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Journal Dtsch Arztebl Int

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Regional Deprivation, Stroke Incidence, and Stroke Care-An Analysis of Billing and Quality Assurance Data From the German State of Rhineland-Palatinate.

Armin J Grau, Sieghard Dienlin, Dirk Bartig, Werner Maier, Florian Buggle, Heiko Becher,

<h4>Background</h4>Regional deprivation can increase the risk of illness and adversely affect care outcomes. In this study, we investigated for the German state of Rhineland-Palatinate whether spatial-structural disadvantages are associated with an increased frequency of ischemic stroke and with less favorable care outcomes.<h4>Methods</h4>We compared billing data from DRG statistics (2008-2017) and ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Diabetic Ketoacidosis at Manifestation of Type 1 Diabetes in Childhood and Adolescence—Incidence and Risk Factors.

Hugo Segerer, Michael Wurm, Julia M Grimsmann, Beate Karges, Andreas Neu, Marina Sindichakis, Katharina Warncke, Axel Dost, Reinhard W Holl,

<h4>Background</h4>Diabetic ketoacidosis (DKA) is a potentially life-threatening metabolic disorder that can occur with manifestation of type 1 diabetes mellitus (T1D). The aim of this study was to analyze the incidence of DKA at the time of the diagnosis of T1D in childhood and adolescence, the risk factors, and regional approaches ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Inhibition of Platelet Aggregation After Coronary Stenting in Patients Receiving Oral Anticoagulation.

Conrad Genz, Ruediger C Braun-Dullaeus,

<h4>Background</h4>Approximately 18% of patients with atrial fibrillation undergo a percutaneous coronary intervention (PCI) to treat coronary heart disease. Pharmacological anticoagulation in patients with atrial fibrillation and PCI involves a trade-off of potential ischemic and hemorrhagic complications.<h4>Methods</h4>This review is based on pertinent publications that were retrieved by a selective literature search, ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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N-Nitrosodimethylamine-Contaminated Valsartan and the Risk of Cancer—A Longitudinal Cohort Study Based on German Health Insurance Data.

Willy Gomm, Christoph Röthlein, Katrin Schüssel, Gabriela Brückner, Helmut Schröder, Steffen Hess, Roland Frötschl, Karl Broich, Britta Haenisch,

<h4>Background</h4>N-nitrosodimethylamine (NDMA) has been classified as a probable human carcinogen and has been found as a contaminant in valsartan, an antihypertensive drug. Potential carcinogenic effects from the consumption of NDMA-contaminated valsartan have not been analyzed to date in large-scale cohort studies. We therefore carried out the study reported here on ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Place of Death Trends and Utilization of Outpatient Palliative Care at the End of Life—Analysis of Death Certificates (2001, 2011, 2017) and Pseudonymized Data From Selected Palliative Medicine Consultation Services (2017) in Westphalia, Germany.

Burkhard Dasch, Peter K Zahn,

<h4>Background</h4>The largest German study on place of death was performed for deaths in selected regions of Westphalia in the years 2001 and 2011. In the period thereafter, provision of palliative care was regionally expanded. This upgrade included the establishment of palliative medicine consultation services (PMCS), combining general and specialized palliative ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Perioperative Psychological Interventions in Heart Surgery: Opportunities and Clinical Benefit.

Katharina Tigges-Limmer, Matthias Sitzer, Jan Gummert,

<h4>Background</h4>Heart surgery is a source of high levels of emotional distress for the patient. If the stress experience is not adequately compensated, it can have a negative impact on postoperative recovery, as can untreated comorbid mental disorders.<h4>Methods</h4>A selective literature review on emotional distress and mental comorbidities in heart surgery patients ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Medical Advice for Travelers.

Sebastian Wendt, Dietmar Beier, Dennis Paquet, Henning Trawinski, André Fuchs, Christoph Lübbert,

<h4>Background</h4>In 2019, 1.5 billion international tourist trips were counted worldwide. Germany, with 70.8 million vacations lasting ≥ 5 days, was one of the populations most willing to travel. These days, even elderly and multimorbid persons regularly travel long-distance, which can be associated with significant health risks. By advising travelers and ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Clinical Practice Guideline: Follicular Lymphoma—Diagnosis, Treatment, and Follow-up.

Anna Zoellner, Klaus Herfarth, Michael Herold, Wolfram Klapper, Nicole Skoetz, Wolfgang Hiddemann,

<h4>Background</h4>Follicular lymphoma (FL) occurs predominantly at advanced age, with an annual incidence of 3-5 cases per 100 000 inhabitants in Western countries. The clinical course is heterogeneous.<h4>Methods</h4>For this new guideline, systematic literature searches were conducted in medical databases (MEDLINE, PubMed Central) (up to November 2017) and in the Guidelines International ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Symptoms During Outpatient Cancer Treatment and Options for Their Management.

