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Journal Dev. Comp. Immunol.

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Xela DS2 and Xela VS2: Two novel skin epithelial-like cell lines from adult African clawed frog (Xenopus laevis) and their response to an extracellular viral dsRNA analogue.

Maxwell P Bui-Marinos, Joseph F A Varga, Nguyen T K Vo, Niels C Bols, Barbara A Katzenback,

The skin epithelial layer acts as an important immunological barrier against pathogens and is capable of recognizing and responding to pathogen-associated molecular patterns (PAMPs) in human and mouse models. Although presumed, it is unknown whether amphibian skin epithelial cells exhibit the ability to respond to PAMPs such as viral double-stranded ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 112:103759]

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Porcine CLEC12B is expressed on alveolar macrophages and blood dendritic cells.

Elvira Nieto-Pelegrín, Belén Álvarez, Paloma Martínez de la Riva, Daisuke Toki, Teresa Poderoso, Concepción Revilla, Hirohide Uenishi, Angel Ezquerra, Javier Domínguez,

CLEC12B is a C-type lectin-like receptor expressed on myeloid cells. In this study, we have characterized the porcine homologue of CLEC12B (poCLEC12B). To this end, we have generated constructs encoding a c-myc tagged version of the whole receptor, or its ectodomain fused to the Fc portion of human IgG1, from ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 111:103767]

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Characterization of the cathepsin D in Procambarus clarkii and its biological role in innate immune responses.

Xiao-Min Yu, Jia-Le Chen, Muhammad Nadeem Abbas, Isma Gul, Saima Kausar, Li-Shang Dai,

Cathepsin D belongs to aspartic protease family, produced in the rough endoplasmic reticulum, and then transported to lysosomes, where it participates in various physiological processes. Despite its importance, only a few reports available on the functional role of cathepsin D in crustaceans. Herein, we cloned a cDNA fragment of cathepsin ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 111:103766]

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DNA synthesis increases during the first hours post-emergence in Anopheles albimanus mosquito midgut.

Krystal Maya-Maldonado, Victor Cardoso-Jaime, Salvador Hernández-Martínez, Carlos Vázquez-Calzada, Fidel de la Cruz Hernández-Hernández, Humberto Lanz-Mendoza,

In hematophagous insects, the midgut is a fundamental barrier against infections and limits the development and transmission of pathogens. However, in mosquitoes, cell differentiation, proliferation, and cell cycle process in the midgut have not been characterized. Here we provide evidence of how cell cycle progression occurs in the newly emerged ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, :103753]

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A cytokine receptor domeless promotes white spot syndrome virus infection via JAK/STAT signaling pathway in red claw crayfish Cherax quadricarinatus.

Ling-Ke Liu, Xiao-Xiao Chen, Rui-Lin Gao, Ke-Jian Wang, Wen-Yun Zheng, Hai-Peng Liu,

The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway is pivotal in immune responses for a variety of pathogens in both vertebrates and invertebrates. Domeless (Dome), as a unique cytokine receptor, involves in the upstream JAK/STAT pathway in invertebrates. In this study, the full-length cDNA sequence of a ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 111:103749]

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Molecular characterization of a heat shock protein 21 (Hsp21) from red swamp crayfish, Procambarus clarkii in response to immune stimulation.

Li-Shang Dai, Saima Kausar, Isma Gul, Hai-Ling Zhou, Muhammad Nadeem Abbas, Ming-Jie Deng,

Small heat shock proteins are a molecular chaperone and implicated in various physiological and stress processes in animals. However, the immunological functions of Hsp genes remain to elucidate in the crustaceans, particularly in red swamp crayfish, Procambarus clarkii. Here we report the cloning of heat shock protein 21 from the ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 111:103755]

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Antibacterial functions of a novel fish-egg lectin from spotted knifejaw (Oplegnathus punctatus) during host defense immune responses.

Kai Zhang, Xiaobing Liu, Xuemei Li, Yuxiang Liu, Haiyang Yu, Jinxiang Liu, Quanqi Zhang,

Fish-egg lectins (FELs) have been identified in several teleost species and have been proved to play important roles in innate immune system against pathogen infection. In this study a novel fish-egg lectin (OppFEL) was identified from spotted knifejaw (Oplegnathus punctatus), and the expression patterns against bacterial infection was characterized. The ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 111:103758]

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The immune function of a novel crustin with an atypical WAP domain in regulating intestinal microbiota homeostasis in Litopenaeus vannamei.

Xinjia Lv, Shihao Li, Yang Yu, Jianhai Xiang, Fuhua Li,

Crustins are a family of antimicrobial peptides (AMP) with multiple functions, including antimicrobial activity, capability of protease inhibition, phagocytosis promotion, and wound healing in crustaceans. Till present, several members of crustins have been identified and their activities were studied. However, there are still less investigations on how they play functions ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 111:103756]

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O-antigen-deficient, live, attenuated Salmonella typhimurium confers efficient uptake, reduced cytotoxicity, and rapid clearance in chicken macrophages and lymphoid organs and induces significantly high protective immune responses that protect chickens against Salmonella infection.

