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Journal Endocrinology

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The Nexus of Endocrine Signaling and Cancer: How Steroid Hormones Influence Genomic Stability.

Shinjini Ganguly, Divya Naik, Andrew Muskara, Omar Y Mian,

Endocrine-driven malignancies, including breast and prostate cancer, are among the most common human cancers. The relationship between sex steroid hormones (eg, androgen, estrogen, and progesterone), their cognate receptors, and genomic stability lie at the center of endocrine-driven cancer development, progression, and therapeutic resistance. A variety of direct and indirect mechanisms ... Read more >>

Endocrinology (Endocrinology)
[2021, 162(1):]

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TPH2 in the Dorsal Raphe Nuclei Regulates Energy Balance in a Sex-Dependent Manner.

Hailan Liu, Chunmei Wang, Meng Yu, Yongjie Yang, Yang He, Hesong Liu, Chen Liang, Longlong Tu, Nan Zhang, Lina Wang, Julia Wang, Feng Liu, Fang Hu, Yong Xu,

AbstractCentral 5-hydroxytryptamine (5-HT), which is primarily synthesized by tryptophan hydroxylase 2 (TPH2) in the dorsal Raphe nuclei (DRN), plays a pivotal role in the regulation of food intake and body weight. However, the physiological functions of TPH2 on energy balance have not been consistently demonstrated. Here we systematically investigated the ... Read more >>

Endocrinology (Endocrinology)
[2021, 162(1):]

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Inflaming the Clock: Effects of Interleukin 1β on Circadian Rhythmicity of Pancreatic β Cells.

Alexandre Martchenko, Patricia L Brubaker,

Endocrinology (Endocrinology)
[2021, 162(1):]

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Proinflammatory Cytokine Interleukin 1β Disrupts β-cell Circadian Clock Function and Regulation of Insulin Secretion.

Naureen Javeed, Matthew R Brown, Kuntol Rakshit, Tracy Her, Satish K Sen, Aleksey V Matveyenko,

Intrinsic β-cell circadian clocks are important regulators of insulin secretion and overall glucose homeostasis. Whether the circadian clock in β-cells is perturbed following exposure to prodiabetogenic stressors such as proinflammatory cytokines, and whether these perturbations are featured during the development of diabetes, remains unknown. To address this, we examined the ... Read more >>

Endocrinology (Endocrinology)
[2021, 162(1):]

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Glucose and Fructose Transport Across the Epitheliochorial Placenta: SLC2A and the Uterine-Placental Interface in Pigs.

Daniel J Mathew,

Endocrinology (Endocrinology)
[2020, 161(12):]

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CACNA1H Calcium Channel Mutations in Primary Aldosteronism - Is Sodium the Culprit?

Gabriel Stölting, Ute I Scholl,

Endocrinology (Endocrinology)
[2020, 161(12):]

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Circadian Rhythms and the Gastrointestinal Tract: Relationship to Metabolism and Gut Hormones.

Alexandre Martchenko, Sarah E Martchenko, Andrew D Biancolin, Patricia L Brubaker,

Circadian rhythms are 24-hour biological rhythms within organisms that have developed over evolutionary time due to predefined environmental changes, mainly the light-dark cycle. Interestingly, metabolic tissues, which are largely responsible for establishing diurnal metabolic homeostasis, have been found to express cell-autonomous clocks that are entrained by food intake. Disruption of ... Read more >>

Endocrinology (Endocrinology)
[2020, 161(12):]

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Commentary for "Sex Steroids as Modulators of Gestural Communication".

Yong Zhu,

Endocrinology (Endocrinology)
[2020, 161(12):]

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GLP-1 Receptor Signaling Differentially Modifies the Outcomes of Sterile vs Viral Pulmonary Inflammation in Male Mice.

Takehiro Sato, Tatsunori Shimizu, Hiroki Fujita, Yumiko Imai, Daniel J Drucker, Yutaka Seino, Yuichiro Yamada,

A number of disease states, including type 2 diabetes (T2D), are associated with an increased risk of pulmonary infection. Glucagon-like peptide-1 (GLP-1) receptor agonists are used to treat T2D and exert anti-inflammatory actions through a single, well-defined GLP-1 receptor (GLP-1R). Although highly expressed in the lung, little is known about ... Read more >>

Endocrinology (Endocrinology)
[2020, 161(12):]

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Hormonal Stimulation of Human Ovarian Xenografts in Mice: Studying Folliculogenesis, Activation, and Oocyte Maturation.

