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Boswellic Acid Synergizes With Low-Level Ionizing Radiation to Modulate Bisphenol Induced-Lung Toxicity in Rats by Inhibiting JNK/ERK/c-Fos Pathway.

Somya Z Mansour, Fatma S M Moawed, Monda M M Badawy, Hebatallah E Mohamed,

Bisphenol A (BPA) is a low molecular weight chemical compound that has a deleterious effect on the endocrine system. It was used in plastics manufacturing with injurious effects on different body systems. Occupational exposure to low-level ionizing radiation (<1 Gy) is shown to attenuate an established inflammatory process and therefore ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820969597]

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miR-152 Attenuates Apoptosis in Chondrocytes and Degeneration of Cartilages in Osteoarthritis Rats via TCF-4 Pathway.

Daqian Wan, Yang Qu, Songtao Ai, Liming Cheng,

Introduction:Osteoarthritis (OA) is associated with deregulation of various miRNAs (miRs). The present study reported protective effect of miR-152 in osteoarthritis. Methods:Tissue cartilage tissues of OA and normal subjects were used, rat model of anterior cruciate ligament transection (ACLT) was developed. Cartilage study was done by Safranin O-fast green, histological and ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820946918]

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Expression of Aquaporin-1 and Aquaporin-5 in a Rat Model of High-Altitude Pulmonary Edema and the Effect of Hyperbaric Oxygen Exposure.

Jiewen Tan, Chunjin Gao, Cong Wang, Linlin Ma, Xiaomin Hou, Xuehua Liu, Zhuo Li,

Objective:To investigate the therapeutic roles of hyperbaric oxygen exposure on high-altitude pulmonary edema and to determine whether aquaporin-1 and aquaporin-5 were involved in the pathogenesis of HAPE in rats. Methods:Rats were divided into 5 groups: The control group, the HAPE group (HAPE model), the HBO group (hyperbaric oxygen exposure), the ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820970821]

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Icariin Promote Stem Cells Regeneration and Repair Acinar Cells in L-arginine / Radiation -Inducing Chronic Pancreatitis in Rats.

Enas M Moustafa, Fatma S M Moawed, Gehan R Abdel-Hamid,

Objective:Chronic Pancreatitis (CP) is a multifactorial disease. It was characterized by severe inflammation and acinar cell destruction. Thus, the present study was initiated to evaluating the ability of bone marrow-based mesenchymal stem cell (MSCs) combined with Icariin to restore and regenerate acinar cells in the pancreas of rats suffering chronic ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820970810]

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Increased M1 Macrophages Infiltration Correlated With Poor Survival Outcomes and Radiation Response in Gliomas.

Zhaoming Zhou, Lei Wen, Mingyao Lai, Changguo Shan, Jian Wang, Rong Wang, Hainan Li, Longhua Chen, Linbo Cai, Meijuan Zhou, Cheng Zhou,

Background:Gliomas are the malignance of a poor prognosis. The current WHO classification remains unable to predict survival outcomes accurately. Novel surrogates are highly required for improved stratification of patients and hence, allowing to delivery of the most appropriate treatment. Methods:Transcriptional profiles of 301 glioma cases on the platform of Chinese ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820964991]

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Therapeutic Potential of Selected Varieties of Phoenix Dactylifera L. Against Microbial Biofilm and Free Radical Damage to DNA.

Nimra Qasim, Muhammad Shahid, Fatima Yousaf, Muhammad Riaz, Fozia Anjum, Muhammad Adeel Faryad, Remsha Shabbir,

Phoenix dactylifera L. (Date palm) is the most widely consumed fruit around the world and is rich source of nutrients containing dietary fibers, minerals, vitamins, sugar, protein and antioxidants with potent bioactivities against various microbial pathogens. This study evaluated the therapeutic potential of 2 varieties of ethanolic extracts of Phoenix ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820962609]

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Response to Letter: Application of Dexmedetomidine in Cardiopulmonary Bypass Prefilling.

Li Wang,

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820964990]

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RNA Profiling Reveals a Common Mechanism of Histone Gene Downregulation and Complementary Effects for Radioprotectants in Response to Ionizing Radiation.

Changhui Ge, Fei Su, Hanjiang Fu, Yuan Wang, Baolei Tian, Bin Liu, Jie Zhu, Yong Ding, Xiaofei Zheng,

High-dose ionizing radiation (IR) alters the expression levels of non-coding RNAs (ncRNAs). However, the roles of ncRNAs and mRNAs in mediating radiation protection by radioprotectants remain unknown. Microarrays were used to determine microRNA (miRNA), long ncRNA (lncRNA), and mRNA expression profiles in the bone marrow of irradiated mice pretreated with ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820968433]

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Foliar Applied Acetylsalicylic Acid Induced Growth and Key-Biochemical Changes in Chickpea (Cicer arietinum L.) Under Drought Stress.

