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Journal Emerg Microbes Infect

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Extremely lethal and hypervirulent Mycobacterium tuberculosis strain cluster emerging in Far East, Russia.

Tatiana Vinogradova, Marine Dogonadze, Natalia Zabolotnykh, Maria Badleeva, Irina Yarusova, Anna Vyazovaya, Alena Gerasimova, Svetlana Zhdanova, Maria Vitovskaya, Natalia Solovieva, Oksana Pasechnik, Oleg Ogarkov, Igor Mokrousov,

<i>Mycobacterium tuberculosis</i> strains of the early ancient sublineage of the Beijing genotype are mostly drug susceptible and mainly circulate in East Asia. We have recently discovered two clusters of this sublineage emerging in the Asian part of Russia (VNTR-defined 1071-32 and 14717-15 types) and, to our surprise, both were strongly ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1691-1701]

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Visualization of yellow fever virus infection in mice using a bioluminescent reporter virus.

Hao-Long Dong, Hong-Jiang Wang, Zhong-Yu Liu, Qing Ye, Xiao-Ling Qin, Dan Li, Yong-Qiang Deng, Tao Jiang, Xiao-Feng Li, Cheng-Feng Qin,

Yellow fever virus (YFV) is a re-emerging flavivirus, which can lead to severe clinical manifestations and high mortality, with no specific antiviral therapies available. The live-attenuated yellow fever vaccine 17D (YF17D) has been widely used for over eighty years. However, the emergence of yellow fever vaccine-associated viscerotropic disease (YFL-AVD) and ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1739-1750]

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Novel murine models for studying Cache Valley virus pathogenesis and in utero transmission.

Krisangel López, Sarah N Wilson, Sheryl Coutermash-Ott, Manette Tanelus, William B Stone, Danielle L Porier, Dawn I Auguste, John A Muller, Orchid M Allicock, Sally L Paulson, Jesse H Erasmus, Albert J Auguste,

Cache Valley virus (CVV) is a prevalent emerging pathogen of significant importance to agricultural and human health in North America. Emergence in livestock can result in substantial agroeconomic losses resulting from the severe embryonic lethality associated with infection during pregnancy. Although CVV pathogenesis has been well described in ruminants, small ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1649-1659]

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Naturally circulating pertactin-deficient Bordetella pertussis strains induce distinct gene expression and inflammatory signatures in human dendritic cells.

Michiel M Kroes, Alberto Miranda-Bedate, Elise S Hovingh, Ronald Jacobi, Corrie Schot, Elder Pupo, René H M Raeven, Arno A J van der Ark, Jos P M van Putten, Jelle de Wit, Rob Mariman, Elena Pinelli,

Respiratory infections caused by <i>Bordetella pertussis</i> are reemerging despite high pertussis vaccination coverage. Since the introduction of the acellular pertussis vaccine in the late twentieth century, circulating <i>B. pertussis</i> strains increasingly lack expression of the vaccine component pertactin (Prn). In some countries, up to 90% of the circulating <i>B. pertussis</i> ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1358-1368]

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Clinical signs and symptoms associated with WHO severe dengue classification: a systematic review and meta-analysis.

Tha Pyai Htun, Zhonghui Xiong, Junxiong Pang,

<b>ABSTRACT</b>The World Health Organization (WHO) introduced the new dengue classification in 2009. We aimed to assess the association of clinical signs and symptoms with WHO severe dengue classification in clinical practice. A systematic literature search was performed using the databases of PubMed, Embase, and Scopus between 2009 and 2018 according ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1116-1128]

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Isolation and characterization of novel reassortant mammalian orthoreovirus from pigs in the United States.

Liping Wang, Yan Li, Timothy Walsh, Zhenyu Shen, Yonghai Li, Nirmalendu Deb Nath, Jinhwa Lee, Baoliang Zheng, Ying Tao, Clinton R Paden, Krista Queen, Shuping Zhang, Suxiang Tong, Wenjun Ma,

Mammalian orthoreovirus (MRV) infects multiple mammalian species including humans. A United States Midwest swine farm with approximately one thousand 3-month-old pigs experienced an event, in which more than 300 pigs showed neurological signs, like "down and peddling", with approximately 40% mortality. A novel MRV was isolated from the diseased pigs. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1137-1147]

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Prime-boost vaccination of mice and rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates.

