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Journal Exp Parasitol

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Stereological analysis of liver, spleen and bone of Leishmania infantum-experimentally infected hamsters.

F Modabberi, S N Ghadimi, R Shahriarirad, E Nadimi, S Karbalay-Doust, S Rashidi, B Sarkari,

Leishmaniasis is remaining as one of the important health problems of many countries around the world. The histopathology of the disease and the effects of the parasite on various tissues have not yet been fully elucidated. The current study aimed to evaluate the stereological features of the liver, spleen, and ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, 228:108137]

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Mouse experiments demonstrate differential pathogenicity and virulence of Trypanosoma brucei rhodesiense strains.

Limo William Kipkorir, Thuita Kibuthu John, Orindi Benedict Owino, Oidho John, Shivairo Robert, Masiga Daniel, Adung'a Vincent Owino,

Trypanosoma brucei rhodesiense is the causative agent for Rhodesian human African trypanosomiasis. The disease is considered acute, but varying clinical outcomes including chronic infections have been observed. The basis for these different clinical manifestations is thought to be associated with a combination of parasite and host factors. In the current ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, :108135]

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Therapeutic effects of benznidazole in Swiss mice that are orally inoculated with Trypanosoma cruzi IV strains from the Western Brazilian Amazon.

Ana Paula Margioto Teston, Nilma de Souza Fernandes, Camila Piva Abegg, Ana Paula de Abreu, Marcella Paula Mansano Sarto, Mônica Lúcia Gomes, Max Jean de Ornelas Toledo,

Strains of Trypanosoma cruzi, etiological agent of Chagas disease, are classified into different discrete typing units that may present distinct dynamics of infection and susceptibility to benznidazole (BZ) treatment. Mice that were orally inoculated with T. cruzi IV strains exhibited a more intense course of infection compared with intraperitoneally inoculated ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, :108136]

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Effect of magnetic field on the growth of the cultured Entamoeba histolytica isolated from patients in Palestine.

Adnan I Al-Hindi, Hala J El-Khozondar, Wael Tabaza, Mariam Alreefi, Ahmed M Al Afifi, Doha Kassem, Reham Al-Bahri, Ghadeer Abu Haseera,

Static magnetic field (SMF) is generated in vicinity of moving charge or current passing through conductor. In this study, we aimed to investigate the effect of SMF on the growth of the cultured Entamoeba histolytica (E. histolytica) trophozoites. Different SMF strengths with maximum value equals 30 mT (mT) was applied on ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, :108126]

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In vivo evaluation of anti-Leishmania activity of alkyltriazoles and alkylphosphocholines by oral route.

Vanessa Silva Gontijo, Fabio Antônio Colombo, Patrícia Ferreira Espuri, Poliany Graziella de Freitas, Juliana Barbosa Nunes, Levy Bueno Alves, Márcia Paranho Veloso, Rosemeire Brondi Alves, Rossimiriam Pereira Freitas, Marcos José Marques,

The failures in the treatment of leishmaniasis is an increasing problem around the world, especially related to resistance. Thus, we describe the synthesis and in vivo anti-Leishmania activity of alkylphosphocholine and alkyltriazoles; besides, their likely action mechanisms stem from some eventual inhibition of parasite enzymes using computational tools. These compounds ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, :108123]

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'de Novo' repurposing of Daflon as anti-intestinal parasitic drug in experimental giardiasis.

Azza Fahmy, Gehan Labib Abuelenain, Nesma Rasheed, Amr Abdou,

<h4>Background</h4>There is a necessity to develop or discover an alternative drug to combat the drug resistance by Giardia duodenalis and minimize the multiple doses and frequency of the conventional drug administration. Progressive repositioning or 'repurposing' of drugs has become widespread due to economic circumstances and medical emergency needs. Daflon 500 mg ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, :108124]

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In vitro and in vivo trypanocidal activity of a benzofuroxan derivative against Trypanosoma cruzi.

