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Journal Emerg Microbes Infect

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Identifying optimal capsid duplication length for the stability of reporter flaviviruses.

Coleman Baker, Yang Liu, Jing Zou, Antonio Muruato, Xuping Xie, Pei-Yong Shi,

ABSTRACT Mosquito-transmitted flaviviruses cause widespread disease across the world. To provide better molecular tools for drug screens and pathogenesis studies, we report a new approach to produce stable NanoLuc-tagged flaviviruses, including dengue virus serotypes 1-4, Japanese encephalitis virus, yellow fever virus, West Nile virus, and Zika virus. Since the reporter ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):2256-2265]

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Multicenter evaluation of two chemiluminescence and three lateral flow immunoassays for the diagnosis of COVID-19 and assessment of antibody dynamic responses to SARS-CoV-2 in Taiwan.

Shey-Ying Chen, Yu-Lin Lee, Yi-Chun Lin, Nan-Yao Lee, Chia-Hung Liao, Yuan-Pin Hung, Min-Chi Lu, Jhong-Lin Wu, Wen-Pin Tseng, Chien-Hao Lin, Ming-Yi Chung, Chun-Min Kang, Ya-Fan Lee, Tai-Fen Lee, Chien-Yu Cheng, Cheng-Pin Chen, Chien-Hua Huang, Chun-Eng Liu, Shu-Hsing Cheng, Wen-Chien Ko, Po-Ren Hsueh, Shyr-Chyr Chen,

This multicenter, retrospective study included 346 serum samples from 74 patients with coronavirus disease 2019 (COVID-19) and 194 serum samples from non-COVID-19 patients to evaluate the performance of five anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody tests, i.e. two chemiluminescence immunoassays (CLIAs): Roche Elecsys® Anti-SARS-CoV-2 Test (Roche Test) and ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):2157-2168]

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Immune responses of a CV-A16 live attenuated candidate strain and its protective effects in rhesus monkeys.

Ting Yang, Tianhong Xie, Hua Li, Xia Song, Lei Yue, Xi Wang, Dong Shen, Kaili Ma, Qinfang Jiang, Runxiang Long, Rong Yang, Xin He, Ye Zhang, Zhongping Xie, Qihan Li,

Coxsackievirus A16 (CV-A16) is a major causative pathogen of hand, foot, and mouth diseases (HFMDs). The licensed HFMD vaccine targets EV-A71 without cross-protection against CV-A16. Thus, a CV-A16 vaccine is needed. In this study, the immunogenicity and protective efficacy of a live attenuated CV-A16 candidate, K168-8Ac, were evaluated in a ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):2136-2146]

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SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease.

Pengfei Wang, Lihong Liu, Manoj S Nair, Michael T Yin, Yang Luo, Qian Wang, Ting Yuan, Kanako Mori, Axel Guzman Solis, Masahiro Yamashita, Ankur Garg, Lawrence J Purpura, Justin C Laracy, Jian Yu, Leemor Joshua-Tor, Joseph Sodroski, Yaoxing Huang, David D Ho,

We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):2091-2093]

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Genomic epidemiology of emerging ESBL-producing Salmonella Kentucky bla CTX-M-14b in Europe.

Claudia E Coipan, Therese Westrell, Angela H A M van Hoek, Erik Alm, Saara Kotila, Bas Berbers, Sigrid C J de Keersmaecker, Pieter-Jan Ceyssens, Maria Louise Borg, Marie Chattaway, Jacquelyn McCormick, Timothy J Dallman, Eelco Franz,

Global dissemination of ciprofloxacin-resistant Salmonella Kentucky has been observed over the past decades. In recent years, there have been reports of extended-spectrum β-lactamase (ESBL) producing S. Kentucky. Routine surveillance at the European Centre for Disease Prevention and Control (ECDC) detected cases with a ciprofloxacin-resistant S. Kentucky with the ESBL-gene bla ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):2124-2135]

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SARS-CoV-2 infection: diagnostic testing results occasionally require special attention.

