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Journal Diabetes Care

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Islet Autoantibody Type-Specific Titer Thresholds Improve Stratification of Risk of Progression to Type 1 Diabetes in Children.

Kenney Ng, Harry Stavropoulos, Vibha Anand, Riitta Veijola, Jorma Toppari, Marlena Maziarz, Markus Lundgren, Kathy Waugh, Brigitte I Frohnert, Frank Martin, William Hagopian, Peter Achenbach, ,

<h4>Objective</h4>To use islet autoantibody titers to improve the estimation of future type 1 diabetes risk in children.<h4>Research design and methods</h4>Prospective cohort studies in Finland, Germany, Sweden, and the U.S. followed 24,662 children at increased genetic or familial risk to develop islet autoimmunity and diabetes. For 1,604 children with confirmed positivity, ... Read more >>

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Gestational Diabetes Mellitus and the Risks of Overall and Type-Specific Cardiovascular Diseases: A Population- and Sibling-Matched Cohort Study.

Yongfu Yu, Melissa Soohoo, Henrik Toft Sørensen, Jiong Li, Onyebuchi A Arah,

To evaluate associations between gestational diabetes mellitus (GDM) and various incident cardiovascular disease (CVD) end points, considering the effects of the mediating role of type 2 diabetes and shared environmental/familial factors. This population-based cohort study included 10,02,486 parous women in Denmark during 1978-2016. We used Cox regression to 1) examine ... Read more >>

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Effect of Loss-of-Function Genetic Variants in PCSK9 on Glycemic Traits, Neurocognitive Impairment, and Hepatobiliary Function.

Jonas Ghouse, Gustav Ahlberg, Henning Bundgaard, Morten S Olesen,

<h4>Objective</h4>To evaluate the association between <i>PCSK9</i> predicted loss-of-function (pLoF) variants and glycemic traits, hepatobiliary function, and neurocognitive traits.<h4>Research design and methods</h4>We identified carriers of <i>PCSK9</i> pLoF variants in UK Biobank exome sequencing data. We assessed the aggregate effects of these variants on lipid and lipoprotein traits, which served as a ... Read more >>

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Clinically Relevant Circulating Protein Biomarkers for Type 1 Diabetes: Evidence From a Two-Sample Mendelian Randomization Study.

Nahid Yazdanpanah, Mojgan Yazdanpanah, Ye Wang, Vincenzo Forgetta, Michael Pollak, Constantin Polychronakos, J Brent Richards, Despoina Manousaki,

<h4>Objective</h4>To identify circulating proteins influencing type 1 diabetes susceptibility using Mendelian randomization (MR).<h4>Research design and methods</h4>We used a large-scale two-sample MR study, using <i>cis</i> genetic determinants (protein quantitative trait loci [pQTL]) of up to 1,611 circulating proteins from five large genome-wide association studies, to screen for causal associations of these ... Read more >>

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[2021, :]

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Emotional Correlates of the COVID-19 Pandemic in Individuals With and Without Diabetes.

Barbara A Myers, Rachel Klingensmith, Mary de Groot,

<h4>Objective</h4>To compare the mental health experiences associated with coronavirus disease 2019 (COVID-19) in adults with and without diabetes.<h4>Research design and methods</h4>Between 29 May 2020 and 30 June 2020, 2,176 U.S. adults completed an online survey including demographics, COVID-19 experiences, depression (eight-item Patient Health Questionnaire) and anxiety (seven-item Generalized Anxiety Disorder) ... Read more >>

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[2021, :]

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Changes in the Prevalence of Symptoms of Depression, Loneliness, and Insomnia in U.S. Older Adults With Type 2 Diabetes During the COVID-19 Pandemic: The Look AHEAD Study.

Ariana M Chao, Thomas A Wadden, Jeanne M Clark, Kathleen M Hayden, Marjorie J Howard, Karen C Johnson, Blandine Laferrère, Jeanne M McCaffery, Rena R Wing, Susan Z Yanovski, Lynne E Wagenknecht, ,

<h4>Objective</h4>To evaluate changes in the prevalence of depressive symptoms, loneliness, and insomnia among older adults with type 2 diabetes from 2016 to 2020 and to assess risk factors for these conditions including demographics, multimorbidity, BMI, treatment group, and pre-coronavirus 2019 (COVID-19) measure scores.<h4>Research design and methods</h4>This was a prospective, observational ... Read more >>

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Hypoglycemic and Hyperglycemic Crises Among U.S. Adults With Diabetes and End-stage Kidney Disease: Population-Based Study, 2013-2017.

