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Journal Differentiation

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CircRNAs and LncRNAs in Osteoporosis.

Tiantian He, Wei Liu, Lihua Cao, Ying Liu, Zi Zou, Yancheng Zhong, Haihua Wang, Yuqing Mo, Shuping Peng, Cijun Shuai,

Osteoporosis is a systemic bone disease with bone fragility and increased fracture risk. The non-coding RNAs (ncRNAs) have appeared as important regulators of cellular signaling and pertinent human diseases. Studies have demonstrated that circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) are involved in the progression of osteoporosis through a ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 116:16-25]

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New frontiers of developmental endocrinology opened by researchers connecting irreversible effects of sex hormones on developing organs.

Taisen Iguchi, Tomomi Sato, Tadaaki Nakajima, Shinichi Miyagawa, Noboru Takasugi,

In the early 1960's, at Professor Bern's laboratory, University of California, Berkeley) in the US, Takasugi discovered ovary-independent, persistent vaginal changes in mice exposed neonatally to estrogen, which resulted in vaginal cancer later in life. Reproductive abnormalities in rodents were reported as a result of perinatal exposure to various estrogenic ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, :]

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Ontogeny of estrogen receptors in human male and female fetal reproductive tracts.

Gerald R Cunha, Yi Li, Cao Mei, Amber Derpinghaus, Laurence S Baskin,

This paper reviews and provides new observations on the ontogeny of estrogen receptor alpha (ESR1) and estrogen receptor beta (ESR2) in developing human male and female internal and external genitalia. Included in this study are observations on the human fetal uterine tube, the uterotubal junction, uterus, cervix, vagina, penis and ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, :]

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The involvement of hsa_circ_0000417 in the development of hypospadias by regulating AR.

Chao Chen, Yong-Yuan Jian, Xiang-You Zhao, Yu-Ling Liu, Qi-Ke Xie,

BACKGROUND:Congenital hypospadias is a common congenital malformation of the urinary system in male children. However, the role of circRNA in congenital hypospadias remains unknown. METHODS:Differentially expressed circRNAs and mRNAs were identified by RNA sequencing. GO and KEEG analysis were performed to uncover the key function and pathways. The interaction networks ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 116:9-15]

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LINC00968 promotes osteogenic differentiation in vitro and bone formation in vivo via regulation of miR-3658/RUNX2.

Chunhui Liao, Yutao Zhou, Mingfei Li, Yixin Xia, Wei Peng,

Osteogenic differentiation of dental pulp stem cells (DPSCs) is considered as a promising strategy in posterior maxilla tooth implantation. Information on the function and mechanisms of long non-coding RNAs (lncRNAs) in osteogenic differentiation of DPSCs is growing, however, the mechanism of LINC00968 and miR-3658 in regulating osteogenic differentiation of DPSCs ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 116:1-8]

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Corrigendum to "Angiotensin II promotes differentiation of mouse embryonic stem cells to smooth muscle cells through PI3-kinase signaling pathway and NF-κB" [Differentiation (2013) 41-54].

Xiaoye Zheng, Yutao Wu, Liangfeng Zhu, Qishan Chen, Yijiang Zhou, Hui Yan, Ting Chen, Qingzhong Xiao, Jianhua Zhu, Li Zhang,

Differentiation (Differentiation; research in biological diversity)
[2020, 116:39]

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Anatomy of the mouse penis and internal prepuce.

Gerald R Cunha, Mei Cao, Adriane Sinclair, Amber Derpinghaus, Laurence S Baskin,

This paper addresses a confusing issue of preputial anatomy of the mouse. The term "internal prepuce" was used in 2013 to describe a preputial structure integral to the mouse glans penis. Subsequently in 2015 the same term was applied by another group to describe entirely different morphology, generating confusion in ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 116:26-37]

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Estrogens and development of the mouse and human external genitalia.

Laurence Baskin, Adriane Sinclair, Amber Derpinghaus, Mei Cao, Yi Li, Maya Overland, Sena Aksel, Gerald R Cunha,

The Jost hypothesis states that androgens are necessary for normal development of the male external genitalia. In this review, we explore the complementary hypothesis that estrogens can elicit abnormal development of male external genitalia. Herein, we review available data in both humans and mice on the deleterious effects of estrogen ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, :]

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Murine in vitro cellular models to better understand adipogenesis and its potential applications.