Shengxue Luo, Panli Zhang, Bochao Liu, Chan Yang, Chaolan Liang, Qi Wang, Ling Zhang, Xi Tang, Jinfeng Li, Shuiping Hou, Jinfeng Zeng, Yongshui Fu, Jean-Pierre Allain, Tingting Li, Yuming Zhang, Chengyao Li,

<b>ABSTRACT</b>COVID-19 vaccines are being developed urgently worldwide. Here, we constructed two adenovirus vectored COVID-19 vaccine candidates of Sad23L-nCoV-S and Ad49L-nCoV-S carrying the full-length gene of SARS-CoV-2 spike protein. The immunogenicity of two vaccines was individually evaluated in mice. Specific immune responses were observed by priming in a dose-dependent manner, and ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1002-1015]

Cited: 4 times

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Scavenger receptor A1 participates in uptake of Leptospira interrogans serovar Autumnalis strain 56606v and inflammation in mouse macrophages.

Yanchun Wang, Xia Fan, Lin Du, Boyu Liu, Haihan Xiao, Yan Zhang, Yunqiang Wu, Fuli Liu, Yung-Fu Chang, Xiaokui Guo, Ping He,

Leptospirosis, caused by pathogenic <i>Leptospira</i> species, has emerged as a widespread zoonotic disease worldwide. Macrophages mediate the elimination of pathogens through phagocytosis and cytokine production. Scavenger receptor A1 (SR-A1), one of the critical receptors mediating this process, plays a complicated role in innate immunity. However, the role of SR-A1 in ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):939-953]

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Blood virosphere in febrile Tanzanian children.

Samuel Cordey, Florian Laubscher, Mary-Anne Hartley, Thomas Junier, Kristina Keitel, Mylène Docquier, Nicolas Guex, Christian Iseli, Gael Vieille, Philippe Le Mercier, Anne Gleizes, Josephine Samaka, Tarsis Mlaganile, Frank Kagoro, John Masimba, Zamzam Said, Hosiana Temba, Gasser H Elbanna, Caroline Tapparel, Marie-Celine Zanella, Ioannis Xenarios, Jacques Fellay, Valérie D'Acremont, Laurent Kaiser,

Viral infections are the leading cause of childhood acute febrile illnesses motivating consultation in sub-Saharan Africa. The majority of causal viruses are never identified in low-resource clinical settings as such testing is either not part of routine screening or available diagnostic tools have limited ability to detect new/unexpected viral variants. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):982-993]

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Serological investigation of asymptomatic cases of SARS-CoV-2 infection reveals weak and declining antibody responses.

Yong Yang, Xi Wang, Rong-Hui Du, Wei Zhang, Hao-Rui Si, Yan Zhu, Xu-Rui Shen, Qian Li, Bei Li, Dong Men, Ya-Na Zhou, Hui Wang, Xiao-Lin Tong, Xian-En Zhang, Zheng-Li Shi, Peng Zhou,

Without an effective vaccine against SARS-CoV-2, the build-up of herd immunity through natural infection has been suggested as a means to control COVID-19. Although population immunity is typically estimated by the serological investigation of recovered patients, humoral immunity in asymptomatic subjects has not been well studied, although they represent a ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):905-912]

Cited: 1 time

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Viral quasispecies quantitative analysis: a novel approach for appraising the immune tolerant phase of chronic hepatitis B virus infection.

Mingjie Wang, Li Chen, MinHui Dong, Jing Li, Beidi Zhu, Zhitao Yang, Qiming Gong, Yue Han, Demin Yu, Donghua Zhang, Fabien Zoulim, Jiming Zhang, Xinxin Zhang,

Few non-invasive models were established for precisely identifying the immune tolerant (IT) phase from chronic hepatitis B (CHB). This study aimed to develop a novel approach that combined next-generation sequencing (NGS) and machine learning algorithms using our recently published viral quasispecies (QS) analysis package. 290 HBeAg positive patients from whom ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):842-851]

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Pan-coronavirus fusion inhibitors possess potent inhibitory activity against HIV-1, HIV-2, and simian immunodeficiency virus.

Danwei Yu, Yuanmei Zhu, Hongxia Yan, Tong Wu, Huihui Chong, Yuxian He,

EK1 peptide is a membrane fusion inhibitor with broad-spectrum activity against human coronaviruses (CoVs). In the outbreak of COVID-19, we generated a lipopeptide EK1V1 by modifying EK1 with cholesterol, which exhibited significantly improved antiviral activity. In this study, we surprisingly found that EK1V1 also displayed potent cross-inhibitory activities against divergent ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):810-821]

Cited: 2 times

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The genetic feature and virulence determinant of highly virulent community-associated MRSA ST338-SCCmec Vb in China.

