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Journal Dtsch Arztebl Int

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The Incidence of Fractures Among the Adult Population of Germany-an Analysis From 2009 through 2019.

Markus Rupp, Nike Walter, Christian Pfeifer, Siegmund Lang, Maximilian Kerschbaum, Werner Krutsch, Florian Baumann, Volker Alt,

<h4>Background</h4>Detailed analyses of epidemiological data on fractures are an important resource for persons and institutions providing health care services, as they yield information on the effects of current treatment strategies and on the need for preventive measures. The epidemiology of fractures in Germany, however, is unknown. The goal of this ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, (Forthcoming):]

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Complementary Medicine in the Treatment of Cancer Patients.

Jutta Hübner, Matthias Beckmann, Markus Follmann, Monika Nothacker, Franz Josef Prott, Bernhard Wörmann,

<h4>Background</h4>Approximately half of all patients with cancer use at least one method of complementary medicine during or after tumor treatment. The substances most commonly taken are micronutrients, food supplements, and plant extracts.<h4>Methods</h4>This guideline is based on pertinent articles retrieved by a systematic search in the Medline, Cochrane Library, Embase, PsycInfo, ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, (Forthcoming):]

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Mitochondrial Disorders.

Thomas Klopstock, Claudia Priglinger, Ali Yilmaz, Cornelia Kornblum, Felix Distelmaier, Holger Prokisch,

<h4>Background</h4>Mitochondrial disorders are among the most common heritable diseases, with an overall lifetime risk of approximately one in 1500. Nonetheless, their diagnosis is often missed because of their extreme phenotypic and genotypic heterogeneity.<h4>Methods</h4>This review is based on publications retrieved by a selective literature search on the clinical features, genetics, pathogenesis, ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, (Forthcoming):]

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The Effect of an Abdominal Binder on Postoperative Pain after Laparoscopic Incisional Hernia Repair-A Multicenter, Randomized Pilot Trial (ABIHR-I) of the Intraperitoneal Onlay-Mesh Technique.

Christoph Paasch, Gianluca De Santo, Nouf Aljedani, Pedro Ortiz, Lisa Bruckert, Michael Hünerbein, Eric Lorenz, Roland Croner,

<h4>Background</h4>Incisional hernias with apertures measuring less than 7 cm can generally be treated adequately with the laparoscopic intraperitoneal onlay-mesh (IPOM) technique. The wearing of an abdominal binder after surgery is often recommended in order to promote wound healing and prevent recurrent herniation. We carried out a multicenter, randomized pilot trial ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, (Forthcoming):]

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Blood sugar targets in surgical intensive care—management and special considerations in patients with diabetes

Johannes Roth, Oliver Sommerfeld, Andreas L Birkenfeld, Christoph Sponholz, Ulrich A Müller, Christian von Loeffelholz,

<h4>Background</h4>30-80% of patients being treated in intensive care units in the perioperative period develop hyperglycemia. This stress hyperglycemia is induced and maintained by inflammatoryendocrine and iatrogenic stimuli and generally requires treatment. There is uncertainty regarding the optimal blood glucose targets for patients with diabetes mellitus.<h4>Methods</h4>This review is based on pertinent ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Fifth Metatarsal Fracture-A Systematic Review of the Treatment of Fractures of the Base of the Fifth Metatarsal Bone.

Viktoria Herterich, Sebastian Felix Baumbach, Antonia Kaiser, Wolfgang Böcker, Hans Polzer,

<h4>Background</h4>Metatarsal fractures are among the most common foot and ankle injuries, with an annual incidence of 6.7 per 100 000 persons. Approximately 30% of metatarsal fractures affect the base of the fifth metatarsal bone. Nevertheless, no evidence-based treatment recommendations are available to date.<h4>Methods</h4>The three fracture localizations according to Lawrence and ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, (Forthcoming):]

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Studies for the evaluation of diagnostic tests—part 28 of a series on evaluation of scientific publications.

Annika Hoyer, Antonia Zapf,

<h4>Background</h4>The accurate diagnosis of a disease is a prerequisite for its appropriate treatment. How well a medical test is able to correctly identify or rule out a target disease can be assessed by diagnostic accuracy studies.<h4>Methods</h4>The main statistical parameters that are derived from diagnostic accuracy studies, and their proper interpretation, ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Sensory Dysfunction in Old Age.

Christiane Völter, Jan Peter Thomas, Walter Maetzler, Rainer Guthoff, Martin Grunwald, Thomas Hummel,

<h4>Background</h4>The senses serve as the crucial interface between the individual and the environment. They are subject to aging and disease processes.<h4>Methods</h4>This review is based on pertinent publications retrieved by a selective search in the Medline and Cochrane Library databases.<h4>Results</h4>Approximately 40% of persons aged 70 to 79 manifest dysfunction in at ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, (Forthcoming):]

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Extravasation Injuries of the Limbs in Neonates and Children-Development of a Treatment Algorithm.

