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Journal Diabetologia

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Impact of insufficient sleep on dysregulated blood glucose control under standardised meal conditions.

Neli Tsereteli, Raphael Vallat, Juan Fernandez-Tajes, Linda M Delahanty, Jose M Ordovas, David A Drew, Ana M Valdes, Nicola Segata, Andrew T Chan, Jonathan Wolf, Sarah E Berry, Matthew P Walker, Timothy D Spector, Paul W Franks,

<h4>Aims/hypothesis</h4>Sleep, diet and exercise are fundamental to metabolic homeostasis. In this secondary analysis of a repeated measures, nutritional intervention study, we tested whether an individual's sleep quality, duration and timing impact glycaemic response to a breakfast meal the following morning.<h4>Methods</h4>Healthy adults' data (N = 953 [41% twins]) were analysed from the PREDICT ... Read more >>

Diabetologia (Diabetologia)
[2021, :]

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The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).

Richard I G Holt, J Hans DeVries, Amy Hess-Fischl, Irl B Hirsch, M Sue Kirkman, Tomasz Klupa, Barbara Ludwig, Kirsten Nørgaard, Jeremy Pettus, Eric Renard, Jay S Skyler, Frank J Snoek, Ruth S Weinstock, Anne L Peters,

The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) convened a writing group to develop a consensus statement on the management of type 1 diabetes in adults. The writing group has considered the rapid development of new treatments and technologies and addressed the following ... Read more >>

Diabetologia (Diabetologia)
[2021, 64(12):2609-2652]

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Prevalence of type 2 diabetes in psychiatric disorders: an umbrella review with meta-analysis of 245 observational studies from 32 systematic reviews.

Nanna Lindekilde, Stine H Scheuer, Femke Rutters, Lenette Knudsen, Mathias Lasgaard, Katrine H Rubin, Jan Erik Henriksen, Mika Kivimäki, Gregers S Andersen, Frans Pouwer,

<h4>Aims/hypothesis</h4>Estimates of the global prevalence of type 2 diabetes vary between 6% and 9%. The prevalence of type 2 diabetes has been investigated in psychiatric populations but a critical appraisal of the existing evidence is lacking, and an overview is needed. This umbrella review summarises existing systematic reviews of observational ... Read more >>

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[2021, :]

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Relative leucocyte telomere length is associated with incident end-stage kidney disease and rapid decline of kidney function in type 2 diabetes: analysis from the Hong Kong Diabetes Register.

Feifei Cheng, Andrea O Luk, Hongjiang Wu, Claudia H T Tam, Cadmon K P Lim, Baoqi Fan, Guozhi Jiang, Luke Carroll, Aimin Yang, Eric S H Lau, Alex C W Ng, Heung Man Lee, Elaine Chow, Alice P S Kong, Anthony C Keech, Mugdha V Joglekar, Wing Yee So, Anandwardhan A Hardikar, Juliana C N Chan, Alicia J Jenkins, Ronald C W Ma,

<h4>Aims/hypothesis</h4>Few large-scale prospective studies have investigated associations between relative leucocyte telomere length (rLTL) and kidney dysfunction in individuals with type 2 diabetes. We examined relationships between rLTL and incident end-stage kidney disease (ESKD) and the slope of eGFR decline in Chinese individuals with type 2 diabetes.<h4>Methods</h4>We studied 4085 Chinese individuals ... Read more >>

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Correction to: The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).

Richard I G Holt, J Hans DeVries, Amy Hess-Fischl, Irl B Hirsch, M Sue Kirkman, Tomasz Klupa, Barbara Ludwig, Kirsten Nørgaard, Jeremy Pettus, Eric Renard, Jay S Skyler, Frank J Snoek, Ruth S Weinstock, Anne L Peters,

Diabetologia (Diabetologia)
[2021, :]

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Fatty acid-binding protein 4: a key regulator of ketoacidosis in new-onset type 1 diabetes.

