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Nomogram Predicting Downgrading in National Comprehensive Cancer Network High-risk Prostate Cancer Patients Treated with Radical Prostatectomy.

Mike Wenzel, Christoph Würnschimmel, Francesco Chierigo, Rocco Simone Flammia, Zhe Tian, Shahrokh F Shariat, Michele Gallucci, Carlo Terrone, Fred Saad, Derya Tilki, Markus Graefen, Andreas Becker, Luis A Kluth, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>Some high-risk prostate cancer (PCa) patients may show more favorable Gleason pattern at radical prostatectomy (RP) than at biopsy.<h4>Objective</h4>To test whether downgrading could be predicted accurately.<h4>Design, setting, and participants</h4>Within the Surveillance, Epidemiology and End Results database (2010-2016), 6690 National Comprehensive Cancer Network (NCCN) high-risk PCa patients were identified.<h4>Outcome measurements and ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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How Should We Assess Stone Ablation Efficacy When Comparing Different Lasers?

Vincent De Coninck, Eugenio Ventimiglia, Olivier Traxer,

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[2021, :]

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Bladder Chemoprophylaxis Following Ureterorenoscopy in Patients with Upper Tract Urothelial Carcinoma.

Federico Ferraris, Jay D Raman, Fabian Yaber,

Kidney-sparing procedures for upper tract urothelial carcinoma (UTUC) have evolved from imperative to elective indications for management of low-risk disease. Ureterorenoscopy is the most common procedure for the diagnosis, treatment, and surveillance of UTUC. A notable consideration following ureterorenoscopy is the higher risk of downstream bladder seeding. Here we review ... Read more >>

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[2021, :]

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Sacral Neuromodulation with the InterStim System for Overactive Bladder: 3-Year Results from the French Prospective, Multicenter, Observational SOUNDS Study.

Emmanuel Chartier-Kastler, Loïc Le Normand, Alain Ruffion, Christian Saussine, Raïssa Braguet, Bertrand Rabut, Evelyne Ragni, Marie-Aimée Perrouin-Verbe, Jean Pierrevelcin, Thierry Rousseau, Xavier Gamé, Yves Tanneau, François Dargent, Xavier Biardeau, Jean Pierre Graziana, Gabriel Stoica, Elena Brassart, Marc Fourmarier, Najdat Yaghi, Gregoire Capon, Jérôme Ferchaud, Nathalie Berrogain, Laurence Peyrat, François Pecoux, Pierre-Emmanuel Bryckaert, Alice Melotti, Abdallah Abouihia, David Urs Josef Keller, Jean-Nicolas Cornu,

<h4>Background</h4>SOUNDS strengthens the evidence basis of sacral neuromodulation (SNM) for overactive bladder (OAB) through real-world data.<h4>Objective</h4>To analyze diary-based effectiveness, quality of life (QoL), disease severity, symptom bother, and safety data for SNM with the InterStim system up to 3 yr after implantation.<h4>Design, setting, and participants</h4>Twenty-five representative French sites enrolled 291 ... Read more >>

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[2021, :]

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Prostate-specific Antigen Testing in Men with Disabilities: A Cross-sectional Analysis of the Health Information National Trends Survey.

Joon Yau Leong, Ruben Pinkhasov, Thenappan Chandrasekar, Oleg Shapiro, Michael Daneshvar, Joseph Jacob, Thomas Sanford, Gennady Bratslavsky, Hanan Goldberg,

<h4>Background</h4>Patients with disabilities represent a unique minority population. The incidence of prostate-specific antigen (PSA) testing among this population is unknown.<h4>Objective</h4>To compare PSA testing rates and associated predictors among men with and without reported disabilities in the USA.<h4>Design, setting, and participants</h4>A cross-sectional study of the Health Information National Trends Survey (HINTS) ... Read more >>

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[2021, :]

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Drug-induced Urinary Retention: An Analysis of a National Spontaneous Adverse Drug Reaction Reporting Database.

Salvatore Crisafulli, Paola Maria Cutroneo, Katia Verhamme, Carmen Ferrajolo, Vincenzo Ficarra, Laura Sottosanti, Valentina Di Giovanni, Edoardo Spina, Gianluca Trifirò,

<h4>Background</h4>Numerous drugs have been associated with urinary retention (UR), but updated information on drugs that may induce UR is limited.<h4>Objective</h4>To evaluate drug-induced UR using the Italian spontaneous adverse drug reactions (ADRs) reporting database.<h4>Design, setting, and participants</h4>We selected all suspected spontaneous reports of drug-induced UR collected into the Italian spontaneous reporting ... Read more >>

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[2021, :]

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Prospective Longitudinal Health-related Quality of Life Analysis of the Finnish Arm of the PRIAS Active Surveillance Cohort: 11 Years of Follow-up.