Roslind K Hackenberg, Koroush Kabir, Andreas Müller, Andreas Heydweiller, Christof Burger, Kristian Welle,

<h4>Background</h4>Hospitalized children and neonates very often receive intravenous treatment. There has not yet been any systematic study of the incidence of extravasation injuries in this age group. In a few studies of neonates in intensive care receiving intravenous treatment, incidence figures in the range of 18-46% have been reported; 2.4-4% ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, (Forthcoming):]

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Adults Born Preterm: Long-Term Health Risks of Former Very Low Birth Weight Infants.

Dominique Singer, Luise Pauline Thiede, Anna Perez,

<h4>Background</h4>Advances in neonatology now enable increasing numbers of very low birth weight neonates (<1500 g) to survive into early adulthood and beyond. What are the implications for their long-term care?<h4>Methods</h4>Selective literature search on the outcome of very low birth weight neonates in adulthood ("adults born preterm").<h4>Results</h4>Robust data are available on ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Fatigue as the Chief Complaint-Epidemiology, Causes, Diagnosis, and Treatment.

Peter Maisel, Erika Baum, Norbert Donner-Banzhoff,

<h4>Background</h4>Fatigue is a main or secondary reason for 10-20% of all consultations with a primary care physician.<h4>Methods</h4>This review is based on pertinent publications retrieved by a comprehensive, selective literature search on the epidemiology, etiology, and diagnostic evaluation of fatigue as a leading symptom of disease, as well as on the ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, :Forthcoming]

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Hospital Mortality and Current Trends in Liver Transplantation in Germany—a Systematic Analysis of Standardized Hospital Discharge Data, 2008–2017

Sven H Loosen, Hans H Bock, Martin Hellmich, Wolfram T Knoefel, Christian Trautwein, Verena Keitel, Johannes G Bode, Ulf P Neumann, Tom Luedde,

<h4>Background</h4>Liver transplantation (LT) has undergone dynamic developments in recent decades. In Germany, the Federal Joint Committee (G-BA) recently tightened the guidelines regarding the minimum number of transplantations a center should perform annually. The aim of the study presented here, was to analyze recent trends in hospital mortality due to LT ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Multiresistant Gram-Negative Pathogens—A Zoonotic Problem.

Robin Köck, Caroline Herr, Lothar Kreienbrock, Stefan Schwarz, Bernd-Alois Tenhagen, Birgit Walther,

<h4>Background</h4>Extended-spectrum-β-lactamase-producing, carbapenemase-producing, and colistin-resistant Enterobacteriaceae (ESBL-E, CPE, and Col-E) are multiresistant pathogens that are increasingly being encountered in both human and veterinary medicine. In this review, we discuss the frequency, sources, and significance of the zoonotic transmission of these pathogens between animals and human beings.<h4>Methods</h4>This review is based on pertinent ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118:]

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Ten-Year Evaluation of the Population-Based Integrated Health Care System "Gesundes Kinzigtal".

Ingrid Schubert, Dominikus Stelzer, Achim Siegel, Ingrid Köster, Claudia Mehl, Peter Ihle, Christian Günster, Patrik Dröge, Andreas Klöss, Erik Farin-Glattacker, Erika Graf, Max Geraedts,

<h4>Background</h4>The population-based integrated health care system called "Gesundes Kinzigtal" (Integrierte Versorgung Gesundes Kinzigtal, IVGK) was initiated more than 10 years ago in the Kinzig River Valley region, which is located in the Black Forest in the German state of Baden-Württemberg. IVGK is intended to optimize health care while maximizing costeffectiveness. ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Monitoring of Treatment for Arterial Hypertension—The Role of Office, Home, and 24 h Ambulatory Blood Pressure Measurement.

Thomas Mengden, Burkhard Weisser,

<h4>Background</h4>The treatment of arterial hypertension can be monitored by office blood pressure (office BP), home blood pressure (home BP), or 24 hours ambulatory blood pressure (ABPM). In this review, we present current recommendations from Germany and from international guidelines as well as the findings of the main studies on the ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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The Effect of the Lockdown on Patients With Myocardial Infarction During the COVID- 19 Pandemic-a Systematic Review and Meta-Analysis.

Michael Baumhardt, Jens Dreyhaupt, Claudia Winsauer, Lina Stuhler, Kevin Thiessen, Tilman Stephan, Sinisa Markovic, Wolfgang Rottbauer, Armin Imhof, Manuel Rattka,

<h4>Background</h4>A decline in the number of patients presenting with myocardial infarction was reported from the beginning of the COVID-19 pandemic onward. It is thought that measures introduced to stem the pandemic, such as the lockdown, contributed to this development. There are, however, conflicting data with respect to hospital referrals, delay ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, (Forthcoming):253]

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Time to Surgery and Outcome in the Treatment of Proximal Femoral Fractures.