Muhammad Sufyan Vohra, Bilal Ahmad, Christopher J Serpell, Ishwar S Parhar, Eng Hwa Wong,

Adipogenesis has been extensively studied using in vitro models of cellular differentiation, enabling long-term regulation of fat cell metabolism in human adipose tissue (AT) material. Many studies promote the idea that manipulation of this process could potentially reduce the prevalence of obesity and its related diseases. It has now become ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 115:62-84]

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A uniform expression library for the exploration of FOX transcription factor biology.

Lavanya Moparthi, Stefan Koch,

Forkhead box (FOX) family transcription factors play essential roles in development, tissue homeostasis, and disease. Although the biology of several FOX proteins has been studied in depth, it is unclear to what extent these findings apply to even closely related family members, which frequently exert overlapping but non-redundant functions. To ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 115:30-36]

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Sox17-mediated expression of adherent molecules is required for the maintenance of undifferentiated hematopoietic cluster formation in midgestation mouse embryos.

Satomi Takahashi, Ikuo Nobuhisa, Kiyoka Saito, Melig Gerel, Ayumi Itabashi, Kaho Harada, Mitsujiro Osawa, Takaho A Endo, Atsushi Iwama, Tetsuya Taga,

Hematopoietic stem cell-containing intra-aortic hematopoietic cell clusters (IAHCs) emerge in the dorsal aorta of the aorta-gonad-mesonephros (AGM) region during midgestation mouse embryos. We previously showed that transduction of Sox17 in CD45lowc-Kithigh cells, which are one component of IAHCs, maintained the cluster formation and the undifferentiated state, but the mechanism of ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 115:53-61]

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Fetal bovine serum-derived exosomes regulate the adipogenic differentiation of human bone marrow mesenchymal stromal cells in a cross-species manner.

Qiongfei Zhou, Fen Xie, Bin Zhou, Chan Li, Yijun Kang, Bo Wu, Lin Li, Ruchun Dai,

Fetal bovine serum (FBS) contains a large number of exosomes which may disturb the analysis of exosomes derived from cultured cells. We investigated the effect of FBS-derived exosomes (FBS-Exos) on the adipogenic differentiation of human bone marrow mesenchymal stromal cells (hBM-MSCs) and the underlying molecular mechanism. The uptake of FBS-Exos ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 115:11-21]

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The cooperative effects of micro-grooved topography and TGF-β1 on the vascular smooth muscle cell contractile protein expression of the mesenchymal stem cells.

Sakhavat Abolhasani, Masoumeh Rajabibazl, Mohammad-Mehdi Khani, Azim Parandakh, Reyhaneh Hoseinpoor,

Cell morphological changes induced by micro-grooved topography have been shown to be an important regulator of smooth muscle (SM) differentiation of mesenchymal stem cells (MSCs). In addition to the micro-grooved topography, transforming growth factor-β1 (TGF-β1) can also modulate MSCs differentiation towards smooth muscle cells (SMCs) through alterations in cell morphological ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 115:22-29]

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Oxygen tension influences embryonic stem cell maintenance and has lineage specific effects on neural and cardiac differentiation.

Regina H Mennen, Victoria C de Leeuw, Aldert H Piersma,

The importance of oxygen tension in in vitro cultures and its effect on embryonic stem cell (ESC) differentiation has been widely acknowledged. Research has mainly focussed on ESC maintenance or on one line of differentiation and only few studies have examined the potential relation between oxygen tension during ESC maintenance ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 115:1-10]

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A comparison of prostatic development in xenografts of human fetal prostate and human female fetal proximal urethra grown in dihydrotestosterone-treated hosts.

Gerald R Cunha, Mei Cao, Omar Franco, Laurence S Baskin,

The goal of this paper is to explore the ability of the human female urogenital sinus immediately below the bladder (proximal urethra) to undergo prostatic development in response to dihydrotestosterone (DHT). To establish this idea, xenografts of human fetal female proximal urethra were grown in castrated nude mouse hosts receiving ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 115:37-52]

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p53 positively regulates osteoprotegerin-mediated inhibition of osteoclastogenesis by downregulating TSC2-induced autophagy in vitro.

Xishuai Tong, Jianhong Gu, Miaomiao Chen, Tao Wang, Hui Zou, Ruilong Song, Hongyan Zhao, Jianchun Bian, Zongping Liu,

Osteoclasts are terminally multinucleated cells that are regulated by nuclear factor-activated T cells c1 (NFATc1), and are responsible for bone resorption while the tartrate resistant acid phosphatase (TRAP) enzymes releases into bone resorption lacunae. Furthermore, tumor suppressor p53 is a negative regulator during osteoclastogenesis. Osteoprotegerin (OPG) inhibits osteoclastogenesis and bone ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 114:58-66]

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Analysis of hiPSCs differentiation toward hepatocyte-like cells upon extended exposition to oncostatin.