Utku Lokman, Hanna Vasarainen, Kanerva Lahdensuo, Andrew Erickson, Timo Muhonen, Tuomas Mirtti, Antti Rannikko,

<h4>Background</h4>Living with an untreated cancer may alter quality of life (QoL) in the long term.<h4>Objective</h4>To prospectively study long-term changes in general, mental, and physical QoL in a contemporary active surveillance (AS) patient cohort with low-risk prostate cancer (PCa).<h4>Design, setting, and participants</h4>The study population consisted of patients enrolled in the PRIAS ... Read more >>

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[2021, :]

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Clipless Robotic-assisted Radical Prostatectomy and Impact on Outcomes.

Spyridon P Basourakos, Patrick J Lewicki, Ashwin Ramaswamy, Emily Cheng, Vanessa Dudley, Miko Yu, Beerinder Karir, Andrew J Hung, Francesca Khani, Jim C Hu,

<h4>Background</h4>The use of surgical clips for athermal dissection of the lateral prostatic pedicles and ligation during pelvic lymph node dissection (PLND) while performing robotic-assisted radical prostatectomy (RARP) has been the gold standard. Clips are used to prevent thermal injury of the unmyelinated nerve fibers and lymphceles, respectively.<h4>Objective</h4>To compare oncological and ... Read more >>

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Rethinking Autonomous Surgery: Focusing on Enhancement over Autonomy.

Edoardo Battaglia, Jacob Boehm, Yi Zheng, Andrew R Jamieson, Jeffrey Gahan, Ann Majewicz Fey,

<h4>Context</h4>As robot-assisted surgery is increasingly used in surgical care, the engineering research effort towards surgical automation has also increased significantly. Automation promises to enhance surgical outcomes, offload mundane or repetitive tasks, and improve workflow. However, we must ask an important question: should autonomous surgery be our long-term goal?<h4>Objective</h4>To provide an ... Read more >>

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[2021, :]

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Reply to Nikolaos Grivas, Nikolaos Kalampokis, and Henk van der Poel's Letter to the Editor re: Loc Trinh, Samuel Mingo, Erik B. Vanstrum, et al. Survival Analysis Using Surgeon Skill Metrics and Patient Factors to Predict Urinary Continence Recovery After Robot-assisted Radical Prostatectomy. Eur Urol Focus. In press. https://doi.org/10.1016/j.euf.2021.04.001.

Andrew J Hung,

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[2021, :]

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Re: Loc Trinh, Samuel Mingo, Erik B. Vanstrum, et al. Survival Analysis Using Surgeon Skill Metrics and Patient Factors to Predict Urinary Continence Recovery After Robot-assisted Radical Prostatectomy. Eur Urol Focus. In press. https://doi.org/10.1016/j.euf.2021.04.001.

Nikolaos Grivas, Nikolaos Kalampokis, Henk van der Poel,

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[2021, :]

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Prognostic Implications of Treatment Delays for Patients with Non-muscle-invasive Bladder Cancer.

Said Ourfali, Xavier Matillon, Estelle Ricci, Hakim Fassi-Fehri, Mélanie Benoit-Janin, Lionel Badet, Marc Colombel,

<h4>Background</h4>Delay in treatment is a prognostic factor in muscle-invasive bladder cancer.<h4>Objective</h4>To evaluate clinical outcomes associated with delays in diagnosis and treatment for patients with non-muscle invasive bladder cancer (NMIBC).<h4>Design, setting, and participants</h4>In this retrospective study we analyzed data for patients treated at our center between November 2008 and December 2016 ... Read more >>

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[2021, :]

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Prostate-specific Membrane Antigen Biology in Lethal Prostate Cancer and its Therapeutic Implications.

Beshara Sheehan, Christina Guo, Antje Neeb, Alec Paschalis, Shahneen Sandhu, Johann S de Bono,

<h4>Context</h4>Prostate-specific membrane antigen (PSMA) is a promising, novel theranostic target in advanced prostate cancer (PCa). Multiple PSMA-targeted therapies are currently in clinical development, with some agents showing impressive antitumour activity, although optimal patient selection and therapeutic resistance remain ongoing challenges.<h4>Objective</h4>To review the biology of PSMA and recent advances in PSMA-targeted ... Read more >>

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[2021, :]

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Siglec-6 as a New Potential Immune Checkpoint for Bladder Cancer Patients.

