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Can iron chelation as an adjunct treatment of COVID-19 improve the clinical outcome?

Anis Abobaker,

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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Validation of self-reported adherence in chronic patients visiting pharmacies and factors associated with the overestimation and underestimation of good adherence.

C Valdés Y Llorca, Ernesto Cortés-Castell, J M Ribera-Casado, P de Lucas-Ramos, L M de Palacio-Guerrero, F Mugarza-Borqué, J L Casteig-Ayestarán, J Díaz-Olmo, A Casteig-Blanco, V F Gil-Guillén, M Rizo-Baeza,

BACKGROUND:Studies validating indirect methods to identify nonadherence in chronic patients who visit pharmacies are lacking. The aim of this study was to validate self-reported adherence and assess the variables associated with both overestimation and underestimation of good adherence when using this method. MATERIALS AND METHODS:An observational, cross-sectional study was undertaken ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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Serotonin transporter gene and escitalopram: depressing medical science.

Alain Braillon,

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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Population pharmacokinetic analysis of bisoprolol in type 2 diabetic patients with hypertension.

Stefan Momčilović, Andriana Jovanović, Danijela Radojković, Valentina N Nikolić, Slobodan M Janković, Milica Pešić, Jasmina R Milovanović,

PURPOSE:Given that it has been reported that type 2 diabetes mellitus may affect the pharmacokinetics of a large number of drugs and that there are still no published population pharmacokinetic (PopPK) analyses in routinely treated patients with hypertension and type 2 diabetes mellitus as comorbid condition, the aim of this ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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Adverse drug reactions to anti-diabetic drugs are commonest in patients whose treatment do not adhere to diabetes management clinical guidelines: cross-sectional study in a tertiary care service in sub-Saharan Africa.

Agnes Elangwe, Jean-Claude Katte, Donald Tchapmi, Albert Figueras, Jean Claude Mbanya,

AIMS:The study aimed to identify and describe adverse drug reactions and adherence to clinical guidelines in patients receiving treatment for type 2 diabetes mellitus (T2DM) in Cameroon. METHODS:The method used was a cross-sectional study at a tertiary diabetes care service in Yaoundé, Cameroon. Adult T2DM patients attending the diabetes clinic ... Read more >>

Eur. J. Clin. Pharmacol. (European Journal of Clinical Pharmacology)
[2020, :]

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Adverse drug reactions in infants, children and adolescents exposed to antidepressants: a French pharmacovigilance study.

Simon Barthez, Alexis Revet, Laurent Chouchana, Annie-Pierre Jonville-Bera, Véronique Pizzoglio, Jean-Philippe Raynaud, Leila Chebane, Maryse Lapeyre-Mestre, François Montastruc,

PURPOSE:Despite their frequent use in children and adolescents, the evidence for efficacy and safety of antidepressants (ATDs) in this population is scarce and off-label prescribing common. The aim of this study was to describe reported adverse drug reactions (ADRs) associated to ATDs over a 30-year period using the French Pharmacovigilance ... Read more >>

Eur. J. Clin. Pharmacol. (European Journal of Clinical Pharmacology)
[2020, :]

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Antibiotic prophylaxis and surgical site infections; a prospective open label study to clinically evaluate the serum and tissue concentration of single dose prophylactic ceftriaxone in laparoscopic cholecystectomy.

Salim Sheikh, Neeraj Kumar Malik, Bushra Ahmed Karim,

OBJECTIVE:The goal of administering preoperative systemic prophylactic antibiotics is to have the concentration in the tissues at its optimum level at the start and throughout the surgery. The rationale for the use of antibiotics is not well accepted, possible side effects and development of microbial resistance patterns are potential risks ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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Optimizing the MIC breakpoints of amoxicillin and tetracycline for antibiotic selection in the rescue therapy of H. pylori with bismuth quadruple regimen.

Ming-Tsung Hsieh, Wei-Lun Chang, Chung-Tai Wu, Hsiao-Bai Yang, Hsin-Yu Kuo, Meng-Ying Lin, Hsiu-Chi Cheng, Yu-Chin Tsai, Bor-Shyang Sheu,

PURPOSE:H. pylori with triple-drug resistance (TR) to clarithromycin, metronidazole, and levofloxacin limits the success of rescue therapy. We aimed to identify the optimal breakpoints of antibiotic minimal inhibitory concentration (MIC) to predict the success of rescue therapy for TR H. pylori infection. METHODS:We consecutively enrolled 430 patients with at least ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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The added value of pirfenidone to fight inflammation and fibrotic state induced by SARS-CoV-2 : Anti-inflammatory and anti-fibrotic therapy could solve the lung complications of the infection?