Mathieu Danoy, Yannick Tauran, Stéphane Poulain, Hiroshi Arakawa, Daiki Mori, Karin Araya, Sachi Kato, Taketomo Kido, Hiroyuki Kusuhara, Yukio Kato, Atsushi Miyajima, Charles Plessy, Yasuyuki Sakai, Eric Leclerc,

The capability to produce and maintain functional human adult hepatocytes remains one of the major challenges for the use of in-vitro models toward liver cell therapy and industrial drug-screening applications. Among the suggested strategies to solve this issue, the use of human-induced pluripotent stem cells (hiPSCs), differentiated toward hepatocyte-like cells ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 114:36-48]

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p53 inhibits the osteogenic differentiation but does not induce senescence in human dental follicle cells.

Oliver Pieles, Anja Reck, Torsten E Reichert, Christian Morsczeck,

Replicative senescence causes a reduced osteogenic differentiation potential of senescent dental follicle cells (DFCs). The transcription factor p53 is often involved in the induction of cellular senescence, but little is known about its role in DFCs. This study examined for the first time the role of p53 compared to its ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 114:20-26]

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Comparison of the biological characteristics of umbilical cord mesenchymal stem cells derived from the human heterosexual twins.

Yuanyuan Zhang, Pengju Lv, Yalong Li, Yonghui Zhang, Chaofei Cheng, Hongbo Hao, Han Yue,

Mesenchymal stromal/stem cells (MSCs) are attracting more and more attention due to their tissue regenerative properties and immunomodulatory functions. MSCs may be the most acceptable, safe, and effective source for allogeneic cell therapy, and have been used in medical treatment. However, the similarities and differences between umbilical cord-derived MSCs (UC-MSCs) ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 114:1-12]

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LncRNA-Gm2044 is transcriptionally activated by A-MYB and regulates Sycp1 expression as a miR-335-3p sponge in mouse spermatocyte-derived GC-2spd(ts) cells.

Meng Liang, Haiyan Wang, Chaofan He, Kejia Zhang, Ke Hu,

Long noncoding RNAs (lncRNAs) have been shown to execute key roles in spermatogenesis. However, little is known about how lncRNAs gene expression is itself regulated in the germ cells of testis. We previously demonstrated that high expression of lncRNA-Gm2044 exists in spermatocytes and can regulate male germ cell proliferation. Here, ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 114:49-57]

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Changes in Nup62 content affect contact-induced differentiation of cultured myoblasts.

Patrick J Bishop, Yayoi Kinoshita, N Natalie Lopes, Avery S Ward, D Stave Kohtz,

Differentiation of cultured skeletal myoblasts is induced by extrinsic signals that include reduction in ambient mitogen concentration and increased cell density. Using an established murine myoblast cell line (C2C12), we have found that experimental reduction of the nucleoporin p62 (Nup62) content of myoblasts enhances differentiation in high-mitogen medium, while forced ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 114:27-35]

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Laminins in osteogenic differentiation and pluripotency maintenance.

Chaozhen Chen, Zhiwei Jiang, Guoli Yang,

Extracellular matrix (ECM) plays an integral role in different developmental stages and in multiple systems. However, due to ECM being composed of various extracellular components (growth factors, cytokines, and hormones), its innate complexity and the lack of any efficient purification techniques limit further research into the detailed mechanisms of its ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 114:13-19]

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Maternal control of early patterning in sea urchin embryos.

Yulia O Kipryushina, Konstantin V Yakovlev,

Sea urchin development has been studied extensively for more than a century and considered regulative since the first experimental evidence. Further investigations have repeatedly supported this standpoint by revealing the presence of inductive mechanisms that alter cell fate decisions at early cleavage stages and flexibility of development in response to ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2020, 113:28-37]

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Comments on Professor Hüseyin Özbey's letter.

Gerald R Cunha, Laurence Baskin,

Differentiation (Differentiation; research in biological diversity)
[2020, 113:26]

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The facts and misconceptions in glans penis anatomy.

Hüseyin Özbey,

Differentiation (Differentiation; research in biological diversity)
[2020, 113:27]

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