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Individualized discovery of rare cancer drivers in global network context.

Iurii Petrov, Andrey Alexeyenko,

Late advances in genome sequencing expanded the space of known cancer driver genes several-fold. However, most of this surge was based on computational analysis of somatic mutation frequencies and/or their impact on the protein function. On the contrary, experimental research necessarily accounted for functional context of mutations interacting with other ... Read more >>

Elife (eLife)
[2022, 11:e74010]

Cited: 0 times

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WhyD tailors surface polymers to prevent premature bacteriolysis and direct cell elongation in Streptococcus pneumoniae.

Josué Flores-Kim, Genevieve S Dobihal, Thomas G Bernhardt, David Z Rudner,

Penicillin and related antibiotics disrupt cell wall synthesis in bacteria causing the downstream misactivation of cell wall hydrolases called autolysins to induce cell lysis. Despite the clinical importance of this phenomenon, little is known about the factors that control autolysins and how penicillins subvert this regulation to kill cells. In ... Read more >>

Elife (eLife)
[2022, 11:e76392]

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