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Journal Exp Clin Psychopharmacol

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Caffeine consumption, toxicity, tolerance and withdrawal; shared genetic influences with normative personality and personality disorder traits.

Nikolai Czajkowski, Kenneth S Kendler, Fartein Ask Torvik, Eivind Ystrom, Tom Rosenström, Nathan A Gillespie, Ted Reichborn-Kjennerud,

Our main aim was to estimate the extent of overlapping etiology between caffeine consumption and response and normative and pathological personality. Linear mixed-effects models were used to identify normative personality domains and personality disorder (PD) traits for inclusion in multivariate twin analyses together with individual caffeine related measures. Data were ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Household-smoking bans are associated with reduced nicotine exposure, increased smoking abstinence, and improved birth outcomes among pregnant women enrolled in smoking-cessation treatment.

Diana R Keith, Joan Skelly, Katherine J Tang, Allison N Kurti, Stephen T Higgins,

Data indicate household-smoking bans aid cessation and reduce secondhand smoke exposure. This study assessed prevalence of antepartum (AP) and postpartum (PP) household-smoking bans and associations with nicotine exposure, abstinence, and birth weight among pregnant women. The current study is a secondary analysis of clinical trials examining the efficacy of financial ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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The prospective interactive effects of alcohol expectancies and subjective response on future drinking behavior.

Jack T Waddell, William R Corbin, Laurie Chassin, Samantha F Anderson,

Although alcohol expectancies and subjective response are independent predictors of drinking, social-cognitive theory suggests that expectancies may distort one's subjective response, creating discrepancies between expected and actual alcohol effects. A recent cross-sectional study found that unmet expectancies (using difference scores) were associated with heavier drinking. However, cross-sectional data cannot establish ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Behavioral economics of substance use: Understanding and reducing harmful use during the COVID-19 pandemic.

Samuel F Acuff, Jalie A Tucker, James G Murphy,

Behavioral economic research demonstrates that alcohol and drug consumption is (a) an inverse function of constraints on access to the substance and (b) a direct function of constraints on access to alternative rewards. Physical distancing interventions and economic consequences of the COVID-19 pandemic have resulted in unprecedented reductions in many ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Bidirectional influence of heroin and cocaine escalation in persons with dual opioid and cocaine dependence diagnoses.

Eduardo R Butelman, Carina Y Chen, Kimberly J Lake, Kate G Brown, Mary Jeanne Kreek,

Persons with dual severe opioid and cocaine use disorders are at risk of considerable morbidity, and the bidirectional relationship of escalation of mu-opioid agonists and cocaine use is not well understood. The aim of this study was to examine the bidirectional relationship between escalation of heroin and cocaine use in ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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The relative impact of acute nicotine and tobacco administration on craving, withdrawal, and cigarette self-administration in dependent and nondependent smokers.

Toni C Spinella, Sean P Barrett, Hera E Schlagintweit,

Negative reinforcement mechanisms, wherein individuals smoke at regular intervals to ameliorate craving and withdrawal, are integral to persistent smoking. This is consistent with the behavior of dependent smokers but does not fully account for the behavior of intermittent smokers, who do not smoke enough to maintain steady nicotine levels. This ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Acute nicotine reinforcement requires ability to discriminate the stimulus effects of nicotine.

Kenneth A Perkins,

This review of research on behavioral discrimination of nicotine and how it informs public health policy for reducing risk of tobacco dependence is adapted from Kenneth A. Perkins's American Psychological Association Division 28 (Psychopharmacology and Substance Abuse) 2020 Med Associates Brady/Schuster Award Lecture. The author's initial programmatic clinical research on ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Can exercise alleviate sleep disturbances during acute nicotine withdrawal in cigarette smokers?

Isabella Soreca, Cynthia A Conklin, Elizabeth J Vella, Ronald P Salkeld, Christopher J Joyce, Joel M Mumma, John M Jakicic, David J Kupfer,

Sleep disturbances, including insomnia (difficulty falling or staying asleep), are common nicotine withdrawal symptoms particularly during the initial stage of nicotine abstinence, and increase the likelihood of relapse within the first 4 weeks of quitting. Although clinically recognized as a key symptom of nicotine withdrawal, sleep disturbances are not addressed ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Validity of the alcohol purchase task with United States military personnel.

