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Pharmaceutical nanotechnology: Antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteria.

Cesar Augusto Roque-Borda, Patricia Bento da Silva, Mosar CorrĂȘa Rodrigues, Leonardo Delello Di Filippo, Jonatas L Duarte, Marlus Chorilli, Eduardo Festozo Vicente, Saulo Santesso Garrido, Fernando RogĂ©rio Pavan,

Nanobiotechnology is a relatively unexplored area that has, nevertheless, shown relevant results in the fight against some diseases. Antimicrobial peptides (AMPs) are biomacromolecules with potential activity against multi/extensively drug-resistant bacteria, with a lower risk of generating bacterial resistance. They can be considered an excellent biotechnological alternative to conventional drugs. However, ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2022, 241:114640]

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An unanticipated discovery of novel naphthalimidopropanediols as potential broad-spectrum antibacterial members.

Peng-Li Zhang, Mouna Hind Laiche, Yan-Liang Li, Wei-Wei Gao, Jian-Mei Lin, Cheng-He Zhou,

Constructing a new antibacterial structural framework is an effective strategy to combat drug resistance. This work discovered a class of naphthalimidopropanediols (NIOLs) as a novel structural type of potential broad-spectrum antibacterial agents. Especially, NIOLs 9u, 12i, 15 against Staphylococcus aureus and NIOLs 9l, 13a against Pseudomonas aeruginosa showed excellent inhibitory ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2022, 241:114657]

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