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Journal Exp Neurol

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Real-time phase and amplitude estimation of neurophysiological signals exploiting a non-resonant oscillator.

Johannes L Busch, Lucia K Feldmann, Andrea A Kühn, Michael Rosenblum,

A recent advancement in the field of neuromodulation is to adapt stimulation parameters according to pre-specified biomarkers tracked in real-time. These markers comprise short and transient signal features, such as bursts of elevated band power. To capture these features, instantaneous measures of phase and/or amplitude are employed, which inform stimulation ... Read more >>

Exp Neurol (Experimental neurology)
[2021, :113869]

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Thioperamide attenuates neuroinflammation and cognitive impairments in Alzheimer's disease via inhibiting gliosis.

Jiangong Wang, Bin Liu, Yong Xu, Haiyun Luan, Chaoyun Wang, Meizi Yang, Runming Zhao, Mengmeng Song, Jing Liu, Linshan Sun, Jingjing You, Wentao Wang, Fengjiao Sun, Haijing Yan,

Alzheimer's disease (AD) is an age-related neurodegenerative disease, which characterized by deposition of amyloid-β (Aβ) plaques, neurofibrillary tangles, neuronal loss, and accompanied by neuroinflammation. Neuroinflammatory processes are well acknowledged to contribute to the progression of AD pathology. Histamine H3 receptor (H3R) is a presynaptic autoreceptor regulating histamine release via negative ... Read more >>

Exp Neurol (Experimental neurology)
[2021, :113870]

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Hypoxic postconditioning promotes neurogenesis by modulating the metabolism of neural stem cells after cerebral ischemia.

Haiyan Li, Sijie Li, Changhong Ren, Chen Gao, Ning Li, Chunxiu Wang, Lin Wang, Wenbo Zhao, Xunming Ji, Kunlin Jin,

Ischemic stroke is one of the most lethal and severely disabling diseases that seriously affects human health and quality of life. The maintenance of self-renewal and differentiation of neural stem cells are closely related to metabolism. This study aimed to investigate whether hypoxic postconditioning (HPC) could promote neurogenesis after ischemic ... Read more >>

Exp Neurol (Experimental neurology)
[2021, :113871]

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Emerging placental biomarkers of health and disease through advanced magnetic resonance imaging (MRI).

Nickie Andescavage, Catherine Limperopoulos,

Placental dysfunction is a major cause of fetal demise, fetal growth restriction, and preterm birth, as well as significant maternal morbidity and mortality. Infant survivors of placental dysfunction are at elevated increased risk for lifelong neuropsychiatric morbidity. However, despite the significant consequences of placental disease, there are no clinical tools ... Read more >>

Exp Neurol (Experimental neurology)
[2021, :113868]

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Mannose-binding lectin promotes blood-brain barrier breakdown and exacerbates axonal damage after traumatic brain injury in mice.

Jordi Pedragosa, Domenico Mercurio, Marco Oggioni, Leonardo Marquez-Kisinousky, Maria-Grazia de Simoni, Anna M Planas,

Leukocyte infiltration and blood-brain barrier breakdown contribute to secondary brain damage after traumatic brain injury (TBI). TBI induces neuroimmune responses triggering pathogenic complement activation through different pathways, including the lectin pathway. We investigated mechanisms underlying mannose-binding lectin (MBL)-mediated brain damage focusing on neutrophil infiltration and blood-brain barrier breakdown in a ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 346:113865]

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Lack of Cdk5 activity is involved on Dopamine Transporter expression and function: Evidences from an animal model of Attention-Deficit Hyperactivity Disorder.

Guillermo Fernández, Favio Krapacher, Soledad Ferreras, Gonzalo Quassollo, Macarena Mariel Mari, María Victoria Pisano, Antonella Montemerlo, María Dolores Rubianes, Claudia Bregonzio, Carlos Arias, María Gabriela Paglini,

Attention deficit/Hyperactivity disorder (ADHD) is one of the most diagnosed psychiatric disorders nowadays. The core symptoms of the condition include hyperactivity, impulsiveness and inattention. The main pharmacological treatment consists of psychostimulant drugs affecting Dopamine Transporter (DAT) function. We have previously shown that genetically modified mice lacking p35 protein (p35KO), which ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 346:113866]

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Ephrin-B2 PB-mononuclear cells reduce early post-stroke deficit in diabetic mice but not long-term memory impairment.

