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Conjunctivitis in patients with atopic dermatitis treated with dupilumab.

Sandra Ferreira, Tiago Torres,

Atopic dermatitis (AD) is a common, chronic, inflammatory skin disorder with high physical and emotional burden. Robust evidence suggests that interleukin (IL)-4 and IL-13 are key cytokines in the immunopathogenesis of AD. New emerging agents include dupilumab, a fully human monoclonal antibody directed against the IL-4 receptor a subunit that ... Read more >>

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[2020, 9:]

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Rectal neuroendocrine carcinoma: case report of a rare entity and perspective review of promising agents.

Gabriela Antelo, Cinta Hierro, Juan Pablo Fernández, Eduardo Baena, Cristina Bugés, Laura Layos, José Luis Manzano, Mónica Caro, Ricard Mesia,

Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of tumours, which can be classified into neuroendocrine tumours (NETs), neuroendocrine carcinomas (NECs) and mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs). To date, there is no consensus regarding the optimal therapy, which usually depends on the primary location and classification, according to morphological features of ... Read more >>

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[2020, 9:]

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Facing the COVID-19 outbreak in children with cancer.

Antonio Ruggiero, Alberto Romano, Giorgio Attinà,

Europe is now the epicenter of the COVID-19 outbreak. Many concerns have arisen about the management and treatment of children with cancer while researchers are wondering how to deal with this devastating pandemic. In view of the epidemiological and clinical characteristics of the COVID-19 outbreak, it is fundamental to stress ... Read more >>

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[2020, 9:]

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Can bone turnover markers help to define the suitability and duration of bisphosphonate drug holidays?

Louise Statham, Sharon Abdy, Terry J Aspray,

Background:On stopping bisphosphonate treatment, bone resorption may increase before evidence of a decrease in bone density. Offset of bisphosphonate effect may therefore be monitored by measuring C-terminal telopeptide (CTX) following long-term bisphosphonate treatment to inform clinical decisions on drug holiday. Methods:Retrospective analysis of 158 patients (83% female, mean age 71 ... Read more >>

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[2020, 9:]

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Use of anti-CD20 therapy in follicular and marginal zone lymphoma: a review of the literature.

Luis Miguel Juárez-Salcedo, Diego Conde-Royo, Keina Quiroz-Cervantes, Samir Dalia,

The identification of the CD20 antigen in 1979 was the first step in what would become a therapeutic milestone opening the use of immunotherapy in hematological diseases. This protein is expressed on the surface of developing B cells, but not the early progenitors or mature plasma cells. In 1997, rituximab ... Read more >>

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[2020, 9:]

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Cinacalcet adherence in dialysis patients with secondary hyperparathyroidism in Lombardy Region: clinical implications and costs.

Alessandro Roggeri, Ferruccio Conte, Carlotta Rossi, Mario Cozzolino, Carlo Zocchetti, Daniela Paola Roggeri,

Patients on dialysis often have secondary hyperparathyroidism (SHPT), a disorder associated with renal osteodystrophy, progressive vascular calcification, cardiovascular disease, and death. The objective of this retrospective observational study was to evaluate, in dialysis patients with SHPT, the impact of different levels of adherence to cinacalcet therapy on hospitalisations and direct ... Read more >>

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[2020, 9:]

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Corrigendum: Efficacy and safety of photodynamic therapy with RLP068 for diabetic foot ulcers: a review of the literature and clinical experience.

[This corrects the article DOI: 10.7573/dic.2019-10-3.]. ... Read more >>

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[2020, 9:]

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Inflammatory bowel disease in patients with psoriasis treated with interleukin-17 inhibitors.

Keira A Fieldhouse, Samantha Ukaibe, Erika L Crowley, Reena Khanna, Ashley O'Toole, Melinda J Gooderham,

Background:Interleukin 17 (IL-17) inhibitors provide an excellent treatment option for patients with psoriasis and psoriatic arthritis, resulting in high levels of efficacy for skin clearance and joint improvement. Safety has also been established in clinical trials for this group of biologic agents; however, rare case reports of exacerbation or induction ... Read more >>

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[2020, 9:]

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Multifocal infantile haemangiomatosis with hepatic involvement: two cases and treatment management.

