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Journal Dose Response

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Effect of Pharmaceutical Effluents on Growth, Oxidative Defense, Secondary Metabolism, and Ion Homeostasis in Carrot.

Iqbal Hussain, Kanwal Rehman, Muhammad Arslan Ashraf, Rizwan Rasheed, Javeria Gul, Muhammad Sajid Hamid Akash, Rohina Bashir,

Pharmaceutical wastes are environmental micro pollutant and potential risk for the ecosystem. Therefore, the present study was planned to find out the effects of different pharmaceutical effluent (PE) regimes on growth, secondary metabolism, and oxidative defense in 2 carrot lines. The seeds of 2 carrot lines (DC-3 and T-29) were ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(2):1559325821998506]

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A Short Critique on the Stance of the Netherlands Food and Consumer Product Safety Authority on Melamine Polymer Formaldehyde Exposures.

Jaap C Hanekamp,

In February 2021, the Netherlands Food and Consumer Product Safety Authority came out with their risk assessment on formaldehyde exposure from melamine crockery with bamboo fiber to especially young children. In this short commentary, I will critique their assessment of this type of food-contact material (FCM). The main flaws are ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(2):15593258211007310]

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The Effectiveness of Dichloroacetate on Human Glioblastoma Xenograft Growth Depends on Na+ and Mg2+ Cations.

Donatas Stakišaitis, Eligija Damanskienė, Rūta Curkūnavičiūtė, Milda Juknevičienė, Marta Maria Alonso, Angelija Valančiūtė, Saulius Ročka, Ingrida Balnytė,

The study's aim was to investigate the effectiveness of sodium dichloroacetate (NaDCA) or magnesium dichloroacetate (MgDCA) on adult U87 MG and pediatric PBT24 cell lines glioblastoma (GB) xenografts in a chicken chorioallantoic membrane (CAM) model. The study groups were: treated with 10 mM, 5 mM of NaDCA, and 5 mM, ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):1559325821990166]

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177Lu-DOTATATE Peptide Receptor Radionuclide Therapy: Indigenously Developed Freeze Dried Cold Kit and Biological Response in In-Vitro and In-Vivo Models.

Samina Roohi, Shakera Khatoon Rizvi, Syed Ali Raza Naqvi,

Somatostatin receptors (SStR) based <sup>177</sup>Lu-DOTATATE therapy is known as one of the highly effective neuroendocrine tumors (NETs) treatment strategy. Development of DOTATATE freeze-dried kit for imaging and therapy of SStR positive NETs is a prime goal in neuroendocrine cancer research. The present work describes the development of <sup>177</sup>Lu-DOTATATE freeze dried ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):1559325821990147]

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Moscatilin Suppresses the Breast Cancer Both In Vitro and In Vivo by Inhibiting HDAC3.

Wenjie Su, Lianfu Zeng, Weida Chen,

Moscatilin, a natural compound isolated from the orchid <i>Dendrobium moscatum</i>, has multiple pharmacological actions. The present study investigated the anti-tumor role of moscatilin in breast cancer and elucidated the underlying mechanisms. Cell proliferation, viability, and apoptosis of moscatilin treated MDA-MB-231 cells were determined by CCK-8 assay and flow cytometry. Histone ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):15593258211001251]

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Are Continued Efforts to Reduce Radiation Exposures from X-Rays Warranted?

Paul A Oakley, Deed E Harrison,

There are pressures to avoid use of radiological imaging throughout all healthcare due to the notion that all radiation is carcinogenic. This perception stems from the long-standing use of the linear no-threshold (LNT) assumption of risk associated with radiation exposures. This societal perception has led to relentless efforts to avoid ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):1559325821995653]

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A Preliminary Study of Personalized Head CT Scan in Pediatric Patients.

