Full Text Journal Articles in
Journal Drug Metabol Drug Interact

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In vitro inhibitory effects of herbal supplements on tamoxifen and irinotecan metabolism.

Fran Grappe, Gwen Nance, Lori Coward, Greg Gorman,

As the use of herbal supplements continues to rise throughout the world, the potential for drug-herbal interactions also increases. For chemotherapeutic prodrugs, this interaction could prevent the metabolic conversion of the prodrug to its active metabolite(s), thereby potentially resulting in subtherapeutic systemic exposure of the drug and reduced efficacy of ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(4):269-279]

Cited: 1 time

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Venlafaxine pharmacokinetics focused on drug metabolism and potential biomarkers.

Paulo Magalhães, Gilberto Alves, Adrián Llerena, Adrián Llerena, Amílcar Falcão,

Venlafaxine (VEN) is one of the safest and most effective drugs used in the treatment of selective serotonin reuptake inhibitors-resistant depression, and thereby it is nowadays one of the most commonly prescribed antidepressants. Nevertheless, patients treated with antidepressant drugs including VEN have exhibited large inter-individual variability in drug outcomes, possibly ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(3):129-141]

Cited: 6 times

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Liver enzyme abnormalities during antipsychotic treatment: a case report of risperidone-associated hepatotoxicity.

Enrique López-Torres, Agnes Süveges, Eva M Peñas-LLedó, Alvaro Doña, Pedro Dorado, Adrián LLerena, Adrián LLerena, Roland Berecz,

Drug-induced liver enzyme abnormalities may indicate hepatic injury. Antipsychotic drugs also may cause increase in the liver enzymes and serum bilirubin levels. The present report evaluates the case of a patient with risperidone-associated hepatocellular damage.A 19-year-old Caucasian man was admitted to the Department of Psychiatry with paranoid schizophrenia and risperidone ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(2):123-126]

Cited: 3 times

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Systems medicine, stratified medicine, personalized medicine but not precision medicine.

Gérard Siest,

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(1):1-2]

Cited: 5 times

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Ethics and law in research with human biological samples: a new approach.

Carlo Petrini,

During the last century a large number of documents (regulations, ethical codes, treatises, declarations, conventions) were published on the subject of ethics and clinical trials, many of them focusing on the protection of research participants. More recently various proposals have been put forward to relax some of the constraints imposed ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(1):61-63]

Cited: 0 times

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The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect.

Zahra Merali, Stephanie Ross, Guillaume Paré,

Human carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are serine esterases responsible for the hydrolysis of ester and amide bonds present in a number of pharmaceutical products. Several common genetic variants of the CES1 and CES2 genes have been shown to influence drug metabolism and clinical outcomes. Polymorphisms of the ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(3):143-151]

Cited: 25 times

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Molecular functionality of CYP2C9 polymorphisms and their influence on drug therapy.

Yazun Bashir Jarrar, Su-Jun Lee,

CYP2C9 metabolizes approximately 20% of clinically used drugs, including the narrow therapeutic window drugs warfarin and phenytoin. More than 16,000 variants have been reported in the National Center for Biotechnology Information CYP2C9 database, as well as 58 alleles in the official P450 Nomenclature Committee website. Two single nucleotide polymorphisms represented ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(4):211-220]

Cited: 7 times

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Frequency of CYP450 enzyme gene polymorphisms in the Greek population: review of the literature, original findings and clinical significance.

Georgia Ragia, Efstathia Giannakopoulou, Makrina Karaglani, Ioanna-Maria Karantza, Anna Tavridou, Vangelis G Manolopoulos,

The cytochrome P450 (CYP450) enzyme family is involved in the oxidative metabolism of many therapeutic drugs and various endogenous substrates. These enzymes are highly polymorphic. Prevalence of CYP450 enzyme gene polymorphisms vary among different populations and substantial inter- and intra-ethnic variability in frequency of CYP450 enzyme gene polymorphisms has been ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(4):235-248]

Cited: 5 times

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Importance of ABC transporters in different tissues.

Umashankar Vetrivel, Gurunathan Subramanian,

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(2):65-66]

Cited: 0 times

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Potential pharmacokinetic interactions of therapeutic cytokines or cytokine modulators on small-molecule drugs: mechanistic understanding via studies using in vitro systems.