Iqbal Hussain, Rizwan Rasheed, Muhammad Arslan Ashraf, Muhammad Mohsin, Syed Muhammad Ali Shah, Dr Abid Rashid, Muhammad Akram, Jaweria Nisar, Muhammad Riaz,

The exogenous application of acetylsalicylic acid (ASA) is stated to increase tolerance of plants against different environmental stresses. Therefore, the present study was planned to get insight into ASA-mediated regulation of growth, secondary metabolism, and oxidative defense in 2 chickpea varieties. Ten seeds of 2 chickpea varieties (DG-89 and Bittle-98) ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820956801]

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Low-Dose Berberine Attenuates the Anti-Breast Cancer Activity of Chemotherapeutic Agents via Induction of Autophagy and Antioxidation.

Bing Han, Kai Wang, Yanbei Tu, Lihua Tan, Chengwei He,

Berberine (BBR), a major active component of Rhizoma coptidis, is one of the most promising agents for breast cancer adjuvant therapy. It is well accepted that BBR could exhibit remarkable anticancer efficacy with few side effects, and when treated with chemotherapeutic agents in combination, BBR could enhance the chemosensitivity of ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820939751]

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Application of Dexmedetomidine in Cardiopulmonary Bypass Prefilling and Several Confounding Factors.

Sung Bae, Ju-Tae Sohn,

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820959540]

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Therapeutic Efficacy of Urinile Against Gouty Arthritis.

Saeed Ahmad, Ejaz Mohiuddin, Syed Muhammad Ali Shah, Muhammad Akram, Muhammad Amjad, Jaweria Nisar, Muhammad Riaz, Naveed Munir, Ghulam Rasool,

Gout is arthritis caused due to Monosodium urate (MSU) crystals deposition occurring particularly in patients with associated comorbidities limiting the use of conventional therapies. This study was planned to evaluate the therapeutic efficacy of urinile (a herbal drug) for the treatment of gouty arthritis. Allopurinol was used as standard drug ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820946934]

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Paclitaxel, Carboplatin, and Bevacizumab in Advanced Cervical Cancer: A Treatment Response and Safety Analysis.

Wanjun Tao, Jia Yang, Yongxian Jiang, Wenwen Chen, Yixin Wang,

Background:Trials reported there are beneficial effects of the addition of bevacizumab to chemotherapy in advanced cervical cancer but might have adverse effects. The purposes of the study were to evaluate the treatment response and safety of the addition of bevacizumab to paclitaxel plus carboplatin in advanced cervical cancer women. Methods:Data ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(3):1559325820941351]

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Identification of Hidradenitis Suppurativa-Related mRNA Expression Patterns Through Analysis of Gene Expression Omnibus.

Yan Teng, Xiaohua Tao, Wei Lu, Youming Huang, Danfeng Xu, Meng Li, Yibin Fan,

Background:Hidradenitis suppurativa (HS) is a chronic, follicular, and inflammatory skin disease with multifactorial pathogenesis, and its definite molecule mechanism is still not fully elucidated. Objective:The purpose of this research was to identify crucial differentially expressed genes (DEGs) and biological processes and pathways involved in HS through bioinformatics analysis. Methods:A total ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(3):1559325820942646]

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Antihypertensive and Antihyperlipidemic Activity of Aqueous Methanolic Extract of Rauwolfia Serpentina in Albino Rats.

Syed Muhammad Ali Shah, Syed Ali Raza Naqvi, Naveed Munir, Sohaib Zafar, Muhammad Akram, Jaweria Nisar,

Rauwolfia serpentina has a wide range of therapeutic effects so this study was planned to explore the antihypertensive and antihyperlipidemic therapeutic responses of R serpentina doses using albino rats by measuring the blood pressure, biochemical parameters, and histological architecture of liver and kidney tissues. Thirty albino rats were divided into ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(3):1559325820942077]

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Multiomic Analysis of Methylation and Transcriptome Reveals a Novel Signature in Esophageal Cancer.

Yi-Qi Jin, Dong-Liu Miao,

Background:Epigenetic alterations have been shown to lead to human carcinogenesis. The aim of this study was to perform an integrative analysis to develop an epigenetic signature to predict overall survival (OS) of esophageal cancer. Methods:DNA methylation and messenger RNA expression data of esophageal cancer samples were downloaded from The Cancer ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(3):1559325820942075]

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Does Green Tea Induce Hormesis?

Edward J Calabrese, Aristidis Tsatsakis, Evgenios Agathokleous, James Giordano, Vittorio Calabrese,

Green tea, and its principal constituent (-)-epigallocatechin-3-gallate (EGCG), are commonly shown to induce biphasic concentration/dose responses in a broad range of cell types, including non-tumor cells, and tumor cell lines. The most active area of research dealt with an assessment of neural cells with application to neurodegenerative diseases such as ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(3):1559325820936170]

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Protective Effect of Metformin on Sepsis Myocarditis in Zebrafish.