Francesco Ferrara, Giovanni Granata, Chiara Pelliccia, Raffaele La Porta, Antonio Vitiello,

AIM:SARS-CoV-2 infection has been divided by scientific opinion into three phases: the first as asymptomatic or slightly symptomatic and the second and the third with greater severity, characterized by a hyperinflammatory and fibrotic state, responsible for lung lesions, in some cases fatal. The development of antiviral drugs directed against SARS-CoV-2 ... Read more >>

Eur. J. Clin. Pharmacol. (European Journal of Clinical Pharmacology)
[2020, :]

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What about COVID-19 and arachidonic acid pathway?

Malvina Hoxha,

BACKGROUND AND OBJECTIVE:COVID-19 is a highly contagious viral disease. In this study, we tried to define and discuss all the findings on the potential association between arachidonic acid (AA) pathway and COVID-19 pathophysiology. METHODS:A literature search across PubMed, Scopus, Embase, and Cochrane database was conducted. A total of 25 studies ... Read more >>

Eur. J. Clin. Pharmacol. (European Journal of Clinical Pharmacology)
[2020, :]

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Better survival in impaired renal function patients with metastatic non-small cell lung cancer treated by cisplatin-pemetrexed.

Louis Magali, Foucher Pascal, Aho Serge, Boulin Mathieu, Zouak Ayoube, Tinel Claire, Mousson Christiane,

PURPOSE:Cisplatin-pemetrexed is the first-line chemotherapy for advanced, metastatic non-squamous non-small cell lung cancer (NSCLC), but the risk of kidney toxicity limits the therapeutic schedule. We performed a retrospective study of patient survival at 1 year and glomerular filtration rate (GFR) outcomes in cisplatin-pemetrexed-treated NSCLC patients. METHODS:Patients (P) treated for NSCLC between ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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Population pharmacokinetics and dose optimization of ceftriaxone for children with community-acquired pneumonia.

Muhammad Wasim Khan, Ya-Kun Wang, Yue-E Wu, Bo-Hao Tang, Min Kan, Hai-Yan Shi, Yi Zheng, Bao-Ping Xu, A-Dong Shen, Evelyne Jacqz-Aigrain, Li-Yuan Tian, Wei Zhao,

PURPOSE:To assess ceftriaxone population pharmacokinetics in a large pediatric population and describe the proper dose for establishing an optimized antibiotic regimen. METHODS:From pediatric patients using ceftriaxone, blood samples were obtained and the concentration was measured using high-performance liquid chromatography ultraviolet detection. The NONMEM software program was used for population pharmacokinetic ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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Accuracy of freely available online GFR calculators using the CKD-EPI equation.

Sarah Seiberth, Theresa Terstegen, Dorothea Strobach, David Czock,

PURPOSE:Estimated glomerular filtration rate (eGFR) as calculated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation is used for detection of chronic kidney disease and drug dose adjustment. The purpose of the present study was to investigate the accuracy of freely available eGFR online calculators. METHODS:All identified CKD-EPI online calculators ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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The parent drugs chloroquine and hydroxychloroquine do not inhibit human CYP3A activity in vitro.

Xia Li, Rainer Höhl, Fritz Sörgel, Uwe Fuhr,

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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Probability of mycobactericidal activity of para-aminosalicylic acid with novel dosing regimens.

Ahmed A Abulfathi, Piyanan Assawasuwannakit, Peter R Donald, Andreas H Diacon, Helmuth Reuter, Elin M Svensson,

PURPOSE:Para-aminosalicylic acid (PAS) is currently one of the add-on group C medicines recommended by the World Health Organization for multidrug-resistant tuberculosis treatment. At the recommended doses (8-12 g per day in two to three divided doses) of the widely available slow-release PAS formulation, studies suggest PAS exposures are lower than those ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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Coenzyme Q10 supplementation and oxidative stress parameters: a systematic review and meta-analysis of clinical trials.

Abolfazl Akbari, Gholam Reza Mobini, Shahram Agah, Mojgan Morvaridzadeh, Amirhossein Omidi, Eric Potter, Siavash Fazelian, Seyed Hossein Ardehali, Elnaz Daneshzad, Sadegh Dehghani,

PURPOSE:Oxidative stress (OS) is associated with several chronic complications and diseases. The use of coenzyme Q10 (CoQ10) as an adjuvant treatment with routine clinical therapy against metabolic diseases has shown to be beneficial. However, the impact of CoQ10 as a preventive agent against OS has not been systematically investigated. METHODS:A ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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Alliance between selective serotonin reuptake inhibitors and fracture risk: an updated systematic review and meta-analysis.

