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Monitoring for glaucoma progression with SAP, electroretinography (PERG and PhNR) and OCT.

Barbara Cvenkel, Maja Sustar, Darko Perovšek,

<h4>Purpose</h4>To investigate the value of pattern electroretinography (PERG) and photopic negative response (PhNR) in monitoring glaucoma compared to standard clinical tests (standard automated perimetry (SAP) and clinical optic disc assessment) and structural measurements using spectral-domain OCT.<h4>Methods</h4>A prospective study included 32 subjects (32 eyes) with ocular hypertension, suspect or early glaucoma ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, :]

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Effects of fixed cutoff filtering on dark- and light-adapted ERG components and the application of variable cutoff filter.

Min Gao, Mirella Telles Salgueiro Barboni, Dora Fix Ventura, Balázs Vince Nagy,

<h4>Purpose</h4>Human oscillatory potentials (OPs) are derived from dark-adapted (DA) electroretinograms (ERGs) with fixed frequency cutoff filters while light-adapted (LA) OPs are generally not isolated from ERGs. Our purpose was to analyze the effect of cutoff frequencies on DA and LA ERG components using a series of fixed and variable filters.<h4>Methods</h4>DA ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, :]

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Interpretation of electrophysiological responses and generalization of findings requires knowledge of physical stimulus characteristics.

Sven P Heinrich,

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, :]

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Response to letter interpretation of electrophysiological responses and generalization of findings requires knowledge of physical stimulus characteristics.

Midori Ura, Hiroshi Morita, Haruna Yamazaki, Mutsuki Matsuo,

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, :]

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Effect of spatial averaging on the amplitude ring ratio in multifocal electroretinography.

Sara Bijan, Su-Yuan Yu, Gaurav Kiri, Swetangi Bhaleeya, Radouil Tzekov,

<h4>Purpose</h4>The purpose of this study was to evaluate the effect of spatial averaging on the multifocal electroretinography (mfERG) amplitude ring ratios used in screening for hydroxychloroquine (HCQ) toxicity.<h4>Methods</h4>This was a retrospective review of the records of patients screened for HCQ retinopathy at the USF Eye Institute (University of South Florida) ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, :]

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Subclinical maculopathy and retinopathy in transcobalamin deficiency: a 10-year follow-up.

Florence Rigaudière, Hala Nasser, Eliane Delouvrier, Paolo Milani, Manuel Schiff,

<h4>Introduction</h4>Transcobalamin (TC) transports cobalamin (vitamin B<sub>12</sub>) from plasma into cells. Its congenital deficiency is a rare autosomal recessive disorder due to mutations in the TCN2 gene. It causes intracellular cobalamin depletion with early onset in the first months of life, failure to thrive with pallor due to megaloblastic anemia. It ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, :]

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Proliferative diabetic retinopathy treated with intravitreal ranibizumab and photocoagulation directed at ischemic retinal areas-A randomized study.

Luiza Toscano, Andre Messias, Katharina Messias, Rafaella de Cenço Lopes, Jefferson A Santana Ribeiro, Ingrid U Scott, Rodrigo Jorge,

<h4>Purpose</h4>To compare ETDRS panretinal laser photocoagulation (PRP) combined with intravitreal injection of ranibizumab (IVR) and photocoagulation targeted to ischemic retina (PIR) combined with IVR in patients with proliferative diabetic retinopathy (PDR).<h4>Methods</h4>PDR patients were randomly assigned to treatment with either PRP + IVR or PIR + IVR. ETRDS Best-corrected visual acuity (BCVA) and central subfield ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, :]

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Compound Heterozygous Mutations in ZNF408 in a Patient with a Late Onset Pigmentary Retinopathy and Relatively Preserved Central Retina.

Jennifer B Nadelmann, Erin C O'Neil, Dale S Kim, Jane Juusola, Tomas S Aleman,

<h4>Purpose</h4>To describe in detail the phenotype of a patient with compound heterozygous mutations in ZNF408 and an adult-onset pigmentary retinopathy rather than familial exudative vitreoretinopathy as expected with heterozygous mutations in this gene.<h4>Methods</h4>A 70-year-old male presented with a pigmentary retinopathy, which prompted a genetic evaluation that revealed two variants in ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, :]

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Electrophysiological and neuroimaging findings in a patient who developed visual loss after attempted suicide by hanging.

