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Key policy and programmatic factors to improve influenza vaccination rates based on the experience from four high-performing countries.

George Kassianos, Ashis Banerjee, Florence Baron-Papillon, Alan W Hampson, Janet E McElhaney, Allison McGeer, Thierry Rigoine de Fougerolles, Mitch Rothholz, Holly Seale, Litjen J Tan, Angus Thomson, Olivier Vitoux,

<h4>Background</h4>Many countries consistently fail to achieve the target influenza vaccine coverage rate (VCR) of 75% for populations at risk of complications, recommended by the World Health Organization and European Council. We aimed to identify factors for achieving a high VCR in the scope of four benchmark countries with high influenza ... Read more >>

Drugs Context (Drugs in context)
[2021, 10:]

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Symptomatic uncomplicated diverticular disease management: an innovative food-grade formulation of Curcuma longa and Boswellia serrata extracts.

Attilio Giacosa, Antonella Riva, Giovanna Petrangolini, Pietro Allegrini, Teresa Fazia, Luisa Bernardinelli, Clara Gasparri, Milena Anna Faliva, Gabriella Peroni, Simone Perna, Mariangela Rondanelli,

<h4>Background</h4>The treatment of symptomatic uncomplicated colonic diverticular disease (SUDD) is still under debate, and new data show a pathogenic role of dysbiosis and low-grade inflammation in intestinal mucosa. Recent research has highlighted the anti-inflammatory effects of botanical extracts such as <i>Curcuma longa</i> L. and <i>Boswellia serrata</i> Roxb. ex Colebr. The ... Read more >>

Drugs Context (Drugs in context)
[2020, 9:]

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Progestogens as a component of menopausal hormone therapy: the right molecule makes the difference.

John C Stevenson, Serge Rozenberg, Silvia Maffei, Christian Egarter, Petra Stute, Thomas Römer,

Optimizing menopausal hormone therapy (MHT) requires an awareness of the benefits and risks associated with the available treatments. This narrative review, which is based on the proceedings of an Advisory Board meeting and supplemented by relevant articles identified in literature searches, examines the role of progestogens in MHT, with the ... Read more >>

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[2020, 9:]

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Ertugliflozin in the treatment of type 2 diabetes mellitus.

Joel C Marrs, Sarah L Anderson,

More than 422 million people worldwide have diabetes, with 90-95% having type 2 diabetes (T2D). Glycemic control of T2D has demonstrated reductions in microvascular complications but recent data have demonstrated improvements in macrovascular outcomes with sodium-glucose cotransporter 2 (SGLT2) inhibitors. Ertugliflozin is the most recent SGLT2 inhibitor approved in the ... Read more >>

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[2020, 9:]

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Cost per response analysis of repository corticotropin injection versus other alternative treatments for acute exacerbations of multiple sclerosis.

George J Wan, Ishveen Chopra, John Niewoehner, Samuel F Hunter,

<h4>Background</h4>Relapses are common in patients with multiple sclerosis (MS) even after the use of disease-modifying therapies. Repository corticotropin injection (RCI), plasmapheresis (PMP), and intravenous immunoglobulin (IVIg) may be utilized as alternative therapies in the management of MS relapse. There is a lack of health economic studies on these alternative therapies ... Read more >>

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[2020, 9:]

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Role of renin-angiotensin-aldosterone system inhibitors in heart failure and chronic kidney disease.

Namrata Singhania, Saurabh Bansal, Shreya Mohandas, Divya P Nimmatoori, Abutaleb A Ejaz, Girish Singhania,

Renin-angiotensin-aldosterone system (RAAS) inhibitors are the key medications for patients with heart failure and chronic kidney disease. Multiple randomized controlled trials have demonstrated their benefits in an outpatient setting for the treatment of chronic heart failure. Additional advantages in acute heart failure treatment during inpatient hospitalization are less clear but ... Read more >>

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[2020, 9:]

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Emerging systemic JAK inhibitors in the treatment of atopic dermatitis: a review of abrocitinib, baricitinib, and upadacitinib.