Tewes Mitra, Baumann Freerk, Teufel Martin, Ostgathe Christoph,

<h4>Background</h4>Cancer patients account for a large segment of the German healthcare system, with a 5-year prevalence of around 1.7 million persons. Advances in oncological treatment, now frequently performed on an outpatient basis, are granting many of these individuals a longer life span. At the same time, cancer patients often suffer ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Incidence and Mortality of Proximal and Distal Colorectal Cancer in Germany—Trends in the Era of Screening Colonoscopy.

Rafael Cardoso, Anna Zhu, Feng Guo, Thomas Heisser, Michael Hoffmeister, Hermann Brenner,

<h4>Background</h4>The use of colonoscopy has increased since its introduction as a screening procedure in Germany, and the incidence of colorectal cancer (CRC) has decreased. It is unclear, however, to what extent this overall reduction applies to the prevention of cancer in the proximal colon, the distal colon, and the rectum.<h4>Methods</h4>We ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Routine Molecular Pathology Diagnostics in Precision Oncology.

Carina Wenzel, Sylvia Herold, Martin Wermke, Daniela E Aust, Gustavo B Baretton,

<h4>Background</h4>Technical advances in the field of molecular genetics permit precise genomic characterization of malignant tumors. This has not only improved our understanding of tumor biology but also paved the way for molecularly stratified treatment strategies in routine clinical practice.<h4>Methods</h4>A selective search of PubMed to identify literature on molecular pathology methods, ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Raynaud's Phenomenon: A Vascular Acrosyndrome That Requires Long-Term Care.

Peter Klein-Weigel, Oliver Sander, Simone Reinhold, Jessica Nielitz, Julia Steindl, Jutta Richter,

<h4>Background</h4>Some 5-10% of the German population are affected by Raynaud's phenomenon (RP). In around 10-20% of cases RP arises from an underlying disease, most commonly a connective tissue disease. This review encompasses the diagnosis and differential diagnosis of RP and examines the efficacy of the currently available pharmaceutical and non-pharmaceutical ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Clinical Practice Guideline: Anal Cancer—Diagnosis, Treatment and Follow-up

Robert Siegel, Ricardo Niklas Werner, Stephan Koswig, Matthew Gaskins, Claus Rödel, Felix Aigner,

<h4>Background</h4>The rate of anal cancer has been rising steadily in recent times, so that the incidence is now double what it was 20 years ago. Almost all anal cancers are induced by persistent infection with human papillomaviruses. Hitherto the care of patients with anal cancer has been extremely heterogeneous; little ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Acute Appendicitis: Trends in Surgical Treatment—A Population-Based Study of Over 800 000 Patients.

Christian Stöß, Ulrich Nitsche, Philipp-Alexander Neumann, Victoria Kehl, Dirk Wilhelm, Reinhard Busse, Helmut Friess, Ulrike Nimptsch,

<h4>Background</h4>Appendectomy is the gold standard for treatment of acute appendicitis. However, recent studies favor primary antibiotic therapy. The aim of this observational study was to explore changes in the numbers of operations for acute appendicitis in the period 2010-2017, paying special attention to disease severity.<h4>Methods</h4>Data from diagnosis-related group statistics were ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Options for Curative Treatment of Localized Prostate Cancer.

Sophie Knipper, Saskia Ott, Heinz-Peter Schlemmer, Marc-Oliver Grimm, Markus Graefen, Thomas Wiegel,

<h4>Background</h4>Prostate cancer is the most frequently occurring malignancy among men in Germany, with 60 000 new cases each year. Three of every four tumors are detected at an early, localized stage, when various curative treatment strategies are possible.<h4>Methods</h4>A selective search of the literature in PubMed accompanied by consideration of guidelines ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Late Sequelae of Radiotherapy: The Effect of Technical and Conceptual Innovations in Radiation Oncology.

Ulrike Hoeller, Kerstin Borgmann, Michael Oertel, Uwe Haverkamp, Volker Budach, Theodor Hans Eich,

<h4>Background</h4>Approximately half of all patients with tumors need radiotherapy. Long-term survivors may suffer from late sequelae of the treatment. The existing radiotherapeutic techniques are being refined so that radiation can be applied more precisely, with the goal of limiting the radiation exposure of normal tissue and reducing late sequelae.<h4>Methods</h4>This review ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Sport and Venous Thromboembolism—Site, Accompanying Features, Symptoms, and Diagnosis.