Mingming Zhang, Wei Sun, Jianan Du, Yawei Gou, Lingling Liu, Ruonan Wang, Xuesong Xu,

Purpose:We found in previous study that metformin could treat sepsis myocarditis in a mouse model. We employed the zebrafish model organism to investigate the effect of metformin on sepsis myocarditis. Methods and Results:Wild-type zebrafish was used to establish a sepsis myocarditis model and combined with image software analysis and cytokine ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(3):1559325820938543]

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α-Glucosidase Inhibitory, Anti-Oxidant, and Anti-Hyperglycemic Effects of Euphorbia nivulia-Ham. in STZ-Induced Diabetic Rats.

Muhammad Younus, Muhammad Mohtasheem Ul Hasan, Khalil Ahmad, Ali Sharif, Hafiz Muhammad Asif, Muhammad Rahil Aslam, Ihsan Ul Haq, Zulfiqar Ahmad,

In this study, we aimed to investigate the antidiabetic effects of Euphorbia nivulia (En), native to Cholistan Desert area of Bahawalpur, Pakistan. First, we performed high-performance liquid chromatography analysis and found that this plant contains ferulic acid, gallic acid, quercetin, benzoic acid, polyphenols, and flavonoids. Then, we performed in vitro ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(3):1559325820939429]

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Susceptibility Assessment of Multidrug Resistant Bacteria to Natural Products.

Essam Hassan Mohamed, Youssef Saeed Alghamdi, Salama Mostafa Abdel-Hafez, Mohamed Mohamed Soliman, Saad H Alotaibi, Magdy Yassin Hassan, Nasr Al-Deen Hany, Hamada H Amer,

Objective:The aim of this study was to examine the effect of some natural compounds against multidrug-resistant bacteria. Methods:Forty-three bacterial strains were collected. Disc diffusion and minimum inhibitory concentration (MIC) tests were carried out for natural compounds including quercetin, Acacia nilotica, Syzygium aromaticum, and Holothuria atra. Scanning electron microscope analysis and ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(3):1559325820936189]

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LncRNA MIR210HG Facilitates Non-Small Cell Lung Cancer Progression Through Directly Regulation of miR-874/STAT3 Axis.

Liang Bu, Libin Zhang, Mei Tian, Zhoubin Zheng, Huijie Tang, Qiuju Yang,

Background:Long noncoding RNAs are involved in the progression of multiple cancers. However, the expression and mechanism of microRNA (miR)210HG in non-small cell lung cancer (NSCLC) remain unclear. Methods:The levels of miR210HG and miR-874 were measured by quantitative real-time polymerase chain reaction in NSCLC tissue samples and cells. Non-small cell lung ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(3):1559325820918052]

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Biomarkers of Brain Damage Induced by Radiotherapy.

Nahida Sultana, Chao Sun, Takanori Katsube, Bing Wang,

Radiotherapy remains currently a critical component for both primary and metastatic brain tumors either alone or in combination with surgery, chemotherapy, and molecularly targeted agents, while it could cause simultaneously normal brain tissue injury leading to serious health consequences, that is, development of cognitive impairments following cranial radiotherapy is considered ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(3):1559325820938279]

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Exposure Doses to Technologists Working in 7 PET/CT Departments.

Weiguo Li, Lianying Fang, Jieqing Li,

Objective:The aim of this study was to measure occupational exposure doses of technologists who dispense and inject radiopharmaceuticals in 7 positron emission tomography/computed tomography (PET/CT) departments. This was done with the goal to help improving protective designs in PET departments and/or establishing national protection standards. Method:Common LiF thermoluminescence dosimeters (TLDs) ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(3):1559325820938288]

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Anhuienoside C Attenuates Podocyte Injury in Diabetic Nephropathy Rats.

Chengjian Wang, Yingsong Jiang, Keping Yu, Ke Liu, Hao Wang,

Objective:The present study evaluated the nephroprotective effects of anhuienoside C (AC) against diabetic nephropathy (DN) in rats. Material and Methods:Diabetic nephropathy was induced by administration of a high-fat diet (HFD) for 8 weeks and intraperitoneal administration of streptozotocin (STZ; 30 mg/kg) at the end of the fourth week of this ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(3):1559325820939010]

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X-Ray Hesitancy: Patients' Radiophobic Concerns Over Medical X-rays.

Paul A Oakley, Deed E Harrison,

All too often the family physician, orthopedic surgeon, dentist or chiropractor is met with radiophobic concerns about X-ray imaging in the clinical setting. These concerns, however, are unwarranted fears based on common but ill-informed and perpetuated ideology versus current understanding of the effects of low-dose radiation exposures. Themes of X-ray ... Read more >>

(Dose-response : a publication of International Hormesis Society)
[2020, 18(3):1559325820959542]

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