Letícia Dos Santos Petry, João Cândido Pillar Mayer, Marjorie de Giacommeti, Dionatan Teixeira de Oliveira, Litiérria Razia Garzon, Ana Martiele Engelmann, Antônio Francisco Igor Magalhães de Matos, Matheus Dellaméa Baldissera, Luciano Dornelles, Cinthia Melazzo de Andrade, Silvia Gonzalez Monteiro,

Chagas disease, caused by Trypanosoma cruzi, is a major public health problem and is described as one of the most neglected diseases worldwide. It affects about 6-7 million people. Currently, only two drugs are available for the treatment of this disease: nifurtimox and benznidazole. However, both drugs are highly toxic ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, :108125]

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Interleukine-22 gene variants are associated with susceptibility to visceral leishmaniasis.

Mehdi Kalani, Seyed Reza Shams, Sadaf Namdarnia, Maral Choopanizadeh, Javad Jamshidi, Ali Moravej,

Visceral leishmaniasis (VL) is an infectious disease caused by an intracellular protozoan belonging to Leishmania species. Interleukin (IL)-22 plays an important role in inflammatory response, chemotaxis, regulation of cellular proliferation and tissue repair. Considering the role of IL-22 in control of leishmaniasis and the effect of its single nucleotide polymorphisms ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, :108122]

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In vitro effects of harmine against Echinococcus granulosus protoscoleces by stimulating DNA damage.

Shuai Lu, Limei Wen, Yuehong Gong, Chunyan Tian, Huijing Gao, Bei Chen, Guodong Lü, Jun Zhao, Jianhua Wang,

Cystic echinococcosis (CE), a parasitic larval cystic stage of a small taeniid-type tapeworm (Echinococcus granulosus), causes illness in intermediate hosts and has become a threat to global public health. Currently, chemical compounds recommended by the WHO targeting CE are albendazole and mebendazole, however, none of them shows enhanced efficacy. Novel ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, :108121]

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Larvicidal and ovicidal activities of phenyl acetic acid isolated from Streptomyces collinus against Culex quinquefasciatus Say and Aedes aegypti L. (Diptera: Culicidae).

Appadurai Daniel Reegan, Pachaiyappan Saravana Kumar, Antony Cruz Asharaja, Chitra Devi, Sithi Jameela, Kedike Balakrishna, Savarimuthu Ignacimuthu,

The bio-efficacy of crude ethyl acetate extract, fractions and a compound phenyl acetic acid from the ethyl acetate extract of Streptomyces collinus was evaluated on Culex quinquefasciatus Say and Aedes aegypti L. mosquitoes (Diptera: Culicidae). The larvae were exposed to concentrations of 2.5, 5.0, 7.5 and 10.0 ppm for fractions and ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, :108120]

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A novel genotyping method for Cryptosporidium hominis.

Jennifer K O' Leary, Liam Blake, Gerard D Corcoran, Roy D Sleator, Brigid Lucey,

Cryptosporidiosis remains the leading protozoan induced cause of diarrhoea-associated mortality worldwide. Cryptosporidium hominis, the anthroponotically transmitted species within the Cryptosporidium genus, contributes significantly to the global burden of infection, accounting for the majority of clinical cases in many countries. This study applied high resolution melting analysis, a post-real-time PCR application, ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, 225:108113]

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Trichinella spiralis excretory-secretory products downregulate MMP-9 in Dark Agouti rats affected by experimental autoimmune encephalomyelitis.

Fabrizio Bruschi, Alisa Gruden-Movesijan, Barbara Pinto, Natasa Ilic, Ljiljana Sofronic-Milosavlјevic,

Matrix metalloproteinases (MMPs), are implicated in the pathogenesis of multiple sclerosis (MS) and in its animal model, experimental autoimmune encephalomyelitis (EAE). Our aim was to investigate whether amelioration of EAE in Dark Agouti (DA) rats, induced by Trichinella spiralis muscle larvae excretory-secretory products (ES L1), could be related to the ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, 225:108112]

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Comparing the efficacy of nutmeg essential oil and a chemical pesticide against Musca domestica and Chrysomya albiceps for selecting a new insecticide agent against synantropic vectors.

