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Blue laser imaging identifies endoscopic findings corresponding to metachronous esophageal squamous cell carcinoma.

Yuka Azuma, Osamu Dohi, Yuji Naito, Takeshi Yasuda, Takuma Yoshida, Tsugitaka Ishida, Hiroaki Kitae, Shinya Matsumura, Toshihumi Doi, Ryohei Hirose, Ken Inoue, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiko Uchiyama, Tomohisa Takagi, Takeshi Ishikawa, Hideyuki Konishi, Ayako Nishimura, Mitsuo Kishimoto, Yoshito Itoh,

This study aimed to evaluate endoscopic findings using non-magnifying blue laser imaging (BLI) to determine the risk factors for metachronous esophageal squamous cell carcinoma (ESCC). All consecutive patients who underwent endoscopic submucosal dissection (ESD) for primary superficial ESCC (SESCC) without a history of ESCC between January 2013 and January 2016 ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Novel pathological staging for patients with locally advanced esophageal squamous cell carcinoma undergoing neoadjuvant chemotherapy followed by surgery.

Junya Oguma, Koshiro Ishiyama, Daisuke Kurita, Kyohei Kanematsu, Yusuke Fujii, Kentaro Kubo, Shun Yamamoto, Yoshitaka Honma, Ken Kato, Hiroyuki Daiko,

<h4>Background</h4>The aim of the present study was to clarify an appropriate staging system for patients with locally advanced esophageal squamous cell carcinoma (LAESCC) after neoadjuvant chemotherapy (NAC) prior to surgery.<h4>Methods</h4>A total of 388 patients with clinical stage II or III LAESCC who had undergone NAC followed by an esophagectomy with ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Usefulness of wearable fitness tracking devices in patients undergoing esophagectomy.

Junko Honke, Yoshihiro Hiramatsu, Sanshiro Kawata, Eisuke Booka, Tomohiro Matsumoto, Yoshifumi Morita, Hirotoshi Kikuchi, Kinji Kamiya, Keiko Mori, Hiroya Takeuchi,

<h4>Background</h4>Esophageal cancer surgery requires maintenance and enhancement of perioperative nutritional status and physical function to prevent postoperative complications. Therefore, awareness of the importance of preoperative patient support is increasing. This study examined the usefulness of using a diary in combination with a wearable fitness tracking device (WFT) in patients undergoing ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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The potential for reducing alcohol consumption to prevent esophageal cancer morbidity in Asian heavy drinkers: a systematic review and meta-analysis.

Yuto Kubo, Yuko Kitagawa, Tatsuya Miyazaki, Makoto Sohda, Taiki Yamaji, Makoto Sakai, Hiroshi Saeki, Kenji Nemoto, Tsuneo Oyama, Manabu Muto, Hiroya Takeuchi, Yasushi Toh, Hisahiro Matsubara, Masayuki Mano, Koji Kono, Ken Kato, Masahiro Yoshida, Hirofumi Kawakubo, Eisuke Booka, Tomoki Yamatsuji, Hiroyuki Kato, Yoshinori Ito, Hitoshi Ishikawa, Ryu Ishihara, Takahiro Tsushima, Hiroshi Kawachi, Takashi Oyama, Takashi Kojima, Shiko Kuribayashi, Tomoki Makino, Satoru Matsuda, Yuichiro Doki, ,

Alcohol consumption is a major risk factor for esophageal cancer. In Asia, heavy drinkers are considered to have a higher risk of esophageal cancer than nondrinkers and light drinkers. However, no study has shown an association between alcohol reduction and the morbidity of esophageal cancer in Asian heavy drinkers. Therefore, ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Outcomes of esophagectomy for patients with esophageal squamous cell carcinoma accompanied by recurrent laryngeal nerve palsy at diagnosis.