Rodolfo J Galindo, Mohammed K Ali, Shealeigh A Funni, Andrew B Dodge, Shaheen S Kurani, Nilay D Shah, Guillermo E Umpierrez, Rozalina G McCoy,

<h4>Objective</h4>We characterized annual trends of severe hypoglycemic and hyperglycemic crises (diabetic ketoacidosis/hyperglycemic hyperosmolar state) in patients with diabetes and end-stage kidney disease (ESKD).<h4>Research design and methods</h4>This was a nationwide, retrospective study of adults (≥18 years old) with diabetes/ESKD, from the United States Renal Data System registry, between 2013 and 2017. ... Read more >>

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Rethinking the Goals of Diabetes Prevention Programs.

Briana Mezuk, Julie Ober Allen,

Diabetes Care (Diabetes care)
[2021, 44(11):2457-2459]

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Response to Comment on Rosenstock et al. Impact of a Weekly Glucagon-Like Peptide 1 Receptor Agonist, Albiglutide, on Glycemic Control and on Reducing Prandial Insulin Use in Type 2 Diabetes Inadequately Controlled on Multiple Insulin Therapy: A Randomized Trial. Diabetes Care 2020;43:2509-2518.

Julio Rosenstock,

Diabetes Care (Diabetes care)
[2021, 44(11):e196-e197]

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Adult-Onset Type 1 Diabetes: Current Understanding and Challenges.

R David Leslie, Carmella Evans-Molina, Jacquelyn Freund-Brown, Raffaella Buzzetti, Dana Dabelea, Kathleen M Gillespie, Robin Goland, Angus G Jones, Mark Kacher, Lawrence S Phillips, Olov Rolandsson, Jana L Wardian, Jessica L Dunne,

Recent epidemiological data have shown that more than half of all new cases of type 1 diabetes occur in adults. Key genetic, immune, and metabolic differences exist between adult- and childhood-onset type 1 diabetes, many of which are not well understood. A substantial risk of misclassification of diabetes type can ... Read more >>

Diabetes Care (Diabetes care)
[2021, 44(11):2449-2456]

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Characteristics of Workplace Psychosocial Resources and Risk of Diabetes: A Prospective Cohort Study.

Tianwei Xu, Alice J Clark, Jaana Pentti, Reiner Rugulies, Theis Lange, Jussi Vahtera, Linda L Magnusson Hanson, Hugo Westerlund, Mika Kivimäki, Naja H Rod,

<h4>Objective</h4>To examine whether characteristics of workplace psychosocial resources are associated with the risk of type 2 diabetes among employees.<h4>Research design and methods</h4>Participants were 49,835 employees (77% women, aged 40-65 years, and diabetes free at baseline) from the Finnish Public Sector cohort study. Characteristics of horizontal (culture of collaboration and support ... Read more >>

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Response to Comment on Paolisso et al. Impact of Admission Hyperglycemia on Heart Failure Events and Mortality in Patients With Takotsubo Syndrome at Long-term Follow-up: Data From HIGH-GLUCOTAKO Investigators. Diabetes Care 2021;44:2158-2161.

Pasquale Paolisso, Luca Bergamaschi, Pietro Rambaldi, Gianluca Gatta, Alberto Foà, Francesco Angeli, Michele Fabrizio, Gianni Casella, Michelangela Barbieri, Nazzareno Galiè, Raffaele Marfella, Carmine Pizzi, Celestino Sardu,

Diabetes Care (Diabetes care)
[2021, 44(11):e201-e202]

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Comment on Rosenstock et al. Impact of a Weekly Glucagon-Like Peptide 1 Receptor Agonist, Albiglutide, on Glycemic Control and on Reducing Prandial Insulin Use in Type 2 Diabetes Inadequately Controlled on Multiple Insulin Therapy: A Randomized Trial. Diabetes Care 2020;43:2509-2518.

Chinmay S Marathe, Karen L Jones, Christopher K Rayner, Tongzhi Wu, Michael Horowitz,

Diabetes Care (Diabetes care)
[2021, 44(11):e194-e195]

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Body Fat Distribution, Cardiometabolic Traits, and Risk of Major Lower-Extremity Arterial Disease in Postmenopausal Women.