Luciana F Cossetin, Eduarda M T Santi, Quelen I Garlet, Antônio F I M Matos, Tiago P De Souza, Luiza Loebens, Berta M Heinzmann, Sílvia G Monteiro,

The insecticidal activity of Myristica fragrans (Houtt) essential seed oil, (Nutmeg) was evaluated against Musca domestica (Linnaeus) and Chrysomya albiceps (Wiedemann); both important infectious pathogenic disease vectors. The oil was extracted by distillation, and 21 components were identified during chemical analysis; principally β-pinene (26%), α-pinene (10.5%), Sabinene (9.1%) and γ-terpinen ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, 225:108104]

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Essential oil of Mentha pulegium induces anthelmintic effects and reduces parasite-associated oxidative stress in rodent model.

Essia Sebai, Amel Abidi, Raja Serairi, Moomen Marzouki, Katerina Saratsi, Mohamed Aziz Darghouth, Smaragda Sotiraki, Hafidh Akkari,

Following the previous findings reported by the present authors on the anthelmintic effect of hydro-ethanolic extract of Mentha pulegium, the volatile constituents of M. pulegium are now assessed in the present study by exploring its anthelmintic and its antioxidant proprieties using in vitro and in vivo assays. Egg hatch assay ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, 225:108105]

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The course of infection of Encephalitozoon cuniculi genotype I in mice possess combination of features reported in genotypes II and III.

Bohumil Sak, Klára Brdíčková, Nikola Holubová, Dana Květoňová, Lenka Hlásková, Martin Kváč,

Out of three genotypes of Encephalitozoon cuniculi (I-III) available for experimental studies, E. cuniculi genotype I remains the less characterized. This study describes for the first time individual phases of microsporidiosis caused by E. cuniculi genotype I and efficacy of albendazole treatment in immunocompetent BALB/c and C57Bl/6 mice and immunodeficient ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, 224:108101]

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(-)-Epicatechin protects from amebic liver abscess development in hamster.

Maritza Velásquez-Torres, Mineko Shibayama-Salas, Judith Pacheco-Yépez, Angélica Silva-Olivares, Virginia Sánchez-Monroy, Laurence A Marchat, Gildardo Rivera, Esther Ramírez-Moreno,

In this work the effect of (-)-epicatechin on the development of amebic liver abscess in hamsters was evaluated. (-)-epicatechin is a flavonoid present in plants that possesses various biological properties, including its activity against some protozoal parasites; however its antiamebic activity in a living model had not been evaluated. Syrian ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, 224:108103]

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Carbohydrate metabolism in trypanosomatids: New insights revealing novel complexity, diversity and species-unique features.

Paul A M Michels, Oriana Villafraz, Erika Pineda, Mayke B Alencar, Ana J Cáceres, Ariel M Silber, Frédéric Bringaud,

The human pathogenic trypanosomatid species collectively called the "TriTryp parasites" - Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. - have complex life cycles, with each of these parasitic protists residing in a different niche during their successive developmental stages where they encounter diverse nutrients. Consequently, they adapt their metabolic network ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, 224:108102]

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Generation and application of a monoclonal antibody against the 18-kDa oncosphere antigen of Taenia pisiformis.

Ze-Xiang Wang, Xi Chen, Liang Han, Huai-Dong Liu, Jun-Hui Guo, Yu Zhao, Xiao-Lin Sun,

Taenia pisiformis is a parasite that causes cysticercosis pisiformis, which has acquired economic relevance because of its effects on animal welfare and production. A useful assay for the detection of T. pisiformis is needed for the prevention of cysticercosis pisiformis and control of the parasite. The 18-kDa oncosphere antigen is ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, 224:108096]

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Phytol suppresses parasitemia and ameliorates anaemia and oxidative brain damage in mice infected with Plasmodium berghei.

Mohammed Aliyu Usman, Fadilat Isah Usman, Muhammad Sani Abubakar, Abdulmalik Abdullahi Salman, Auwal Adamu, Mohammed Auwal Ibrahim,

The quest for the development of a novel antimalarial drug informed the decision to subject phytol to in vivo trials following a demonstration of therapeutic potential against chloroquine sensitive strain of Plasmodium falciparum under in vitro condition. On this basis, the in vivo anti-Plasmodium berghei activity of phytol including the ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, 224:108097]

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Furan derivatives impair proliferation and affect ultrastructural organization of Trypanosoma cruzi and Leishmania amazonensis.