Sulayman Benmerzoug, Mathieu F Chevalier, Maëlle Verardo, Sylvain Nguyen, Valérie Cesson, Anna K Schneider, Florence Dartiguenave, Sonia-Christina Rodrigues-Dias, Ilaria Lucca, Patrice Jichlinski, Beat Roth, Denise Nardelli-Haefliger, Laurent Derré,

Among the growing family of inhibitory receptors regulating immunity, sialic acid-binding immunoglobulin domain-containing lectins (Siglecs) have recently emerged as immunoregulatory receptors recognizing sialylated ligands on tumor cell surface. However, their role in the immunoregulation of bladder cancer (BCa) remains unknown. Here, we determined the presence of eight Siglec ligands (SLs) ... Read more >>

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[2021, :]

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Robot-assisted Versus Open Radical Cystectomy in Bladder Cancer: An Economic Evaluation Alongside a Multicentre Comparative Effectiveness Study.

Charlotte T J Michels, Carl J Wijburg, Gerjon Hannink, J Alfred Witjes, Maroeska M Rovers, Janneke P C Grutters, ,

<h4>Background</h4>Open radical cystectomy (ORC) is regarded as the standard treatment for muscle-invasive bladder cancer, but robot-assisted radical cystectomy (RARC) is increasingly used in practice. A recent study showed that RARC resulted in slightly fewer minor but slightly more major complications, although the difference was not statistically significant. Some differences were ... Read more >>

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[2021, :]

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Risks and Benefits of Live Surgical Broadcast: A Systematic Review.

Umberto Carbonara, Fabio Crocerossa, Giacomo Novara, Pasquale Ditonno, Vito Pansadoro, Alberto Breda, Bernardo Rocco, Giovanni E Cacciamani, Alastair D Lamb, Jihad Kaouk, Francesco Porpiglia, Riccardo Autorino,

<h4>Context</h4>Live surgical broadcast (LSB), also known as live surgery, has become a popular format for many types of surgical education meetings. However, concerns have been raised in relation to patient safety, ethical issues, and the actual educational value of LSB.<h4>Objective</h4>To summarize current evidence on LSB with a focus on the ... Read more >>

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[2021, :]

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Impact of Hospital volume on postoperative outcomes after radical prostatectomy: A 5-Year nationwide database analysis.

Guillaume Ploussard, Annabelle Grabia, Jean-Baptiste Beauval, Romain Mathieu, Laurent Brureau, François Rozet, Morgan Rouprêt, Charles-Edouard Lequeu, ,

<h4>Background</h4>Hospital volume is considered to be a quality measure for outcomes after major oncological surgery. However, countrywide data are lacking for radical prostatectomy (RP).<h4>Objective</h4>To assess the impact of hospital volume on postoperative outcomes after RP performed using an open (ORP) versus a minimally invasive surgery (MIS, including pure and robot-assisted ... Read more >>

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[2021, :]

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Evaluation of Oncological Outcomes and Data Quality in Studies Assessing Nerve-sparing Versus Non-Nerve-sparing Radical Prostatectomy in Nonmetastatic Prostate Cancer: A Systematic Review.

Lisa Moris, Giorgio Gandaglia, Antoni Vilaseca, Thomas Van den Broeck, Erik Briers, Maria De Santis, Silke Gillessen, Nikos Grivas, Shane O'Hanlon, Ann Henry, Thomas B Lam, Michael Lardas, Malcolm Mason, Daniela Oprea-Lager, Guillaume Ploussard, Olivier Rouviere, Ivo G Schoots, Henk van der Poel, Thomas Wiegel, Peter-Paul Willemse, Cathy Y Yuan, Jeremy P Grummet, Derya Tilki, Roderick C N van den Bergh, Philip Cornford, Nicolas Mottet,

<h4>Context</h4>Surgical techniques aimed at preserving the neurovascular bundles during radical prostatectomy (RP) have been proposed to improve functional outcomes. However, it remains unclear if nerve-sparing (NS) surgery adversely affects oncological metrics.<h4>Objective</h4>To explore the oncological safety of NS versus non-NS (NNS) surgery and to identify factors affecting the oncological outcomes of ... Read more >>

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[2021, :]

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Accuracy of Frozen Section Analysis of Urethral and Ureteral Margins During Radical Cystectomy for Bladder Cancer: A Systematic Review and Diagnostic Meta-Analysis.