Monica Anne Wall, Vasantha Padmanabhan, Ariella Shikanov,

Ovarian tissue cryopreservation and banking provides a fertility preservation option for patients who cannot undergo oocyte retrieval; it is quickly becoming a critical component of assisted reproductive technology programs across the world. While the transplantation of cryopreserved ovarian tissue has resulted in over 130 live births, the field has ample ... Read more >>

Endocrinology (Endocrinology)
[2020, 161(12):]

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Commentary on "The Immp2l Mutation Causes Ovarian Aging Through ROS-Wnt/β-Catenin-Estrogen Pathway: Preventive Effect of Melatonin".

Fei Sun,

Endocrinology (Endocrinology)
[2020, 161(12):]

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Iodine Deficiency Increases Fat Contribution to Energy Expenditure in Male Mice.

Barbara M L C Bocco, Gustavo W Fernandes, Tatiana L Fonseca, Antonio C Bianco,

More than a billion people worldwide are at risk of iodine deficiency (ID), with well-known consequences for development of the central nervous system. Furthermore, ID has also been associated with dyslipidemia and obesity in humans. To further understand the metabolic consequences of ID, here we kept 8-week-old C57/Bl6 mice at ... Read more >>

Endocrinology (Endocrinology)
[2020, 161(12):]

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Mechanisms of Estradiol-induced EGF-like Factor Expression and Oocyte Maturation via G Protein-coupled Estrogen Receptor.

Hui Zhang, Sihai Lu, Rui Xu, Yaju Tang, Jie Liu, Chan Li, Juncai Wei, Ru Yao, Xiaoe Zhao, Qiang Wei, Baohua Ma,

Estrogen is an important modulator of reproductive activity through nuclear receptors and G protein-coupled estrogen receptor (GPER). Here, we observed that both estradiol and the GPER-specific agonist G1 rapidly induced cyclic adenosine monophosphate (cAMP) production in cumulus cells, leading to transient stimulation of phosphorylated cAMP response element binding protein (CREB), ... Read more >>

Endocrinology (Endocrinology)
[2020, 161(12):]

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Ablation of Ephrin B2 in Col2 Expressing Cells Delays Fracture Repair.

Yongmei Wang, Lin Ling, Faming Tian, Sun Hee Won Kim, Sunita Ho, Daniel D Bikle,

Ephrin B2 is critical for endochondral bone development. In this study, we investigated its role in fracture repair by deleting ephrin B2 in type II collagen (Col.2) expressing cells. We used a nonstable tibia fracture model to evaluate fracture repair at 3 sites: intramembranous bone formation, endochondral bone formation, and ... Read more >>

Endocrinology (Endocrinology)
[2020, 161(12):]

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Targeting Cancer Cells via N-degron-based PROTACs.

Mohamed A Eldeeb, Cornelia E Zorca, Richard P Fahlman,

In mammals, protein degradation is mediated selectively by the ubiquitin proteasome system (UPS) and the autophagic-lysosomal system. Over the past decades, N-degron pathways have been shown to be responsible for the selective degradation of proteins that harbor destabilizing N-terminal motifs. Recent studies have employed these pathways in the development of ... Read more >>

Endocrinology (Endocrinology)
[2020, 161(12):]

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Towards an Epigenetic Treatment of Leiomyomas?

Daniel Vaiman,

Endocrinology (Endocrinology)
[2020, 161(12):]

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Uterine Epithelial Progesterone Receptor Governs Uterine Receptivity Through Epithelial Cell Differentiation.