Asako Ozaki, Shinji Mine, Kouhei Yoshino, Daisuke Fujiwara, Motomi Nasu, Tadasuke Hashiguchi, Takashi Hashimoto, Yoshiaki Kajiyama, Masahiko Tsurumaru, Atsushi Arakawa,

<h4>Background</h4>Hoarseness is one of the classical symptoms in patients with locally advanced thoracic esophageal squamous cell carcinoma (ESCC), and it results from recurrent laryngeal nerve palsy, which is caused by nodal metastasis along the recurrent laryngeal nerve or by main tumors. We reviewed the short-term and long-term results of esophagectomy ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Influence of laparoscopy-aided gastrostomy on gastroesophageal reflux in neurologically impaired patients using multichannel intraluminal impedance pH measurements.

Daisuke Masui, Suguru Fukahori, Naoki Hashizume, Shinji Ishii, Naruki Higashidate, Yoshinori Koga, Saki Sakamoto, Shiori Tsuruhisa, Hirotomo Nakahara, Nobuyuki Saikusa, Yoshiaki Tanaka,

<h4>Background</h4>Development of gastroesophageal reflux disease (GERD) after gastrostomy remains debatable. Therefore, this study aimed to evaluate whether laparoscopy-aided gastrostomy (LAG) influence on the occurrence of GERD in neurologically impaired (NI) patients. Furthermore, we investigated whether preoperatively excluding NI patients with GERD can reduce the number of patients requiring subsequent anti-reflux ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Determinants of reflux perception in patients with non-erosive reflux disease who have reflux-related symptoms on potassium-competitive acid blocker therapy.

Noriyuki Kawami, Shintaro Hoshino, Yoshimasa Hoshikawa, Tomohide Tanabe, Mai Koeda, Eri Momma, Nana Takenouchi, Yuriko Hanada, Mitsuru Kaise, Katsuhiko Iwakiri,

<h4>Background</h4>This study investigated potential determinants of reflux perception in patients with non-erosive reflux disease (NERD) who had reflux-related symptoms on potassium-competitive acid blocker (P-CAB) therapy.<h4>Methods</h4>This study included 23 patients with reflux-related symptoms despite P-CAB therapy. Esophageal impedance-pH monitoring was performed on P-CAB and the following potential determinants of reflux perception ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Second-line pembrolizumab versus chemotherapy in Japanese patients with advanced esophageal cancer: subgroup analysis from KEYNOTE-181.

Kei Muro, Takashi Kojima, Toshikazu Moriwaki, Ken Kato, Fumio Nagashima, Hisato Kawakami, Ryu Ishihara, Takashi Ogata, Taroh Satoh, Keiichi Iwakami, Shirong Han, Naoyoshi Yatsuzuka, Tomoko Takami, Pooja Bhagia, Toshihiko Doi,

<h4>Background</h4>Safe and effective treatments for advanced esophageal cancer are an unmet need in Japan. We report results of a subgroup analysis of Japanese patients enrolled in KEYNOTE-181, a randomized, open-label, phase 3 study of pembrolizumab versus chemotherapy as second-line therapy for patients with advanced or metastatic esophageal cancer whose disease ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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The treatment effects of acotiamide in esophagogastric outflow obstruction: a prospective longitudinal observational study.

Eikichi Ihara, Haruei Ogino, Kazumasa Muta, Shohei Hamada, Masafumi Wada, Yoshitaka Hata, Hiroko Ikeda, Xiaopeng Bai, Yosuke Minoda, Mitsuru Esaki, Yoshimasa Tanaka, Takatoshi Chinen, Yoshihiro Ogawa,

<h4>Objectives</h4>We have found that an altered lower esophageal sphincter (LES) accommodation response is an underlying cause of esophagogastric junction outflow obstruction (EGJOO). The objective of this study was to examine the treatment effect of acotiamide, a prokinetic agent which improves impaired gastric accommodation in functional dyspepsia, in patients with EGJOO.<h4>Methods</h4>A ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Esophageal wall thickness on CT scans: can it predict the T stage of primary thoracic esophageal squamous cell carcinoma?