Novin Nezamololama, Keira Fieldhouse, Kristy Metzger, Melinda Gooderham,

The Janus kinases (JAK) are a group of molecules, composed of JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2), which are key components within the JAK-signal transducers and activators of transcription pathway, where cytokine receptor signaling takes place. These molecules play a foundational role in the underlying pathogenesis of multiple ... Read more >>

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[2020, 9:]

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Dabigatran, the oral anticoagulant of choice at discharge in patients with non-valvular atrial fibrillation and COVID-19 infection: the ANIBAL protocol.

Teodoro Iturbe-Hernandez, Luis García de Guadiana Romualdo, Ignacio Gil Ortega, Antonio Martínez Francés, Olga Meca Birlanga, Juan José Cerezo-Manchado,

Atrial fibrillation is a frequent complication among patients with severe coronavirus disease-2019 (COVID-19) infection. Both direct and indirect mechanisms through COVID-19 have been described to explain this relationship. COVID-19 infection increases the risk of developing both arterial and venous thrombotic complications through systemic coagulation activation, leading to increased mortality. Chronic ... Read more >>

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[2020, 9:]

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TAS-102 in metastatic colorectal cancer (mCRC): efficacy, tolerability, and quality of life in heavily pretreated elderly patients: a real-life study.

Giuseppe Cicero, Raffaele Addeo, Rossella De Luca, Giuseppe Lo Re, Leonardo Gulotta, Pierenrico Marchesa, Gaspare Gulotta,

<h4>Background</h4>TAS-102 is an oral monotherapy, combining trifluridine and tipiracil hydrochloride, indicated for the treatment of pretreated metastatic colorectal cancer (mCRC). The aim of this real-life study is to evaluate the efficacy and safety of TAS-102 in heavily pretreated elderly patients with mCRC whose disease has progressed with standard therapies.<h4>Methods</h4>In this ... Read more >>

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[2020, 9:]

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Cutaneous adverse events and quality of life in outpatients receiving anticancer agents: results from an observational, cross-sectional study.

Hae-Jin Suh Oh, Ángeles Flórez Menéndez, Víctor Sacristán Santos, Francisca Fernández Ribeiro, Lucía Vilanova-Trillo, Manuel Constenla Figueiras, Manuel Pereiro Ferreiros,

<h4>Background</h4>Despite growing interest in cutaneous adverse events (CAEs) and their management in patients with cancer, they are often underreported and there are no extensive data on their impact on quality of life (QoL). Healthcare professionals should consider this issue in order to minimize its negative impact on QoL and improve ... Read more >>

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[2020, 9:]

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Mepolizumab: an alternative therapy for idiopathic chronic eosinophilic pneumonia with glucocorticoid intolerance.

Adam Kisling, Jason Jones, Caleb Hixson, David Hostler, Jordanna Hostler,

A 55-year-old woman with cough-variant asthma presented for 1 month of worsening wheezing, cough, and dyspnea refractory to treatment. Initial laboratory findings revealed profound peripheral eosinophilia, and a chest computed tomography showed bi-apical consolidation. Bronchio-alveolar lavage demonstrated alveolar eosinophilia. She was diagnosed with idiopathic chronic eosinophilic pneumonia (ICEP). Her peripheral ... Read more >>

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[2020, 9:]

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Pharmacotherapy patterns in patients with chronic idiopathic constipation beginning treatment with linaclotide or lubiprostone in the United States.

Arpita Nag, Rebecca Bornheimer, Gerry Oster,

<h4>Background</h4>Chronic idiopathic constipation (CIC) is a common gastrointestinal disorder in community settings. Limited information exists on its treatment with the prosecretory agents linaclotide and lubiprostone. This retrospective cohort study investigated real-world pharmacotherapy patterns of linaclotide and lubiprostone.<h4>Methods</h4>Patients (≥18 years) with CIC who received linaclotide or lubiprostone between January 2013 and ... Read more >>

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[2020, 9:]

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Potential risk of drug-drug interactions with hormonal contraceptives and antiretrovirals: prevalence in women living with HIV.

