still unclear. In the present study, we proved that PD regulated LncRNA-XIST/miR-335 axis to hamper the development of bladder cancer in vitro and in vivo. Mechanistically, ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, 396(1):112281]

Cited: 0 times

View full text PDF listing >>



PTPN13 acts as a tumor suppressor in clear cell renal cell carcinoma by inactivating Akt signaling.

Qingzhi Long, Jiping Sun, Jia Lv, Yu Liang, Huixian Li, Xudong Li,

Protein tyrosine phosphatase, nonreceptor type 13 (PTPN13), has emerged as a critical cancer-related gene that is implicated in a wide range of cancer types. However, the role of PTPN13 in clear cell renal cell carcinoma (ccRCC) is poorly understood. In the present study, we aimed to evaluate whether PTPN13 participates ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, :112286]

Cited: 0 times

View full text PDF listing >>



MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes.

Kumi Matsuura, Naoki Tani, Shingo Usuki, Satomi Torikai-Nishikawa, Masaki Okano, Hitoshi Niwa,

Myst family genes encode lysine acetyltransferases that mainly mediate histone acetylation to control transcription, DNA replication and DNA damage response. They form tetrameric complexes with PHD-finger proteins (Brpfs or Jades) and small non-catalytic subunits Ing4/5 and Meaf6. Although all the components of the complex are well-conserved from yeast to mammals, ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, 396(1):112279]

Cited: 0 times

View full text PDF listing >>



Rho-GEF trio regulates osteoclast differentiation and function by Rac1/Cdc42.

Jiawen Gu, Zhiwen Yang, Lichan Yuan, Shuyu Guo, Dan Wang, Na Zhao, Li Meng, Haojie Liu, Wenjing Chen, Junqing Ma,

Many bone diseases result from abnormal bone resorption by osteoclasts (OCs). Studying OC related regulatory genes is necessary for the development of new therapeutic strategies. Rho GTPases have been proven to regulate OC differentiation and function and only mature OCs can carry out bone resorption. Here we demonstrate that Rac1 ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, 396(1):112265]

Cited: 0 times

View full text PDF listing >>



Buparlisib modulates PD-L1 expression in head and neck squamous cell carcinoma cell lines.

Mathias Fiedler, Daniela Schulz, Gerhard Piendl, Gero Brockhoff, Jonas Eichberger, Ayse-Nur Menevse, Philipp Beckhove, Matthias Hautmann, Torsten E Reichert, Tobias Ettl, Richard J Bauer,

High expression of the immune checkpoint receptor PD-L1 is associated with worse patient outcome in a variety of human cancers, including head and neck squamous cell carcinoma (HNSCC). Binding of PD-L1 with its partner PD-1 generates an inhibitory signal that dampens the immune system. Immunotherapy, that is blocking the PD-1/PD-L1 ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, 396(1):112259]

Cited: 0 times

View full text PDF listing >>



Cellular uptake of vitamin B12: Role and fate of TCblR/CD320, the transcobalamin receptor.

Gregory G Gick, Kaveri Arora, Jeffrey M Sequeira, Yasumi Nakayama, Shao-Chiang Lai, Edward V Quadros,

Cellular uptake of vitamin B12 (cobalamin, Cbl) is mediated by a cell surface receptor (TCblR/CD320) that binds transcobalamin (TC) saturated with Cbl. TC is secreted by the vascular endothelium, has a relatively short half-life, binds Cbl with high affinity and presents the vitamin to the receptor for cellular uptake. Here ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, 396(1):112256]

Cited: 0 times

View full text PDF listing >>



Study of mitophagy and ATP-related metabolomics based on β-amyloid levels in Alzheimer's disease.

Xiaomin Xiong, Shijie Li, Ting-Li Han, Fanlin Zhou, Xiong Zhang, Mingyuan Tian, Li Tang, Yu Li,

The aggregation of β-amyloid (Aβ) peptide in Alzheimer's disease (AD) is characterized by mitochondrial dysfunction and mitophagy impairment. Mitophagy is a homeostatic mechanism by which autophagy selectively eliminates damaged mitochondria. Valinomycin is a respiratory chain inhibitor that activates mitophagy via the PINK1/Parkin signaling pathway. However, the mechanism underlying the association ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, 396(1):112266]

Cited: 0 times

View full text PDF listing >>



ROCK-II inhibition suppresses impaired mechanobiological responses in early estrogen deficient osteoblasts.

Irene Simfia, Jessica Schiavi, Laoise M McNamara,

Mechanobiological responses by osteoblasts are governed by downstream Rho-ROCK signalling through actin cytoskeleton re-arrangements but whether these responses are influenced by estrogen deficiency during osteoporosis remains unknown. The objective of this study was to determine alterations in the mechanobiological responses of estrogen-deficient osteoblasts and investigate whether an inhibitor of the ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, 396(1):112264]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
0.9856 s