Jin Zhou, Feng Li,

The potential pharmacokinetic interactions between macromolecules and small-molecule drugs have received more and more attention with the increasing development of macromolecule therapeutics. Studies have shown that cytokines can differentially modulate drug-metabolizing enzymes and transporters, which raises concerns on the potential interactions of therapeutic cytokines and cytokine modulators on the disposition ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(1):17-28]

Cited: 1 time

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Interaction of vitamin K antagonists and trimethoprim-sulfamethoxazole: ignore at your patient's risk.

Sarah Fetterman Hale, Timothy S Lesar,

The aim of the study was to summarize available literature regarding the interaction between vitamin K antagonists (VKAs) and trimethoprim-sulfamethoxazole (co-trimoxazole, TMP-SMX), and to provide recommendations for managing patient risk from this interaction. Data sources were English-language publications in the medical literature and Internet databases. Relevant publications that directly or ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(1):53-60]

Cited: 3 times

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Etomidate with or without flumazenil anesthesia for stem cell transplantation in autistic children.

Yong-wang Li, Li Ma, Bo Sui, Cai-hong Cao, Xiang-dong Liu,

BACKGROUND: The aim of this study was to investigate etomidate administration with or without flumazenil in autistic children who underwent intrathecal transplantation of stem cells by lumbar puncture. METHODS: Forty autistic children aged 2-12, who were scheduled for stem cell transplantation via lumbar puncture under anesthesia, were randomized for a ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(1):47-51]

Cited: 2 times

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CYP 2C19 and UDP-glucuronosyltransferases not only for drugs but also for endobiotics.

Gérard Siest, Sylvie Fournel-Gigleux, Jacques Magdalou,

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(4):207-209]

Cited: 0 times

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Pharmacogenetics in Jewish populations.

Yao Yang, Inga Peter, Stuart A Scott,

Spanning over 2000 years, the Jewish population has a long history of migration, population bottlenecks, expansions, and geographical isolation, which has resulted in a unique genetic architecture among the Jewish people. As such, many Mendelian disease genes and founder mutations for autosomal recessive diseases have been discovered in several Jewish ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(4):221-233]

Cited: 9 times

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Role of OATP-1B1 and/or OATP-1B3 in hepatic disposition of tyrosine kinase inhibitors.

Varun Khurana, Mukul Minocha, Dhananjay Pal, Ashim K Mitra,

The metabolism of tyrosine kinase inhibitors (TKIs) is mainly mediated via hepatic route, but the mechanism responsible for their hepatocellular accumulation is still unknown. This study was designed to understand the contribution of organic anion transporting polypeptides (OATPs) in the hepatic uptake of selected TKIs - pazopanib, canertinib, erlotinib, vandetanib ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(3):179-190]

Cited: 16 times

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Raloxifene pharmacodynamics is influenced by genetic variants in the RANKL/RANK/OPG system and in the Wnt signaling pathway.

Simona Mencej-Bedrač, Janja Zupan, Simona Jurković Mlakar, Andrej Zavratnik, Janez Preželj, Janja Marc,

BACKGROUND: Raloxifene is a selective estrogen receptor (ER) modulator (SERM) used for the treatment of osteoporosis. However, its efficacy and also its safety vary greatly among treated patients, and it might be influenced by the individuals' genetic background. As the receptor activator of the nuclear factor κB (RANK) ligand (RANKL)/RANK/osteoprotegerin ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(2):111-114]

Cited: 4 times

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Characterization of ABC transporters in human skin.

Hanan Osman-Ponchet, Anais Boulai, Magali Kouidhi, Karine Sevin, Marion Alriquet, Alexandre Gaborit, Béatrice Bertino, Pierre Comby, Bernard Ruty,

Most identified drug transporters belong to the ATP-binding cassette (ABC) and solute carrier (SLC) families. Recent research indicates that these transporters play an important role in the absorption, distribution and excretion of drugs, and are involved in clinically relevant drug-drug interactions for systemic drugs. However, very little is known about ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(2):91-100]

Cited: 9 times

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Binary and ternary combinations of anti-HIV protease inhibitors: effect on gene expression and functional activity of CYP3A4 and efflux transporters.