Bian Bingyang, Wang Gang, Shao Zhiqing, Nan Li, BoXu Zhou, ShuJia Xu, Dan Li,

<h4>Objectives</h4>In the present study, we introduced a practical approach to quantify organ-specific radiation doses and investigated whether low-dose head circumference (HC)-based protocols for non-enhanced head computed tomography (CT) could reduce organs-specific radiation dose in pediatric patients while maintaining high image quality.<h4>Methods</h4>A total of 83 pediatric patients were prospectively recruited. Without ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):1559325820985660]

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Buspirone Dose-Response on Facilitating Forelimb Functional Recovery in Cervical Spinal Cord Injured Rats.

Rakib Uddin Ahmed, V Reggie Edgerton, Shuai Li, Yong-Ping Zheng, Monzurul Alam,

Buspirone, widely used as a neuropsychiatric drug, has also shown potentials for motor function recovery of injured spinal cord. However, the optimum dosages of such treatment remain unclear. In this study, we investigated the dose-response of Buspirone treatment on reaching and grasping function in cervical cord injured rats. Seventeen adult ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):1559325821998136]

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Mesenchymal Stem Cell-Conditioned Medium Protects Hippocampal Neurons From Radiation Damage by Suppressing Oxidative Stress and Apoptosis.

Yue Huang, Xiaolong Mei, Weishi Jiang, Hui Zhao, Zhenyu Yan, Haixia Zhang, Ying Liu, Xia Hu, Jingyi Zhang, Wenshuo Peng, Jing Zhang, Qingling Qi, Naiyao Chen,

<h4>Objective</h4>To investigate the effects of mesenchymal stem cell-conditioned medium (MSC-CM) on radiation-induced oxidative stress, survival and apoptosis in hippocampal neurons.<h4>Methods</h4>The following groups were defined: Control, radiation treatment (RT), RT+MSC-CM, MSC-CM, RT + N-Acetylcysteine (RT+NAC), and RT + MSC-CM + PI3 K inhibitor (LY294002). A cell Counting Kit-8 (CCK-8) was used ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):1559325820984944]

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Radiophobic Fear-Mongering, Misappropriation of Medical References and Dismissing Relevant Data Forms the False Stance for Advocating Against the Use of Routine and Repeat Radiography in Chiropractic and Manual Therapy.

Paul A Oakley, Deed E Harrison,

There is a faction within the chiropractic profession passionately advocating against the routine use of X-rays in the diagnosis, treatment and management of patients with spinal disorders (aka subluxation). These activists reiterate common false statements such as "there is no evidence" for biomechanical spine assessment by X-ray, "there are no ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):1559325820984626]

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Possible Potential Effects of Honey and Its Main Components Against Covid-19 Infection.

Farshid Abedi, Saeedeh Ghasemi, Tahereh Farkhondeh, Mohsen Azimi-Nezhad, Mehdi Shakibaei, Saeed Samarghandian,

Coronavirus disease 2019 (COVID-19) is a viral pneumonia that is spreading rapidly worldwide. The main feature of this disease is a severe acute respiratory syndrome and caused by coronavirus 2 (SARS-CoV-2). There are several unknowns about the pathogenesis and therapeutically treatment of COVID-19 infection. In addition, available treatment protocols have ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):1559325820982423]

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Giant Epidermoid Cyst of Posterior Fossa-Our Experience and Literature Review.

Giacomo Spinato, Piergiorgio Gaudioso, Maurizio Falcioni, Maria Cristina Da Mosto, Salvatore Cocuzza, Antonino Maniaci, Cristoforo Fabbris, Doriano Politi, Tiziana Volo, Emanuele Ferri, Giovanni Cristalli, Lorenzo Mannelli, Marco Salvatore, Paolo Boscolo Rizzo, Daniele Frezza,

<h4>Introduction</h4>Intracranial epidermoid cysts are the most frequent congenital intracranial lesion. They rare and benign tumors that can present in different clinical situations depending on location and extension of the disease. Diagnosis is obtained with radiological imaging with RM and non-enhanced TC as elective investigating methods. Elective treatment is surgery, based ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):15593258211002061]

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In Vitro Antioxidant Activities and the Therapeutic Potential of Some Newly Synthesized Chalcones Against 4-Acetaminophenol Induced Hepatotoxicity in Rats.