Ye Jin, Wangxiao Zhou, Zhidong Yin, Shuntian Zhang, Yunbo Chen, Ping Shen, Jinru Ji, Weiwei Chen, Beiwen Zheng, Yonghong Xiao,

ST59 is the predominant pathotype of community-associated methicillin-resistant <i>Staphylococcus aureus</i> (CA-MRSA) in China. As a variant of ST59, there is relatively little known about the detailed information of ST338. To address this issue, here, we described thirteen ST338 CA-MRSA strains isolated from severe bloodstream infection cases, and focused on their ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1052-1064]

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Introduction of SARS-CoV-2 variant of concern 20h/501Y.V2 (B.1.351) from Malawi to Italy.

Federica Novazzi, Angelo Genoni, Pietro Giorgio Spezia, Daniele Focosi, Cristian Zago, Alberto Colombo, Gianluca Cassani, Renee Pasciuta, Antonio Tamborini, Agostino Rossi, Martina Prestia, Riccardo Capuano, Daniela Dalla Gasperina, Francesco Dentali, Paolo Severgnini, Walter Ageno, Cinzia Gambarini, Paola Stefanelli, Andreina Baj, Fabrizio Maggi,

We report here an imported case of SARS-CoV-2 variant of concern B.1.1.351 (also known as 20H/501Y.V2 or "South African variant" or VOC 202012/02) in a 66-years old symptomatic male who returned from Malawi to Italy. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):710-712]

Cited: 4 times

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Experimental re-infected cats do not transmit SARS-CoV-2.

Natasha N Gaudreault, Mariano Carossino, Igor Morozov, Jessie D Trujillo, David A Meekins, Daniel W Madden, Konner Cool, Bianca Libanori Artiaga, Chester McDowell, Dashzeveg Bold, Velmurugan Balaraman, Taeyong Kwon, Wenjun Ma, Jamie Henningson, Dennis W Wilson, William C Wilson, Udeni B R Balasuriya, Adolfo García-Sastre, Juergen A Richt,

SARS-CoV-2 is the causative agent of COVID-19 and responsible for the current global pandemic. We and others have previously demonstrated that cats are susceptible to SARS-CoV-2 infection and can efficiently transmit the virus to naïve cats. Here, we address whether cats previously exposed to SARS-CoV-2 can be re-infected with SARS-CoV-2. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):638-650]

Cited: 9 times

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Phialemoniopsis limonesiae sp. nov. causing cutaneous phaeohyphomycosis in an immunosuppressed woman.

D Alvarez Martinez, C Alberto, A Riat, C Schuhler, P Valladares, B Ninet, B Kraak, P W Crous, L W Hou, L Toutous Trellu,

Rare or opportunistic fungal infections are mostly described in immunosuppressed patients. We present a case of a cutaneous phaeohyphomycosis that developed on the dorsal foot in an immunosuppressed woman suffering from AIDS, caused by a novel <i>Phialemoniopsis</i> species. It clinically presented as an indurated violaceous plaque, surmounted by nodules exuding ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):400-406]

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Epidemiological profile and molecular genetic characterization of HIV-1 among female sex workers and elderly male clients in Guangxi, China.

Xiu Chen, Chunwei Qin, Rongfeng Chen, Yunxuan Huang, Yuexiang Xu, Qiao Tang, Xianjun Liang, Bing Peng, Yi Shao, Yao Yang, Jie Chen, Xinwei Wang, Liufang Wen, Bingyu Liang, Li Ye, Xionglin Qin, Junjun Jiang, Hao Liang,

The HIV/AIDS prevalence in female sex workers (FSWs) and elderly male clients is increasing in Guangxi, China, but the transmission relationship between them remains unclear. This study aims to illuminate the transmission network between FSWs and elderly male clients using molecular epidemiological analyses. Phylogenetic analysis indicated that CRF01_AE was the ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):384-395]

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Amoebae can promote the survival of Francisella species in the aquatic environment.

Aurélie Hennebique, Julien Peyroux, Camille Brunet, Amandine Martin, Thomas Henry, Masa Knezevic, Marina Santic, Sandrine Boisset, Max Maurin,

<i>Francisella tularensis</i>, a tier 1 select agent, is the causative bacterium of tularemia, a zoonosis with a large animal reservoir. However, <i>F. tularensis</i>, like many other <i>Francisella</i> species, is assumed to have an aquatic reservoir. The mechanisms of <i>Francisella</i> species persistence in surface water remain poorly characterized. In this study, ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):277-290]

Cited: 2 times

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COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue.