Adrien Cogo, Gabrielle Mangin, Sarah Mouazan, Tatiana Merkulova-Rainon, Jean-Pierre Riveline, Jean-François Gautier, Mathilde Varret, Nathalie Kubis,

<h4>Background and purpose</h4>Post-stroke cognitive impairment (PSCI) has become a major public health issue, as a leading cause of dementia. The inflammation that develops soon after cerebral artery occlusion and may persist for weeks or months after stroke is a key component of PSCI. Our aim was to take advantage of ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 346:113864]

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PLA2G6 mutations cause motor dysfunction phenotypes of young-onset dystonia-parkinsonism type 14 and can be relieved by DHA treatment in animal models.

Tu-Hsueh Yeh, Han-Fang Liu, Ching-Chi Chiu, Mei-Ling Cheng, Guo-Jen Huang, Yin-Cheng Huang, Yu-Chien Liu, Ying-Zu Huang, Chin-Song Lu, Yi-Chieh Chen, Hao-Yuan Chen, Yi-Chuan Cheng,

Parkinson's disease (PD), the most common neurodegenerative motor disorder, is currently incurable. Although many studies have provided insights on the substantial influence of genetic factors on the occurrence and development of PD, the molecular mechanism underlying the disease is largely unclear. Previous studies have shown that point mutations in the ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 346:113863]

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Corrigendum to "Zuckerkandl's organ improves long-term survival and function of neural stem cell's derived dopaminergic neurons in parkinsonian rats" [Experimental Neurology Volume 210, Issue 2, April 2008, Pages 608-623].

R K Chaturvedi, S Shukla, K Seth, A K Agrawal,

Exp Neurol (Experimental neurology)
[2021, :113859]

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Widening spinal injury research to consider all supraspinal cell types: Why we must and how we can.

Murray Blackmore, Elizabeth Batsel, Pantelis Tsoulfas,

The supraspinal connectome consists of dozens of neuronal populations that project axons from the brain to the spinal cord to influence a wide range of motor, autonomic, and sensory functions. The complexity and wide distribution of supraspinal neurons present significant technical challenges, leading most spinal cord injury research to focus ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 346:113862]

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Nitro-oleic acid-mediated blood-brain barrier protection reduces ischemic brain injury.

Chao Zhou, Moxi Su, Ping Sun, Xuelian Tang, Ke-Jie Yin,

Nitro-oleic acid (OA-NO<sub>2</sub>), a nitroalkene formed in nitric oxide-dependent oxidative reactions, has been found in human plasma and is thought to regulate pathophysiological functions. Recently, accumulating evidence suggests that OA-NO<sub>2</sub> may function as an anti-inflammatory mediator, and ameliorate the progression of diabetes and cardiovascular diseases. However, the role of OA-NO<sub>2</sub> ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 346:113861]

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Low pressure voiding induced by stimulation and 1 kHz post-stimulation block of the pudendal nerves in cats.

Jialiang Chen, Jianan Jian, Jicheng Wang, Zhijun Shen, Bing Shen, William Wang, Jonathan Beckel, William C de Groat, Christopher Chermansky, Changfeng Tai,

The goal of this study is to induce low-pressure voiding by stimulation and bilateral 1 kHz post-stimulation block of the pudendal nerves. In anesthetized cats, wire hook electrodes were placed on the left and/or right pudendal nerves. Stimulus pulses (30 Hz, 0.2 ms) were applied to one pudendal nerve to induce a reflex ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 346:113860]

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PLXNA2 knockdown promotes M2 microglia polarization through mTOR/STAT3 signaling to improve functional recovery in rats after cerebral ischemia/reperfusion injury.

