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Journal Drugs Aging

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Potentially Inappropriate Medications, Drug-Drug Interactions, and Anticholinergic Burden in Elderly Hospitalized Patients: Does an Association Exist with Post-Discharge Health Outcomes?

Antonio De Vincentis, Paolo Gallo, Panaiotis Finamore, Claudio Pedone, Luisa Costanzo, Luca Pasina, Laura Cortesi, Alessandro Nobili, Pier Mannuccio Mannucci, Raffaele Antonelli Incalzi,

BACKGROUND:Polypharmacy is very common in elderly patients and is associated with detrimental outcomes. OBJECTIVE:Our objective was to evaluate the associations between a large panel of therapy quality indicators, including explicit lists of potentially inappropriate medications (PIMs; Beers criteria and Screening Tool of Older Persons' potentially inappropriate Prescriptions [STOPP] criteria), the ... Read more >>

Drugs Aging (Drugs & aging)
[2020, :]

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Treatment Patterns of Lipid-Lowering Therapy in Patients with Coronary Artery Disease Aged Above and Below 75 Years: A Retrospective Cross-Sectional Study of 1500 Patients in a Tertiary Care Referral Center in Germany.

Iryna Dykun, Daniela Wiefhoff, Matthias Totzeck, Fadi Al-Rashid, R Alexander Jánosi, Stefanie Hendricks, Tienush Rassaf, Amir A Mahabadi,

INTRODUCTION:Lipid-lowering therapy of elderly patients with coronary artery disease (CAD) inherits a medical challenge, as these patients experience a higher absolute risk reduction but may be more prone to side effects. We aimed to evaluate the treatment patterns in lipid-lowering therapy, comparing CAD patients above versus below 75 years of age. ... Read more >>

Drugs Aging (Drugs & aging)
[2020, :]

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Bimatoprost Implant: First Approval.

Matt Shirley,

Bimatoprost implant (Durysta™), developed by Allergan, is a sustained-release drug delivery system containing bimatoprost, a prostaglandin analogue with ocular hypotensive activity. The implant, administered intracamerally, involves the use of a biodegradable, solid polymer drug delivery system for slow, sustained drug release, designed to lower intraocular pressure (IOP) over a 4- ... Read more >>

Drugs Aging (Drugs & aging)
[2020, :]

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Hand Grip Strength May Affect the Association Between Anticholinergic Burden and Mortality Among Older Patients Discharged from Hospital.

Sonia D'Alia, Francesco Guarasci, Luca Bartucci, Ramona Caloiero, Maurizio Leonardo Guerrieri, Luca Soraci, Daniele Colombo, Lucia Crescibene, Graziano Onder, Stefano Volpato, Antonio Cherubini, Carmelinda Ruggiero, Andrea Corsonello, Fabrizia Lattanzio, Paolo Fabbietti,

BACKGROUND AND OBJECTIVE:The relationship between anticholinergic burden and mortality is unclear, and the impact of anticholinergic burden on prognosis may vary in the presence of other conditions common in old age. We aimed to investigate the role of hand grip strength as a potential effect modifier in the association between ... Read more >>

Drugs Aging (Drugs & aging)
[2020, :]

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Management of Older Adults with Mantle Cell Lymphoma.

Jason T Romancik, Jonathon B Cohen,

Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma that is largely a disease of older adults with a median age at diagnosis of 67 years. MCL is considered incurable with current therapies and has historically been associated with a poor prognosis. A subset of patients will present with features of ... Read more >>

Drugs Aging (Drugs & aging)
[2020, :]

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Prescribed Doses of CYP2D6-Metabolized Drugs and Hemodynamic Responses in Relation to CYP2D6 Genotype Among Older Patients Exposed to Polypharmacy.

Rita Romskaug, Torgeir Bruun Wyller, Jørund Straand, Hege Kersten, Espen Molden,

BACKGROUND:Many drugs with dose-dependent effects on hemodynamic variables are metabolized by cytochrome P450 2D6 (CYP2D6). The aim of this study was to compare prescribed dosages and hemodynamic responses of such drugs in relation to pharmacogenetic variability in CYP2D6 metabolism among patients aged ≥ 70 years exposed to polypharmacy. MATERIALS AND METHODS:We included 173 ... Read more >>

Drugs Aging (Drugs & aging)
[2020, :]

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Frailty and Co-Prescribing of Potentially Interacting Drugs in New Users of Warfarin.

Milka Hauta-Aho, Simo Teperi, Maarit J Korhonen, J Simon Bell, Nicholas Farinola, Sally Johns, Sepehr Shakib, Risto Huupponen,

BACKGROUND:Warfarin is underutilised in frail older people because of the fear of bleeding complications. Drug interactions are an independent bleeding risk factor. However, the extent to which potential drug interactions are taken into account at warfarin therapy initiation in frail patients is not known. OBJECTIVE:The objective of this study was ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(5):373-382]

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Measuring Medication Self-Management Capacity: A Scoping Review of Available Instruments.