Hanna Leicht, Thomas Gaertner, Christian Günster, Andreas M Halder, Reinhard Hoffmann, Elke Jeschke, Jürgen Malzahn, Almut Tempka, Josef Zacher,

<h4>Background</h4>It has not been conclusively established whether, or to what extent, the time to surgery affects mortality and the risk of complications after the surgical treatment of proximal femoral fractures.<h4>Methods</h4>Data on 106 187 hospitalizations over the period 2015-2017 involving insurees of the German AOK health insurance company aged 20 and ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Antithrombotic Treatment for Peripheral Arterial Occlusive Disease.

David Hardung, Andrea Behne, Mehmet Boral, Carsten Giesche, Ralf Langhoff,

<h4>Background</h4>Patients with peripheral arterial occlusive disease (PAOD) are at elevated risk for cardiovascular events and vascular events affecting the limbs. The goals of antithrombotic treatment are to keep vessels open after revascularization, to prevent cardiovascular events, and to lessen the frequency of peripheral ischemia and of amputation.<h4>Methods</h4>This review is based ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Patients With Somatoform Disorders Are Prone to Expensive and Potentially Harmful Medical Procedures—Results of a Retrospective Cohort Study Over 15 Years.

Antonius Schneider, Ewan Donnachie, Stephan Zipfel, Paul Enck,

<h4>Background</h4>Patients with functional somatic syndromes (FSS) might be prone to potentially harmful medical investigations in ambulatory care. The primary aim of this study was to investigate which diagnostic tests such as X-ray, CT scans, MRT, and surgical procedures FSS patients receive in an outpatient setting. Its secondary aim was to ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Diabetes in the Hospital—A Nationwide Analysis of all Hospitalized Cases in Germany With and Without Diabetes, 2015-2017.

Marie Auzanneau, Andreas Fritsche, Andrea Icks, Erhard Siegel, Reinhold Kilian, Wolfram Karges, Stefanie Lanzinger, Reinhard W Holl,

<h4>Background</h4>Comprehensive data on the frequency of diabetes mellitus among hospitalized patients in Germany have not been published to date.<h4>Methods</h4>Among all inpatient cases aged ≥20 years that were documented in the German DRG statistics for 2015-2017, we analyzed the frequencies of five types of diabetes (type 1, type 2, other/pancreatic diabetes, ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Regional Deprivation, Stroke Incidence, and Stroke Care—An Analysis of Billing and Quality Assurance Data From the German State of Rhineland-Palatinate.

Armin J Grau, Sieghard Dienlin, Dirk Bartig, Werner Maier, Florian Buggle, Heiko Becher,

<h4>Background</h4>Regional deprivation can increase the risk of illness and adversely affect care outcomes. In this study, we investigated for the German state of Rhineland-Palatinate whether spatial-structural disadvantages are associated with an increased frequency of ischemic stroke and with less favorable care outcomes.<h4>Methods</h4>We compared billing data from DRG statistics (2008-2017) and ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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The Diagnosis and Management of Endocrine Side Effects of Immune Checkpoint Inhibitors.

Knut Mai, Martin Fassnacht, Dagmar Führer-Sakel, Jürgen B Honegger, Matthias M Weber, Matthias Kroiss,

<h4>Background</h4>The immunologically mediated side effects of immune checkpoint inhibitors (CPI) often involve the endocrine system as well, and they can even be fatal, as in the case of unrecognized hypophysitis. Distinguishing such side effects from tumor-related changes is often difficult, because their clinical features can be nonspecific.<h4>Methods</h4>This review is based ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Diabetic Ketoacidosis at Manifestation of Type 1 Diabetes in Childhood and Adolescence—Incidence and Risk Factors.

Hugo Segerer, Michael Wurm, Julia M Grimsmann, Beate Karges, Andreas Neu, Marina Sindichakis, Katharina Warncke, Axel Dost, Reinhard W Holl,

<h4>Background</h4>Diabetic ketoacidosis (DKA) is a potentially life-threatening metabolic disorder that can occur with manifestation of type 1 diabetes mellitus (T1D). The aim of this study was to analyze the incidence of DKA at the time of the diagnosis of T1D in childhood and adolescence, the risk factors, and regional approaches ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Partnership and Emotional Support in the Doctor-Patient Relationship.

Steffen Walter, Vladimir Hrabal, Johannes Kahle, Margrit-Ann Geibel, Stephan Frisch, Lucia Jerg-Bretzke,

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(23):405-406]

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Consider Fructose Intolerance.

Karin Jordan, Camilla Leithold,

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(22):378]

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