Sisi Li, Xuyun Hua, Mouxiong Zheng, Jiajia Wu, Zhenzhen Ma, Xiangxin Xing, Jie Ma, Junpeng Zhang, Chunlei Shan, Jianguang Xu,

Ischemic stroke is an acute cerebrovascular disease characterized by high mortality, morbidity and disability rates. Ischemia/reperfusion is a critical pathophysiological basis of motor and cognitive dysfunction caused by ischemic stroke. Microglia, innate immune cells of the central nervous system, mediate the neuroinflammatory response to ischemia/reperfusion. PlexinA2 (PLXNA2) plays an important ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 346:113854]

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Impact of nocturnal oxygen and CPAP on the ventilatory response to hypoxia in OSA patients free of overt cardiovascular disease.

Matiram Pun, Andrew E Beaudin, Jill K Raneri, Todd J Anderson, Patrick J Hanly, Marc J Poulin,

A primary characteristic of obstructive sleep apnea (OSA) is chronic exposure to intermittent hypoxia (IH) due to repeated upper airway obstruction. Chronic IH exposure is believed to increase OSA severity over time by enhancing the acute ventilatory response to hypoxia (AHVR), thus promoting ventilatory overshoot when apnea ends and perpetuation ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 346:113852]

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AIM2 inflammasome mediates apoptotic and pyroptotic death in the cerebellum following chronic hypoperfusion.

Luting Poh, Siti Maryam Binte Abdul Razak, Hong Meng Lim, Mitchell K P Lai, Christopher Li-Hsian Chen, Lina H K Lim, Thiruma V Arumugam, David Y Fann,

Vascular dementia (VaD) is the second most common form of dementia and is caused by vascular pathologies resulting in chronic cerebral hypoperfusion (CCH)- induced brain injury, and ultimately cognitive impairment and memory loss. Several lines of evidence have demonstrated chronic inflammation may be involved in VaD disease progression. It is ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 346:113856]

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Neuropathology of blepharospasm.

Maggie Fagan, Laura Scorr, Doug Bernhardt, Ellen J Hess, Joel S Perlmutter, Carlos A Pardo, H A Jinnah,

<h4>Background</h4>The dystonias are a group of disorders characterized by excessive muscle contractions leading to abnormal repetitive movements or postures. In blepharospasm, the face is affected, leading to excessive eye blinking and spasms of muscles around the eyes. The pathogenesis of blepharospasm is not well understood, but several imaging studies have ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 346:113855]

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Eccentric rehabilitation induces white matter plasticity and sensorimotor recovery in chronic spinal cord injury.

Timothy D Faw, Bimal Lakhani, Petra Schmalbrock, Michael V Knopp, Keith R Lohse, John L K Kramer, Hanwen Liu, Huyen T Nguyen, Eileen G Phillips, Anna Bratasz, Lesley C Fisher, Rochelle J Deibert, Lara A Boyd, Dana M McTigue, D Michele Basso,

Experience-dependent white matter plasticity offers new potential for rehabilitation-induced recovery after neurotrauma. This first-in-human translational experiment combined myelin water imaging in humans and genetic fate-mapping of oligodendrocyte lineage cells in mice to investigate whether downhill locomotor rehabilitation that emphasizes eccentric muscle actions promotes white matter plasticity and recovery in chronic, ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 346:113853]

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Astrocyte inflammatory signaling mediates α-synuclein aggregation and dopaminergic neuronal loss following viral encephalitis.

Collin M Bantle, Savannah M Rocha, C Tenley French, Aaron T Phillips, Kevin Tran, Kenneth E Olson, Todd A Bass, Tawfik Aboellail, Richard J Smeyne, Ronald B Tjalkens,

Viral infection of the central nervous system (CNS) can cause lasting neurological decline in surviving patients and can present with symptoms resembling Parkinson's disease (PD). The mechanisms underlying postencephalitic parkinsonism remain unclear but are thought to involve increased innate inflammatory signaling in glial cells, resulting in persistent neuroinflammation. We therefore ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 346:113845]

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Painful diabetic neuropathy leads to functional CaV3.2 expression and spontaneous activity in skin nociceptors of mice.