Elisabetta Riva, Pier Paolo Sainaghi, Ombretta Turriziani, Guido Antonelli, Giuseppe Patti,

The case refers to a 51-year-old symptomatic man with a new SARS-CoV-2 RNA positive nasopharyngeal swab after two negative ones and the lack of significant development of antibody response measured by different diagnostic serological test. Our case underlines that a discrepancy between clinical course of SARS-CoV-2 infection and results from ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1955-1957]

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Misdiagnosis of imported falciparum malaria from African areas due to an increased prevalence of pfhrp2/pfhrp3 gene deletion: the Djibouti case.

Xavier Iriart, Sandie Menard, Pamela Chauvin, Hasna S Mohamed, Elena Charpentier, Mohamed A Mohamed, Antoine Berry, Mohamed H Aboubaker,

Following the diagnosis of a falciparum malaria case imported from Djibouti and not detected by a pfHRP2-based rapid diagnostic test (RDT), we investigated the prevalence of the pfhrp2/pfhrp3-deleted parasites in Djibouti using 378 blood samples collected between January and May 2019, from Djiboutian patients with suspected malaria. Malaria diagnosis by ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1984-1987]

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Emerging Enterococcus isolates in postoperative endophthalmitis by selection pressure of fluoroquinolones: an 11-year multicenter and experimental study.

Jiyeun Kate Kim, Ki Yup Nam, In Young Chung, Woo Jin Jeung, Yoon Hyung Kwon, Jung Min Park, Yong Seop Han, Ji Eun Lee, Ik Soo Byon, Sung Hu Park, Hyun Wong Kim, Kang Yun Park, Hee Sung Yoon, Indal Park, Han Woo Kim, Sang Joon Lee,

Postoperative endophthalmitis (PE) is the devastating complication that frequently results in vision loss. Recently, enterococcus have emerged as a major cause of PE in several countries and resulted in poor visual outcome. However, the reason remains elusive. We investigate whether selection pressure of fluoroquinolone exerts effects on microorganism profiles isolated ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1892-1899]

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Dynamic changes of throat swabs RNA and serum antibodies for SARS-CoV-2 and their diagnostic performances in patients with COVID-19.

Xueping Qiu, Yang Xiang, Jianbin Sun, Xinrui Wang, Guoqiang Chen, Xianqun Xu, Shengjun Liao, Na Yang, Siwei Li, Gang Yang, Yueting Tang, Junli Fan, Wen Xie, Hanning Hu, Yirong Li, Fang Zheng,

Dynamic changes of RNA and antibodies in SARS-CoV-2 infected patients remain largely unknown, and influence factors for antibody production have not been fully clarified. In this study, consecutive throat swabs specimens (n = 1875) from 187 patients were collected to analyse the dynamic changes of RNA. Moreover, 162 serial serum samples from ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1974-1983]

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Precise diagnosis of Neisseria macacae infective endocarditis assisted by nanopore sequencing.

Jing-Wen Ai, Hong Liu, Hui-Xia Li, Qing-Xia Ling, Yan-Qin Ai, Si-Jia Sun, Xuan Wang, Bing-Yan Zhang, Jian-Ming Zheng, Jia-Lin Jin, Wen-Hong Zhang,

Infective endocarditis caused by Neisseria macacae in humans is extremely rare. We presented here a case of N. macacae infective endocarditis in a 61-year-old man with a native aortic valve infection. N. macacae was isolated from blood culture and was detected by nanopore-based metagenomic sequencing in the vegetations. Finally, the ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1864-1868]

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Lassa fever in Benin: description of the 2014 and 2016 epidemics and genetic characterization of a new Lassa virus.

Anges Yadouleton, Caroline Picard, Toni Rieger, Frederic Loko, Daniel Cadar, Emile Cossi Kouthon, Emmanuel Obolli Job, Honoré Bankolé, Lisa Oestereich, Fernand Gbaguidi, Meike Pahlman, Beate Becker-Ziaja, Alexandra Journeaux, Delphine Pannetier, Stéphane Mély, Stéphanie Mundweiler, Damien Thomas, Leon Kohossi, Raoul Saizonou, Clement Glele Kakaï, Magloire Da Silva, Sonia Kossoubedie, André Lukusa Kakonku, Pierre M'Pelé, Stephan Gunther, Sylvain Baize, Elisabeth Fichet-Calvet,

We report two outbreaks of Lassa fever that occurred in Benin in 2014 and 2016 with 20 confirmed cases and 50% (10/20) mortality. Benin was not previously considered to be an endemic country for Lassa fever, resulting in a delay to diagnose the disease and its human transmission. Molecular investigations ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1761-1770]

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Kawasaki-like diseases and thrombotic coagulopathy in COVID-19: delayed over-activation of the STING pathway?