Noah Gruber, Moran Rathaus, Idit Ron, Rinat Livne, Sharon Sheinvald, Ehud Barhod, Rina Hemi, Amit Tirosh, Orit Pinhas-Hamiel, Amir Tirosh,

<h4>Aims/hypothesis</h4>Fatty acid-binding protein 4 (FABP4) is an adipokine with a key regulatory role in glucose and lipid metabolism. We prospectively evaluated the role of FABP4 in the pathophysiology of diabetic ketoacidosis (DKA) in new-onset type 1 diabetes.<h4>Methods</h4>Clinical and laboratory data were prospectively collected from consecutive children presenting with new-onset type ... Read more >>

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[2021, :]

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Up front.

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[2021, :]

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Differences in the prevalence of erectile dysfunction between novel subgroups of recent-onset diabetes.

Haifa Maalmi, Christian Herder, Gidon J Bönhof, Klaus Strassburger, Oana-Patricia Zaharia, Wolfgang Rathmann, Volker Burkart, Julia Szendroedi, Michael Roden, Dan Ziegler, ,

<h4>Aims/hypothesis</h4>In men with diabetes, the prevalence of erectile dysfunction increases with advanced age and longer diabetes duration and is substantially higher in men with type 2 diabetes than those with type 1 diabetes. This study aimed to evaluate the prevalence of erectile dysfunction among the five novel subgroups of recent-onset ... Read more >>

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[2021, :]

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Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet.

Karin M Kirschner, Anna Foryst-Ludwig, Sabrina Gohlke, Chen Li, Roberto E Flores, Ulrich Kintscher, Michael Schupp, Tim J Schulz, Holger Scholz,

<h4>Aims/hypothesis</h4>Despite a similar fat storing function, visceral (intra-abdominal) white adipose tissue (WAT) is detrimental, whereas subcutaneous WAT is considered to protect against metabolic disease. Recent findings indicate that thermogenic genes, expressed in brown adipose tissue (BAT), can be induced primarily in subcutaneous WAT. Here, we investigate the hypothesis that the ... Read more >>

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[2021, :]

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Interpreting global trends in type 2 diabetes complications and mortality.

Mohammed K Ali, Jonathan Pearson-Stuttard, Elizabeth Selvin, Edward W Gregg,

International trends in traditional diabetes complications (cardiovascular, renal, peripheral vascular, ophthalmic, hepatic or neurological diseases) and mortality rates are poorly characterised. An earlier review of studies published up to 2015 demonstrated that most data come from a dozen high-income countries (HICs) in North America, Europe or the Asia-Pacific region and ... Read more >>

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[2021, :]

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Breastfeeding and circulating immunological markers during the first 3 years of life: the DIABIMMUNE study.

Maija E Miettinen, Jarno Honkanen, Sari Niinistö, Outi Vaarala, Suvi M Virtanen, Mikael Knip, ,

<h4>Aims/hypothesis</h4>Our aim was to study the association between duration of breastfeeding and circulating immunological markers during the first 3 years of life in children with HLA-conferred susceptibility to type 1 diabetes.<h4>Methods</h4>We performed a longitudinal analysis of 38 circulating immunological markers (cytokines, chemokines and growth factors) in serum samples from Finnish (56 ... Read more >>

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[2021, :]

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Correction to: Flash glucose monitoring and automated bolus calculation in type 1 diabetes treated with multiple daily insulin injections: a 26 week randomised, controlled, multicentre trial.

Anna Lilja Secher, Ulrik Pedersen-Bjergaard, Ole L Svendsen, Birthe Gade-Rasmussen, Thomas Almdal, Linda Raimond, Dorte Vistisen, Kirsten Nørgaard,

Diabetologia (Diabetologia)
[2021, :]

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Correction to: Subgroups of patients with young-onset type 2 diabetes in India reveal insulin deficiency as a major driver.