Aline Araujo Zuma, Sara Teixeira de Macedo-Silva, Anushree Achari, Jayaraman Vinayagam, Pinaki Bhattacharjee, Sourav Chatterjee, Vivek Kumar Gupta, Amanda Cristina de Sousa Leite, Lucas Souza de Castro, Parasuraman Jaisankar, Wanderley de Souza,

Chagas disease and leishmaniasis are neglected diseases caused by parasites of the Trypanosomatidae family and together they affect millions of people in the five continents. The treatment of Chagas disease is based on benznidazole, whereas for leishmaniasis few drugs are available, such as amphotericin B and miltefosine. In both cases, ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, 224:108100]

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Inactivation of Trichinella muscle larvae at different time-temperature heating profiles simulating home-cooking.

Frits Franssen, Huifang Deng, Arno Swart, Axel Bonačić Marinović, Xiaolei Liu, Mingyuan Liu, Joke van der Giessen,

<h4>Background</h4>Trichinellosis is caused by consumption of raw or undercooked meat containing infective Trichinella muscle larvae (ML). Only few studies on heat-inactivation of Trichinella ML are available in literature and more validated data concerning heat inactivation is needed to improve the risk estimation.<h4>Objective and methods</h4>The aim of the present study was ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, 224:108099]

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Rapid parasite detection utilizing a DNA dipstick.

Oyime Poise Aula, Donald Peter McManus, Michael Glenn Mason, José Ramón Botella, Catherine Amy Gordon,

Molecular diagnostics are powerful tools for disease detection but are typically confined to the laboratory environment due to the cumbersome methods required to extract nucleic acids from biological samples. Accurate diagnosis is essential for early detection of parasitic worm infections and for monitoring control programs, particularly during new transmission outbreaks ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, 224:108098]

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Cryptosporidium abrahamseni n. sp. (Apicomplexa: Cryptosporidiiae) from red-eye tetra (Moenkhausia sanctaefilomenae).

Alireza Zahedi, Samuel J Bolland, Charlotte L Oskam, Una Ryan,

The morphological, biological, and molecular characterisation of Cryptosporidium piscine genotype 7 from red-eye tetras (Moenkhausia sanctaefilomenae) are described, and the species name Cryptosporidium abrahamseni n. sp. is proposed. Histological analysis of intestinal tissue identified large numbers of Cryptosporidium organisms along the epithelial lining of the intestine. Sequence and phylogenetic analysis ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, 223:108089]

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Evaluation of protection induced by in vitro maturated BMDCs presenting CD8+ T cell stimulating peptides after a heterologous vaccination regimen in BALB/c model against Leishmania major.

Atefeh Sadeghi Shermeh, Farnaz Zahedifard, Sima Habibzadeh, Tahereh Taheri, Sima Rafati, Negar Seyed,

Leishmaniasis is a complex vector-borne disease mediated by Leishmania parasite and a strong and long-lasting CD4<sup>+</sup> Th1 and CD8<sup>+</sup>-T cell immunity is required to control the infection. Thus far multivalent subunit vaccines have met this requirement more promisingly. However several full protein sequences cannot be easily arranged in one construct. ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, 223:108082]

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Updating specific PCR primer for detection of Cryptocaryon irritans from reared Larimichthys polyactis.

Xiao Xie, Chao Zheng, Aysha Zahid, Jindong Kong, Bushra, Dong Qian, Fei Yin, Bao Lou,

Artificial breeding of small yellow croaker (Larimichthys polyactis) was recently achieved, providing a bright future for its commercial farming. In May 2019, a disease outbreak occurred among small yellow croakers in an aquaculture farm near Xiangshan Bay, charactering by white spots spotted on the surface of fish skin, gills and ... Read more >>

Exp Parasitol (Experimental parasitology)
[2021, 223:108081]

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