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Journal Environ. Health Perspect.

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Daily Temperature and Bacillary Dysentery: Estimated Effects, Attributable Risks, and Future Disease Burden in 316 Chinese Cities.

Zhidong Liu, Michael Xiaoliang Tong, Jianjun Xiang, Keith Dear, Changke Wang, Wei Ma, Liang Lu, Qiyong Liu, Baofa Jiang, Peng Bi,

BACKGROUND:Bacillary dysentery (BD) remains a significant public health issue, especially in developing countries. Evidence assessing the risk of BD from temperature is limited, particularly from national studies including multiple locations with different climatic characteristics. OBJECTIVES:We estimated the effect of temperature on BD across China, assessed heterogeneity and attributable risks across ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(5):57008]

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Current and Projected Distributions of Aedes aegypti and Ae. albopictus in Canada and the U.S.

Salah Uddin Khan, Nicholas H Ogden, Aamir A Fazil, Philippe H Gachon, Guillaume U Dueymes, Amy L Greer, Victoria Ng,

BACKGROUND:Aedes aegypti and Ae. albopictus are mosquito vectors of more than 22 arboviruses that infect humans. OBJECTIVES:Our objective was to develop regional ecological niche models for Ae. aegypti and Ae. albopictus in the conterminous United States and Canada with current observed and simulated climate and land-use data using boosted regression ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(5):57007]

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A Combined Morphometric and Statistical Approach to Assess Nonmonotonicity in the Developing Mammary Gland of Rats in the CLARITY-BPA Study.

Maël Montévil, Nicole Acevedo, Cheryl M Schaeberle, Manushree Bharadwaj, Suzanne E Fenton, Ana M Soto,

BACKGROUND:The Consortium Linking Academic and Regulatory Insights on Bisphenol-A (CLARITY-BPA) is a rare collaboration of guideline-compliant (core) studies and academic hypothesis-based studies to assess the effects of bisphenol A (BPA). OBJECTIVES:We aimed to a) determine whether BPA showed effects on the developing rat mammary gland using new quantitative and established ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(5):57001]

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It Takes a Conscious Effort: Helping Society Benefit from the Open Science Movement.

Janet L Pelley,

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(5):54001]

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Exposure to Drinking Water Chlorination by-Products and Fetal Growth and Prematurity: A Nationwide Register-Based Prospective Study.

Melle Säve-Söderbergh, Jonas Toljander, Carolina Donat-Vargas, Marika Berglund, Agneta Åkesson,

BACKGROUND:Chlorination is globally used to produce of safe drinking water. Chlorination by-products are easily formed, and there are indications that these are associated with adverse reproductive outcomes. OBJECTIVES:We conducted a nationwide register-based prospective study to assess whether gestational exposure to the four most common chlorination by-products [total trihalomethanes (TTHMs)] via ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(5):57006]

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Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication: A Danish Cohort Study.

Jesse D Thacher, Aslak H Poulsen, Nina Roswall, Ulla Hvidtfeldt, Ole Raaschou-Nielsen, Steen Solvang Jensen, Matthias Ketzel, Jørgen Brandt, Kim Overvad, Anne Tjønneland, Thomas Münzel, Mette Sørensen,

BACKGROUND:Epidemiological research on effects of transportation noise on incident hypertension is inconsistent. OBJECTIVES:We aimed to investigate whether residential road traffic noise increases the risk for hypertension. METHODS:In a population-based cohort of 57,053 individuals 50-64 years of age at enrollment, we identified 21,241 individuals who fulfilled our case definition of filling ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(5):57004]

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Global Access to Handwashing: Implications for COVID-19 Control in Low-Income Countries.

Michael Brauer, Jeff T Zhao, Fiona B Bennitt, Jeffrey D Stanaway,

BACKGROUND:Low-income countries have reduced health care system capacity and are therefore at risk of substantially higher COVID-19 case fatality rates than those currently seen in high-income countries. Handwashing is a key component of guidance to reduce transmission of the SARS-CoV-2 virus, responsible for the COVID-19 pandemic. Prior systematic reviews have ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(5):57005]

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Challenges Raised by Mediation Analysis in a High-Dimension Setting.

Michaël G B Blum, Linda Valeri, Olivier François, Solène Cadiou, Valérie Siroux, Johanna Lepeule, Rémy Slama,

BACKGROUND:Mediation analysis is used in epidemiology to identify pathways through which exposures influence health. The advent of high-throughput (omics) technologies gives opportunities to perform mediation analysis with a high-dimension pool of covariates. OBJECTIVE:We aimed to highlight some biostatistical issues of this expanding field of high-dimension mediation. DISCUSSION:The mediation techniques used ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(5):55001]

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Early Life Exposure to Perfluoroalkyl Substances (PFAS) and ADHD: A Meta-Analysis of Nine European Population-Based Studies.

Joan Forns, Marc-Andre Verner, Nina Iszatt, Nikola Nowack, Cathrine Carlsen Bach, Martine Vrijheid, Olga Costa, Ainara Andiarena, Eva Sovcikova, Birgit Bjerre Høyer, Jürgen Wittsiepe, Maria-Jose Lopez-Espinosa, Jesus Ibarluzea, Irva Hertz-Picciotto, Gunnar Toft, Hein Stigum, Mònica Guxens, Zeyan Liew, Merete Eggesbø,

INTRODUCTION:To date, the evidence for an association between perfluoroalkyl substances (PFAS) exposure and attention deficit and hyperactivity disorder (ADHD) is inconclusive. OBJECTIVE:We investigated the association between early life exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), and ADHD in a collaborative study including nine European population-based studies, encompassing 4,826 ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(5):57002]

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Vaper, Beware: The Unique Toxicological Profile of Electronic Cigarettes.

