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Journal Diagn. Cytopathol.

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The cytopathological spectrum of lymphomas in effusions in a tertiary center in Taiwan.

Ren Ching Wang, Yi-Hsiao Chen, Bo-Jung Chen, Shih-Sung Chuang,

Lymphomas presenting in effusions could either be primary or secondary, with very limited data from Taiwan. METHODS:We retrospectively reviewed effusion lymphomas from our archives in a tertiary center from July 2011 to June 2019. RESULTS:We identified 59 specimens from 43 patients, including 7 cases with primary effusion lymphoma (PEL) and ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Impact of ongoing COVID-19 pandemic on cytology: An institutional experience.

Chanchal Rana, Sumit Kumar, Suresh Babu, Rashmi Kushwaha, Uma S Singh, Pooja Ramakant, Kulranjan Singh, Anand Mishra,

BACKGROUND:The ongoing COVID-19 pandemic has greatly impacted the health services worldwide, challenging the way modern medicine has been practiced for decades. AIM:The present study documents an institutional experience on its impact on cytology services. MATERIALS & METHODS:The cytology samples received during lock down period in India (24 March to 17 ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Comparison of intraoperative imprints cytology with frozen section for lymph node metastasis in patients with head and neck squamous cell carcinoma.

Saheer Neduvanchery, Debasis Gochhait, Bheemanathi Hanuman Srinivas, K T Harichandrakumar, Pradeep Subramanian, Naveeth Shukkur, K Keerthana, Prasanth Penumadu,

BACKGROUND:Intraoperative evaluation of lymph nodal metastasis in head and neck squamous cell carcinoma (HNSCC) assumes importance and avoids over-treatment in clinically node negative (N0) neck. Frozen section (FZ) is the commonly employed technique, but it requires significant investment in resources, time, and personnel. Intraoperative imprint cytology (IC) is a rapid, ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Amyloid goiter diagnosis by ultrasound-guided fine needle aspiration performed by interventional pathologist.

Juan Carlos Celis Pinto, Héctor-Enrique Torres-Rivas, Luis Manuel Fernández Fernández, Karen Villar Zarra, María de la Paz González Gutiérrez,

Amyloid goiter (AG) (primary or secondary) is extremely rare. An abdominal fat pad core needle biopsy (CNB) is the diagnostic gold standard for secondary amyloidosis. Although CNB is useful to detect amyloid infiltration of a specific organ, fine-needle aspiration (FNA) is proven to be the best diagnostic method for thyroid ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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A second endoscopic ultrasound with fine-needle aspiration for cytology identifies high-risk pancreatic cysts overlooked by current guidelines.

Sandra Faias, Luisa Pereira, Ricardo Fonseca, Paula Chaves, António Dias Pereira, Marília Cravo,

BACKGROUND:Endoscopic ultrasound with fine-needle aspiration (EUS-FNA) is recommended for diagnosis of pancreatic cystic lesions (PCLs). Its role in surveillance is unclear. Our goal was to determine if a second EUS-FNA changes diagnosis or management of PCLs. METHODS:A retrospective analysis of an EUS database, searching for EUS-FNAs in PCLs from 2007 ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Fine Needle Aspiration Cytology of Malignant Digestive System Gastrointestinal Neuroectodermal Tumor in a Lymph Node Metastasis from a Previously Diagnosed Liver Primary: A Case Report and Review of Literature.

Ramya Gadde, Konstantinos Linos, Mikhail Lisovsky, Timothy Kerrigan, Andrew P Loehrer, Gyulnara Kasumova, Darcy A Kerr, Xiaoying Liu,

Malignant gastrointestinal neuroectodermal tumor (GNET) is an extremely rare neoplasm. Immunohistochemically, GNET typically demonstrates neural differentiation but lacks melanocytic differentiation, making it distinct from clear cell sarcoma of the soft tissues (CCS). Herein we report for the first time the cytomorphologic features of lymph node metastasis from presumably liver GNET. ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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An institutional experience: A retrospective analysis of the effect of transitioning from follicular lesion of undetermined significance to atypia of undetermined significance with subclassified atypia on interobserver concordance, rates of neoplasia, and rates of malignancy.

Lauren Kroll-Wheeler, Richard Cantley, Judy C Pang, Brian S Soles, Brian Smola, Xin Jing, Madelyn Lew,

INTRODUCTION:The rate of malignancy (ROM) in thyroid fine needle aspirations (FNA) classified under "atypia of undetermined significance (AUS)/follicular lesion of undetermined significance (FLUS), including Hürthle cell type (HLUS)" category of The Bethesda system for reporting thyroid cytopathology (TBSRTC) in literature is highly variable. The 2018 TBSRTC was updated to note ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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The prevalence, genotype distribution of human papillomavirus and cervical cytology in Wenzhou, China: a retrospective research of 7391 cases.