Amal M Badawoud, Teresa M Salgado, Juan Lu, Pamela Parsons, Emily P Peron, Patricia W Slattum,

BACKGROUND:Managing a medication regimen is a complex self-care activity that requires a high level of integration and coordination between cognitive and physical skills. This scoping review aims to identify available instruments designed to assess an adult individual's ability to manage a medication regimen independently and to identify reliable and valid ... Read more >>

Drugs Aging (Drugs & aging)
[2020, :]

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Immunotherapy in Older Patients with Advanced Melanoma: A Review of the Current Evidence.

Tiffany Foo, Gonzalo Tapia Rico, Rachel Roberts-Thomson,

Despite the increasing incidence of metastatic melanoma in the older population, there is relatively limited specific data surrounding the use of immunotherapy for the treatment of advanced melanoma for patients above the age of 65 years. To date, there has not been a prospective trial done to evaluate the safety and ... Read more >>

Drugs Aging (Drugs & aging)
[2020, :]

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An Analysis of Anesthesia Induction Dosing in Female Older Adults.

Eric Y Chen, George Michel, Bin Zhou, Feng Dai, Shamsuddin Akhtar, Robert B Schonberger,

BACKGROUND/OBJECTIVES:In the context of an aging surgical population, appropriate anesthetic induction dose adjustments for the older adult remain poorly defined. In the present study, we describe the prevalence of excess induction agent dose in reference to US Food and Drug Administration (FDA) guidance and seek to investigate the possible association of ... Read more >>

Drugs Aging (Drugs & aging)
[2020, :]

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Chronic Post-Surgical Pain in the Frail Older Adult.

Gary Esses, Stacie Deiner, Fred Ko, Yury Khelemsky,

Older adults are the fastest growing segment of the population and surgical procedures in this group increase each year. Chronic post-surgical pain is an important consideration in the older adult as it affects recovery, physical functioning, and overall quality of life. It is increasingly recognized as a public health issue ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(5):321-329]

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Prevalence and Factors Associated with Analgesic Prescribing in Poly-Medicated Elderly Patients.

Aymen Ali Al-Qurain, Lemlem G Gebremichael, Muhammad Suleman Khan, Desmond B Williams, Lorraine Mackenzie, Craig Phillips, Patrick Russell, Michael S Roberts, Michael D Wiese,

BACKGROUND:Pain is common in older patients and management guidelines rarely consider the effect of multiple comorbidities and concurrent medications on analgesic selection. OBJECTIVES:The objectives of this study were to identify the prevalence and pattern of analgesic prescribing and associated factors in older patients with polypharmacy. METHODS:Older patients (aged ≥ 75 years) admitted to ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(4):291-300]

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Psychotropic Drug-Associated Pneumonia in Older Adults.

Blair Rajamaki, Sirpa Hartikainen, Anna-Maija Tolppanen,

The use of psychotropic drugs (antipsychotics, benzodiazepines and benzodiazepine-related drugs, and antidepressants) is common, with a prevalence estimates range of 19-29% among community dwelling older adults. These drugs are often prescribed for off-label use, including neuropsychiatric symptoms. The older adult population also has high rates of pneumonia and some of ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(4):241-261]

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Comparison of Healthcare Resource Utilization and Costs between Rivaroxaban and Warfarin for Nonvalvular Atrial Fibrillation in a Skilled Nursing Facility Setting.

Dheeraj Mahajan, Bingcao Wu, Ji Song, Dejan Milentijevic, Veronica Ashton, V Simon Mittal,

BACKGROUND:Use of direct-acting oral anticoagulants for patients with nonvalvular atrial fibrillation (NVAF) in skilled nursing facilities (SNFs) is increasing. Rivaroxaban is commonly used in this setting as an alternative to warfarin, based on comparable or increased efficacy in preventing stroke and a similar or lower risk of major bleeding. OBJECTIVE:The ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(4):281-289]

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Benzodiazepine Prescribing in People with Chronic Obstructive Pulmonary Disease: Clinical Considerations.

David C Currow, Meera R Agar,

Benzodiazepines, available clinically for almost six decades, are still one of the most widely prescribed classes of medication. The proportion of the population prescribed benzodiazepines increases with age, and harms also increase with age. The prevalence of prescribing in people > 85 years of age is as high as one in three, including ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(4):263-270]

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The Evolving Complexity of Treating Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor-2 (HER2)-Negative Breast Cancer: Special Considerations in Older Breast Cancer Patients-Part II: Metastatic Disease.

Addie Hill, Eutiquio Gutierrez, Jennifer Liu, Sarah Sammons, Gretchen Kimmick, Mina S Sedrak,

Breast cancer is a disease of aging, and the incidence of breast cancer is projected to increase dramatically as the global population ages. The majority of breast cancers that occur in older adults are hormone-receptor positive, human epidermal growth factor receptor-2 (HER2)-negative phenotypes, with favorable tumor biology; yet, because of ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(5):349-358]

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Trends in the Dispensing and Costs of Glucose-Lowering Medications Among Older Australians: Findings from National Claims Data.

