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Journal Dtsch Arztebl Int

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Adults Born Preterm: Long-Term Health Risks of Former Very Low Birth Weight Infants.

Dominique Singer, Luise Pauline Thiede, Anna Perez,

<h4>Background</h4>Advances in neonatology now enable increasing numbers of very low birth weight neonates (<1500 g) to survive into early adulthood and beyond. What are the implications for their long-term care?<h4>Methods</h4>Selective literature search on the outcome of very low birth weight neonates in adulthood ("adults born preterm").<h4>Results</h4>Robust data are available on ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Hospital Mortality and Current Trends in Liver Transplantation in Germany-a Systematic Analysis of Standardized Hospital Discharge Data, 2008-2017.

Sven H Loosen, Hans H Bock, Martin Hellmich, Wolfram T Knoefel, Christian Trautwein, Verena Keitel, Johannes G Bode, Ulf P Neumann, Tom Luedde,

<h4>Background</h4>Liver transplantation (LT) has undergone dynamic developments in recent decades. In Germany, the Federal Joint Committee (G-BA) recently tightened the guidelines regarding the minimum number of transplantations a center should perform annually. The aim of the study presented here, was to analyze recent trends in hospital mortality due to LT ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Multiresistant Gram-Negative Pathogens-A Zoonotic Problem.

Robin Köck, Caroline Herr, Lothar Kreienbrock, Stefan Schwarz, Bernd-Alois Tenhagen, Birgit Walther,

<h4>Background</h4>Extended-spectrum-β-lactamase-producing, carbapenemase-producing, and colistin-resistant Enterobacteriaceae (ESBL-E, CPE, and Col-E) are multiresistant pathogens that are increasingly being encountered in both human and veterinary medicine. In this review, we discuss the frequency, sources, and significance of the zoonotic transmission of these pathogens between animals and human beings.<h4>Methods</h4>This review is based on pertinent ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Ten-Year Evaluation of the Population-Based Integrated Health Care System "Gesundes Kinzigtal".

Ingrid Schubert, Dominikus Stelzer, Achim Siegel, Ingrid Köster, Claudia Mehl, Peter Ihle, Christian Günster, Patrik Dröge, Andreas Klöss, Erik Farin-Glattacker, Erika Graf, Max Geraedts,

<h4>Background</h4>The population-based integrated health care system called "Gesundes Kinzigtal" (Integrierte Versorgung Gesundes Kinzigtal, IVGK) was initiated more than 10 years ago in the Kinzig River Valley region, which is located in the Black Forest in the German state of Baden-Württemberg. IVGK is intended to optimize health care while maximizing costeffectiveness. ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Monitoring of Treatment for Arterial Hypertension—The Role of Office, Home, and 24 h Ambulatory Blood Pressure Measurement.

Thomas Mengden, Burkhard Weisser,

<h4>Background</h4>The treatment of arterial hypertension can be monitored by office blood pressure (office BP), home blood pressure (home BP), or 24 hours ambulatory blood pressure (ABPM). In this review, we present current recommendations from Germany and from international guidelines as well as the findings of the main studies on the ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Antithrombotic Treatment for Peripheral Arterial Occlusive Disease.

David Hardung, Andrea Behne, Mehmet Boral, Carsten Giesche, Ralf Langhoff,

<h4>Background</h4>Patients with peripheral arterial occlusive disease (PAOD) are at elevated risk for cardiovascular events and vascular events affecting the limbs. The goals of antithrombotic treatment are to keep vessels open after revascularization, to prevent cardiovascular events, and to lessen the frequency of peripheral ischemia and of amputation.<h4>Methods</h4>This review is based ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Time to Surgery and Outcome in the Treatment of Proximal Femoral Fractures.

Hanna Leicht, Thomas Gaertner, Christian Günster, Andreas M Halder, Reinhard Hoffmann, Elke Jeschke, Jürgen Malzahn, Almut Tempka, Josef Zacher,

<h4>Background</h4>It has not been conclusively established whether, or to what extent, the time to surgery affects mortality and the risk of complications after the surgical treatment of proximal femoral fractures.<h4>Methods</h4>Data on 106 187 hospitalizations over the period 2015-2017 involving insurees of the German AOK health insurance company aged 20 and ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Patients With Somatoform Disorders Are Prone to Expensive and Potentially Harmful Medical Procedures – Results of a Retrospective Cohort Study Over 15 Years.

Antonius Schneider, Ewan Donnachie, Stephan Zipfel, Paul Enck,

<h4>Background</h4>Patients with functional somatic syndromes (FSS) might be prone to potentially harmful medical investigations in ambulatory care. The primary aim of this study was to investigate which diagnostic tests such as X-ray, CT scans, MRT, and surgical procedures FSS patients receive in an outpatient setting. Its secondary aim was to ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Diabetes in the Hospital—A Nationwide Analysis of all Hospitalized Cases in Germany With and Without Diabetes, 2015-2017.