Milena M Murray, Ashley Jensen, Thomas Cieslik, Susan E Cohn,

<h4>Background</h4>Family planning services are vital for women living with HIV (WLH); however, the use of concomitant antiretroviral therapy (ART) and hormonal contraceptives (HCs) may pose challenges due to the risk of potential drug-drug interactions (DDIs). The objectives of this study were to assess ART and HC use among WLH and ... Read more >>

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[2020, 9:]

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Mycosis fungoides-type cutaneous T-cell lymphoma (MF-CTCL) epidemiology and treatment pathway in Spain: new insights for an accurate description.

Paolo D'Agostino, Alan Kent, Eric Sharp, Fabian Schmidt, Marco Turini,

<h4>Background</h4>Mycosis fungoides-type cutaneous T-cell lymphoma (MF-CTCL) is a rare lymphoma localized in the skin. Due to its indolent nature and similarity to other skin conditions, diagnosis is often delayed or incorrect. Consequently, accurate calculations of incidence and prevalence are difficult to make. The treatment pathway taken by MF-CTCL patients can ... Read more >>

Drugs Context (Drugs in context)
[2020, 9:]

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Use of biologic agents and risk of tuberculosis in Brazil, a tuberculosis high-burden country.

Fernanda Gomes Gonçalves Chaer, Juliana Miranda de Lucena Valim, Rogério Castro Reis, Giselle Burlamaqui Klautau, Branca Dias Batista de Souza,

Background:Brazil is a country with a high burden of tuberculosis (TB). The immunomodulatory effect of biological therapies is associated with an increased risk of infection. This study evaluated the frequency of TB infection in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), juvenile idiopathic arthritis (JIA), and psoriatic arthritis (PsA) ... Read more >>

Drugs Context (Drugs in context)
[2020, 9:212598]

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The impact of antidepressants on depressive symptom severity, quality of life, morbidity, and mortality in heart failure: a systematic review.

Rebecca Hedrick, Samuel Korouri, Emile Tadros, Tarneem Darwish, Veronica Cortez, Desiree Triay, Mia Pasini, Linda Olanisa, Nathalie Herrera, Sophia Hanna, Asher Kimchi, Michele Hamilton, Itai Danovitch, Waguih William IsHak,

Objective:The purpose of this paper is to review the literature on the impact of antidepressants on depressive symptom severity, quality of life (QoL), morbidity, and mortality in patients with heart failure (HF). Methods:Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) Reporting Items for Systematic Reviews and Meta-Analyses ... Read more >>

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[2020, 9:]

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Urinary tract infections in the elderly: a review of disease characteristics and current treatment options.

Leocadio Rodriguez-Mañas,

Urinary tract infections (UTIs) are common in the elderly, and cover a range of conditions from asymptomatic bacteriuria to urosepsis. Risk factors for developing symptomatic UTIs include immunosenescence, exposure to nosocomial pathogens, multiple comorbidities, and a history of UTIs. European guidelines on urological infections recommend antimicrobial treatment only for symptomatic ... Read more >>

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[2020, 9:]

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Hydroxychloroquine-induced hyperpigmentation in a 14-year-old female with systemic lupus erythematosus.

Alexander Kc Leung, Tara McMillan, Andrea Human, Joseph M Lam,

Hydroxychloroquine (HCQ)-induced hyperpigmentation is uncommon but is increasingly recognized. To our knowledge, HCQ-induced hyperpigmentation has not been reported in the pediatric age group. Herein, we present the case of a 14-year-old girl with systemic lupus erythematosus, who developed hyperpigmentation on her shins and dorsum of the left foot, approximately 3 ... Read more >>

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[2020, 9:]

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Experience with ospemifene in a patient with vulvovaginal atrophy and dyslipidemia: a case study.