Ken Lee Chin, Frisky Maulida Hidayat, Richard Ofori-Asenso, Jenni Ilomäki, J Simon Bell, Sophia Zoungas, Danny Liew,

BACKGROUND:Temporal changes in the dispensing of glucose-lowering drugs (GLD) and their associated costs among elderly populations is unclear. This information is especially relevant to countries in which medications are partly or fully government subsidized. OBJECTIVE:Our objective was to estimate the trends in prevalence, incidence and costs associated with GLD dispensed ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(5):393-398]

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Use of SGLT2 Inhibitors in Older Adults: Scientific Evidence and Practical Aspects.

Joaquim Silva Custódio, Jarbas Roriz-Filho, Catarina Addobbati Jordão Cavalcanti, Amanda Martins, João Eduardo Nunes Salles,

Diabetes mellitus (DM) is an increasingly prevalent condition that has a significant impact on health systems worldwide, particularly in older people. It is estimated that 30% of people aged > 65 years fulfil the diagnostic criteria for DM, with 90% having type 2 DM (T2DM). Generally, specific guidelines for the treatment of T2DM ... Read more >>

Drugs Aging (Drugs & aging)
[2020, :]

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Risk of Cataract Surgery and Age-Related Macular Degeneration After Initiation of Denosumab vs Zoledronic Acid for Osteoporosis: A Multi-Database Cohort Study.

Hemin Lee, Yinzhu Jin, Miin Roh, Theodore N Tsacogianis, Sangshin Park, Nam-Kyong Choi, Seoyoung C Kim,

BACKGROUND AND OBJECTIVE:There is a relative lack of head-to-head comparisons of denosumab against other osteoporosis drugs on safety. We aimed to explore ocular outcomes in patients with osteoporosis initiating denosumab vs zoledronic acid. METHODS:We conducted a cohort study using claims data (2010-15) from two large US commercial insurance databases including ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(4):311-320]

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Safety and Efficacy of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain Receiving Opioid Therapy: A Subgroup Analysis of Patients ≥ 65 Years of Age.

James Wild, Lynn Webster, Tadaaki Yamada, Martin Hale,

BACKGROUND:Opioid-induced constipation (OIC), the most common side effect of opioid treatment, is under-recognized and undertreated in older patients. Naldemedine, an oral, peripherally acting μ-opioid receptor antagonist (PAMORA), is approved in Japan, the United States, and the European Union for treatment of OIC in adult patients. OBJECTIVE:This integrated analysis of three ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(4):271-279]

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Adverse Effects of Anticholinergic Drugs on Cognition and Mobility: Cutoff for Impairment in a Cross-Sectional Study in Young-Old and Old-Old Adults.

Elpidio Attoh-Mensah, Gilles Loggia, Pascale Schumann-Bard, Rémy Morello, Pablo Descatoire, Christian Marcelli, Chantal Chavoix,

BACKGROUND:Drugs with anticholinergic properties are commonly prescribed in older adults despite growing evidence of their adverse outcomes. Several issues regarding these detrimental effects remain unresolved, such as the putative existence of a threshold above which anticholinergic drug consumption impairs cognitive or mobility performance. OBJECTIVES:We aimed to investigate the number of ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(4):301-310]

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Comment on: "Pharmacological Management of Osteoporosis in Rheumatoid Arthritis Patients: A Review of the Literature and Practical Guide".

Gulistan Bahat, Birkan Ilhan, Mehmet Akif Karan,

Drugs Aging (Drugs & aging)
[2020, 37(3):237-238]

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Utilization Patterns of Amantadine in Parkinson's Disease Patients Enrolled in the French COPARK Study.

Olivier Rascol, Laurence Negre-Pages, Philippe Damier, Arnaud Delval, Pascal Derkinderen, Alain Destée, Margherita Fabbri, Wassilios G Meissner, Amine Rachdi, François Tison, Santiago Perez-Lloret, ,

INTRODUCTION:Immediate-release (IR) amantadine has been marketed for Parkinson's disease (PD) therapy for 50 years, while two novel extended-release formulations have only recently reached the market in the US. OBJECTIVES:The aim of this study was to describe amantadine IR utilization patterns in the French COPARK cohort, at baseline and after 2 ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(3):215-223]

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Atopic Dermatitis in Older Adults: A Review of Treatment Options.

Ryoji Tanei,

Atopic dermatitis (AD) in older adults (elderly AD) has recently emerged as a newly defined subgroup of AD. When selecting treatment options, clinical characteristics of elderly AD and age-specific factors of older patients must be considered. As in other age groups, regular application of moisturizers in combination with topical corticosteroids ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(3):149-160]

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Nursing Home Residents' Thoughts on Discussing Deprescribing of Preventive Medications.

Wade Thompson, Ida Theemann Jacobsen, Dorte Ejg Jarbøl, Peter Haastrup, Jesper Bo Nielsen, Carina Lundby,

BACKGROUND:Deprescribing of preventive medications may be considered in some nursing home residents. It is important to understand how to effectively communicate around this complex decision, from both a physician and resident perspective. OBJECTIVE:The objective of this study was to explore how nursing home residents would like to discuss deprescribing of ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(3):187-192]

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