Marie Auzanneau, Andreas Fritsche, Andrea Icks, Erhard Siegel, Reinhold Kilian, Wolfram Karges, Stefanie Lanzinger, Reinhard W Holl,

<h4>Background</h4>Comprehensive data on the frequency of diabetes mellitus among hospitalized patients in Germany have not been published to date.<h4>Methods</h4>Among all inpatient cases aged ≥20 years that were documented in the German DRG statistics for 2015-2017, we analyzed the frequencies of five types of diabetes (type 1, type 2, other/pancreatic diabetes, ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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The Diagnosis and Management of Endocrine Side Effects of Immune Checkpoint Inhibitors.

Knut Mai, Martin Fassnacht, Dagmar Führer-Sakel, Jürgen B Honegger, Matthias M Weber, Matthias Kroiss,

<h4>Background</h4>The immunologically mediated side effects of immune checkpoint inhibitors (CPI) often involve the endocrine system as well, and they can even be fatal, as in the case of unrecognized hypophysitis. Distinguishing such side effects from tumor-related changes is often difficult, because their clinical features can be nonspecific.<h4>Methods</h4>This review is based ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Regional Deprivation, Stroke Incidence, and Stroke Care—An Analysis of Billing and Quality Assurance Data From the German State of Rhineland-Palatinate.

Armin J Grau, Sieghard Dienlin, Dirk Bartig, Werner Maier, Florian Buggle, Heiko Becher,

<h4>Background</h4>Regional deprivation can increase the risk of illness and adversely affect care outcomes. In this study, we investigated for the German state of Rhineland-Palatinate whether spatial-structural disadvantages are associated with an increased frequency of ischemic stroke and with less favorable care outcomes.<h4>Methods</h4>We compared billing data from DRG statistics (2008-2017) and ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Diabetic Ketoacidosis at Manifestation of Type 1 Diabetes in Childhood and Adolescence—Incidence and Risk Factors.

Hugo Segerer, Michael Wurm, Julia M Grimsmann, Beate Karges, Andreas Neu, Marina Sindichakis, Katharina Warncke, Axel Dost, Reinhard W Holl,

<h4>Background</h4>Diabetic ketoacidosis (DKA) is a potentially life-threatening metabolic disorder that can occur with manifestation of type 1 diabetes mellitus (T1D). The aim of this study was to analyze the incidence of DKA at the time of the diagnosis of T1D in childhood and adolescence, the risk factors, and regional approaches ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Inhibition of Platelet Aggregation After Coronary Stenting in Patients Receiving Oral Anticoagulation.

Conrad Genz, Ruediger C Braun-Dullaeus,

<h4>Background</h4>Approximately 18% of patients with atrial fibrillation undergo a percutaneous coronary intervention (PCI) to treat coronary heart disease. Pharmacological anticoagulation in patients with atrial fibrillation and PCI involves a trade-off of potential ischemic and hemorrhagic complications.<h4>Methods</h4>This review is based on pertinent publications that were retrieved by a selective literature search, ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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N-Nitrosodimethylamine-Contaminated Valsartan and the Risk of Cancer—A Longitudinal Cohort Study Based on German Health Insurance Data.

Willy Gomm, Christoph Röthlein, Katrin Schüssel, Gabriela Brückner, Helmut Schröder, Steffen Hess, Roland Frötschl, Karl Broich, Britta Haenisch,

<h4>Background</h4>N-nitrosodimethylamine (NDMA) has been classified as a probable human carcinogen and has been found as a contaminant in valsartan, an antihypertensive drug. Potential carcinogenic effects from the consumption of NDMA-contaminated valsartan have not been analyzed to date in large-scale cohort studies. We therefore carried out the study reported here on ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Bullous Autoimmune Dermatoses: Clinical Features, Diagnostic Evaluation, and Treatment Options.

Nina van Beek, Detlef Zillikens, Enno Schmidt,

<h4>Background</h4>Bullous autoimmune dermatoses are a clinically and immunopathologically heterogeneous group of diseases, characterized clinically by blisters or erosions of the skin and/or mucous membranes. In Germany, their prevalence is approximately 40 000 cases nationwide, and their incidence approximately 20 new cases per million people per year.<h4>Methods</h4>This review is based on ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Place of Death Trends and Utilization of Outpatient Palliative Care at the End of Life—Analysis of Death Certificates (2001, 2011, 2017) and Pseudonymized Data From Selected Palliative Medicine Consultation Services (2017) in Westphalia, Germany.

Burkhard Dasch, Peter K Zahn,

<h4>Background</h4>The largest German study on place of death was performed for deaths in selected regions of Westphalia in the years 2001 and 2011. In the period thereafter, provision of palliative care was regionally expanded. This upgrade included the establishment of palliative medicine consultation services (PMCS), combining general and specialized palliative ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Perioperative Psychological Interventions in Heart Surgery: Opportunities and Clinical Benefit.