Manoj Kumar, Ram Bajpai, Abdul Rahaman Shaik, Swati Srivastava, Divya Vohora,

PURPOSE:In the past few years, several fracture-related events have been reported with chronic use of selective serotonin reuptake inhibitors (SSRIs) throughout the globe. Hence, an updated systematic review and meta-analysis was necessary to ascertain the risk involved. The present work evaluated the association of SSRIs with the risk of fracture ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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The association between acid-suppressive agent use and the risk of cancer: a systematic review and meta-analysis.

Hyun Jin Song, Nakyung Jeon, Patrick Squires,

BACKGROUND:Acid-suppressive agents (ASAs) may be associated with cancer; previous studies reported that the risk of cancer with acid suppressants has differed depending on the site of cancer. Here, we conducted a systematic review and meta-analysis of the association between ASA use and the type of cancer risk. METHODS:MEDLINE, EMBASE, and ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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ABCB1 and ERCC1 gene polymorphisms are associated with nephro- and hepatotoxicity to carboplatin/paclitaxel-based chemotherapy in patients with gynecologic cancers.

Luiz Carlos da Costa Junior, Clarissa Lourenço de Castro, Daniely Regina Freitas-Alves, Rosane Vianna-Jorge, Paulo Caleb Júnior Lima Santos,

BACKGROUND:Paclitaxel/carboplatin combination is the standard chemotherapeutic protocol for gynecologic cancers, but severe toxicities may compromise treatment. There is great inter-individual variability regarding the incidence and severity of toxicities, which may be due to single-nucleotide polymorphisms (SNPs) affecting drug disposition or cellular sensitivity. Here we investigate the impact of selected SNPs ... Read more >>

Eur. J. Clin. Pharmacol. (European Journal of Clinical Pharmacology)
[2020, :]

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A survey about label enhancement methods for parenteral medication in European hospital pharmacies.

K H M Larmené-Beld, R N Keers, K Taxis,

PURPOSE:Unclear labeling has been recognized as an important cause of look-alike medication errors. Little is known about which labeling practices are currently used in European hospitals. The aim of this article is to obtain an overview of the labeling practices for parenteral medications, in relation to national guidelines, in the ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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Safety and CSF distribution of high-dose erlotinib and gefitinib in patients of non-small cell lung cancer (NSCLC) with brain metastases.

Bharati Shriyan, Deepali Patil, Murari Gurjar, Manjunath Nookala, Anand Patil, Sadhana Kannan, Vijay Patil, Amit Joshi, Vanita Noronha, Kumar Prabhash, Vikram Gota,

PURPOSE:Patients of non-small cell lung cancer (NSCLC) with brain metastases have limited treatment options. High-dose erlotinib (HDE) and gefitinib (HDG) have been tried in the past. This study investigates the cerebrospinal fluid (CSF) disposition and safety of both, high-dose erlotinib and gefitinib regimens. METHODS:Eleven and nine patients were treated with ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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Calling for an exponential escalation scheme in vaccine development for COVID-19.

Martin Wehling,

PURPOSE:COVID-19 as a pandemic calls for rapid development of vaccines. METHODS:Here a proposal of a seamless, adaptive, phase 1-3 trial for accelerated vaccine development is described. RESULTS:Starting at 10, the number of vaccinated volunteers would exponentially increase by tenfold at an interval of 2 weeks; close surveillance of antibody responses, safety ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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Absence of QTc prolongation in a thorough QT study with imeglimin, a first in class oral agent for type 2 diabetes mellitus.

Julie Dubourg, Sandrine Perrimond-Dauchy, Mathieu Felices, Sébastien Bolze, Pascal Voiriot, Pascale Fouqueray,

PURPOSE:Imeglimin is the first in a new class of oral antidiabetic agents, the glimins, currently in development to improve glycemic control in patients with type 2 diabetes mellitus. A thorough QT study was conducted to establish electrophysiological effects of therapeutic and supratherapeutic doses of imeglimin on cardiac repolarization. METHODS:In this ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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Professor Folke Sjöqvist peacefully passed away on March 30, 2020.

Ylva Böttiger, Pierre Marquet, Lars L Gustafsson,

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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Evaluation of dose-tapering strategies for intravenous tocilizumab in rheumatoid arthritis patients using model-based pharmacokinetic/pharmacodynamic simulations.

Carla Bastida, Alwin D R Huitema, Merel J l'Ami, Virginia Ruiz-Esquide, Gerrit Jan Wolbink, Raimon Sanmartí, Dolors Soy,

PURPOSE:Tocilizumab is a humanized monoclonal antibody approved for rheumatoid arthritis treatment. In clinical practice, empirical dose-tapering strategies are implemented in patients showing sustained remission or low disease activity (LDA) to avoid overtreatment and reduce costs. Since rational adaptive-dosing algorithms taking the full pharmacokinetic (PK)/pharmacodynamic (PD) characteristics into account are currently ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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