Silvia Pilar González Rodríguez,

The changes that occur in sex hormone levels, body composition, and lipid/lipoprotein levels during the menopause transition, together with vascular remodeling, increase the risk of cardiovascular disease (CVD) in postmenopausal women. Any treatments prescribed for concomitant conditions during menopause should not exacerbate CVD risk factors. Ospemifene is the first non-hormonal, ... Read more >>

Drugs Context (Drugs in context)
[2020, 9:]

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Tinea corporis: an updated review.

Alexander Kc Leung, Joseph M Lam, Kin Fon Leong, Kam Lun Hon,

<h4>Background</h4>Tinea corporis is a common fungal infection that mimics many other annular lesions. Physicians must familiarize themselves with this condition and its treatment.<h4>Objective</h4>This article aimed to provide a narrative updated review on the evaluation, diagnosis, and treatment of tinea corporis.<h4>Methods</h4>A PubMed search was performed with Clinical Queries using the key ... Read more >>

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[2020, 9:]

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Comparison of modafinil and pitolisant in narcolepsy: a non-inferiority meta-analytical approach.

Philippe Lehert, Cassandra Szoeke,

<h4>Aim</h4>To assess the non-inferiority of pitolisant, a new compound for the relief of excessive daytime sleepiness (EDS) and cataplexy in narcolepsy, compared with modafinil.<h4>Methods</h4>Randomized controlled trials (RCTs) in narcolepsy were searched systematically. Network meta-analysis (NMA) compared the efficacy and safety of pitolisant and modafinil. The main endpoints are Epworth Sleepiness ... Read more >>

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[2020, 9:]

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Reducing residual thrombotic risk in patients with peripheral artery disease: impact of the COMPASS trial.

José Luis Hernández, Francisco S Lozano, Vincent Riambau, Manuel Almendro-Delia, Juan Cosín-Sales, Sergi Bellmunt-Montoya, Javier Garcia-Alegria, Xavier Garcia-Moll, Juan José Gomez-Doblas, José R Gonzalez-Juanatey, Carmen Suarez Fernández,

Patients with peripheral artery disease (PAD) are at a high risk not only for the classical cardiovascular (CV) outcomes (major adverse cardiovascular events; MACE) but also for vascular limb events (major adverse limb events; MALE). Therefore, a comprehensive approach for these patients should include both goals. However, the traditional antithrombotic ... Read more >>

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[2020, 9:]

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Experience with ospemifene in patients with vulvar and vaginal atrophy and urinary incontinence: case studies.

Zuramis Estrada Blanco, Mariella Lilue, Santiago Palacios,

Pelvic floor muscle atrophy and collagen loss in connective tissue due to declining estrogen production in women as they age may underlie the increasing prevalence of urge and stress incontinence. Estrogen therapy can correct the deficiency of estrogen receptors in genitourinary structures after menopause, but estrogen is not suitable for ... Read more >>

Drugs Context (Drugs in context)
[2020, 9:]

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Kawasaki disease in siblings and a review of drug treatment.

Steven King-Fan Loo, Kam Lun Hon, Alexander Kc Leung, Tak Cheung Yung, Man Ching Yam,

We have managed two anonymized siblings with Kawasaki disease (KD). The occurrence of KD in the elder brother alerted us to the occurrence of incomplete KD in the younger brother. Both siblings were treated with intravenous immunoglobulin and a high dose of dipyridamole with resolution of the coronary artery aneurysm. ... Read more >>

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[2020, 9:]

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Experience with ospemifene in patients with vulvar and vaginal atrophy and associated sexual dysfunction: case studies.

Ana Rosa Jurado López, Francisca Molero Rodríguez,

The pathophysiological changes associated with hypoestrogenism of menopause, a condition known as genitourinary syndrome of menopause, are responsible for the hallmark symptoms of vulvovaginal atrophy (VVA), namely dyspareunia secondary to vaginal dryness. Many postmenopausal women with VVA find sexual relations to be challenging or impossible. Ospemifene has estrogen-like effects on ... Read more >>

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[2020, 9:]

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