Qiongqiong Lin, Xiangjie Lin, Xiaoping Zhuang, Yibing Tang, Zhiguang Zhao,

BACKGROUND:Human papillomavirus (HPV) infection is the main pathogen of precancerous transformation and finally progress to cervical cancer. It associated with cervical squamous and glandular lesions. However, the genotype distribution of HPV and the relationship between HPV infection and cervical disease are still remind unclear. MATERIAL AND METHODS:A total of 7391 ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Axillary lymph node metastasis: Fine-needle aspiration biopsy sensitivity as a function of node size, percent replacement of lymph node by tumor and tumor deposit size.

Lester J Layfield, Tao Zhang, Magda Esebua, Robert Schmidt,

BACKGROUND:Fine-needle aspiration (FNA) is commonly used to investigate lymphadenopathy of suspected metastatic origin. While diagnostic accuracy of FNA for lymph node disease is well described, the relationship between node size, percent tumor replacement, and size of metastatic deposit with diagnostic accuracy is less well documented. METHODS:All axillary lymph nodes undergoing ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Insulin-induced amyloidoma-A cytological catch.

Santosh Tummidi, Pavithra Balakrishna, Yashita Gupta,

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Cytomorphology and diagnostic pitfalls of sebaceous and nonsebaceous salivary gland lymphadenoma: A multi-institutional study.

Kartik Viswanathan, Zahra Maleki, Liron Pantanowitz, Richard Cantley, William C Faquin,

BACKGROUND:Salivary gland lymphadenoma (LAD) is a rare benign neoplasm comprising sebaceous (SLAD) and nonsebaceous (NSLAD) types. Despite established histologic criteria, limited data on cytomorphology, tumor heterogeneity, and overlap with other entities make the diagnosis of LAD by fine needle aspiration (FNA) challenging. We describe a multi-institutional cohort of 14 LADs ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Squash smear cytology of pituitary granular cell tumor: A case report and review of literature with special emphasis on cytological differential diagnosis in pituitary region.

Ujjawal Khurana, Adesh Shrivastava, Rubal Jain, Garima Goel, Deepti Joshi, Neelkamal Kapoor,

Neurohypophysis granular cell tumor (NGCT) is a rare entity and is classified under thyroid transcription factor 1 (TTF-1) expressing tumors of pituitary. It is considered as an uncommon differential during sellar and suprasellar mass evaluation. Its intraoperative squash cytology is distinct and has rarely been reported in literature. A 65-year-old ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Giant cell-rich extrapleural solitary fibrous tumor: Cytological findings and differential diagnosis of a rare neoplasm.

Andrea Ronchi, Immacolata Cozzolino, Marco Montella, Anna Donadio, Gaetano Motta, Renato Franco, Lucio Palombini,

Extrapleural solitary fibrous tumor (ESFT) is a rare neoplasm with a variable biological behavior that may occur almost everywhere in the body, as it has been reported in head and neck, back, retroperitoneum, inguinal region and more. The diagnosis of ESFT may be challenging, especially in case of its morphological ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Pathologist-performed palpation-guided fine needle aspiration cytology of lingual actinomycosis: A case report and review of literature.

Zühal Özcan, Fügen Vardar Aker, Veysel Alparslan Gölcük,

"Lingual actinomycosis" is an uncommon, suppurative inflammation of lingual mucosa, caused by Actinomyces. Infectious oral lesions can mimic benign or malignant neoplasms and fine needle aspiration cytology (FNAC) is a simple, minimally invasive procedure for the assessment of patients with such lesions. Here, we describe the case of a 28-year ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Cytologic features of a case of mixed medullary and follicular cell-derived thyroid carcinoma with review of the literature.

Meagan Chambers, Laura J Tafe, Edward J Gutmann, Darcy A Kerr,

Mixed medullary and follicular cell-derived thyroid carcinoma (MMFTC) is a rare primary thyroid carcinoma with morphologic and immunophenotypic evidence of admixed parafollicular and follicular cell-derived tumor populations within the same tumor. We herein present the fine-needle aspiration biopsy (FNAB) cytology of a case of MMFTC that was diagnosed histologically and ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Liquid phase human papillomavirus genotype analysis of aspirated metastatic head and neck squamous cell carcinoma: Fine needle aspiration supernatant is a rich source of tumor DNA that can increase the diagnostic yield.

Yansheng Hao, Meenakshi Mehrotra, Hansen Lam, Qiusheng Si, Fadi Salem, Dan Lu, Melissa Gitman, Brett Miles, Marshall Posner, Jane Houldsworth, William H Westra,

BACKGROUND:Most patients with human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSC) present with lymph node metastasis. In these patients, fine needle aspiration (FNA) is not only a diagnostic tool, but a means for determining HPV status. HPV status, in turn, is used to determine tumor origin, prognosis, and ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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The role of cytology in endobronchial ultrasound-guided transbronchial needle aspiration: A study of 813 cases focusing on diagnostic yield, an analysis of misdiagnosed cases and diagnostic accordance rate of cytological subtyping.