Jean-Marie Berthelot, Ludovic Drouet, Frédéric Lioté,

We previously made the hypothesis that STING contributes to COVID-19. The present review detail new arguments for over-activation of STING pathways in COVID-19, following the description of hyper-coagulability and Kawasaki-like diseases in children. Indeed, Kawasaki disease is induced by overreaction of innate cells following exposition to various viruses, including herpes ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1514-1522]

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Epidemiology of COVID-19 in Brazil: using a mathematical model to estimate the outbreak peak and temporal evolution.

Yuanji Tang, Tamires D A Serdan, Laureane N Masi, Sherry Tang, Renata Gorjao, Sandro M Hirabara,

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1453-1456]

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Diagnosing Balamuthia mandrillaris encephalitis via next-generation sequencing in a 13-year-old girl.

Xia Wu, Gangfeng Yan, Shuzhen Han, Yingzi Ye, Xunjia Cheng, Hairong Gong, Hui Yu,

Balamuthia amoebic encephalitis has a subacute-to-chronic course and is almost invariably fatal owing to delayed diagnosis and a lack of effective therapy. Here, we report a 13-year-old girl with cutaneous lesions and multifocal granulomatous encephalitis. The patient underwent a series of tests and was suspected as having tuberculosis. She was ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1379-1387]

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Dynamic surveillance of SARS-CoV-2 shedding and neutralizing antibody in children with COVID-19.

Pengcheng Liu, Jiehao Cai, Ran Jia, Shuai Xia, Xiangshi Wang, Lingfeng Cao, Mei Zeng, Jin Xu,

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China and quickly spread globally. In this study, we investigated the characteristics of viral shedding from different sites and the neutralizing antibody (NAb) response during the acute and convalescent phases of nine children with COVID-19. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1254-1258]

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Active and prospective latent tuberculosis are associated with different metabolomic profiles: clinical potential for the identification of rapid and non-invasive biomarkers.

A Albors-Vaquer, A Rizvi, M Matzapetakis, P Lamosa, A V Coelho, A B Patel, S C Mande, S Gaddam, A Pineda-Lucena, S Banerjee, L Puchades-Carrasco,

Although 23% of world population is infected with Mycobacterium tuberculosis (M. tb), only 5-10% manifest the disease. Individuals surely exposed to M. tb that remain asymptomatic are considered potential latent TB (LTB) cases. Such asymptomatic M. tb.-exposed individuals represent a reservoir for active TB cases. Although accurate discrimination and early ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1131-1139]

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Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry.

Huan Sun, Yan Li, Peipei Liu, Chengpeng Qiao, Xiaomin Wang, Lianao Wu, Kefang Liu, Yu Hu, Chao Su, Shuguang Tan, Shumei Zou, Guizhen Wu, Jinghua Yan, George Fu Gao, Jianxun Qi, Qihui Wang,

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1238-1241]

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Analytical comparisons of SARS-COV-2 detection by qRT-PCR and ddPCR with multiple primer/probe sets.

Xinjin Liu, Jiangpeng Feng, Qiuhan Zhang, Dong Guo, Lu Zhang, Tao Suo, Wenjia Hu, Ming Guo, Xin Wang, Zhixiang Huang, Yong Xiong, Guozhong Chen, Yu Chen, Ke Lan,

Different primers/probes sets have been developed all over the world for the nucleic acid detection of SARS-CoV-2 by quantitative real time polymerase chain reaction (qRT-PCR) as a standard method. In our recent study, we explored the feasibility of droplet digital PCR (ddPCR) for clinical SARS-CoV-2 nucleic acid detection compared with ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1175-1179]

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Impact of the gonococcal FC428 penA allele 60.001 on ceftriaxone resistance and biological fitness.