Amal Senevirathne, Chamith Hewawaduge, Sungwoo Park, Ji-Young Park, Perumalraja Kirthika, John Hwa Lee,

In the present study, we developed an O-antigen-deficient, live, attenuated Salmonella Typhimurium (ST) strain (JOL2377) and assessed its safety, macrophage toxicity, invasion into lymphoid tissues, immunogenicity, and protection against Salmonella infection in chickens. The JOL2377 induced significantly lower cytotoxicity and higher level of cytokine response in IL-2, IL-10, IL-4, and ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 111:103745]

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Loss of control of the culturable bacteria in the hindgut of Bombyx mori after Cry1Ab ingestion.

Kai Wu, Jing Wang, Lei Geng, Kai Chen, Wuren Huang, Qiuning Liu, Brenda T Beerntsen, Erjun Ling,

Bt protein, produced by Bacillus thuringiensis, can bind receptors to destroy the physiological functions of the insect midgut. It is unknown whether Bt can also target the hindgut and influence its defense against fecal bacteria. Here we show that Crystal protein 1Ab (Cry1Ab), a Bt protein, was detected in the ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 111:103754]

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The involvement of ecdysone and ecdysone receptor in regulating the expression of antimicrobial peptides in Chinese mitten crab, Eriocheir sinensis.

Shu Huang, Qilin Yi, Xingye Lian, Siqi Xu, Chuanyan Yang, Jiejie Sun, Lingling Wang, Linsheng Song,

The ecdysone, 20-hydroxyecdysone (20E) and ecdysone receptor (EcR), are regarded as the key regulators of development, metamorphosis, and growth in arthropods. In the present study, the role of 20E and EsEcR in regulating the expression of antimicrobial peptides (AMPs) was investigated in Chinese mitten crab, Eriocheir sinensis. The concentration of ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 111:103757]

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Deletion mutant of PGE2 receptor using CRISPR-Cas9 exhibits larval immunosuppression and adult infertility in a lepidopteran insect, Spodoptera exigua.

Yonggyun Kim, Shabbir Ahmed, Md Abdullah Al Baki, Sunil Kumar, Kunwoo Kim, Youngjin Park, David Stanley,

Prostaglandins (PGs) mediate various physiological processes in insects and other invertebrates, but there is very little information on PG receptors. This study identified a PGE2 receptor (SePGE2R) in the lepidopteran insect, Spodoptera exigua, and addressed its functional association with cellular immunity, development, and reproduction. SePGE2R is expressed in most developmental ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 111:103743]

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Serum amyloid P-component/C-reactive proteins in fugu (Takifugu rubripes) egg with binding ability to disease-causing bacteria by carbohydrate-recognition.

Shigeyuki Tsutsui, Shintaro Matsui, Osamu Nakamura,

Two galactose-binding proteins were purified from the eggs of Takifugu rubripes by affinity chromatography. These proteins were detected at 26 and 23 kDa under reducing and at 40 and 45 kDa under non-reducing conditions at SDS-PAGE. The peptide sequences from both proteins matched to short-type pentraxin. The 26-kDa lectin was glycosylated, while ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 111:103748]

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Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM+ B cells.

Beatriz Abos, Tiehui Wang, Christopher J Secombes, Carolina Tafalla,

In mammals, conventional B (B2) cells are activated within lymphoid follicles through a close relationship with T follicular helper (Tfh) cells. The interaction between CD40 expressed on B cells and its ligand (CD40L) expressed on Tfh cells is a key signal that regulates the formation of germinal centers (GCs), B ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 111:103752]

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Immunoglobulin light chain κ precedes λ rearrangement in swine but a majority of λ+ B cells are generated earlier.

Marek Sinkora, Katerina Stepanova, Jana Sinkorova,

Developmental pathways for B cell lymphogenesis are sufficiently known only in mice and humans. However, both of these species rearrange immunoglobulin heavy chains (IgH) before light chains (IgL) while IgL precedes IgH rearrangement in swine. We demonstrate here that this reversed order of rearrangements have some concealed consequences: (1) we ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 111:103751]

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Infection and microbial molecular motifs modulate transcription of the interferon-inducible gene ifit5 in a teleost fish.

Dennis Berbulla Bela-Ong, Linn Greiner-Tollersrud, Yorick Andreas van der Wal, Ingvill Jensen, Ole Morten Seternes, Jorunn B Jørgensen,

Interferon-induced proteins with tetratricopeptide repeats (IFITs) are involved in antiviral defense. Members of this protein family contain distinctive multiple structural motifs comprising tetratricopeptides that are tandemly arrayed or dispersed along the polypeptide. IFIT-encoding genes are upregulated by type I interferons (IFNs) and other stimuli. IFIT proteins inhibit virus replication by ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 111:103746]

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Complement component C1q plays a critical role in VLRA/VLRC-mediated immune response.