Deep Kwatra, Aswani Dutt Vadlapudi, Ramya Krishna Vadlapatla, Varun Khurana, Dhananjay Pal, Ashim K Mitra,

The purpose of this study is to identify the effect of binary and ternary combinations of anti-HIV protease inhibitors (PIs) on the expression of metabolizing enzyme (CYP3A4) and efflux transporters [multidrug resistance-associated protein 2 (MRP2), P-glycoprotein (P-gp) and breast cancer resistant protein (BCRP)] in a model intestinal cell line (LS-180).LS-180 ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(2):101-110]

Cited: 0 times

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Present status and perspective of pharmacogenetics in Mexico.

Patricia Cuautle-Rodríguez, Adrián Llerena, Adrián Llerena, Juan Molina-Guarneros,

Drug costs account for up to 24% of the country's health expenditure and there are 13,000 registered drugs being prescribed. Diabetes is the main cause of death in the country, with over 85% of diabetic patients currently under drug treatment. The importance of knowing interindividual variability in drug metabolism on ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(1):37-45]

Cited: 3 times

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Effect of selective cyclooxygenase-2 inhibitor lumiracoxib on phenolsulfonphthalein disposition in rats.

Hiroaki Honjo, Yuichi Uwai, Tomohiro Nabekura,

Selective cyclooxygenase-2 inhibitor lumiracoxib was shown to have the strong inhibitory potencies on the renal organic anion transporter (OAT)1 and also on OAT3 from drug transport experiments. The purpose of this study was to examine the effect of lumiracoxib on disposition of phenolsulfonphthalein (PSP) - which is mainly excreted into ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(3):203-206]

Cited: 1 time

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Lurasidone drug-drug interaction studies: a comprehensive review.

Yu-Yuan Chiu, Larry Ereshefsky, Sheldon H Preskorn, Nagaraju Poola, Antony Loebel,

BACKGROUND: To evaluate potential drug-drug interactions with the atypical antipsychotic lurasidone. METHODS: Seven phase I studies were conducted to investigate the effects of repeated dosing of ketoconazole, diltiazem, rifampin, or lithium on the pharmacokinetics (PK) of single oral doses of lurasidone, or the effects of repeated dosing of lurasidone on ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(3):191-202]

Cited: 9 times

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The pharmacogenetics of drug metabolizing enzymes in the Lebanese population.

Safaa Ossaily, Nathalie K Zgheib,

Drug metabolizing enzymes (DMEs) play a major role in the metabolism and final elimination of most drugs and xenobiotics from the body. Both phase I and phase II enzymes are highly polymorphic. Most studies on the pharmacogenetics (PGx) of DMEs and its influence on interindividual variability have been conducted in ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(2):81-90]

Cited: 2 times

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Pharmacogenetic potential biomarkers for carbamazepine adverse drug reactions and clinical response.

Nancy Monroy Jaramillo, Ingrid Fricke Galindo, Alberto Ortega Vázquez, Helgi Jung Cook, Adrián LLerena, Adrián LLerena, Marisol López López,

Carbamazepine (CBZ) is a first-line widely used anticonvulsant. It has a narrow therapeutic index and exhibits considerable interindividual and interethnic variability in clinical efficacy and adverse drug reactions including potentially life-threatening hypersensitivity reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis. The most important pharmacogenetic finding is related to the ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(2):67-79]

Cited: 5 times

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Effect of silymarin pretreatment on the bioavailability of domperidone in healthy human volunteers.

Shravan Kumar Yamsani, Madhusudan Rao Yamsani,

BACKGROUND: The aim of this study was to investigate the effect of silymarin pretreatment on domperidone oral bioavailability in humans. METHODS: The rats were pretreated with silymarin for 7 days. The transport of domperidone across the rat intestine (duodenum, jejunum, ileum, and colon) was studied by using in vitro everted ... Read more >>

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(4):261-267]

Cited: 4 times

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Systems Medicine in the era of 'Big Data': a game-changer for Personalized Medicine?

Ndeye Coumba Ndiaye,

Drug Metabol Drug Interact (Drug metabolism and drug interactions)
[2014, 29(3):127]

Cited: 0 times

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