Silke Schmidt,

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(5):52001]

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Evaluating the Role of the Steroid and Xenobiotic Receptor (SXR/PXR) in PCB-153 Metabolism and Protection against Associated Adverse Effects during Perinatal and Chronic Exposure in Mice.

Riann Jenay Egusquiza, Maria Elena Ambrosio, Shuyi Gin Wang, Kaelen Marie Kay, Chunyun Zhang, Hans-Joachim Lehmler, Bruce Blumberg,

BACKGROUND:Polychlorinated biphenyls (PCBs) are environmental toxicants; PCB exposure has been associated with adverse effects on wildlife and humans. However, the mechanisms underlying these adverse effects are not fully understood. The steroid and xenobiotic receptor [SXR; also known as the pregnane X receptor (PXR) and formally known as NR1I2] is a ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(4):47011]

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Maternal Plasma Perfluoroalkyl Substances and Miscarriage: A Nested Case-Control Study in the Danish National Birth Cohort.

Zeyan Liew, Jiajun Luo, Ellen A Nohr, Bodil Hammer Bech, Rossana Bossi, Onyebuchi A Arah, Jørn Olsen,

BACKGROUND:Per- and polyfluoroalkyl substances (PFAS) are widespread persistent organic pollutants and endocrine disruptors. High doses of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) exposure can cause pregnancy loss and infant deaths in animals, but the associations between PFAS exposures and risk of miscarriage in humans are not well studied. METHODS:Using ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(4):47007]

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Reduced Bone Mineral Density in Children: Another Potential Health Effect of PFAS.

Charles W Schmidt,

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(4):44002]

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Expanded View of PAHs: Identifying Especially Harmful Constituents of Bituminous Coal Smoke.

Nate Seltenrich,

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(4):44001]

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Effect of GenX on P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance-Associated Protein 2 at the Blood-Brain Barrier.

Ronald E Cannon, Alicia C Richards, Andrew W Trexler, Christopher T Juberg, Birandra Sinha, Gabriel A Knudsen, Linda S Birnbaum,

BACKGROUND:Ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid (GenX) is a replacement for perfluorooctanoic acid in the production of fluoropolymers used in a variety of consumer products. GenX alters fetal development and antibody production and elicits toxic responses in the livers and kidneys of rodents. The GenX effect on the blood-brain barrier (BBB) is unknown. ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(3):37002]

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Uterine Patterning, Endometrial Gland Development, and Implantation Failure in Mice Exposed Neonatally to Genistein.

Wendy N Jefferson, Elizabeth Padilla-Banks, Alisa A Suen, Lindsey J Royer, Sharon M Zeldin, Ripla Arora, Carmen J Williams,

BACKGROUND:Embryo implantation relies on precise hormonal regulation, associated gene expression changes, and appropriate female reproductive tract tissue architecture. Female mice exposed neonatally to the phytoestrogen genistein (GEN) at doses similar to those in infants consuming soy-based infant formulas are infertile due in part to uterine implantation defects. OBJECTIVES:Our goal was ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(3):37001]

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Erratum: “The Art of the Algorithm: Machine Learning in Environmental Health Research, with Nicole Kleinstreuer”.

Ashley Ahearn,

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(3):]

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Metal/Metalloid Levels in Electronic Cigarette Liquids, Aerosols, and Human Biosamples: A Systematic Review.

Di Zhao, Atul Aravindakshan, Markus Hilpert, Pablo Olmedo, Ana M Rule, Ana Navas-Acien, Angela Aherrera,

BACKGROUND:Electronic cigarettes (e-cigarettes) have become popular, in part because they are perceived as a safer alternative to tobacco cigarettes. An increasing number of studies, however, have found toxic metals/metalloids in e-cigarette emissions. OBJECTIVE:We summarized the evidence on metal/metalloid levels in e-cigarette liquid (e-liquid), aerosols, and biosamples of e-cigarette users across ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(3):36001]

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Subchronic Noise and Metabolism: Rodent Model Identifies Potential Mechanistic Links.

Silke Schmidt,

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(3):34004]

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Erratum: "Prenatal Exposure to DDT and Pyrethroids for Malaria Control and Child Neurodevelopment: The VHEMBE Cohort, South Africa".

Brenda Eskenazi, Sookee An, Stephen A Rauch, Eric S Coker, Angelina Maphula, Muvhulawa Obida, Madelein Crause, Katherine R Kogut, Riana Bornman, Jonathan Chevrier,

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(3):39001]

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Erratum: "Into the Black Box: What Can Machine Learning Offer Environmental Health Research?"

Charles W Schmidt,

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(3):39002]

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Acknowledging Receipts? New Evidence for Dermal Absorption of Bisphenols.

Silke Schmidt,

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(3):34003]

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Looking Ahead at Environmental Health Perspectives.

Joel D Kaufman,

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(3):31001]

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Potential Male and Female Reproductive Toxicants: Applying the Key Characteristics Approach.

Wendee Nicole,

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(3):34001]

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Role of TET Dioxygenases and DNA Hydroxymethylation in Bisphenols-Stimulated Proliferation of Breast Cancer Cells.

Zhe Li, Cong Lyu, Yun Ren, Hailin Wang,

BACKGROUND:Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor targeting estrogen receptors (ERs), has been implicated in the promotion of breast cancer. Perinatal exposure of BPA could induce longitudinal alteration of DNA hydroxymethylation in imprinted loci of mouse blood cells. To date, no data has been reported on the effects of ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(2):27008]

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