Kinsey Pebley, James G Murphy, Xin-Qun Wang, G Wayne Talcott, Robert C Klesges, Meghan E McDevitt-Murphy, Timothy L McMurry, Melissa A Little,

Alcohol use is common among military personnel. However, alcohol use and problems are challenging to measure because military personnel do not have similar levels of confidentiality as civilians and can face sanctions for reporting illegal behavior (e.g., underage drinking) or for drinking during prohibited times (e.g., during basic training). The ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Behavioral economic assessment of abuse liability for Black & Mild cigar flavors among young adults.

Rose S Bono, Caroline O Cobb, Catherine S Wall, Rebecca C Lester, Cosima Hoetger, Thokozeni Lipato, Mignonne C Guy, Thomas Eissenberg, Warren K Bickel, Andrew J Barnes,

Cigars are available in a variety of flavors that may impact uptake and use, but little is known about how different flavors affect abuse liability. This study used 3 behavioral economic tasks to examine abuse liability of Black & Mild cigars differing in flavor among young adult cigarette smokers. Participants ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Pregestational oxycodone exposure does not impact future maternal care or drug preference in the postpartum mouse.

Amanda B Watters, L Paul Sands, Katharine M Cammack,

Females are uniquely sensitive to drugs of abuse at specific points in their reproductive cycle. Females' endogenous opioid system contributes to both reward-related processes and maternally relevant physiological functions, yet less is known about how adolescent opioid exposure impacts females' future behavior, ranging from parental caregiving to opioid preference. The ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Sexual discounting: A systematic review of discounting processes and sexual behavior.

Matthew W Johnson, Justin C Strickland, Evan S Herrmann, Sean B Dolan, David J Cox, Meredith S Berry,

Behavioral processes underlying sexual behavior are important for understanding normal human functioning and risk behavior leading to sexually transmitted infections (STIs). This systematic review examines delay and probability discounting in human sexual behavior through synthesis of 50 peer-reviewed, original research articles. Sixteen studies focusing exclusively on monetary delay discounting found ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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The phenotype of recovery II: The association between delay discounting, self-reported quality of life, and remission status among individuals in recovery from substance use disorders.

Liqa N Athamneh, Roberta Freitas Lemos, Julia C Basso, Devin C Tomlinson, William H Craft, Madison D Stein, Warren K Bickel,

Quality of life (QOL) and delay discounting (preference for smaller, immediate rewards) are significantly associated with substance use status, severity, and treatment outcomes. Associations between delay discounting and QOL among individuals in recovery from substance use have not been investigated. In this 2-study investigation, using data collected from The International ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Behavioral economic interactions between cannabis and alcohol purchasing: Associations with disordered use.

Sean B Dolan, Tory R Spindle, Ryan Vandrey, Matthew W Johnson,

As cannabis policy changes, there is an urgent need to understand interactions between cannabis and alcohol couse. An online sample of 711 adult past-month cannabis and alcohol users completed both single-item hypothetical purchasing tasks for cannabis and alcohol and cross-commodity purchasing tasks assessing adjusting-price cannabis with concurrently available, fixed-price alcohol, ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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The effects of artificially induced proestrus on heroin intake: A critical role for estradiol.

Mark A Smith, Sarah B Ethridge, Abigail N Gibson, Karl T Schmidt, Jessica L Sharp,

Heroin intake decreases markedly during proestrus in normally cycling female rats; however, it is not known whether estradiol, progesterone, or both hormones are responsible for these decreases in heroin intake. The purpose of the present study was to examine the roles of estradiol and progesterone in heroin intake by artificially ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Methamphetamine administration dose effects on sexual desire, sexual decision making, and delay discounting.

Meredith S Berry, Natalie R Bruner, Evan S Herrmann, Patrick S Johnson, Matthew W Johnson,

Correlational evidence has linked methamphetamine use and HIV sexual risk behavior, but the direct effects of methamphetamine on sexual desire and sexual decision making in humans have not been tested. This study was designed to test the effect of methamphetamine administration on sexual desire and hypothetical condom-use decisions as measured ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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PKC inhibition decreases amphetamine-maintained responding under a progressive-ratio schedule of reinforcement.

Rachel D Altshuler, Ryan C Mac, Margaret E Gnegy, Emily M Jutkiewicz,

Protein kinase C (PKC) is important for the mechanism of action of amphetamine (AMPH). Inhibiting PKC blocks AMPH-stimulated increases in extracellular dopamine levels and AMPH-stimulated locomotor activity. This study examined the effects of PKC inhibition on the reinforcing properties of AMPH. Male Sprague-Dawley rats were trained to respond for infusions ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Why adolescents engage in early alcohol use: A study of drinking motives.