Thomas Hilberg, Pia Ransmann, Thorsten Hagedorn,

<h4>Background</h4>The occurrence of venous thromboembolisms (VTE) in association with sporting activity has been described but not yet systematically explored. The aim of this study was to determine the sites at which VTE occur in athletes, the accompanying features, and the special features of the symptoms and diagnosis, so that physicians ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Clinical Practice Guideline: Sore Throat.

Karen Krüger, Nicole Töpfner, Reinhard Berner, Jochen Windfuhr, Jan Hendrik Oltrogge,

<h4>Background</h4>Sore throat is a common reason for consultation of primary care physicians, pediatricians, and ENT specialists. The updated German clinical practice guideline on sore throat provides evidence-based recommendations for treatment in the German healthcare system.<h4>Methods</h4>Guideline revision by means of a systematic search of the literature for international guidelines and systematic ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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The Diagnosis and Treatment of Pulmonary Fibrosis.

Michael Kreuter, Ulf Müller Ladner, Ulrich Costabel, Danny Jonigk, Claus Peter Heussel,

<h4>Background</h4>The different types of pulmonary fibrosis are a subgroup of the interstitial lung diseases (ILDs). They are associated with a chronic and often progressive course.<h4>Methods</h4>This review is based on pertinent publications retrieved by a selective search in the EMBASE and PubMed databases, with an emphasis on articles published from 2000 ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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The COVID-19 Disease Burden in Germany in 2020—Years of Life Lost to Death and Disease Over the Course of the Pandemic.

Alexander Rommel, Elena von der Lippe, Dietrich Plass, Thomas Ziese, Michaela Diercke, Matthias An der Heiden, Sebastian Haller, Annelene Wengler,

<h4>Background</h4>The SARS-CoV-2 pandemic presented major challenges to the health sector in 2020. The burden of disease arising from COVID-19 can be expressed as the number of years of life lost to disease or death. For example, death at age 40 involves a loss of far more years of life than ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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The German National Case Collection for Familial Pancreatic Carcinoma (FaPaCa)—Knowledge Gained in 20 Years.

Detlef Klaus Bartsch, Elvira Matthäi, Ioannis Mintziras, Christian Bauer, Jens Figiel, Mercede Sina-Boemers, Thomas M Gress, Peter Langer, Emily P Slater,

<h4>Background</h4>Familial pancreatic carcinoma (FPC) is a rare hereditary tumor syndrome with a heterogeneous clinical phenotype. The study of FPC also contributes to a better understanding of the more common sporadic pancreatic ductal adenocarcinoma (PDAC). We report on the past 20 years' experience of the German National Case Collection for Familial ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Gliflozins for the Treatment of Congestive Heart Failure and Renal Failure in Type 2 Diabetes.

Anna Katharina Seoudy, Dominik M Schulte, Tim Hollstein, Ruwen Böhm, Ingolf Cascorbi, Matthias Laudes,

<h4>Background</h4>Gliflozins are effective drugs for the treatment of type 2 diabetes. They inhibit sodium glucose cotransporter 2 in the proximal renal tubule, leading to increased glucose excretion. On the basis of findings from relevant studies, gliflozins are also increasingly used in clinical practice to treat congestive heart failure and renal ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Neonatal Screening for Congenital Metabolic and Endocrine Disorders—Results From Germany for the Years 2006–2018

Anja Lüders, Oliver Blankenstein, Inken Brockow, Regina Ensenauer, Martin Lindner, Andreas Schulze, Uta Nennstiel,

<h4>Background</h4>The purpose of neonatal screening is the early detection of congenital metabolic and endocrine disorders that, if untreated, could lead to fatal crises or other long-term adverse sequelae. In Germany, neonatal screening is legally regulated. Quality-assurance reports ("DGNS reports") are created and published annually by the German Society for Neonatal ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Protection from COVID-19: The Efficacy of Face Masks.

Christoph Josef Hemmer, Frank Hufert, Stefan Siewert, Emil Reisinger,

<h4>Background</h4>Since the beginning of 2020 the SARS-CoV-2 virus has spread to nearly every country in the world. The mainly airborne pathogen has led to large numbers of deaths, principally in elderly and vulnerable segments of the population. Protective vaccines have recently become available, but it is not yet clear whether ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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The Risk of Knee Osteoarthritis in Professional Soccer Players—a Systematic Review With Meta-Analyses.

Alice Freiberg, Ulrich Bolm-Audorff, Andreas Seidler,

<h4>Background</h4>We address the question whether professional soccer players with and without macroinjury of the knee joint are at an elevated risk for knee osteoarthritis.<h4>Methods</h4>A systematic review with meta-analyses was conducted. The study protocol was prospectively registered (registration number CRD42019137139). The MEDLINE, EMBASE, and Web of Science databases were searched for ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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