Jun Li, Qinghua Ma, Huaixiu Liu, Xiaoping Song, Yue Pang, Peng Su, Feng Sun, Meng Gou, Jingjing Lu, Yue Shan, Xin Liu, Qingwei Li, Yinglun Han,

In jawless vertebrates, the lamprey complement component C1q (LC1q) acts as a lectin and activates lamprey complement component C3 (LC3) in association with mannose-binding lectin (MBL)-associated serine protease (MASP) via the lectin pathway. Furthermore, LC1q may interact with variable lymphocyte receptor B (VLRB) in a complex with antigens and mediate ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 111:103750]

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Grouper PKR activation inhibits red-spotted grouper nervous necrosis virus (RGNNV) replication in infected cells.

Jingguang Wei, Shaoqing Zang, Chen Li, Xin Zhang, Pin Gao, Qiwei Qin,

The double-stranded RNA-activated protein kinase (PKR) is a Type I interferon (IFN) stimulated gene that has important biological and immunological functions. In viral infections, PKR inhibits or promotes viral replication. In the present study, PKR homologues of orange-spotted grouper (Epinephelus coioides) (EcPKR) were cloned and the involvement of EcPKR during ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 111:103744]

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Pattern recognition receptors in grass carp Ctenopharyngodon idella: II. Organization and expression analysis of NOD-like receptors.

Tianbing Xu, Zhiwei Liao, Jianguo Su,

Nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs) are a pivotal intracellular pattern recognition receptor family. However, studies on NLR genes in important economic fish grass carp (Ctenopharyngodon idella) are sporadic. The accumulations of genomic resource and transcriptomic sequences make it feasible to conduct a systematic analysis of these genes. ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 110:103734]

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Identification and functional characterization of ribosomal protein S23 as a new member of antimicrobial protein.

Zengyu Ma, Baozhen Qu, Lan Yao, Zhan Gao, Shicui Zhang,

Previous studies show that some ribosomal proteins possess antimicrobial peptide (AMP) activity. However, information as such remains rather fragmentary and rather limited. We showed here for the first time that amphioxus RPS23, BjRPS23, was a previously uncharacterized AMP. It not only acted as a pattern recognition receptor, capable of identifying ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 110:103730]

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Molecular evolution and functional characterization of SOCS3a and SOCS3b in miiuy croaker (Miichthys miiuy).

Ruixuan Huo, Qing Chu, Xueyan Zhao, Xuezhu Liu, Tianjun Xu,

The suppressor of cytokine signaling 3 (SOCS3), as a negative regulator in inferferon (IFN) signaling pathways in mammals, has a vital role in immune systems. However, studies on the function of SOCS3 in lower vertebrates are limited. In this study, we identified SOCS3a and fish-specific SOCS3b gene in miiuy croaker. ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 110:103723]

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The innate immune gene Relish and Caudal jointly contribute to the gut immune homeostasis by regulating antimicrobial peptides in Galleria mellonella.

Mehdi Sarvari, Azam Mikani, Mohammad Mehrabadi,

Gut microbiota modulates various physiologic processes in insects, such as nutrition, metabolic homeostasis, and pathogen exclusion. Maintaining a normal microbiome is an essential element of the gut homeostasis, requiring an extensive network of regulatory immune responses. The molecular mechanisms driving these various effects and the events leading to the establishment ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 110:103732]

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Black carp RIPK1 negatively regulates MAVS-mediated antiviral signaling during the innate immune activation.

Xinchi Xie, Yingyi Cao, Yuhan Dai, Zhaoyuan Chen, Jing Wei, Yaqi Tan, Hui Wu, Hao Feng,

Receptor-interacting serine/threonine protein kinase 1 (RIPK1) is an important regulator of necroptosis and involved in innate immune response in human and mammal; however, its function in teleost fish mains largely unknown. In this paper, the RIPK1 homologue of black carp (Mylopharyngodon piceus) has been cloned and characterized to explore its ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 109:103726]

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Splicing variants of grass carp (Ctenopharyngodon idellus) IL-21: Functions in IgM+ B cell proliferation and IgM secretion.

Zheng-Wei Cui, Xiang-Yang Zhang, Xiao-Hua Chen, Xu-Jie Zhang, Yong-An Zhang,

In mammals, interleukin 21 (IL-21) is a type I four-helical bundle cytokine produced by activated T cells that has pleiotropic functions on immune cells. Although IL-21 has been discovered in fish, the splicing variants of this cytokine and their functions on B cells are unclear. In this study, based on ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 110:103728]

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B-type allatostatin modulates immune response in hepatopancreas of the mud crab Scylla paramamosain.

Zhanning Xu, Yujie Wei, Songlin Guo, Dongdong Lin, Haihui Ye,

B-type allatostatin (AST-B) is a pleiotropic neuropeptide, widely found in arthropods. However, the information about its immune effect in crustaceans is unknown. In this study, we identified the nervous tissue as the main site for Sp-AST-B expression, while its receptor gene (Sp-AST-BR) is widely expressed in various tissues, including the ... Read more >>

Dev. Comp. Immunol. (Developmental and comparative immunology)
[2020, 110:103725]

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