Piyush Kohli, K N Jayasri, A Rupa, Mahesh Kumar, A Kowsalya,

<h4>Purpose</h4>To report the electrophysiological and neuroimaging findings in a patient who developed visual loss after attempted suicide by hanging.<h4>Methods</h4>A 45-year-old male presented with bilateral visual loss and difficulty in walking following a suicide attempt by hanging six months ago. He underwent a complete ophthalmologic examination, posterior segment optical coherence tomography ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, :]

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New criteria for evaluation of electroretinogram in patients with retinitis pigmentosa.

Hamideh Sabbaghi, Soroor Behbahani, Narsis Daftarian, Hamid Ahmadieh,

<h4>Background</h4>Electroretinogram (ERG) plays an essential role in the diagnosis of retinal disease. Choosing appropriate methods could extract valuable information from ERG. In this study, a new criterion based on time-frequency domain analysis was proposed to investigate the retina in retinitis pigmentosa (RP) patients.<h4>Materials and methods</h4>The total number of 16 eyes ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, :]

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Correlation between electroretinography, foveal anatomy and visual acuity in aniridia due to PAX6 mutations.

Tucker Dangremond, Kai Wang, Megan Helms, Sajag Bhattarai, Wanda Pfeifer, Arlene V Drack,

<h4>Background</h4>Aniridia patients have poor visual acuity and iris malformation. The fovea in these patients is underdeveloped, but the relationship between structure and electrophysiologic function remains incompletely understood. This study correlates electrophysiology, visual acuity and optical coherence tomography (OCT) in patients with aniridia secondary to mutations in the PAX6 gene and ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, :]

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Is white the right light for the clinical electrooculogram?

Paul A Constable, Garima Kapoor,

<h4>Purpose</h4>To investigate if a lower luminance monochromatic LED stimulus could be used as an alternative to a high luminance white light for the clinical electrooculogram.<h4>Methods</h4>Clinical electrooculograms were recorded in color normal participants (N = 23) aged 22.6 ± 1.2 years, 7 male and 16 female using the standard 100 cd.m<sup>-2</sup> white illuminant and four monochromatic LEDs ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, :]

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Correction to: Leber hereditary optic neuropathy following head trauma and ocular trauma on contralateral eye: a case report.

Hoon Dong Kim,

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, 142(3):369]

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Homozygous single nucleotide duplication of SLC38A8 in autosomal recessive foveal hypoplasia: The first Japanese case report.

Takaaki Hayashi, Hiroyuki Kondo, Itsuka Matsushita, Kei Mizobuchi, Akinori Baba, Kie Iida, Hiroyuki Kubo, Tadashi Nakano,

<h4>Purpose</h4>To characterize the clinical and genetic features of a Japanese male patient with foveal hypoplasia caused by a homozygous single nucleotide duplication in the SLC38A8 gene.<h4>Methods</h4>We performed a comprehensive ophthalmic examination including full-field electroretinography (FF-ERG) and pattern-reversal visual evoked potentials (PR-VEPs). Whole-exome sequencing (WES) was performed to identify the disease-causing ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, :]

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Anti-angiogenic activity and safety of intraocular application of triterpenes.

Cibele Rodrigues Toledo, Vinicius Viana Pereira, Lucienir Pains Duarte, Grasiely Faria Sousa, Armando Silva-Cunha,

<h4>Purpose</h4>Assessment of the anti-angiogenic activity and the safety of ophthalmic use of four pentacyclic triterpenes (friedelin, friedelinol, lupenone, and lupeol).<h4>Methods</h4>Triterpenes cytotoxicity (5-640 µmol L<sup>-1</sup>) was examined in ARPE-19 cells by sulforhodamine B colorimetric method, and the anti-angiogenic activity (50-1000 µmol L<sup>-1</sup>) was evaluated in the chorioallantoic membrane model. Full-field electroretinography and histological ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, :]

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VEP-based acuity estimation: unaffected by translucency of contralateral occlusion.

Sven P Heinrich, Isabell Strübin, Michael Bach,

<h4>Purpose</h4>Visual evoked potential (VEP) recordings for objective visual acuity estimates are typically obtained monocularly with the contralateral eye occluded. Psychophysical studies suggest that the translucency of the occluder has only a minimal effect on the outcome of an acuity test. However, there is literature evidence for the VEP being susceptible ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, :]

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Evolution of the retinal function by flash-ERG in one child suffering from neuronal ceroid lipofuscinosis CLN2 treated with cerliponase alpha: case report.