Koen Smit, Carmen Voogt, Roy Otten, Marloes Kleinjan, Emmanuel Kuntsche,

Shortly after young adolescents initiate alcohol use, we investigated whether (1) drinking motives are associated with current alcohol use and binge drinking, (2) motives predict these alcohol outcomes 6 months later, and (3) alcohol outcomes predict motives 6 months later. Data on adolescents' drinking motives and alcohol use were drawn ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Pain interference and cognitive processes of e-cigarette use: The differential effect of sex.

Tanya Smit, JeanFelix Chavez, Lorra Garey, Nubia A Mayorga, Andrew H Rogers, Michael J Zvolensky,

Recent years have been marked by an increase in electronic cigarette (e-cigarette) use. Although some evidence suggests that e-cigarettes used in isolation may be less harmful than combustible cigarettes, e-cigarette use carries significant health risks. Data are critically needed to identify risk factors that promote and maintain e-cigarette use. The ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Alcohol demand and supersized alcopop consumption among undergraduate college students.

Mackenzie L Olson, Matthew E Rossheim, Sadie B Sanders, Ali M Yurasek,

Supersized alcopops are sugar-sweetened beverages with extraordinarily high alcohol content; consumption is highly prevalent among college students and is associated with a variety of negative alcohol-related consequences. However, few studies have examined risk factors for consumption of these products. The objective of this study was to examine, among a college ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Effects of substance use on monetary delay discounting among people who use stimulants with and without HIV: An ecological momentary assessment study.

Yunan Xu, Sheri L Towe, Shakiera T Causey, Paul A Dennis, Christina S Meade,

Exploration of the real-time relationship between substance use and delay discounting may reveal potential mechanisms driving high-risk behaviors. We conducted an ecological momentary assessment (EMA) study to investigate the effects of substance use on delay discounting in a sample of people who use stimulants (HIV+: 30; HIV-: 34). Participants completed ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Differences in serum orexin-A levels between the acute and subacute withdrawal phases in individuals who use methamphetamine.

Wan-Chen Lee, Po-Yu Chen, Chung-Feng Kao, Ming-Chyi Huang,

Orexin has been suggested to play a role in regulating the reward circuits and enhancing drug-seeking behaviors; however, its role in methamphetamine (METH) addiction remains unclear. We previously found that blood orexin-A levels are upregulated in individuals with recent METH exposure. Whether the levels would be altered following withdrawal is ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Statistically derived patterns of behavioral economic risk among heavy-drinking college students: A latent profile analysis.

Kevin W Campbell, Andrew T Voss, Samuel F Acuff, Kinsey Pebley, Kristoffer S Berlin, Matthew P Martens, Brian Borsari, Ashley A Dennhardt, James G Murphy,

High levels of 3 behavioral economic indices (delay discounting, alcohol demand, and proportionate substance-related reinforcement) are consistently associated with greater alcohol misuse and alcohol-related problems. However, it is unclear whether and how these variables jointly increase the risk for alcohol-related outcomes among college students who engage in heavy episodic drinking ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Association of SAPAP3 allelic variants with symptom dimensions and pharmacological treatment response in obsessive-compulsive disorder.

Safoora Naaz, Srinivas Balachander, Nithyananda Srinivasa Murthy, Bhagyalakshmi Ms, Reeteka Sud, Priyanka Saha, Janardhanan C Narayanaswamy, Janardhan Reddy Yc, Sanjeev Jain, Meera Purushottam, Biju Viswanath,

Though several SAPAP3 gene knockout studies in mice have implicated its role in compulsivity, human studies have failed to demonstrate its association with obsessive-compulsive disorder (OCD). We examined the association between allelic variants of a single nucleotide polymorphism in the SAPAP3 gene (rs6662980) with specific aspects of the OCD phenotype. ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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Anxiety sensitivity and opioid use motives among adults with chronic low back pain.

Andrew H Rogers, Lorra Garey, Amanda M Raines, Nicholas P Allan, Norman B Schmidt, Michael J Zvolensky,

The opioid epidemic is a significant public health crisis in the United States, and chronic pain is a leading precipitating and maintaining factor for opioid misuse. To better understand substance misuse generally, research has examined motivational models of why people use substances, and pain management and affect-driven coping are cited ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2020, :]

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