Wen-Hao Ren, Shuang-Mei Zou, Yue-Ming Zhang, Lei Zhang, Lin-Lin Zhao, Ning Lu, Jian Cao,

BACKGROUND:Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive technique for cytological and histological diagnosis. The objective of this study was to explore the role of cytological diagnosis in EBUS-TBNAs. METHODS:Eight hundred and thirteen consecutive cases performed EBUS-TBNA with both cytological and histological diagnoses were retrospectively reviewed. All patients ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Fine-needle aspiration cytology of Bacille Calmette-Guerin adenitis: A perplexing distinct clinical entity.

Aleena Jain, Shruti Gupta, Parikshaa Gupta, Manish Rohilla, Nalini Gupta, Radhika Srinivasan, Arvind Rajwanshi, Pranab Dey,

BACKGROUND:Bacille Calmette-Guerin (BCG) adenitis is a common complication of post-BCG vaccination. Awareness of this lesser known entity in fine-needle aspiration (FNA) is important to prevent misdiagnosis. AIM:This study described the clinical presentation, cytomorphological features and disease pattern in patients with BCG adenitis. MATERIALS AND METHODS:We analyzed a series of 15 ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Aspergillus encephalitis masquerading as brain tumor: Diagnosis in a challenging case by intraoperative cytology.

Jai Kumar Chaurasia, Ashwani Tandon, Karuna Tadepalli, Bitan Naik, Neelkamal Kapoor,

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Optimized liquid-based cytology for the cellular and molecular analysis of oral keratinocytes: A promising diagnostic tool.

Yuliana Andrea Osorio-Osorno, David Arboleda Toro, Julian Camilo Arango, Monica Tatiana Parada-Sanchez,

BACKGROUND:Liquid-based cytology (LBC) has improved exfoliative cytology by facilitating the extraction of more precise information from epithelial cells. The aim of this study was to optimize a protocol using a conventional cytobrush to perform LBC, obtaining oral keratinocytes for their further cellular and molecular analysis. METHODS:LBC was performed in 30 ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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How useful are cervical Pap smears in detecting endometrial carcinomas? A tertiary cancer center experience.

Shailee P Mehta, Trupti S Patel, Torsha Jana, Satarupa T Samanta, Rujuta Malvania, Priti P Trivedi, Swati Girdher,

OBJECTIVE:To determine the role of routine cervical Pap smears in detecting endometrial carcinomas. METHOD:A retrospective study was carried out from the histopathology archives for cases diagnosed as endometrial carcinomas with Pap smears within 6 months before histological diagnosis. The demographic details, reports of Pap smears and other tumor parameters on ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Metastatic low-grade endometrial stromal sarcoma after 24 years: A case report and review of recent molecular genetics.

Andres E Mindiola-Romero, Xiaoying Liu, Jessica L Dillon, Michael Talarico, Geoffrey Smith, Linsheng Zhang, Konstantinos Linos,

Low-grade endometrial stromal sarcoma (LGESS) is a rare malignant uterine tumor with the potential to metastasize years after the primary resection. There is a broad differential diagnosis for endometrial stromal sarcomas (ESS), including both benign and malignant entities. Herein, we present the case of a 64-year-old female with metastatic LGESS ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Cytomorphological features of an unusual case of a multifocal pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma in a young adult male.

Bharat Rekhi, Mukta Ramadwar,

Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma (PMHE) is a relatively newly described vascular neoplasm, characterized by distinct clinicopathological and molecular features, with no report on its cytomorphological features on smears, till date. A 17-year-old male presented with multiple nodules on his left upper limb. Radiologic imaging disclosed multiple lesions involving the soft ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Conditions associated with the need for additional needle passes in ultrasound-guided thyroid fine-needle aspiration with rapid on-site pathology evaluation.

Ramin Zargham, Hannah Johnson, Scott Anderson, Allison Ciolino,

BACKGROUND:Rapid on-site evaluation (ROSE) is a valuable tool for specimen adequacy assessment in thyroid ultrasound (US)-guided fine-needle aspiration (US-guided FNA). To reduce the risk of nondiagnostic samples, additional needle passes may be needed at ROSE to ensure adequate sampling. Recommendations regarding the number of aspirates to ensure specimen adequacy are ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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A rare sporadic pancreatic desmoid fibromatosis diagnosed by endoscopic ultrasound-guided fine-needle aspiration: Case report and literature review.

Andrew B Stone, J Shawn Mallery, Jimmie Stewart, Khalid Amin,

Intra-abdominal desmoid fibromatosis (also known as desmoid tumor) is a rare benign but often locally aggressive infiltrative fibrous proliferation. Pancreatic desmoid fibromatosis is even rarer, with only 31 cases previously reported in the English-language literature. These tumors present a distinct diagnostic challenge due to their rarity and non-specific image findings ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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