Muhammad Shoaib Akhtar, Aziz-Ur- Rehman, Haroon Arshad, Abdul Malik, Muheer Fatima, Tahira Tabassum, Abdul Rauf Raza, Munnaza Bukhsh, Mian Anjum Murtaza, Malik Hassan Mehmood, Ayesha Sultan, Ghulam Rasool, Muhammad Riaz,

The lack of safety and efficacy of existing hepatoprotective agents urge the need to explore novel hepatoprotective agents. The research work was planned to study the therapeutic potential of some newly synthesized chalcones against 4-acetaminophenol induced hepatotoxicity in rats. Male albino rats (N = 30) were divided into 6 groups ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):1559325821996955]

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Full Analysis of Lung Cancer Mortality/Radon Relationship with Simple Nonlinear Concepts.

Ralph W Lai,

We analyze the relationship between the lung cancer mortality and the indoor radon intensity from the viewpoint of nonlinear mathematics. We conclude that their relationship is governed by the proportionality law where the cumulative lung cancer mortality Y is negatively proportional to the cumulative radon intensity X; or specifically, the ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):1559325820960994]

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Hormesis Shifts the No-Observed-Adverse-Effect Level (NOAEL).

Evgenios Agathokleous, Costas Saitanis, Athina Markouizou,

Data from recent dose-response toxicological studies suggest that the no-observed-adverse-effect-level (NOAEL) may depend upon whether hormesis is present. A further examination of these data supports this hypothesis by showing that the NOAEL was greater for living units (organisms or cells) showing hormesis than for living units showing no hormesis. For ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):15593258211001667]

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Corrigendum to "Benefits of Low-Dose CT Scan of Head for Patients with Intracranial Hemorrhage".

[This corrects the article DOI: 10.1177/1559325820909778.]. ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):15593258211002755]

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Chemical Profiling and Dose-Dependent Assessment of Fear Reducing and Memory-Enhancing Effects of Solanum virginianum in Rats.

Usman Javaid, Sana Javaid, Waseem Ashraf, Muhammad Fawad Rasool, Omar M Noman, Ali S Alqahtani, Abdul Majeed, Waleed Shakeel, Thamer H Albekairi, Faleh Alqahtani, Imran Imran,

The current study was planned to investigate the pharmacological basis of <i>Solanum virginianum</i> extract (SV.CR) pertaining to anxiolytic, antidepressant and memory-enhancing effects in rats. The SV.CR was analyzed in-vitro for phytoconstituents, antioxidant potential and anticholinesterase activity. The rats treated in a dose-dependent manner (25, 50 and 100 mg/kg of SV.CR) ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):1559325821998486]

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China: The New Powerhouse of Hormesis Research?

Evgenios Agathokleous,

More than one third of the worldwide hormesis research has been produced at institutions in the United States (US). Although the US ranked first in terms of hormesis publication records from the mid. 1980s to the mid-late 2010s, China became the largest producer of hormesis publications in the years 2019-2020. ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):1559325821995655]

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Sulpiride Serves, a Substrate for the Gut Microbiome.

Imran Mukhtar, Haseeb Anwar, Osman Asghar Mirza, Qasim Ali, Muhammad Umar Ijaz, Michael Hume, Bala Krishna Prabhala, Arslan Iftikhar, Ghulam Hussain, Muhammad Umar Sohail, Kashif Ur Rehman Khan,

In the contemporary research world, the intestinal microbiome is now envisioned as a new body organ. Recently, the gut microbiome represents a new drug target in the gut, since various orthologues of intestinal drug transporters are also found present in the microbiome that lines the small intestine of the host. ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):1559325820987943]

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Reduced High-Dose Radiation-Induced Residual Genotoxic Damage by Induction of Radioadaptive Response and Prophylactic Mild Dietary Restriction in Mice.