Rashmi B Prasad, Olof Asplund, Sharvari R Shukla, Rucha Wagh, Pooja Kunte, Dattatrey Bhat, Malay Parekh, Meet Shah, Sanat Phatak, Annemari Käräjämäki, Anupam Datta, Sanjeeb Kakati, Tiinamaija Tuomi, Banshi Saboo, Emma Ahlqvist, Leif Groop, Chittaranjan S Yajnik,

Diabetologia (Diabetologia)
[2021, :]

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Environmental risk factors of type 2 diabetes-an exposome approach.

Joline W J Beulens, Maria G M Pinho, Taymara C Abreu, Nicole R den Braver, Thao M Lam, Anke Huss, Jelle Vlaanderen, Tabea Sonnenschein, Noreen Z Siddiqui, Zhendong Yuan, Jules Kerckhoffs, Alexandra Zhernakova, Milla F Brandao Gois, Roel C H Vermeulen,

Type 2 diabetes is one of the major chronic diseases accounting for a substantial proportion of disease burden in Western countries. The majority of the burden of type 2 diabetes is attributed to environmental risks and modifiable risk factors such as lifestyle. The environment we live in, and changes to ... Read more >>

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[2021, :]

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Predicting non-insulin-dependent state in patients with slowly progressive insulin-dependent (type 1) diabetes mellitus or latent autoimmune diabetes in adults.

Kazutoshi Sugiyama, Yoshifumi Saisho,

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[2021, :]

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Artificial intelligence utilising corneal confocal microscopy for the diagnosis of peripheral neuropathy in diabetes mellitus and prediabetes.

Frank G Preston, Yanda Meng, Jamie Burgess, Maryam Ferdousi, Shazli Azmi, Ioannis N Petropoulos, Stephen Kaye, Rayaz A Malik, Yalin Zheng, Uazman Alam,

<h4>Aims/hypothesis</h4>We aimed to develop an artificial intelligence (AI)-based deep learning algorithm (DLA) applying attribution methods without image segmentation to corneal confocal microscopy images and to accurately classify peripheral neuropathy (or lack of).<h4>Methods</h4>The AI-based DLA utilised convolutional neural networks with data augmentation to increase the algorithm's generalisability. The algorithm was trained ... Read more >>

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[2021, :]

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Associations of plasma glycerophospholipid profile with modifiable lifestyles and incident diabetes in middle-aged and older Chinese.

Shuangshuang Chen, Geng Zong, Qingqing Wu, Huan Yun, Zhenhua Niu, He Zheng, Rong Zeng, Liang Sun, Xu Lin,

<h4>Aims/hypothesis</h4>Glycerophospholipid (GPL) perturbance was linked to the pathogenesis of diabetes in animal studies but prospective studies in humans are rare, particularly in Asians. We aimed to investigate the associations between plasma GPLs and incident diabetes and to explore effects of lifestyle on the associations in a Chinese population.<h4>Methods</h4>The study included ... Read more >>

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[2021, :]

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Diets for weight management in adults with type 2 diabetes: an umbrella review of published meta-analyses and systematic review of trials of diets for diabetes remission.

Chaitong Churuangsuk, Julien Hall, Andrew Reynolds, Simon J Griffin, Emilie Combet, Michael E J Lean,

<h4>Aims/hypothesis</h4>Weight reduction is fundamental for type 2 diabetes management and remission, but uncertainty exists over which diet type is best to achieve and maintain weight loss. We evaluated dietary approaches for weight loss, and remission, in people with type 2 diabetes to inform practice and clinical guidelines.<h4>Methods</h4>First, we conducted a ... Read more >>

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[2021, :]

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The role of circulating galectin-1 in type 2 diabetes and chronic kidney disease: evidence from cross-sectional, longitudinal and Mendelian randomisation analyses.

Isabel Drake, Emanuel Fryk, Lena Strindberg, Annika Lundqvist, Anders H Rosengren, Leif Groop, Emma Ahlqvist, Jan Borén, Marju Orho-Melander, Per-Anders Jansson,

<h4>Aims/hypothesis</h4>Galectin-1 modulates inflammation and angiogenesis, and cross-sectional studies indicate that galectin-1 may be a uniting factor between obesity, type 2 diabetes and kidney function. We examined whether circulating galectin-1 can predict incidence of chronic kidney disease (CKD) and type 2 diabetes in a middle-aged population, and if Mendelian randomisation (MR) ... Read more >>

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[2021, :]

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Kidney outcomes and all-cause mortality in people with type 2 diabetes exhibiting non-albuminuric kidney insufficiency.