Katharina Tigges-Limmer, Matthias Sitzer, Jan Gummert,

<h4>Background</h4>Heart surgery is a source of high levels of emotional distress for the patient. If the stress experience is not adequately compensated, it can have a negative impact on postoperative recovery, as can untreated comorbid mental disorders.<h4>Methods</h4>A selective literature review on emotional distress and mental comorbidities in heart surgery patients ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Prenatal Methamphetamine Exposure: Effects on Child Development – A Systematic Review.

Lorenz Harst, Stefanie Deckert, Frederik Haarig, Jörg Reichert, Jürgen Dinger, Peter Hellmund, Jochen Schmitt, Mario Rüdiger,

<h4>Background</h4>In Germany, the 12-month prevalence of methamphetamine use among persons aged 15 to 34 is 1.9%. An increasing number of newborns are being born after a prenatal methamphetamine exposure (PME). In 2014, in the German state of Saxony, approximately four out of 1000 newborns were affected.<h4>Methods</h4>This systematic review (Prospero registration ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Clinical Practice Guideline: Follicular Lymphoma—Diagnosis, Treatment, and Follow-up.

Anna Zoellner, Klaus Herfarth, Michael Herold, Wolfram Klapper, Nicole Skoetz, Wolfgang Hiddemann,

<h4>Background</h4>Follicular lymphoma (FL) occurs predominantly at advanced age, with an annual incidence of 3-5 cases per 100 000 inhabitants in Western countries. The clinical course is heterogeneous.<h4>Methods</h4>For this new guideline, systematic literature searches were conducted in medical databases (MEDLINE, PubMed Central) (up to November 2017) and in the Guidelines International ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Medical Advice for Travelers.

Sebastian Wendt, Dietmar Beier, Dennis Paquet, Henning Trawinski, André Fuchs, Christoph Lübbert,

<h4>Background</h4>In 2019, 1.5 billion international tourist trips were counted worldwide. Germany, with 70.8 million vacations lasting ≥ 5 days, was one of the populations most willing to travel. These days, even elderly and multimorbid persons regularly travel long-distance, which can be associated with significant health risks. By advising travelers and ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Wishes and Needs at the End of Life: Communication Strategies, Counseling, and Administrative Aspects.

Katja Welsch, Sven Gottschling,

<h4>Background</h4>Managing the last phase of life properly, i.e., taking care that a patient's wishes are respected at the end of life and beyond, is very important and can relieve the patient and his or her family of unnecessary burdens.<h4>Methods</h4>This review is based on guidelines, reviews, meta-analyses, selected publications, and the ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Symptoms During Outpatient Cancer Treatment and Options for Their Management.

Mitra Tewes, Freerk Baumann, Martin Teufel, Christoph Ostgathe,

<h4>Background</h4>Cancer patients account for a large segment of the German healthcare system, with a 5-year prevalence of around 1.7 million persons. Advances in oncological treatment, now frequently performed on an outpatient basis, are granting many of these individuals a longer life span. At the same time, cancer patients often suffer ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Incidence and Mortality of Proximal and Distal Colorectal Cancer in Germany—Trends in the Era of Screening Colonoscopy.

Rafael Cardoso, Anna Zhu, Feng Guo, Thomas Heisser, Michael Hoffmeister, Hermann Brenner,

<h4>Background</h4>The use of colonoscopy has increased since its introduction as a screening procedure in Germany, and the incidence of colorectal cancer (CRC) has decreased. It is unclear, however, to what extent this overall reduction applies to the prevention of cancer in the proximal colon, the distal colon, and the rectum.<h4>Methods</h4>We ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Routine Molecular Pathology Diagnostics in Precision Oncology.

Carina Wenzel, Sylvia Herold, Martin Wermke, Daniela E Aust, Gustavo B Baretton,

<h4>Background</h4>Technical advances in the field of molecular genetics permit precise genomic characterization of malignant tumors. This has not only improved our understanding of tumor biology but also paved the way for molecularly stratified treatment strategies in routine clinical practice.<h4>Methods</h4>A selective search of PubMed to identify literature on molecular pathology methods, ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Raynaud's Phenomenon: A Vascular Acrosyndrome That Requires Long-Term Care.

Peter Klein-Weigel, Oliver Sander, Simone Reinhold, Jessica Nielitz, Julia Steindl, Jutta Richter,

<h4>Background</h4>Some 5-10% of the German population are affected by Raynaud's phenomenon (RP). In around 10-20% of cases RP arises from an underlying disease, most commonly a connective tissue disease. This review encompasses the diagnosis and differential diagnosis of RP and examines the efficacy of the currently available pharmaceutical and non-pharmaceutical ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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