Bing Wang, Kaoru Tanaka, Takanori Katsube, Kouichi Maruyama, Yasuharu Ninomiya, Guillaume Varès, Cuihua Liu, Hirokazu Hirakawa, Masahiro Murakami, Zeenath Fardous, Nahida Sultana, Kazuko Fujita, Akira Fujimori, Tetsuo Nakajima, Mitsuru Nenoi,

Radioadaptive response (RAR) describes a phenomenon in a variety of in vitro and in vivo systems that a low-dose of priming ionizing radiation (IR) reduces detrimental effects of a subsequent challenge IR at higher doses. Among in vivo investigations, studies using the mouse RAR model (Yonezawa Effect) showed that RAR ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):1559325820982166]

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Anti-Oxidative and Immuno-Protective Effect of Camel Milk on Radiation-Induced Intestinal Injury in C57BL/6 J Mice.

Yu-Zhong Chen, Chao Li, Jia Gu, Si-Chen Lv, Jia-Ying Song, Zhi-Bing Tang, Guang-Xin Duan, Li-Qiang Qin, Lin Zhao, Jia-Ying Xu,

<h4>Purpose</h4>The main objective is to investigate the protective effect of camel milk (CM) on radiation-induced intestinal injury.<h4>Methods</h4>The C57BL/6 J mice in 2 experiments were assigned into control group (Con), irradiation group (IR), and CM+irradiation group (CM+IR). After receiving the CM via gavage for 14 days, the mice in the first ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):15593258211003798]

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Anti-Proliferative Activity of Glucagon-Like Peptide-1 Receptor Agonist on Obesity-Associated Breast Cancer: The Impact on Modulating Adipokines' Expression in Adipocytes and Cancer Cells.

Alaa A Alanteet, Hala A Attia, Sameerah Shaheen, Musaed Alfayez, Bisher Alshanawani,

Obesity is associated with high risk and poor prognosis of breast cancer (BC). Obesity promotes BC cells proliferation via modulating the production of adipokines, including adiponectin (anti-neoplastic adipokine), leptin (carcinogenic adipokine) and inflammatory mediators. In the present study we investigated the anti-proliferative effects of liraglutide (LG; anti-diabetic and weight reducing ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):1559325821995651]

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Antibacterial Activity of Tris NaCl and PBS Buffer Protein Extract of Cassia fistula, Saccharum officinarum, Albizia lebbeck and Cymbopogon citrates Against Bacterial Strains.

Ume Habiba, Jaweria Nisar, Muhammad Akram Choohan, Syed Muhammad Ali Shah, Zonaira Nisar, Imtiaz Mustafa,

Medicinal plants are gaining popularity over synthetic medicines because antibiotic resistance demands the alternative source of medication. In the present research, the crude protein extraction of 4 medicinal plants <i>Cassia fistula, Saccharum officinarum, Albizia lebbeck</i> and <i>Cymbopogon citrates</i> was carried out. Crude protein extraction was done by 2 different buffers ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):1559325821992239]

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On X-Ray Hesitancy: Patients' Radiophobic Concerns Over Medical X-Rays.

Mehdi Sohrabi,

Dose Response (Dose-response : a publication of International Hormesis Society)
[2021, 19(1):1559325820982418]

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Boswellic Acid Synergizes With Low-Level Ionizing Radiation to Modulate Bisphenol Induced-Lung Toxicity in Rats by Inhibiting JNK/ERK/c-Fos Pathway.

Somya Z Mansour, Fatma S M Moawed, Monda M M Badawy, Hebatallah E Mohamed,

Bisphenol A (BPA) is a low molecular weight chemical compound that has a deleterious effect on the endocrine system. It was used in plastics manufacturing with injurious effects on different body systems. Occupational exposure to low-level ionizing radiation (<1 Gy) is shown to attenuate an established inflammatory process and therefore ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820969597]

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