Xi Yongzhi,

SARS-CoV-2 has claimed 2,137,908 lives in more than a year. Some COVID-19 patients experience sudden and rapid deterioration with the onset of fatal cytokine storm syndrome (CSS), which have increased interest in CSS's mechanisms, diagnosis and therapy. Although the prototypic concept of CSS was first proposed 116 years ago, we ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):266-276]

Cited: 7 times

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Identification of key residues involved in the neuraminidase antigenic variation of H9N2 influenza virus.

Fei Wang, Jinsen Wu, Yajuan Wang, Zhimin Wan, Hongxia Shao, Kun Qian, Jianqiang Ye, Aijian Qin,

Influenza A H9N2 virus causes economic loss to the poultry industry and has likely contributed to the genesis of H5N1 and H7N9 viruses. The neuraminidase (NA) of H9N2 virus, like haemagglutinin, is under antibody selective pressure and may undergo antigenic change; however, its antigenic structure remains to be elucidated. In ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):210-219]

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Mycobacterium tuberculosis ESX-1-secreted substrate protein EspC promotes mycobacterial survival through endoplasmic reticulum stress-mediated apoptosis.

Qinglong Guo, Jing Bi, Honghai Wang, Xuelian Zhang,

EsxA, secreted by the ESAT-6 secretion system 1 (ESX-1) secretion system, is considered the major <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) virulence determinant. However, the roles of the individual ESX-1 substrates, such as EspC, remain unclear due to their interdependency for secretion with EsxA. Here, we validated that EspC triggered ER stress-mediated apoptosis ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):19-36]

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A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge.

Xiangchuan He, Longfei Ding, Kangli Cao, Haoran Peng, Chenjian Gu, Yutang Li, Duoduo Li, Lanlan Dong, Xiujing Hong, Xiangwei Wang, Meilan Fu, Chenli Qiu, Cuisong Zhu, Ziling Zhang, Shu Song, Chenguang Wang, Zhengfan Jiang, Youhua Xie, Zhongtian Qi, Chen Zhao, Ping Zhao, Xiaoyan Zhang, Jianqing Xu,

To curb the pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), multiple platforms have been employed toward a safe and highly effective vaccine. Here, we develop a novel cell-based vaccine candidate, namely K562-S, by utilizing human cell K562 as a cellular carrier ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1555-1573]

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High performance of a novel point-of-care blood test for Toxoplasma infection in women from diverse regions of Morocco.

Bouchra El Mansouri, Fatima Amarir, François Peyron, El Bachir Adlaoui, Raphaël Piarroux, Joseph Lykins, Majda El Abbassi, Nesma Nekkal, Nadia Bouhlal, Kamar Makkaoui, Amina Barkat, Aziza Lyaghfouri, Ying Zhou, Samira Rais, Mounia Oudghiri, Ismail Elkoraichi, Mustapha Zekri, Nezha Belkadi, Hajar Mellouk, Mohamed Rhajaoui, Allal Boutajangout, Abderrahim Sadak, Denis Limonne, Rima McLeod, Kamal El Bissati,

Point-of-care (POC) testing for <i>Toxoplasma</i> infection has the potential to revolutionize diagnosis and management of toxoplasmosis, especially in high-risk populations in areas with significant environmental contamination and poor health infrastructure precluding appropriate follow-up and preventing access to medical care. Toxoplasmosis is a significant public health challenge in Morocco, with a ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1675-1682]

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Streptococcus Pneumoniae septic arthritis in adults in Bristol and Bath, United Kingdom, 2006-2018: a 13-year retrospective observational cohort study.

Catherine Hyams, Zahin Amin-Chowdhury, Norman K Fry, Paul North, Adam Finn, Andrew Judge, Shamez N Ladhani, O Martin Williams,

Few studies on adult pneumococcal septic arthritis are sufficiently large enough to assess both epidemiological trends following routine pneumococcal immunization and clinical disease. With major shifts in serotypes causing invasive pneumococcal disease (IPD), we wanted to determine the clinical phenotype of adult septic arthritis caused by <i>Streptococcus pneumoniae</i>. We conducted ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1369-1377]

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Rapidly emerging SARS-CoV-2 B.1.1.7 sub-lineage in the United States of America with spike protein D178H and membrane protein V70L mutations.

Lishuang Shen, Jennifer Dien Bard, Timothy J Triche, Alexander R Judkins, Jaclyn A Biegel, Xiaowu Gai,

The SARS-CoV-2 B.1.1.7 lineage is highly infectious and as of April 2021 accounted for 92% of COVID-19 cases in Europe and 59% of COVID-19 cases in the U.S. It is defined by the N501Y mutation in the receptor-binding domain (RBD) of the Spike (S) protein, and a few other mutations. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1293-1299]

Cited: 1 time

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