Guo-Chong Chen, Rhonda Arthur, Victor Kamensky, Jin Choul Chai, Bing Yu, Aladdin H Shadyab, Matthew Allison, Yangbo Sun, Nazmus Saquib, Robert A Wild, Wei Bao, Andrew J Dannenberg, Thomas E Rohan, Robert C Kaplan, Sylvia Wassertheil-Smoller, Qibin Qi,

<h4>Objective</h4>To assess the relationship between body fat distribution and incident lower-extremity arterial disease (LEAD).<h4>Research design and methods</h4>We included 155,925 postmenopausal women with anthropometric measures from the Women's Health Initiative who had no known LEAD at recruitment. A subset of 10,894 participants had body composition data quantified by DXA. Incident cases ... Read more >>

Diabetes Care (Diabetes care)
[2021, :]

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Remission of Type 2 Diabetes Following a Short-term Intensive Intervention With Insulin Glargine, Sitagliptin, and Metformin: Results of an Open-label Randomized Parallel-Design Trial.

Natalia McInnes, Stephanie Hall, Irene Hramiak, Ronald J Sigal, Ronald Goldenberg, Nikhil Gupta, Remi Rabasa-Lhoret, Manoela Braga, Vincent Woo, Farah Sultan, Rose Otto, Ada Smith, Diana Sherifali, Yan Yun Liu, Hertzel C Gerstein, , ,

<h4>Objective</h4>The aim of the study was to evaluate remission of type 2 diabetes following a short-term intervention with insulin glargine, sitagliptin/metformin, and lifestyle approaches.<h4>Research design and methods</h4>In this open multicenter trial, 102 patients with type 2 diabetes were randomized to <i>1</i>) a 12-week intervention with sitagliptin/metformin, insulin glargine and lifestyle ... Read more >>

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Relationships of Changes in Physical Activity and Sedentary Behavior With Changes in Physical Fitness and Cardiometabolic Risk Profile in Individuals With Type 2 Diabetes: The Italian Diabetes and Exercise Study 2 (IDES_2).

Stefano Balducci, Jonida Haxhi, Massimo Sacchetti, Giorgio Orlando, Patrizia Cardelli, Martina Vitale, Lorenza Mattia, Carla Iacobini, Lucilla Bollanti, Francesco Conti, Silvano Zanuso, Antonio Nicolucci, Giuseppe Pugliese, , ,

<h4>Objective</h4>In the Italian Diabetes and Exercise Study_2 (IDES_2), behavioral counseling promoted a sustained increase in physical activity (PA) volume (+3.3 MET h ⋅ week<sup>-1</sup>), moderate- to vigorous-intensity PA (MVPA) (+6.4 min ⋅ day<sup>-1</sup>), and light-intensity PA (LPA) (+0.8 h ⋅ day<sup>-1</sup>) and decrease in sedentary time (SED-time) (-0.8 h ⋅ ... Read more >>

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The Impact of Racial and Ethnic Health Disparities in Diabetes Management on Clinical Outcomes: A Reinforcement Learning Analysis of Health Inequity Among Youth and Young Adults in the SEARCH for Diabetes in Youth Study.

Anna R Kahkoska, Teeranan Pokaprakarn, G Rumay Alexander, Tessa L Crume, Dana Dabelea, Jasmin Divers, Lawrence M Dolan, Elizabeth T Jensen, Jean M Lawrence, Santica Marcovina, Amy K Mottl, Catherine Pihoker, Sharon H Saydah, Michael R Kosorok, Elizabeth J Mayer-Davis,

<h4>Objective</h4>To estimate difference in population-level glycemic control and the emergence of diabetes complications given a theoretical scenario in which non-White youth and young adults (YYA) with type 1 diabetes (T1D) receive and follow an equivalent distribution of diabetes treatment regimens as non-Hispanic White YYA.<h4>Research design and methods</h4>Longitudinal data from YYA ... Read more >>

Diabetes Care (Diabetes care)
[2021, :]

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Cluster Analysis of Cardiovascular Phenotypes in Patients With Type 2 Diabetes and Established Atherosclerotic Cardiovascular Disease: A Potential Approach to Precision Medicine.