Yui Yamamoto, Ko Hanai, Tomomi Mori, Yoichi Yokoyama, Naoshi Yoshida, Hidekazu Murata, Tomohiro Shinozaki, Tetsuya Babazono,

<h4>Aim/hypothesis</h4>It remains unclear whether people with diabetes exhibiting non-albuminuric kidney insufficiency have higher risk of kidney function decline and mortality compared with those exhibiting preserved kidney function without albuminuria. Furthermore, information regarding the incidence of albuminuria in people with this unique phenotype is sparse. Here, we aimed to elucidate the ... Read more >>

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[2021, :]

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A PSAD Group response to the consensus report on the definition and interpretation of remission in type 2 diabetes: a psychosocial perspective is needed.

Jane Speight, Timothy C Skinner, Jörg W Huber, Amelia J Lake, Rossella Messina, Andreia Mocan, Giesje Nefs, Lisa Newson, Rachel Povey, Michael Vallis, Ingrid Willaing, ,

Diabetologia (Diabetologia)
[2021, :]

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Predicting non-insulin-dependent state in patients with slowly progressive insulin-dependent (type 1) diabetes mellitus or latent autoimmune diabetes in adults. Reply to Sugiyama K and Saisho Y [letter].

Eri Wada, Takeshi Onoue, Tamaki Kinoshita, Ayaka Hayase, Tomoko Handa, Masaaki Ito, Mariko Furukawa, Takayuki Okuji, Tomoko Kobayashi, Shintaro Iwama, Mariko Sugiyama, Hiroshi Takagi, Daisuke Hagiwara, Hidetaka Suga, Ryoichi Banno, Motomitsu Goto, Hiroshi Arima,

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[2021, :]

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Lipotoxicity-induced circGlis3 impairs beta cell function and is transmitted by exosomes to promote islet endothelial cell dysfunction.

Li Xiong, Li Chen, Liting Wu, Weiman He, Dubo Chen, Zishan Peng, Jin Li, Xiaonan Zhu, Lei Su, Yanbing Li, Yingying Gong, Haipeng Xiao,

<h4>Aims/hypothesis</h4>Lipotoxicity constitutes the major driving force for type 2 diabetes. Circular RNAs (circRNAs) play important roles in regulating beta cell function and exosomes are essential mediators of intercellular communication. The role of exosomal circRNAs in type 2 diabetes remains largely unknown. We aimed to examine whether lipotoxicity induces dysregulation of ... Read more >>

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[2021, :]

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Exercise facilities and the prevalence of obesity and type 2 diabetes in the city of Madrid.

Luis Cereijo, Pedro Gullón, Isabel Del Cura, David Valadés, Usama Bilal, Hannah Badland, Manuel Franco,

<h4>Aims/hypothesis</h4>We aimed to study the association between the availability of exercise facilities and the likelihood of obesity and type 2 diabetes in the adult population of Madrid, Spain.<h4>Methods</h4>We analysed the electronic medical records of all 1,270,512 residents of Madrid aged 40-75 years in 2017. Exercise facility availability was defined as the ... Read more >>

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[2021, :]

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Individualised screening of diabetic foot: creation of a prediction model based on penalised regression and assessment of theoretical efficacy.

Iztok Štotl, Rok Blagus, Vilma Urbančič-Rovan,

<h4>Aims/hypothesis</h4>A large proportion of people with diabetes do not receive proper foot screening due to insufficiencies in healthcare systems. Introducing an effective risk prediction model into the screening protocol would potentially reduce the required screening frequency for those considered at low risk for diabetic foot complications. The main aim of ... Read more >>

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[2021, :]

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