Tal Hoffmann, Katrin Kistner, Sonja L J Joksimovic, Slobodan M Todorovic, Peter W Reeh, Susanne K Sauer,

Painful diabetic neuropathy occurs in approximately 20% of diabetic patients with underlying pathomechanisms not fully understood. We evaluated the contribution of the Ca<sub>V</sub>3.2 isoform of T-type calcium channel to hyperglycemia-induced changes in cutaneous sensory C-fiber functions and neuropeptide release employing the streptozotocin (STZ) diabetes model in congenic mouse strains including ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 346:113838]

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Cannabidiol reduces lesion volume and restores vestibulomotor and cognitive function following moderately severe traumatic brain injury.

L K Friedman, H Peng, R J Zeman,

Despite the high incidence of traumatic brain injury (TBI), there is no universal treatment to safely treat patients. Blunt brain injuries destroy primary neural tissue that results in impaired perfusion, excessive release of glutamate, inflammation, excitotoxicity, and progressive secondary neuronal cell death. We hypothesized that administration of cannabidiol (CBD) directly ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 346:113844]

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Protein kinase C theta (Prkcq) affects nerve degeneration and regeneration through the c-fos and c-jun pathways in injured rat sciatic nerves.

Yi Wang, Nannan Gao, Yumei Feng, Min Cai, Yuting Li, Xi Xu, Huanhuan Zhang, Dengbing Yao,

<h4>Background</h4>Previous finding using DNA microarray and bioinformatics analysis, we have reported some key factors which regulated gene expression and signaling pathways in injured sciatic nerve during Wallerian Degeneration (WD). This research is focused on protein kinase C theta (Prkcq) participates in the regulation of the WD process.<h4>Methods</h4>In this study, we ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 346:113843]

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Corrigendum to "Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-β1-40 administration in mice: Evidence for dissociation between cognitive deficits and neuronal damage": [Experimental Neurology, 226:2 (2010) 274-284].

Tetsadê C B Piermartiri, Cláudia P Figueiredo, Daniel Rial, Filipe S Duarte, Sarah C Bezerra, Gianni Mancini, Andreza F de Bem, Rui D S Prediger, Carla I Tasca,

Exp Neurol (Experimental neurology)
[2021, 345:113840]

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Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection.

Yo Sasaki, Jian Zhu, Yun Shi, Weixi Gu, Bostjan Kobe, Thomas Ve, Aaron DiAntonio, Jeffrey Milbrandt,

SARM1 is an inducible NAD<sup>+</sup> hydrolase that is the central executioner of pathological axon loss. Recently, we elucidated the molecular mechanism of SARM1 activation, demonstrating that SARM1 is a metabolic sensor regulated by the levels of NAD<sup>+</sup> and its precursor, nicotinamide mononucleotide (NMN), via their competitive binding to an allosteric ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 345:113842]

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LncRNA TCONS_00041002 improves neurological outcomes in neonatal rats with hypoxic-ischemic encephalopathy by inhibiting apoptosis and promoting neuron survival.

Liu-Lin Xiong, Lu-Lu Xue, Ruo-Lan Du, Yang Xu, Ying-Jie Niu, Qiao Hu, Hao-Li Zhou, Fei Liu, Zhao-Qiong Zhu, Chang-Yin Yu, Ting-Hua Wang,

It has been reported that Neonatal hypoxic-ischemic encephalopathy (HIE) could induce apoptosis in neonates and result in cognitive and sensory impairments, which are associated with poor developmental outcomes. Despite the improvement in neonatology, there is still no clinically effective treatment for HIE presently. Long non-coding RNAs (lncRNAs) play important roles ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 346:113835]

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New insights into methoxetamine mechanisms of action: Focus on serotonergic 5-HT2 receptors in pharmacological and behavioral effects in the rat.

Matteo Marti, Giuseppe Talani, Cristina Miliano, Sabrine Bilel, Francesca Biggio, Jessica Bratzu, Marco Diana, Maria Antonietta De Luca, Liana Fattore,

Methoxetamine (MXE) is a dissociative substance of the arylcyclohexylamine class that has been present on the designer drug market as a ketamine-substitute since 2010. We have previously shown that MXE (i) possesses ketamine-like discriminative and positive rewarding effects in rats, (ii) affects brain processing involved in cognition and emotional responses, ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 345:113836]

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