Abhinav Sharma, Yinggan Zheng, Justin A Ezekowitz, Cynthia M Westerhout, Jacob A Udell, Shaun G Goodman, Paul W Armstrong, John B Buse, Jennifer B Green, Robert G Josse, Keith D Kaufman, Darren K McGuire, Giuseppe Ambrosio, Lee-Ming Chuang, Renato D Lopes, Eric D Peterson, Rury R Holman,

<h4>Objective</h4>Phenotypic heterogeneity among patients with type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD) is ill defined. We used cluster analysis machine-learning algorithms to identify phenotypes among trial participants with T2DM and ASCVD.<h4>Research design and methods</h4>We used data from the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) study (<i>n</i> ... Read more >>

Diabetes Care (Diabetes care)
[2021, :]

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Diabetic Peripheral Neuropathy and Urological Complications in Type 1 Diabetes: Findings From the Epidemiology of Diabetes Interventions and Complications Study.

Rodica Pop-Busui, Barbara H Braffett, Hunter Wessells, William H Herman, Catherine L Martin, Alan M Jacobson, Aruna V Sarma, ,

<h4>Objective</h4>To evaluate associations between diabetic peripheral neuropathy (DPN) and urological complications in men and women with type 1 diabetes (T1D).<h4>Research design and methods</h4>Measurements of DPN at Epidemiology of Diabetes Intervention and Complications (EDIC) years 1, 14, and 17 and urological complications at EDIC year 17 were examined in 635 men ... Read more >>

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Response to Comment on Choi et al. Alcohol Abstinence and the Risk of Atrial Fibrillation in Patients With Newly Diagnosed Type 2 Diabetes Mellitus: a Nationwide Population-Based Study. Diabetes Care 2021;44:1393-1401.

You-Jung Choi, Kyung-Do Han, So-Ryoung Lee, Eue-Keun Choi, Seil Oh, Gregory Y H Lip,

Diabetes Care (Diabetes care)
[2021, 44(11):e199]

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Prognostic Models for Predicting Remission of Diabetes Following Bariatric Surgery: A Systematic Review and Meta-analysis.

Pushpa Singh, Nicola J Adderley, Jonathan Hazlehurst, Malcolm Price, Abd A Tahrani, Krishnarajah Nirantharakumar, Srikanth Bellary,

Remission of type 2 diabetes following bariatric surgery is well established, but identifying patients who will go into remission is challenging. To perform a systematic review of currently available diabetes remission prediction models, compare their performance, and evaluate their applicability in clinical settings. A comprehensive systematic literature search of MEDLINE, ... Read more >>

Diabetes Care (Diabetes care)
[2021, 44(11):2626-2641]

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Prediction of Personal Glycemic Responses to Food for Individuals With Type 1 Diabetes Through Integration of Clinical and Microbial Data.

Smadar Shilo, Anastasia Godneva, Marianna Rachmiel, Tal Korem, Dmitry Kolobkov, Tal Karady, Noam Bar, Bat Chen Wolf, Yitav Glantz-Gashai, Michal Cohen, Nehama Zuckerman Levin, Naim Shehadeh, Noah Gruber, Neriya Levran, Shlomit Koren, Adina Weinberger, Orit Pinhas-Hamiel, Eran Segal,

<h4>Objective</h4>Despite technological advances, results from various clinical trials have repeatedly shown that many individuals with type 1 diabetes (T1D) do not achieve their glycemic goals. One of the major challenges in disease management is the administration of an accurate amount of insulin for each meal that will match the expected ... Read more >>

Diabetes Care (Diabetes care)
[2021, :]

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Comment on Choi et al. Alcohol Abstinence and the Risk of Atrial Fibrillation in Patients With Newly Diagnosed Type 2 Diabetes Mellitus: A Nationwide Population-Based Study. Diabetes Care 2021;44:1393-1401.

Tsung-Kun Lin, Ya-Hui Lin, Gwo-Ping Jong,

Diabetes Care (Diabetes care)
[2021, 44(11):e198]

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Paul Zimmet: A Voice for Diabetes.

Jonathan E Shaw,

Diabetes Care (Diabetes care)
[2021, 44(11):2460-2463]

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Comment on Paolisso et al. Impact of Admission Hyperglycemia on Heart Failure Events and Mortality in Patients With Takotsubo Syndrome at Long-term Follow-up: Data From HIGH-GLUCOTAKO Investigators. Diabetes Care 2021;44:2158-2161.

John E Madias,

Diabetes Care (Diabetes care)
[2021, 44(11):e200]

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