Yue Wang, Yong Huang, Qi-Yu Zhao, Xiao-Qin Li, Ling Wang, Ning-Ning Wang, Jin-Zhi Wang, Qing Wang,

<h4>Background</h4>CT is the most commonly used method to stage esophageal cancer (EC). However, the reported CT T-staging criteria for EC are controversial.<h4>Purpose</h4>To determine and validate the optimal esophageal wall thickness (EWT) threshold on CT to distinguish lesions with different T stages in esophageal squamous cell carcinoma (ESCC) patients.<h4>Methods</h4>One thousand, one ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Efficacy and safety of peroral endoscopic myotomy in 100 older patients.

Hiroki Okada, Hironari Shiwaku, Toshihiro Ohmiya, Akio Shiwaku, Suguru Hasegawa,

<h4>Background</h4>Peroral endoscopic myotomy (POEM) is a standard treatment for achalasia. Several reports have described the efficacy and safety of POEM for elderly patients, but none has reported the efficacy and safety of POEM in a large number of elderly patients for > 3 years postoperatively. In this study, we examined the safety and ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Significance of chemotherapy-free interval and tumor regression grade in patients with recurrent esophageal squamous cell carcinoma receiving chemotherapy with fluorouracil and platinum after esophagectomy following preoperative chemotherapy.

Mashiro Okunaka, Daisuke Kotani, Ken Demachi, Hisashi Fujiwara, Shingo Sakashita, Takayuki Yoshino, Takeo Fujita, Takashi Kojima,

<h4>Background</h4>In Japan, standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC) includes preoperative chemotherapy with fluorouracil plus cisplatin followed by esophagectomy. However, its efficacy is unclear in patients with recurrent disease with < 6 months of chemotherapy-free interval (CFI) after preoperative chemotherapy followed by esophagectomy and in those with ≥ 6 months of CFI and ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Clinical outcomes of surgical resection for recurrent lesion after curative esophagectomy for esophageal squamous cell carcinoma: a nationwide, large-scale retrospective study.

Kensuke Kudou, Hiroshi Saeki, Yuichiro Nakashima, Yasue Kimura, Eiji Oki, Masaki Mori, Mototsugu Shimokawa, Yoshihiro Kakeji, Yasushi Toh, Yuichiro Doki, Hisahiro Matsubara,

<h4>Background</h4>Several studies have reported the efficacy of resection for recurrent lesions. However, they involved a limited number of subjects. This study aimed to identify a subset of patients who benefit from surgical resection of recurrent lesions after curative esophagectomy for esophageal squamous cell carcinoma.<h4>Methods</h4>Clinicopathological features of 186 patients with esophageal ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Fruit and vegetable consumption and risk of esophageal cancer in the Asian region: a systematic review and meta-analysis.

Makoto Sakai, Yuko Kitagawa, Hiroshi Saeki, Tatsuya Miyazaki, Taiki Yamaji, Kenji Nemoto, Tsuneo Oyama, Manabu Muto, Hiroya Takeuchi, Yasushi Toh, Hisahiro Matsubara, Masayuki Mano, Koji Kono, Ken Kato, Masahiro Yoshida, Hirofumi Kawakubo, Eisuke Booka, Tomoki Yamatsuji, Hiroyuki Kato, Yoshinori Ito, Hitoshi Ishikawa, Ryu Ishihara, Takahiro Tsushima, Hiroshi Kawachi, Takashi Oyama, Takashi Kojima, Shiko Kuribayashi, Tomoki Makino, Satoru Matsuda, Makoto Sohda, Yuto Kubo, Yuichiro Doki, ,

The consumption of fruit and vegetables was reported to be associated with a reduced risk of esophageal cancer (EC) in many studies of esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC) from different regions worldwide. Therefore, to provide precise information to reduce the risk of EC in Asia, we ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Telomere lengths in Barrett's esophagus as a precancerous lesion.