Florence Rigaudière, Hala Nasser, Samia Pichard-Oumlil, Eliane Delouvrier, Elisa Lopez-Hernandez, Paolo Milani, Stéphane Auvin, Catherine Delanoë,

<h4>Introduction</h4>Neuronal ceroid lipofuscinoses (CLN) are neurodegenerative disorders among the most frequent, inherited as an autosomal recessive trait. Affected patients can present with progressive decline in cognitive and motor functions, seizures, a shortened life span and visual deficiency. CLN2 is one of the rare CLN that benefits from treatment by cerliponase ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, 143(1):99-106]

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Insufficient evidence to support the clinical diagnosis of an epileptic seizure.

Ruth Hamilton, Sameer M Zuberi,

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, 142(3):399-400]

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Epileptic seizure? Certainly uncertain.

Sven P Heinrich, Hansjürgen Agostini,

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, 142(3):401-402]

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Long-term follow-up of a patient with JAG1-associated retinopathy.

Muhammad R Cheema, Lydia G Stone, Peter W Sellar, Stephanie Quinn, Stephen C Clark, Richard J Martin, Jill M O'Brien, Clare Warriner, Andrew C Browning,

<h4>Purpose</h4>To report the long-term structural and functional changes in the posterior segments of an adult with an unusual retinal dystrophy caused by a novel mutation in JAG1.<h4>Methods</h4>A 33-year-old female underwent comprehensive ophthalmic examination, including best corrected visual acuity (BCVA) measurement, dilated fundus imaging (wide-angle fundus colour and short wavelength autofluorescence ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, 143(2):237-247]

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Reference ranges for clinical electrophysiology of vision.

C Quentin Davis, Ruth Hamilton,

<h4>Introduction</h4>Establishing robust reference intervals for clinical procedures has received much attention from international clinical laboratories, with approved guidelines. Physiological measurement laboratories have given this topic less attention; however, most of the principles are transferable.<h4>Methods</h4>Herein, we summarise those principles and expand them to cover bilateral measurements and one-tailed reference intervals, which ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, 143(2):155-170]

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The influence of temporal frequency and stimulus size on the relative contribution of luminance and L-/M-cone opponent mechanisms in heterochromatic flicker ERGs.

Jan Kremers, Avinash J Aher, Yassen Popov, Maziar Mirsalehi, Cord Huchzermeyer,

<h4>Purpose</h4>To study the effect of stimulus size and temporal frequency on the relative contribution of luminance and L-/M-cone opponent signals in the ERG.<h4>Methods</h4>In four healthy, color normal subjects, ERG responses to heterochromatic stimuli with sinusoidal, counter-phase modulation of red and green LEDs were measured. By inverse variation of red and ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, 143(2):207-220]

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Evaluation of the neuronal and microvascular components of the macula in patients with diabetic retinopathy.

Ali Mert Koçer, Mehmet Ali Şekeroğlu,

<h4>Purpose</h4>To investigate whether abnormal retinal microcirculation correlates with retinal neuronal changes in untreated diabetic eyes without macular edema.<h4>Methods</h4>This study enrolled 29 diabetic patients without diabetic retinopathy (DR), 18 patients with mild non-proliferative diabetic retinopathy (NPDR), 15 patients with moderate NPDR, 14 patients with severe NPDR, 27 patients with proliferative diabetic ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, 143(2):193-205]

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Effect of biological factors on latency of pattern-reversal visual evoked potentials associated with cathode ray tubes and liquid crystal display monitors in normal young subjects.

Midori Ura, Mutsuki Matsuo, Haruna Yamazaki, Hiroshi Morita,

<h4>Purpose</h4>Owing to several factors, peak latencies of pattern-reversal visual evoked potentials (p-VEP) are delayed when viewing liquid crystal display (LCD) monitors compared to those evoked when viewing cathode ray tube (CRT) monitors. However, few studies have examined whether biological factors affect latency in LCD. This study aimed to investigate whether ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, 143(2):185-192]

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Case of cystoid macular edema induced by systemic administration of paclitaxel: evaluations with electroretinograms.

Kumiko Kato, Ryunosuke Nagashima, Masahiko Sugimoto, Kengo Ikesugi, Hisashi Matsubara, Mineo Kondo,

<h4>Purpose</h4>To report abnormal full-field electroretinograms (ERGs) in a patient with cystoid macular edema (CME) induced by systemic paclitaxel.<h4>Methods</h4>This is an observational case report. Full-field ERGs were recorded to evaluate the retinal function using the RETeval system and conventional ERGs using contact lens electrodes with built-in white light-emitting diodes. Optical coherence ... Read more >>

Doc Ophthalmol (Documenta ophthalmologica. Advances in ophthalmology)
[2021, 143(2):229-235]

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