Ekaterina Laukhtina, Pawel Rajwa, Keiichiro Mori, Marco Moschini, David D'Andrea, Mohammad Abufaraj, Francesco Soria, Andrea Mari, Wojciech Krajewski, Simone Albisinni, Jeremy Yuen-Chun Teoh, Fahad Quhal, Reza Sari Motlagh, Hadi Mostafaei, Satoshi Katayama, Nico C Grossmann, Dmitry Enikeev, Kristin Zimmermann, Harun Fajkovic, Petr Glybochko, Shahrokh F Shariat, Benjamin Pradere, ,

<h4>Context</h4>The question of the ability of frozen section analysis (FSA) to accurately detect malignant pathology intraoperatively has been discussed for many decades.<h4>Objective</h4>We aimed to conduct a systematic review and meta-analysis assessing the diagnostic estimates of FSA of the urethral and ureteral margins in patients treated with radical cystectomy (RC) for ... Read more >>

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[2021, :]

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Common Pitfalls and Recommendations for Grand Challenges in Medical Artificial Intelligence.

Annika Reinke, Minu D Tizabi, Matthias Eisenmann, Lena Maier-Hein,

With the impact of artificial intelligence (AI) algorithms on medical research on the rise, the importance of competitions for comparative validation of algorithms, so-called challenges, has been steadily increasing, to a point at which challenges can be considered major drivers of research, particularly in the biomedical image analysis domain. Given ... Read more >>

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[2021, :]

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Re: Paolo Dell'Oglio, Elio Mazzone, Edward Lambert, et al. The Effect of Surgical Experience on Perioperative and Oncological Outcomes After Robot-assisted Radical Cystectomy with Intracorporeal Urinary Diversion: Evidence from a Referral Centre with Extensive Experience in Robotic Surgery. Eur Urol Focus 2021;7:352-8.

Francesco Montorsi, Giorgio Gandaglia, Federico Dehò, Andrea Gallina, Marco Moschini, Andrea Salonia, Alberto Briganti,

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[2021, :]

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Role of Radiomics in the Prediction of Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis.

Mieszko Kozikowski, Rodrigo Suarez-Ibarrola, Rafał Osiecki, Konrad Bilski, Christian Gratzke, Shahrokh F Shariat, Arkadiusz Miernik, Jakub Dobruch,

<h4>Context</h4>Radiomics is a field of science that aims to develop improved methods of medical image analysis by extracting a large number of quantitative features. New data have emerged on the successful application of radiomics and machine-learning techniques to the prediction of muscle-invasive bladder cancer (MIBC).<h4>Objective</h4>To systematically review the diagnostic performance ... Read more >>

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[2021, :]

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European Association of Urology and European Society for Paediatric Urology Guidelines on Paediatric Urinary Stone Disease.

Serdar Tekgül, Raimund Stein, Guy Bogaert, Rien J M Nijman, Josine Quaedackers, Lisette 't Hoen, M Selcuk Silay, Christian Radmayr, Hasan Serkan Doğan,

<h4>Context</h4>Paediatric stone disease is an important clinically entity and management is often challenging. Although it is known that the condition is endemic in some geographic regions of the world, the global incidence is also increasing. Patient age and sex; the number, size, location, and composition of the stone; and the ... Read more >>

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[2021, :]

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Accuracy and Clinical Utility of a Tumor Grade- and Stage-based Predictive Model in Localized Upper Tract Urothelial Carcinoma.

Satoshi Katayama, Keiichiro Mori, Victor M Schuettfort, Benjamin Pradere, Hadi Mostafaei, Fahad Quhal, Pawel Rajwa, Reza Sari Motlagh, Ekaterina Laukhtina, Marco Moschini, Nico C Grossmann, Motoo Araki, Jeremy Yuen-Chun Teoh, Morgan Rouprêt, Vitaly Margulis, Dmitry Enikeev, Pierre I Karakiewicz, Mohammad Abufaraj, Eva Compérat, Yasutomo Nasu, Shahrokh F Shariat,

<h4>Background</h4>Among various clinicopathologic factors used to identify low-risk upper tract urothelial carcinoma (UTUC), tumor grade and stage are of utmost importance. The clinical value added by inclusion of other risk factors remains unproven.<h4>Objective</h4>To assess the performance of a tumor grade- and stage-based (GS) model to identify patients with UTUC for ... Read more >>

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[2021, :]

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Global Trends in Prevalence, Treatments, and Costs of Penile Prosthesis for Erectile Dysfunction in Men.

Taylor P Kohn, Saneal Rajanahally, Wayne J G Hellstrom, Tung-Chin Hsieh, Omer A Raheem,

<h4>Context</h4>Penile prosthesis is a durable and effective treatment for erectile dysfunction (ED). Even as other treatment options for ED have been brought to market, penile prosthetic surgery remains a mainstay for urologists treating ED. No systematic study has yet summarized the global trends in penile prosthetic surgery.<h4>Objective</h4>To systematically review studies ... Read more >>

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[2021, :]

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