Mona Gebril, Yasushi Hirota, Shizu Aikawa, Yamato Fukui, Tetsuaki Kaku, Mitsunori Matsuo, Tomoyuki Hirata, Shun Akaeda, Takehiro Hiraoka, Ryoko Shimizu-Hirota, Norihiko Takeda, Tamer Taha, Osama Al Balah, Mohamed Amr H Elnoury, Tomoyuki Fujii, Yutaka Osuga,

Progesterone receptor (PGR) is indispensable for pregnancy in mammals. Uterine PGR responds to the heightened levels of ovarian progesterone (P4) after ovulation and regulates uterine gene transcription for successful embryo implantation. Although epithelial and stromal P4-PGR signaling may interact with each other to form appropriate endometrial milieu for uterine receptivity ... Read more >>

Endocrinology (Endocrinology)
[2020, 161(12):]

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Transcriptomic and Quantitative Proteomic Profiling Reveals Signaling Pathways Critical for Pancreatic Islet Maturation.

Yu-Chin Lien, Kyoung-Jae Won, Rebecca A Simmons,

Pancreatic β-cell dysfunction and reduced insulin secretion play a key role in the pathogenesis of diabetes. Fetal and neonatal islets are functionally immature and have blunted glucose responsiveness and decreased insulin secretion in response to stimuli and are far more proliferative. However, the mechanisms underlying functional immaturity are not well ... Read more >>

Endocrinology (Endocrinology)
[2020, 161(12):]

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Metabolic Syndrome and COVID-19: Endocrine-Immune Vascular Interactions Shape the Clinical Course.

Andreas Barthel, Karthikeyan Mohanraj, Anne Marie Biener, Stefan R Bornstein,

Endocrinology (Endocrinology)
[2020, 161(12):]

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The Circadian Clock, Shift Work, and Tissue-Specific Insulin Resistance.

Johanneke E Oosterman, Suzan Wopereis, Andries Kalsbeek,

Obesity and type 2 diabetes (T2D) have become a global health concern. The prevalence of obesity and T2D is significantly higher in shift workers compared to people working regular hours. An accepted hypothesis is that the increased risk for metabolic health problems arises from aberrantly timed eating behavior, that is, ... Read more >>

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[2020, 161(12):]

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Corticosterone Is Essential for Survival Through Frog Metamorphosis.

Leena H Shewade, Jamee A Schoephoerster, Matthew D Patmann, Saurabh S Kulkarni, Daniel R Buchholz,

Thyroid hormone (TH) is required for frog metamorphosis, and corticosterone (CORT) increases TH signaling to accelerate metamorphic progression. However, a requirement for CORT in metamorphosis has been difficult to assess prior to the recent development of gene-editing technologies. We addressed this long-standing question using transcription activator-like effector nuclease (TALEN) gene ... Read more >>

Endocrinology (Endocrinology)
[2020, 161(12):]

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Loss of Inhibin Advances Follicle Activation and Female Puberty Onset but Blocks Oocyte Maturation in Zebrafish.

Huijie Lu, Cheng Zhao, Bo Zhu, Zhiwei Zhang, Wei Ge,

Inhibin was first characterized in mammals as a gonadal dimeric protein that inhibited pituitary follicle-stimulating hormone (FSH) secretion. As in mammals, the inhibin-specific α subunit (INHA/Inha/inha) has also been characterized in teleosts; however, its functions and physiological importance in fish reproduction remain unknown. Using CRISPR/Cas9 method, we generated an inha-deficient ... Read more >>

Endocrinology (Endocrinology)
[2020, 161(12):]

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Reproductive Function During Chronodisruption: Model of Shiftwork in Rodents.

Valerie Leysen, Vincent Prevot,

Endocrinology (Endocrinology)
[2020, 161(12):]

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COVID-19 and Hypercoagulability: Potential Impact on Management with Oral Contraceptives, Estrogen Therapy and Pregnancy.

Daniel I Spratt, Rachel J Buchsbaum,

Endocrinology (Endocrinology)
[2020, 161(12):]

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Activation of preoptic arginine vasopressin neurons induces hyperthermia in male mice.

Iustin V Tabarean,

Arginine vasopressin (AVP) is a neuropeptide acting as a neuromodulator in the brain and plays multiple roles, including a thermoregulatory one. However, the cellular mechanisms of action are not fully understood. We have carried out patch clamp recordings and calcium imaging combined with pharmacological tools and single cell RT/PCR to ... Read more >>

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[2020, :]

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