Antonio Ruggiero, Palma Maurizi, Silvia Triarico, Michele Antonio Capozza, Stefano Mastrangelo, Giorgio Attinà,

Infantile haemangiomas (IHs) are the most common benign tumours of childhood; despite the benign histology, prognosis depends on severity of visceral involvement, with a mortality rate ranging from 50 to 90%. In this paper, we describe two infants with multifocal infantile haemangiomatosis and hepatic involvement. This condition should receive appropriate ... Read more >>

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[2020, 9:]

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Tics and Tourette's syndrome.

Shivam Om Mittal,

Tics and Tourette's syndrome are common hyperkinetic movement disorders seen mostly in the pediatric age group. Tics are defined as sudden, rapid, recurrent, nonrhythmic motor movements or vocalization, generally preceded by urge. Tourette's syndrome is defined as the presence of both motor and phonic tics for more than 1 year ... Read more >>

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[2020, 9:]

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HIV, drugs and the kidney.

Nicola Wearne, Bianca Davidson, Marc Blockman, Annoesjka Swart, Erika Sw Jones,

Human immunodeficiency virus (HIV) affects over 36 million people worldwide. Antiretroviral therapy (ART) is expanding and improving HIV viral suppression, resulting in increasing exposure to drugs and drug interactions. Polypharmacy is a common complication as people are living longer on ART, increasing the risk of drug toxicities. Polypharmacy is related ... Read more >>

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[2020, 9:]

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Management of psoriasis in pregnancy - a review of the evidence to date.

Clara Ferreira, Alexandra Azevedo, Miguel Nogueira, Tiago Torres,

The onset of psoriasis collides with women's reproductive timeframe, and pregnancy brings challenges to its treatment. Indeed, the health of both mother and foetus must be considered. When choosing to treat pregnant women affected by psoriasis with pharmacological therapy, it is important to be aware of all possible options and ... Read more >>

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[2020, 9:]

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Tumor lysis syndrome in childhood malignancies.

Wing Lum Cheung, Kam Lun Hon, Cheuk Man Fung, Alexander Kc Leung,

Background:Tumor lysis syndrome (TLS) is the most common life-threatening oncological emergency encountered by physicians treating children with lymphoproliferative malignancies. Healthcare providers should be aware of the condition in order to prevent occurrence and prompt timely management to avoid severe consequences. Objective:To provide an update on the current understanding, evaluation, and ... Read more >>

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[2020, 9:]

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Vedolizumab in the treatment of inflammatory bowel disease: evolving paradigms.

Benjamin Crooks, Tom Barnes, Jimmy K Limdi,

Inflammatory bowel diseases, comprising Crohn's disease (CD) and ulcerative colitis (UC), are chronic, relapsing and remitting immune-mediated inflammatory diseases affecting the gastrointestinal tract. Vedolizumab is the first licensed drug in a group of 'gut-selective' biological agents used to treat inflammatory bowel diseases. The GEMINI registrational trials established the efficacy of ... Read more >>

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[2020, 9:]

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DAPA-HF trial: dapagliflozin evolves from a glucose-lowering agent to a therapy for heart failure.

Edgardo Kaplinsky,

Heart failure (HF) continues to be a major global health problem with a notable impact in terms of morbidity and mortality and so, in consequence, with a large unmet necessity for new therapies. The inhibition of sodium-glucose cotransporter 2 (SGLT2) causes glycosuria and natriuresis, leading to reductions in hyperglycemia (antidiabetic ... Read more >>

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[2020, 9:]

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Considerations for the US health-system pharmacist in a world of biosimilars.

Andrea Zlatkus, Todd Bixby, Kavitha Goyal,

As numerous biosimilar products are forecast to enter the US market in the coming years, health-system pharmacists will be faced with novel challenges while incorporating them into clinical practice. The current regulatory approval framework and guidance from the US Food and Drug Administration do not address many real-world scenarios that ... Read more >>

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[2020, 9:]

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Efficacy and safety of photodynamic therapy with RLP068 for diabetic foot ulcers: a review of the literature and clinical experience.

Felicia Pantò, Liboria Adamo, Carla Giordano, Carmelo Licciardello,

This article is the second part of a literature review concerning diabetic foot ulcers (DFUs) and the use of antimicrobial photodynamic therapy (PDT). PDT involves the topical application of a photosensitiser into the tissue, followed by illumination that induces the formation of reactive oxygen species (ROS). PDT provides bacterial inactivation ... Read more >>

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[2020, 9:]

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Clinical use of Capilen, a liposomal cream based on fresh plant extracts enriched with omega fatty acids.