Ke Zhou, Shao-Chun Chen, Fan Yang, Stijn van der Veen, Yue-Ping Yin,

Global dissemination of the Neisseria gonorrhoeae ceftriaxone-resistant FC428 clone jeopardizes the currently recommended ceftriaxone-based first-line therapies. Ceftriaxone resistance in the FC428 clone has been associated with the presence of its mosaic penA allele 60.001. Here we investigated the contribution penA allele 60.001 to ceftriaxone resistance and its impact on biological ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1219-1229]

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Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture.

Ya-Nan Zhang, Qiu-Yan Zhang, Xiao-Dan Li, Jin Xiong, Shu-Qi Xiao, Zhen Wang, Zhe-Rui Zhang, Cheng-Lin Deng, Xing-Lou Yang, Hong-Ping Wei, Zhi-Ming Yuan, Han-Qing Ye, Bo Zhang,

The emerging SARS-CoV-2 infection associated with the outbreak of viral pneumonia in China is ongoing worldwide. There are no approved antiviral therapies to treat this viral disease. Here we examined the antiviral abilities of three broad-spectrum antiviral compounds gemcitabine, lycorine and oxysophoridine against SARS-CoV-2 in cell culture. We found that ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1170-1173]

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Lack of cross-neutralization by SARS patient sera towards SARS-CoV-2.

Danielle E Anderson, Chee Wah Tan, Wan Ni Chia, Barnaby E Young, Martin Linster, JennyG H Low, Yee-Joo Tan, Mark I-C Chen, Gavin J D Smith, Yee Sin Leo, David C Lye, Lin-Fa Wang,

Despite initial findings indicating that SARS-CoV and SARS-CoV-2 are genetically related belonging to the same virus species and that the two viruses used the same entry receptor, angiotensin-converting enzyme 2 (ACE2), our data demonstrated that there is no detectable cross-neutralization by SARS patient sera against SARS-CoV-2. We also found that ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):900-902]

Cited: 2 times

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Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow.

Lin Wang, Li Yan, Jieling Jiang, Yuyi Zhang, Qiyu He, Hui Zhuang, Ling Wang,

Hepatitis E virus (HEV) infection is primarily manifesting as acute hepatitis, but extra-hepatic replication and injury are frequently reported. During the study period, we discovered two acute myeloid leukaemia (AML) patients infected with HEV genotype 3 and 4, respectively, and HEV RNA and/or viral proteins were persistently detected in the ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):994-997]

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First report of Rickettsia felis in mosquitoes, USA.

Subarna Barua, Md Monirul Hoque, Patrick John Kelly, Anil Poudel, Folasade Adekanmbi, Anwar Kalalah, Yi Yang, Chengming Wang,

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1008-1010]

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Impact of population movement on the spread of 2019-nCoV in China.

Chi Zhang, Cai Chen, Wei Shen, Feng Tang, Hao Lei, Yu Xie, Zicheng Cao, Kang Tang, Junbo Bai, Lehan Xiao, Yutian Xu, Yanxin Song, Jiwei Chen, Zhihui Guo, Yichen Guo, Xiao Wang, Modi Xu, Huachun Zou, Yuelong Shu, Xiangjun Du,

Since Dec 2019, China has experienced an outbreak caused by a novel coronavirus, 2019-nCoV. A travel ban was implemented for Wuhan, Hubei on Jan 23 to slow down the outbreak. We found a significant positive correlation between population influx from Wuhan and confirmed cases in other cities across China (R2 = 0.85, ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):988-990]

Cited: 2 times

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First detection of highly pathogenic H5N6 avian influenza virus on the African continent.

Ismaila Shittu, Alice Bianco, Dorcas Gado, Nicodemus Mkpuma, Lanre Sulaiman, Agnes Laleye, Federica Gobbo, Alessio Bortolami, Francesco Bonfante, Columba Vakuru, Clement Meseko, Alice Fusaro, David Shamaki, Olaniran Alabi, Calogero Terregino, Tony Joannis,

Since 2013, highly pathogenic avian influenza (HPAI) subtype H5N6 (clade 2.3.4.4) has been reported in wild birds and poultry in Asia as well as in other parts of the globe. In Africa, information on the presence of this virus subtype is lacking. This study reports the first detection of a ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):886-888]

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