Junko Aida, Kaiyo Takubo, Michael Vieth, Horst Neuhaus, Mutsunori Fujiwara, Tomio Arai, Toshiyuki Ishiwata,

<h4>Background</h4>We have reported that precancerous conditions and lesions invariably have shorter telomeres and associated chromosomal instability relative to normal tissue.<h4>Methods</h4>Using the Q-FISH method and our original software, Tissue Telo, we estimated telomere lengths in cardiac- and intestinal-type mucosae in 48 cases of Barrett's esophagus (short-segment (SS) n = 18; long-segment (LS) n = 30).<h4>Results</h4>There ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Survival impact of perioperative changes in prognostic nutritional index levels after esophagectomy.

Ryoma Haneda, Yoshihiro Hiramatsu, Sanshiro Kawata, Junko Honke, Wataru Soneda, Tomohiro Matsumoto, Yoshifumi Morita, Hirotoshi Kikuchi, Kinji Kamiya, Hiroya Takeuchi,

<h4>Background</h4>The correlation between perioperative changes in nutritional status during esophagectomy and prognosis remains unclear. This study aimed to evaluate the impact of changes in prognostic nutritional index levels during the perioperative period on esophageal cancer patient survivals.<h4>Methods</h4>From January 2009 to May 2019, 158 patients with esophageal squamous cell carcinoma were ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Comprehensive registry of esophageal cancer in Japan, 2014.

Masayuki Watanabe, Yasushi Toh, Ryu Ishihara, Koji Kono, Hisahiro Matsubara, Kentaro Murakami, Kei Muro, Hodaka Numasaki, Tsuneo Oyama, Soji Ozawa, Hiroshi Saeki, Koji Tanaka, Takahiro Tsushima, Masaki Ueno, Takashi Uno, Toshiyuki Yoshio, Shiyori Usune, Arata Takahashi, Hiroaki Miyata, ,

<h4>Background</h4>The registration committee for esophageal cancer in the Japan Esophageal Society (JES) has collected the patients' characteristics, treatment, and outcomes annually.<h4>Methods</h4>We analyzed the data of patients who had visited the participating hospitals in 2014. We collected the data with a web-based data collection system using the National Clinical Database. We ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Saliva secretion is reduced in mild reflux esophagitis patients.

Mai Koeda, Tomohide Tanabe, Yuichi Kitasako, Eri Momma, Yoshimasa Hoshikawa, Shintaro Hoshino, Noriyuki Kawami, Mitsuru Kaise, Katsuhiko Iwakiri,

<h4>Background</h4>Salivary secretion in patients with mild reflux esophagitis has not been examined. In this study, saliva secretion and salivary epidermal growth factor (EGF) in patients with mild reflux esophagitis were investigated.<h4>Methods</h4>Thirty-eight mild reflux esophagitis patients and 38 control subjects were recruited for this case-control study. Saliva secretion testing was performed. ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Health-related quality of life after esophagectomy in patients with esophageal cancer.

Yasushi Toh, Masaru Morita, Manabu Yamamoto, Yuichiro Nakashima, Masahiko Sugiyama, Hideo Uehara, Yoshiaki Fujimoto, Yuki Shin, Keiichi Shiokawa, Emi Ohnishi, Tomonari Shimagaki, Yohei Mano, Keishi Sugimachi,

Esophageal cancer is one of the malignant tumors with the poorest prognosis. Esophagectomy, which is the mainstay of curative-intent treatments, imposes excessive surgical stress on the patients, and postoperative morbidity and mortality rates after esophagectomy remain high. On the other hand, the number of survivors after esophagectomy for esophageal cancer ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Clinical outcomes and prognostic factors for esophageal cancer in patients aged 80 years or older who were treated with definitive radiotherapy and chemoradiotherapy.