Luca Giacomelli, Alessandra Moglia, Gianedoardo Losa, Pietro Quaglino,

The skin is the largest organ in the human body; beyond its regulatory and sensory roles, it is meant to protect and act like a barrier against foreign matter. Products intended to restore the skin health should reintegrate the structure of the stratum corneum in which the corneocytes are surrounded ... Read more >>

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[2020, 9:]

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Efficacy and safety of a GABAergic drug (Gamalate® B6): effects on behavior and cognition in young adults with borderline-to-mild intellectual developmental disabilities and ADHD.

Ramón Novell, Susanna Esteba-Castillo, Emili Rodriguez,

Background:We evaluated Gamalate® B6 (GB6) in patients with borderline intellectual functioning (BIF) or mild intellectual development disability (IDD). Patients and methods:This was a prospective phase IV observational pilot study in 30 patients who underwent neuropsychological evaluation during treatment with GB6 for 12 weeks. Results:In comparison with baseline, the responses were ... Read more >>

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[2020, 9:212601]

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Management of type 2 diabetes: consensus of diabetes organizations.

Elaena Quattrocchi, Tamara Goldberg, Nino Marzella,

Despite the advances in diabetes management, people with diabetes are not reaching their target glycemic goals. Healthcare professionals often fail to initiate, escalate, or de-intensify therapy when indicated. There are several organizations that provide guidance on the management of diabetes to assist the practitioner in achieving improved glycemic control, and ... Read more >>

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[2020, 9:212607]

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Combination checkpoint inhibitors for treatment of non-small-cell lung cancer: an update on dual anti-CTLA-4 and anti-PD-1/PD-L1 therapies.

Sonam Puri, Michael Shafique,

Immunotherapy has revolutionized cancer treatment. In non-small-cell lung cancer (NSCLC), monotherapy with immune checkpoint inhibitors has improved survival in metastatic disease. Combinations of immune checkpoint inhibitors have shown synergy in preclinical models and are being studied as part of the treatment armamentarium in NSCLC. This review discusses the rationale, outcomes, ... Read more >>

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[2020, 9:]

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Activity of platinum and cetuximab in cutaneous squamous cell cancer not amenable to curative treatment.

Donata Galbiati, Stefano Cavalieri, Salvatore Alfieri, Carlo Resteghini, Cristiana Bergamini, Ester Orlandi, Francesca Platini, Laura Locati, Luca Giacomelli, Lisa Licitra, Paolo Bossi,

Background:Unresectable or metastatic cutaneous squamous cell cancers (cSCCs) are rare but potentially life-threatening diseases. In this setting, systemic therapy has a palliative intent with limited benefit, but there is no established consensus regarding the proper management of this tumour. This retrospective study aimed to review outcomes in patients with non-curable ... Read more >>

Drugs Context (Drugs in Context)
[2019, 8:212611]

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Thyrotoxicosis after massive triiodothyronine (LT3) overdose: a coast-to-coast case series and review.

Zhiheng H He, Yan Li, Nitin Trivedi, Sabrina Gill, James V Hennessey,

Excessive exogenous thyroid hormone ingestion may lead to severe thyrotoxicosis and cause potential harm. We have reviewed the literature and suggested that thyroid hormone supplementation should not be used to alleviate nonspecific complaints in patients with normal endogenous thyroid function. Failure to do so may cause serious harm, as demonstrated ... Read more >>

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[2020, 9:]

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Corrigendum: Breakthroughs in hereditary angioedema management: a systematic review of approved drugs and those under research.

[This corrects the article on p. 212605 in vol. 8, PMID: 31645881.]. ... Read more >>

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[2019, 8:]

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Drug therapy for double-hit lymphoma.

Vania Phuoc, Jose Sandoval-Sus, Julio C Chavez,

Double-hit lymphoma (DHL) is a rare type of aggressive B-cell lymphoma defined as a high-grade B-cell lymphoma (HGBCL) with the presence of MYC, BCL2 and/or BCL6 rearrangements. Patients usually present with rapidly progressive and advanced stage of disease and, commonly, with extranodal involvement. Typically, patients become refractory to standard R-CHOP, ... Read more >>

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[2019, 8:]

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