Noriyoshi Takahashi, Rei Umezawa, Keita Kishida, Takaya Yamamoto, Yojiro Ishikawa, Kazuya Takeda, Yu Suzuki, Kousei Kawabata, Satoshi Teramura, Keiichi Jingu,

<h4>Objective</h4>Aging of populations has been rapidly increasing worldwide. The aim of this study was to identify prognostic factors of overall survival (OS) and progression-free survival (PFS) in patients aged 80 years or older who had esophageal cancer and received radiotherapy.<h4>Methods</h4>Patients aged 80 years or older who received radiotherapy between 2004 and 2015 ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Characteristics of patients with esophageal motility disorders on high-resolution manometry and esophagography-a large database analysis in Japan.

Chiaki Sato, Hiroki Sato, Takashi Kamei, Yuto Shimamura, Shinwa Tanaka, Hironari Shiwaku, Junya Shiota, Ryo Ogawa, Hiroshi Yokomichi, Haruhiro Inoue,

<h4>Background</h4>With the development of high-resolution manometry (HRM) and peroral endoscopy, more patients with esophageal motility disorders (EMDs) including achalasia are diagnosed and treated. The characteristics of Japanese patients with EMDs are unknown and should be elucidated.<h4>Methods</h4>A large-scale database analysis was performed at seven high-volume centers in Japan. EMDs between 2010 ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Impact of preoperative 6-minute walk distance on long-term prognosis after esophagectomy in patients with esophageal cancer.

Shin Kondo, Shin Kondo, Tatsuro Inoue, Takahiro Yoshida, Takashi Saito, Seiya Inoue, Takeshi Nishino, Masakazu Goto, Nori Sato, Rei Ono, Akira Tangoku, Shinsuke Katoh,

<h4>Background</h4>The 6-minute walk distance (6MWD) is a simple way of assessing exercise capacity. The purpose of this study was to investigate the relationship between preoperative 6MWD and long-term prognosis after esophagectomy.<h4>Methods</h4>This retrospective cohort study involved 108 patients who underwent radical esophagectomy for esophageal cancer between 2013 and 2020. The patients ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Nationwide survey of the follow-up practices for patients with esophageal carcinoma after radical treatment: historical changes and future perspectives in Japan.

Tomonori Nakanoko, Masaru Morita, Yuichiro Nakashima, Mitsuhiko Ota, Masahiko Ikebe, Manabu Yamamoto, Eisuke Booka, Hiroya Takeuchi, Yuko Kitagawa, Hisahiro Matsubara, Yuichiro Doki, Yasushi Toh,

<h4>Background</h4>No post-treatment follow-up methods have been established yet for patients with esophageal carcinoma who undergo radical esophagectomy (Surg) or who show complete response to definitive chemoradiotherapy (dCRT-CR). The purpose of this study was to investigate the current status of follow-up of the Surg and dCRT-CR patients in Japan, and understand ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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In vitro anti-cancer effect of marmesin by suppression of PI3K/Akt pathway in esophagus cancer cells.

Qi Wang, Sheng Zhong, Hua Wu, Qingquan Wu,

<h4>Background</h4>Marmesin, an important coumarin isolated from Broussonetia kazinoki, has been proposed to possess many pharmacological activities including anti-tumor activity. However, the anti-cancer effect of marmesin on esophageal cancer (EC) has not been characterized. The study aimed to explore the anti-cancer role of marmesin using EC cell lines in vitro.<h4>Methods and ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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Ineffective esophageal motility in Chicago Classification version 4.0 better predicts abnormal acid exposure.

Qian-Jun Zhuang, Nian-di Tan, Meng-Yu Zhang, Song-Feng Chen, Yu Luo, Ying-Lian Xiao,

<h4>Background</h4>The updated Chicago Classification version 4.0 (CCv4.0) establishes a more stringent criteria to diagnose ineffective esophageal motility (IEM). This study aims to investigate the clinical significance of IEM in CCv4.0 in the context of gastroesophageal reflux disease (GERD).<h4>Methods</h4>A retrospective study was conducted among suspected GERD patients who had heartburn and/or ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, :]

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